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RCB1126 : MC3T3-E1  update : 2018/07/06
CommentDifferentiate to osteoblasts. Collagen producing.
Comment from the depositor
Restriction (Category)a
Terms and conditionsBasically, there is no restriction regarding academic use.
Remarks
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor Kodama, Hiroaki
Originator Kodama, Hiroaki
Year of deposit 1994
Original cell MC3T3-E1
Animal mouse < Mammals
Strain name C57BL/6
Gender Unknown
Age at sampling 0 day
Tissue newborn, calvaria
Classification other
Lifespan infinite
Morphology fibroblast-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives MEM ALPHA + 10% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 4 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Animal PCR OK
SSLP (mouse) OK
Images
deposit info
lot info
Reference information Reference 8
User's Publication 320


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Reference
Kodama,H., Amagai,Y., Sudo,H., Kasai,S. and Yamamoto,S.    Jpn J Oral Biol  1981  23:899-901 
Yamaguchi A, Katagiri T, Ikeda T, Wozney, J M, Rosen V, Wang, E A, Kahn, A J, Suda T, Yoshiki S    J cell Biol  1991  113:681-687 
Hiura K, Sumitani K, Kawata T, Higashino K, Okawa M, Sato T, Hakeda Y, Kumegawa M  Mouse osteoblastic cells (MC3T3-E1) at different stages of differentiation have opposite effects on osteoclastic cell formation.  Endocrinology  1991  128:1630-7 
Hakeda Y, Nakatani Y, Hiramatsu M, Kurihara N, Tsunoi M, Ikeda E, Kumegawa M  Inductive effects of prostaglandins on alkaline phosphatase in osteoblastic cells, clone MC3T3-E1  J Biochem (Tokyo)  1985  97:97-104 
Sudo H, Kodama, H A, Amagai Y, Yamamoto S, Kasai S    J Cell Biochem  1983  69:191-198 
Zhou, H Y, Takita H, Fujisawa R, Mizuno M, Kuboki Y  Stimulation by bone sialoprotein of calcification in osteoblast-like MC3T3-E1 cells.  Calcif Tissue Int  1995  56:403-7 
Kobayashi T, Sugimoto T, Saijoh K, Fukase M, Chihara K  Calcitonin directly acts on mouse osteoblastic MC3T3-E1 cells to stimulate mRNA expression of c-fos, insulin-like growth factor-1 and osteoblastic phenotypes (type 1 collagen and osteocalcin).  Biochem Biophys Res Commun  1994  199:876-80 
Tsukamoto T, Matsui T, Takaishi T, Ito M, Fukase M, Chihara K  Retinoic acid differentially affects platelet-derived growth factor-regulated cell growth of mouse osteoblast-like cells  Cell Growth Differ  1994  5:207-212 

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User's Publication
Ouyang, Xinshou, Fujimoto, Minoru, Nakagawa, Reiko, Serada, Satoshi, Tanaka, Toshio, Nomura, Shintaro, Kawase, Ichiro, Kishimoto, Tadamitsu, Naka, Tetsuji  SOCS-2 interferes with myotube formation and potentiates osteoblast differentiation through upregulation of JunB in C2C12 cells.  J Cell Physiol  2006  207:428-36  PubMed ID: 16419040
Motokawa M, Kaku M, Tohma Y, Kawata T, Fujita T, Kohno S, Tsutsui K, Ohtani J, Tenjo K, Shigekawa M, Kamada H, Tanne K  Effects of cyclic tensile forces on the expression of vascular endothelial growth factor (VEGF) and macrophage-colony-stimulating factor (M-CSF) in murine osteoblastic MC3T3-E1 cells.  J Dent Res  2005  84:422-7  PubMed ID: 15840777
