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RCB1003 : MKN1  update : 2018/07/06
CommentPotentially differentiatable to both direction of adenomatous and squamous epithelial cells.
Comment from the depositor
Restriction (Category)a
Terms and conditionsBasically, there is no restriction regarding academic use.
Remarks
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor Motoyama, Teiichi
Originator Hojo, Haruto
Year of deposit 1994
Animal human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Male
Age at sampling 72 years
Tissue stomach, lymph node meta
Case history Gastric cancer.
Metastastatic ability Yes
Metastatsd tissue lymph node
Classification cancer
Year of origin 1975
History Hojo, Haruto - Motoyama, Teiichi
Lifespan infinite
Morphology epithelial-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR (human) OK
Virus (HIV) (-)
Isozyme LD, NP
Chromosome mode 63-71(50) : /65(5),66(5),67(6),68(5),69(17),70(6)/
Images
deposit info
lot info
Reference information Reference 1
User's Publication 15


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Reference
Aizawa K, Motoyama T, Watanabe H  Placental alkaline phosphatase-like isoenzymes produced by human gastric cancer cells.  Acta Pathol Jpn  1989  39:630-7 

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User's Publication
Shida D, Kitayama J, Yamaguchi H, Hama K, Aoki J, Arai H, Yamashita H, Mori K, Sako A, Konishi T, Watanabe T, Sakai T, Suzuki R, Ohta H, Takuwa Y, Nagawa H  Dual mode regulation of migration by lysophosphatidic acid in human gastric cancer cells.  Exp Cell Res  2004  301:168-78  PubMed ID: 15530853
Nishizuka S, Tamura G, Maesawa C, Sakata K, Suzuki Y, Iwaya T, Terashima M, Saito K, Satodate R  Analysis of the DPC4 gene in gastric carcinoma  Jpn J Cancer Res  1997  88:335-339 
Horie, Nobuyuki, Hirabayashi, Naomi, Takahashi, Yoshie, Miyauchi, Yuko, Taguchi, Hiroko, Takeishi, Keiichi  Synergistic effect of green tea catechins on cell growth and apoptosis induction in gastric carcinoma cells.  Biol Pharm Bull  2005  28:574-9  PubMed ID: 15802789
Kamoshida G, Matsuda A, Sekine W, Mizuno H, Oku T, Itoh S, Irimura T, Tsuji T.  Monocyte differentiation induced by co-culture with tumor cells involves RGD-dependent cell adhesion to extracellular matrix.  Cancer Lett.  2011  315:145-52  PubMed ID: 22104730
Hiraki M, Kitajima Y, Koga Y, Tanaka T, Nakamura J, Hashiguchi K, Noshiro H, Miyazaki K.  Aberrant gene methylation is a biomarker for the detection of cancer cells in peritoneal wash samples from advanced gastric cancer patients.  Ann. Surg. Oncol.  2011  18:3013-9  PubMed ID: 21409489
Ramachandran S, Shida D, Nagahashi M, Fang X, Milstien S, Takabe K, Spiegel S.  Lysophosphatidic acid stimulates gastric cancer cell proliferation via ERK1-dependent upregulation of sphingosine kinase 1 transcription.  FEBS Lett.  2010  584:4077-82  PubMed ID: 20804754
Seto M, Ohta M, Ikenoue T, Sugimoto T, Asaoka Y, Tada M, Mohri D, Kudo Y, Ijichi H, Tateishi K, Otsuka M, Hirata Y, Maeda S, Koike K, Omata M.  Reduced expression of RAS protein activator like-1 in gastric cancer.  Int. J. Cancer  2010  128:1293-302  PubMed ID: 20473946
Saito Y, Sekine W, Sano R, Komatsu S, Mizuno H, Katabami K, Shimada K, Oku T, Tsuji T.  Potentiation of cell invasion and matrix metalloproteinase production by alpha3beta1 integrin-mediated adhesion of gastric carcinoma cells to laminin-5.  Clin. Exp. Metastasis  2010  27:197-205  PubMed ID: 20352300
Nukuda A, Endoh H, Yasuda M, Mizutani T, Kawabata K, Haga H.  Role of ATF5 in the invasive potential of diverse human cancer cell lines.  Biochem. Biophys. Res. Commun.  2016  474:509-514  PubMed ID: 27125458
Deguchi Y, Okabe H, Oshima N, Hisamori S, Minamiguchi S, Muto M, Sakai Y.  PTEN loss is associated with a poor response to trastuzumab in HER2-overexpressing gastroesophageal adenocarcinoma.  Gastric Cancer  2017  20:416-427  PubMed ID: 27517839
Ito C, Nishizuka SS, Ishida K, Uesugi N, Sugai T, Tamura G, Koeda K, Sasaki A.  Analysis of PIK3CA mutations and PI3K pathway proteins in advanced gastric cancer.  J. Surg. Res.  2017  212:195-204  PubMed ID: 28550907
Devanand P, Oya Y, Sundaramoorthy S, Song KY, Watanabe T, Kobayashi Y, Shimizu Y, Hong SA, Suganuma M, Lim IK.  Inhibition of TNFα-interacting protein α (Tipα)-associated gastric carcinogenesis by BTG2/TIS21 via downregulating cytoplasmic nucleolin expression.  Exp. Mol. Med.  2018  50:e449  PubMed ID: 29472702
Wang Z, Qu H, Gong W, Liu A.  Up-regulation and tumor-promoting role of SPHK1 were attenuated by miR-330-3p in gastric cancer.  IUBMB Life  2018    PubMed ID: 30281914
Sekino N, Kano M, Matsumoto Y, Sakata H, Murakami K, Toyozumi T, Otsuka R, Yokoyama M, Shiraishi T, Okada K, Kamata T, Ryuzaki T, Matsubara H.  The Antitumor Effects of Metformin on Gastric Cancer In Vitro and on Peritoneal Metastasis.  Anticancer Res.  2018    PubMed ID: 30396946
Oku T, Shimada K, Kenmotsu H, Ando Y, Kurisaka C, Sano R, Tsuiji M, Hasegawa S, Fukui T, Tsuji T.  Stimulation of Peritoneal Mesothelial Cells to Secrete Matrix Metalloproteinase-9 (MMP-9) by TNF-α: A Role in the Invasion of Gastric Carcinoma Cells.  Int J Mol Sci  2018    PubMed ID: 30544870



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