Kato, H., Ypnezawa, T., Shirai, H., Sano, K., Abe, M.  An Improved Method for the Evaluation of the Effects of Laser Irradiation on Cultured Osteoblastic Cells  Bull Osaka Med Coll  1998  44:19-26 
Arai M., Nagasawa T., Tsunashima Y., Matsuda T., Kawamura H., Mogi M., Togari A  A simple and useful method for evaluating biocompatibility of titanium alloy with heterotopic bone induced by demineralized bone matrix (DBM) pellet in mice  Oral Therapeutics Pharmacology   2003  22:117-125 
Sogo, Y. et al  Zinc containing hydroxyapatite ceramics to promote osteoblastic cell activity  Materials Schience and Technology  2004  20:1079-1083 
Arai M., Kinpara K., Takeuchi T., Tsuboi T., Togari A.  The release of alkaline phosphatase from osteoblastic cells stimulated by calcium ionophore A23187  Asia Pacific J of Pharmacology  2000  14:117-119 
Adachi, T. et al  Effect of Actin Filament on Deformation-Induced Ca2+ Response in Osteoblast-Like Cells  JSME International Journal, Series C  2001  44:914-919 
Inoue M, LeGeros RZ, Inoue M, Tsujigiwa H, Nagatsuka H, Yamamoto T, Nagai N  In vitro response of osteoblast-like and odontoblast-like cells to unsubstituted and substituted apatites  J Biomed Mater Res  2004  70A:585-593  PubMed ID: 15307163
Sakiyama H, Nonaka T, Masuda R, Inoue N, Kuboki Y, Iijima M, Hirabayasi Y, Takahagi M, Yoshida K, Kuriiwa K, Yoshida M, Imajoh-Ohmi S  Characterization of mineral deposits formed in cultures of a hamster tartrate-resistant acid phosphatase (TRAP) and alkaline phosphatase (ALP) double-positive cell line (CCP).  Cell Tissue Res  2002  309:269-79  PubMed ID: 12172786
Fukuyama R, Fujita T, Azuma Y, Hirano A, Nakamuta H, Koida M, Komori T  Statins inhibit osteoblast migration by inhibiting Rac-Akt signaling.  Biochem Biophys Res Commun  2004  315:636-42  PubMed ID: 14975748
Notoya M, Otsuka E, Yamaguchi A, Hagiwara H  Runx-2 is not essential for the vitamin D-regulated expression of RANKL and osteoprotegerin in osteoblastic cells.  Biochem Biophys Res Commun  2004  324:655-60  PubMed ID: 15474477
Kim SW, Her SJ, Kim SY, Shin CS  Ectopic overexpression of adipogenic transcription factors induces transdifferentiation of MC3T3-E1 osteoblasts.  Biochem Biophys Res Commun  2005  327:811-9  PubMed ID: 15649418
Nobta M, Tsukazaki T, Shibata Y, Xin C, Moriishi T, Sakano S, Shindo H, Yamaguchi A  Critical regulation of bone morphogenetic protein-induced osteoblastic differentiation by Delta1/Jagged1-activated Notch1 signaling.  J Biol Chem  2005  280:15842-8  PubMed ID: 15695512
Adachi T, Sato K, Tomita Y  Directional dependence of osteoblastic calcium response to mechanical stimuli.  Biomech Model Mechanobiol  2003  2:73-82  PubMed ID: 14586810
Sato K, Adachi T, Matsuo M, Tomita Y  Quantitative evaluation of threshold fiber strain that induces reorganization of cytoskeletal actin fiber structure in osteoblastic cells.  J Biomech  2005  38:1895-901  PubMed ID: 16023478
Mogi M, Togari A  Activation of caspases is required for osteoblastic differentiation.  J Biol Chem  2003  278:47477-82  PubMed ID: 12954609
Mogi M, Ozeki N, Nakamura H, Togari A  Dual roles for NF-kappaB activation in osteoblastic cells by serum deprivation: osteoblastic apoptosis and cell-cycle arrest.  Bone  2004  35:507-16 
Kinpara K, Mogi M, Kuzushima M, Togari A, Kinpara K, Mogi M, Kuzushima M, Togari A, Kinpara K, Mogi M, Kuzushima M, Togari A  Osteoclast differentiation factor in human osteosarcoma cell line.  J Immunoassay  2000  21:327-40 
Inoue H, Nishimura K, Oka D, Nakai Y, Shiba M, Tokizane T, Arai Y, Nakayama M, Shimizu K, Takaha N, Nonomura N, Okuyama A  Prostate cancer mediates osteoclastogenesis through two different pathways.  Cancer Lett  2005  223:121-8  PubMed ID: 15890244
Kawate H, Wu Y, Ohnaka K, Nawata H, Takayanagi R  Tob proteins suppress steroid hormone receptor-mediated transcriptional activation.  Mol Cell Endocrinol  2005  230:77-86  PubMed ID: 15664454
Fujishige K, Yanaka N, Akatsuka H, Omori K  Localization of clearance receptor in rat lung and trachea : association with chondrogenic differentiation  Am J Physiol  1998  274(3 Pt 1):425-431 
Yamamoto S, Mogi M, Kinpara K, Ishihara Y, Ueda N, Amano K, Nishihara T, Noguchi T, Togari A  Anti-proliferative capsular-like polysaccharide antigen from Actinobacillus actinomycetemcomitans induces apoptotic cell death in mouse osteoblastic MC3T3-E1 cells.  J Dent Res  1999  78:1230-7 
Mogi M, Kinpara K, Kondo A, Togari A  Involvement of nitric oxide and biopterin in proinflammatory cytokine-induced apoptotic cell death in mouse osteoblastic cell line MC3T3-E1.  Biochem Pharmacol  1999  58:649-54 
Yuhara S, Kasagi S, Inoue A, Otsuka E, Hirose S, Hagiwara H  Effects of nicotine on cultured cells suggest that it can influence the formation and resorption of bone.  Eur J Pharmacol  1999  383:387-93 
Mogi M, Kondo A, Kinpara K, Togari A  Anti-apoptotic action of nerve growth factor in mouse osteoblastic cell line.  Life Sci  2000  67:1197-206 
Maeda T, Abe M, Kurisu K, Jikko A, Furukawa S  Molecular cloning and characterization of a novel gene, CORS26, encoding a putative secretory protein and its possible involvement in skeletal development.  J Biol Chem  2001  276:3628-34 
Fujita T, Izumo N, Fukuyama R, Meguro T, Nakamuta H, Kohno T, Koida M  Phosphate provides an extracellular signal that drives nuclear export of Runx2/Cbfa1 in bone cells.  Biochem Biophys Res Commun  2001  280:348-52 
Taira M, Nakao H, Matsumoto T, Takahashi J  Cytotoxic effect of methyl methacrylate on 4 cultured fibroblasts.  Int J Prosthodont  2000  13:311-5 
Kusumi T, Nishi T, Tanaka M, Tsuchida S, Kudo H  A murine osteosarcoma cell line with a potential to develop ossification upon transplantation  Jpn J Cancer Res  2001  92:649-658 
Sakiyama H, Masuda R, Inoue N, Yamamoto K, Kuriiwa K, Nakagawa K, Yoshida K  Establishment and characterization of macrophage-like cell lines expressing osteoclast-specific markers.  J Bone Miner Metab  2001  19:220-7 
Ozeki, Nobuaki, Mogi, Makio, Nakamura, Hiroshi, Togari, Akifumi  Differential expression of the Fas-Fas ligand system on cytokine-induced apoptotic cell death in mouse osteoblastic cells.  Arch Oral Biol  2002  47:511-7  PubMed ID: 12208075
Zhang, Gui Xia, Mizuno, Morimichi, Tsuji, Kiyomi, Tamura, Masato  Regulation of mRNA expression of matrix extracellular phosphoglycoprotein (MEPE)/ osteoblast/osteocyte factor 45 (OF45) by fibroblast growth factor 2 in cultures of rat bone marrow-derived osteoblastic cells.  Endocrine  2004  24:15-24  PubMed ID: 15249699
French, Dorothy M, Kaul, Raji J, D'Souza, Aloma L, Crowley, Craig W, Bao, Min, Frantz, Gretchen D, Filvaroff, Ellen H, Desnoyers, Luc  WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair.  Am J Pathol  2004  165:855-67  PubMed ID: 15331410
Ito, Mikiko, Sakai, Yuko, Furumoto, Mari, Segawa, Hiroko, Haito, Sakiko, Yamanaka, Setsuko, Nakamura, Rie, Kuwahata, Masashi, Miyamoto, Ken-ichi  Vitamin D and phosphate regulate fibroblast growth factor-23 in K-562 cells.  Am J Physiol Endocrinol Metab  2005  288:E1101-9  PubMed ID: 15671080
Keselowsky, Benjamin G, Collard, David M, Garcia, Andres J  Integrin binding specificity regulates biomaterial surface chemistry effects on cell differentiation.  Proc Natl Acad Sci U S A  2005  102:5953-7  PubMed ID: 15827122
M Azadi, A Teimouri, G Mehranzadeh  Preparation, characterization and biocompatible properties of β-chitin/silk fibroin/nanohydroxyapatite composite scaffolds prepared by freeze-drying method.  RSC Adv  2016  6:7048-7060 
Demirta? TT, Goz E, Karakecili A, Gumu?derelio?lu M.  Combined delivery of PDGF-BB and BMP-6 for enhanced osteoblastic differentiation.  J Mater Sci Mater Med  2015  27:12  PubMed ID: 26676858
Shirakawa J, Harada H, Noda M, Ezura Y.  PTH-Induced Osteoblast Proliferation Requires Upregulation of the Ubiquitin-Specific Peptidase 2 (Usp2) Expression.  Calcif. Tissue Int.  2015  98:306-15  PubMed ID: 26643174
Valanezhad A, Odatsu T, Udoh K, Shiraishi T, Sawase T, Watanabe I.  Modification of resin modified glass ionomer cement by addition of bioactive glass nanoparticles.  J Mater Sci Mater Med  2015  27:3  PubMed ID: 26610926
Nishide Y, Tousen Y, Tadaishi M, Inada M, Miyaura C, Kruger MC, Ishimi Y.  Combined Effects of Soy Isoflavones and β-Carotene on Osteoblast Differentiation.  Int J Environ Res Public Health  2015  12:13750-61  PubMed ID: 26516892
Yoneshima E, Okamoto K, Sakai E, Nishishita K, Yoshida N, Tsukuba T.  The Transcription Factor EB (TFEB) Regulates Osteoblast Differentiation Through ATF4/CHOP-Dependent Pathway.  J. Cell. Physiol.  2015  231:1321-33  PubMed ID: 26519689
Chen P, Nagai A, Tsutsumi Y, Ashida M, Doi H, Hanawa T.  Differences in the calcification of preosteoblast cultured on sputter-deposited titanium, zirconium, and gold.  J Biomed Mater Res A  2015  104:639-651  PubMed ID: 26488234
Nakamoto T, Izu Y, Kawasaki M, Notomi T, Hayata T, Noda M, Ezura Y.  Mice Deficient in CIZ/NMP4 Develop an Attenuated Form of K/BxN-Serum Induced Arthritis.  J. Cell. Biochem.  2015  117:970-7  PubMed ID: 26378628
Yang YJ, Tsou HK, Chen YH, Chung CJ, He JL.  Enhancement of bioactivity on medical polymer surface using high power impulse magnetron sputtered titanium dioxide film.  Mater Sci Eng C Mater Biol Appl  2015  57:58-66  PubMed ID: 26354240
Inoue K, Imai Y.  Fatostatin, an SREBP inhibitor, prevented RANKL-induced bone loss by suppression of osteoclast differentiation.  Biochim. Biophys. Acta  2015  1852:2432-41  PubMed ID: 26319416
Noguchi T, Ebina K, Hirao M, Kawase R, Ohama T, Yamashita S, Morimoto T, Koizumi K, Kitaguchi K, Matsuoka H, Kaneshiro S, Yoshikawa H.  Progranulin plays crucial roles in preserving bone mass by inhibiting TNF-α-induced osteoclastogenesis and promoting osteoblastic differentiation in mice.  Biochem. Biophys. Res. Commun.  2015  465:638-43  PubMed ID: 26297947
Taniguchi Y, Kakura K, Yamamoto K, Kido H, Yamazaki J.  Accelerated Osteogenic Differentiation and Bone Formation on Zirconia with Surface Grooves Created with Fiber Laser Irradiation.  Clin Implant Dent Relat Res  2015  18:883-894  PubMed ID: 26179832
Uchino K, Okamoto K, Sakai E, Yoneshima E, Iwatake M, Fukuma Y, Nishishita K, Tsukuba T.  Dual Effects of Liquiritigenin on the Proliferation of Bone Cells: Promotion of Osteoblast Differentiation and Inhibition of Osteoclast Differentiation.  Phytother Res  2015  29:1714-21  PubMed ID: 26172226
Wang CH, Guo ZS, Pang F, Zhang LY, Yan M, Yan JH, Li KW, Li XJ, Li Y, Bi L, Han YS.  Effects of graphene modification on the bioactivation of polyethylene-terephthalate-based artificial ligaments.  ACS Appl Mater Interfaces  2015  7:15263-76  PubMed ID: 26111253
Hatano M, Matsumoto Y, Fukushi J, Matsunobu T, Endo M, Okada S, Iura K, Kamura S, Fujiwara T, Iida K, Fujiwara Y, Nabeshima A, Yokoyama N, Fukushima S, Oda Y, Iwamoto Y.  Cadherin-11 regulates the metastasis of Ewing sarcoma cells to bone.  Clin. Exp. Metastasis  2015  32:579-91  PubMed ID: 26092671
Fukuda K, Sugihara E, Ohta S, Izuhara K, Funakoshi T, Amagai M, Saya H.  Periostin Is a Key Niche Component for Wound Metastasis of Melanoma.  PLoS ONE  2015  10:e0129704  PubMed ID: 26083413
Tanaka K, Hirai T, Ishibashi Y, Izumo N, Togari A.  Modulation of osteoblast differentiation and bone mass by 5-HT2A receptor signaling in mice.  Eur. J. Pharmacol.  2015  762:150-7  PubMed ID: 26026645
Gumu?derelio?lu M, Tuncay EO, Kaynak G, Demirta? TT, Ayd?n ST, Hakk? SS.  Encapsulated boron as an osteoinductive agent for bone scaffolds.  J Trace Elem Med Biol  2015  31:120-8  PubMed ID: 26004902
Kaneshiro S, Otsuki D, Yoshida K, Yoshikawa H, Higuchi C.  MEK5 suppresses osteoblastic differentiation.  Biochem. Biophys. Res. Commun.  2015  463:241-7  PubMed ID: 25998381
Yang D, Okamura H, Teramachi J, Haneji T.  Histone demethylase Utx regulates differentiation and mineralization in osteoblasts.  J. Cell. Biochem.  2015  116:2628-36  PubMed ID: 25920016
Lin H, Gao X, Chen G, Sun J, Chu J, Jing K, Li P, Zeng R, Wei B.  Indole-3-carbinol as inhibitors of glucocorticoid-induced apoptosis in osteoblastic cells through blocking ROS-mediated Nrf2 pathway.  Biochem. Biophys. Res. Commun.  2015  460:422-7  PubMed ID: 25795137
Terasawa K, Rajapakshe AR, Podyma-Inoue KA, Mishima-Tsumagari C, Yanagishita M, Hara-Yokoyama M.  Preferential recognition of isocitrate dehydrogenase by a rabbit monoclonal antibody (ab124797) against the C-terminal peptide of RANKL.  J. Immunol. Methods  2015  420:1-10  PubMed ID: 25771969
Siddiqi MZ, Siddiqi MH, Kim YJ, Jin Y, Huq MA, Yang DC.  Effect of Fermented Red Ginseng Extract Enriched in Ginsenoside Rg3 on the Differentiation and Mineralization of Preosteoblastic MC3T3-E1 Cells.  J Med Food  2015  18:542-8  PubMed ID: 25764149
Koike T, Mikami T, Shida M, Habuchi O, Kitagawa H.  Chondroitin sulfate-E mediates estrogen-induced osteoanabolism.  Sci Rep  2015  5:8994  PubMed ID: 25759206
Yamamura K, Miura T, Kou I, Muramatsu T, Furusawa M, Yoshinari M.  Influence of various superhydrophilic treatments of titanium on the initial attachment, proliferation, and differentiation of osteoblast-like cells.  Dent Mater J  2015  34:120-7  PubMed ID: 25748468
Saito T, Teraoka K, Ota K.  Arrayed three-dimensional structures designed to induce and maintain a cell pattern by a topographical effect on cell behavior.  Mater Sci Eng C Mater Biol Appl  2015  49:256-61  PubMed ID: 25686947
Okito A, Nakahama K, Akiyama M, Ono T, Morita I.  Involvement of the G-protein-coupled receptor 4 in RANKL expression by osteoblasts in an acidic environment.  Biochem. Biophys. Res. Commun.  2015  458:435-40  PubMed ID: 25668130
Abbas Teimouri, Mohammad Azadi, Rahmatollah Emadi, Jalil Lari, Alireza Najafi Chermahini  Preparation, characterization, degradation and biocompatibility of different silk fibroin based composite scaffolds prepared by freeze-drying method for tissue engineering application.  Polym Degrad Stab  2015  121:18-29 
Hsien-Te Chen, Hui-Ying Shu, Chi-Jen Chung, Ju-Liang He  Assessment of Bone Morphogenic Protein and Hydroxyapatite-Titanium Dioxide Composites for Bone Implant Materials.  Surface and Coatings Technology  2015  276:168-174 
Katsuya SATO, Yuki OGAWA, Shin-ichi ITO, Shoichiro FUJISAWA, Kazuyuki MINAMI  Strain magnitude dependent intracellular calcium signaling response to uniaxial stretch in osteoblastic cells.  J Biomechanical Science and Engineering  2015  10:p.15-00242 
L.T. Bang, S. Ramesha,. Purbolaksono, Y.C. Chinga, B.D. Long, Hari Chandran, S. Rameshc, R. Othmand  Effects of silicate and carbonate substitution on the properties of hydroxyapatite prepared by aqueous co-precipitation method.  Materials and Design  2015  87:788?796 
M. Hirano, M. Yamane, N. Ohtsu  Surface characteristics and cell-adhesion performance of titanium treated with direct-current gas plasma comprising nitrogen and oxygen.  Appl Surf Sci.   2015  354:161-167 
Megumi Fuse, Tohru Hayakawa, Tomomi Hashizume-Takizawa, Reiri Takeuchi, Tomoko Kurita-Ochiai, Junko Fujita-Yoshigaki, Masahiko Fukumoto  MC3T3-E1 Cell Assay on Collagen or Fibronectin Immobilized Poly (Lactic Acid-ε-Caprolactone) Film.  J Hard Tissue Biology  2015  24:249-256 
Momoko Takahashi, Masaru Yamaguchi, Yasuhiro Tanimoto, Eriko Yao-Umezawa, Kazutaka Kasai  Biological Evaluation of a Prototype Material made of Polyglycolic Acid and Hydroxyapatite.  J Hard Tissue Biology  2015  24:375-384 
Naofumi Ohtsu, Taro Kozuka, Mitsuhiro Hirano, Hirofumi Arai  Electrolyte effects on the surface chemistry and cellular response of anodized titanium.  Appl Surf Sci.   2015  349:911-915 
Takaaki Arahira, Mitsugu Todo.  Effects of osteoblast-like cell seeding on the mechanical properties of porous composite scaffolds.  Advanced Composite Materials  2015  24:79-90 
Yun Kee Jo, Bong-Hyuk Choi, Cong Zhou, Jin-Soo Ahn, Sang Ho Jun, Hyung Joon Cha  Bioengineered mussel glue incorporated with a cell recognition motif as an osteostimulating bone adhesive for titanium implants.  J Mater Chem B.  2015  3:8102-8114 
Masuda E, Shirai K, Maekubo K, Hirai Y.  A newly established culture method highlights regulatory roles of retinoic acid on morphogenesis and calcification of mammalian limb cartilage.  BioTechniques  2014  58:318-24  PubMed ID: 26054768
Aira Matsugaki, Gento Aramoto, Takayoshi Nakano  The alignment of MC3T3-E1 osteoblasts on steps of slip traces introduced by dislocation motion  Biomaterials  2012  33・30:7327-7335 
Inaguma T, Han J, Isoda H.  Improvement of insulin resistance by Cyanidin 3-glucoside, anthocyanin from black beans through the up-regulation of GLUT4 gene expression.  BMC Proc  2012  5 Suppl 8:P21  PubMed ID: 22373152
Odkhuu E, Koide N, Haque A, Tsolmongyn B, Naiki Y, Hashimoto S, Komatsu T, Yoshida T, Yokochi T.  Inhibition of receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation by pyrroloquinoline quinine (PQQ).  Immunol. Lett.  2011  142:34-40  PubMed ID: 22193059
Wei K, Li Y, Mugishima H, Teramoto A, Abe K.  Fabrication of core-sheath structured fibers for model drug release and tissue engineering by emulsion electrospinning.  Biotechnol J  2011  7:677-85  PubMed ID: 22125296
Skrtic D, Antonucci JM.  Bioactive polymeric composites for tooth mineral regeneration: physicochemical and cellular aspects.  J Funct Biomater  2011  2:271-307  PubMed ID: 22102967
Han SH, Kim KH, Han JS, Koo KT, Kim TI, Seol YJ, Lee YM, Ku Y, Rhyu IC.  Response of osteoblast-like cells cultured on zirconia to bone morphogenetic protein-2.  J Periodontal Implant Sci  2011  41:227-33  PubMed ID: 22087413
Kim DY, Park YG, Quan HY, Kim SJ, Jung MS, Chung SH.  Ginsenoside Rd stimulates the differentiation and mineralization of osteoblastic MC3T3-E1 cells by activating AMP-activated protein kinase via the BMP-2 signaling pathway.  Fitoterapia  2011  83:215-22  PubMed ID: 22061660
Watanabe K, Tsunoda K, Itoh M, Fukui M, Mori H, Hitomi K.  Transglutaminase 2 and Factor XIII catalyze distinct substrates in differentiating osteoblastic cell line: utility of highly reactive substrate peptides.  Amino Acids  2011  44:209-14  PubMed ID: 22045386
Takeuchi N, Machigashira M, Yamashita D, Shirakata Y, Kasuga T, Noguchi K, Ban S.  Cellular compatibility of a gamma-irradiated modified siloxane-poly(lactic acid)-calcium carbonate hybrid membrane for guided bone regeneration.  Dent Mater J  2011  30:730-8  PubMed ID: 21946495
Choi EM.  Deoxyactein stimulates osteoblast function and inhibits bone-resorbing mediators in MC3T3-E1 cells.  J Appl Toxicol  2011  33:190-5  PubMed ID: 21910134
Choi BH, Choi YS, Hwang DS, Cha HJ.  Facile surface functionalization with glycosaminoglycans by direct coating with mussel adhesive protein.  Tissue Eng Part C Methods  2011  18:71-9  PubMed ID: 21895565
Kriebitzsch C, Verlinden L, Eelen G, van Schoor NM, Swart K, Lips P, Meyer MB, Pike JW, Boonen S, Carlberg C, Vitvitsky V, Bouillon R, Banerjee R, Verstuyf A.  1,25-dihydroxyvitamin D3 influences cellular homocysteine levels in murine preosteoblastic MC3T3-E1 cells by direct regulation of cystathionine β-synthase.  J. Bone Miner. Res.  2011  26:2991-3000  PubMed ID: 21898591
Takahata Y, Takarada T, Hinoi E, Nakamura Y, Fujita H, Yoneda Y.  Osteoblastic γ-aminobutyric acid, type B receptors negatively regulate osteoblastogenesis toward disturbance of osteoclastogenesis mediated by receptor activator of nuclear factor κB ligand in mouse bone.  J. Biol. Chem.  2011  286:32906-17  PubMed ID: 21828041
Yoshida K, Higuchi C, Nakura A, Yoshikawa H.  Spleen tyrosine kinase suppresses osteoblastic differentiation through MAPK and PKCα.  Biochem. Biophys. Res. Commun.  2011  411:774-9  PubMed ID: 21782794
Ren G, Wang K, Chang R, Su Y, Wang J, Su J, Han B.  Simultaneous administration of fluoride and selenite regulates proliferation and apoptosis in murine osteoblast-like MC3T3-E1 cells by altering osteoprotegerin.  Biol Trace Elem Res  2011  144:1437-48  PubMed ID: 21739163
Tsukasaki M, Yamada A, Suzuki D, Aizawa R, Miyazono A, Miyamoto Y, Suzawa T, Takami M, Yoshimura K, Morimura N, Yamamoto M, Kamijo R.  Expression of POEM, a positive regulator of osteoblast differentiation, is suppressed by TNF-α.  Biochem. Biophys. Res. Commun.  2011  410:766-70  PubMed ID: 21689636
Furugaki K, Moriya Y, Iwai T, Yorozu K, Yanagisawa M, Kondoh K, Fujimoto-Ohuchi K, Mori K.  Erlotinib inhibits osteolytic bone invasion of human non-small-cell lung cancer cell line NCI-H292.  Clin. Exp. Metastasis  2011  28:649-59  PubMed ID: 21688034
Okamura H, Yoshida K, Ochiai K, Haneji T.  Reduction of protein phosphatase 2A Cα enhances bone formation and osteoblast differentiation through the expression of bone-specific transcription factor Osterix.  Bone  2011  49:368-75  PubMed ID: 21683816
Kataoka Y, Tamaki Y, Miyazaki T.  Synergistic responses of superficial chemistry and micro topography of titanium created by wire-type electric discharge machining.  Biomed Mater Eng  2011  21:113-21  PubMed ID: 21654067
Zhang W, Wang H, Oyane A, Tsurushima H, Chu PK.  Osteoblast differentiation and disinfection induced by nitrogen plasma-treated surfaces.  Biomed Mater Eng  2011  21:75-82  PubMed ID: 21654064
Tagaya M, Ikoma T, Takemura T, Hanagata N, Yoshioka T, Tanaka J.  Effect of interfacial proteins on osteoblast-like cell adhesion to hydroxyapatite nanocrystals.  Langmuir  2011  27:7645-53  PubMed ID: 21615097
Tagaya M, Ikoma T, Takemura T, Hanagata N, Okuda M, Yoshioka T, Tanaka J.  Detection of interfacial phenomena with osteoblast-like cell adhesion on hydroxyapatite and oxidized polystyrene by the quartz crystal microbalance with dissipation.  Langmuir  2011  27:7635-44  PubMed ID: 21595447
Yonezawa T, Lee JW, Hibino A, Asai M, Hojo H, Cha BY, Teruya T, Nagai K, Chung UI, Yagasaki K, Woo JT.  Harmine promotes osteoblast differentiation through bone morphogenetic protein signaling.  Biochem. Biophys. Res. Commun.  2011  409:260-5  PubMed ID: 21570953
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