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RCB1002 : MKN74  update : 2018/07/06
CommentModerately differentiated adenocarcinoma. Once they were hypodiploids. Cell growth is slow.
Comment from the depositor
Restriction (Category)a
Terms and conditionsBasically, there is no restriction regarding academic use.
Remarks
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor Motoyama, Teiichi
Originator Hojo, Haruo
Year of deposit 1994
Animal human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Male
Age at sampling 37 years
Tissue stomach, liver meta
Case history Gastric adenocarcinoma
Metastastatic ability Yes
Metastatsd tissue liver
Classification cancer
Year of origin 1975
History Hojo, Haruo - Motoyama, Teiichi
Lifespan infinite
Morphology epithelial-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 4 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR (human) OK
Virus (HIV) (-)
Virus (HBV) (-)
Virus (HCV) (-)
Isozyme LD, NP
Chromosome mode 42-49(50) : 42(2),45(4),46(10),47(25),48(7),49(2)
Images
deposit info
lot info
Reference information Reference 1
User's Publication 46


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Reference
1889  Motoyama T, Hojo H, Watanabe H  Comparison of seven cell lines derived from human gastric carcinomas.  Acta Pathol Jpn  1986  36:65-83  PubMed ID: 3962675

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User's Publication
3376  Shida, Dai, Kitayama, Joji, Mori, Ken, Watanabe, Toshiaki, Nagawa, Hirokazu  Transactivation of epidermal growth factor receptor is involved in leptin-induced activation of janus-activated kinase 2 and extracellular signal-regulated kinase 1/2 in human gastric cancer cells.  Cancer Res  2005  65:9159-63  PubMed ID: 16230373
2807  Shida D, Kitayama J, Yamaguchi H, Hama K, Aoki J, Arai H, Yamashita H, Mori K, Sako A, Konishi T, Watanabe T, Sakai T, Suzuki R, Ohta H, Takuwa Y, Nagawa H  Dual mode regulation of migration by lysophosphatidic acid in human gastric cancer cells.  Exp Cell Res  2004  301:168-78  PubMed ID: 15530853
2194  Nishizuka S, Tamura G, Maesawa C, Sakata K, Suzuki Y, Iwaya T, Terashima M, Saito K, Satodate R  Analysis of the DPC4 gene in gastric carcinoma  Jpn J Cancer Res  1997  88:335-339  PubMed ID: 9197522
3103  Adachi, Keiko, Osaki, Mitsuhiko, Kase, Satoru, Takeda, Ami, Ito, Hisao  Anti-Fas antibody-induced apoptosis and its signal transduction in human gastric carcinoma cell lines.  Int J Oncol  2003  23:713-9  PubMed ID: 12888908
3206  Wen, Xian-Zi, Miyake, Satoshi, Akiyama, Yoshimitsu, Yuasa, Yasuhito  BMP-2 modulates the proliferation and differentiation of normal and cancerous gastric cells.  Biochem Biophys Res Commun  2004  316:100-6  PubMed ID: 15003517
3105  Osaki M, Moriyama M, Adachi K, Nakada C, Takeda A, Inoue Y, Adachi H, Sato K, Oshimura M, Ito H  Expression of RUNX3 protein in human gastric mucosa, intestinal metaplasia and carcinoma.  Eur J Clin Invest  2004  34:605-12  PubMed ID: 15379759
3109  Honjo, Soichiro, Osaki, Mitsuhiko, Ardyanto, Tonang Dwi, Hiramatsu, Toshiki, Maeta, Noritaka, Ito, Hisao  COX-2 inhibitor, NS398, enhances Fas-mediated apoptosis via modulation of the PTEN-Akt pathway in human gastric carcinoma cell lines.  DNA Cell Biol  2005  24:141-7  PubMed ID: 15767780
3167  Horie, Nobuyuki, Hirabayashi, Naomi, Takahashi, Yoshie, Miyauchi, Yuko, Taguchi, Hiroko, Takeishi, Keiichi  Synergistic effect of green tea catechins on cell growth and apoptosis induction in gastric carcinoma cells.  Biol Pharm Bull  2005  28:574-9  PubMed ID: 15802789
7097  Otsuka S, Matsumoto K, Nakajima M, Tanaka T, Ogura S.  Oxygen Availability for Porphyrin Biosynthesis Enzymes Determines the Production of Protoporphyrin IX (PpIX) during Hypoxia.  PLoS ONE  2015  10:e0146026  PubMed ID: 26717566
7255  Nukatsuka M, Nakagawa F, Takechi T.  Efficacy of Combination Chemotherapy Using a Novel Oral Chemotherapeutic Agent, TAS-102, with Oxaliplatin on Human Colorectal and Gastric Cancer Xenografts.  Anticancer Res.  2015  35:4605-15  PubMed ID: 26254349
7512  Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N.  Gastric cancer cell proliferation is suppressed by frizzled-2 short hairpin RNA.  Int. J. Oncol.  2015  46:1018-24  PubMed ID: 25586465
7876  Hiraki M, Kitajima Y, Koga Y, Tanaka T, Nakamura J, Hashiguchi K, Noshiro H, Miyazaki K.  Aberrant gene methylation is a biomarker for the detection of cancer cells in peritoneal wash samples from advanced gastric cancer patients.  Ann. Surg. Oncol.  2011  18:3013-9  PubMed ID: 21409489
7937  Saito S, Tomida A.  Use of chemical genomics in assessment of the UPR.  Meth. Enzymol.  2011  491:327-41  PubMed ID: 21329808
7990  Aoki M, Ishigami S, Uenosono Y, Arigami T, Uchikado Y, Kita Y, Kurahara H, Matsumoto M, Ueno S, Natsugoe S.  Expression of BMP-7 in human gastric cancer and its clinical significance.  Br. J. Cancer  2011  104:714-8  PubMed ID: 21224856
8253  Seto M, Ohta M, Ikenoue T, Sugimoto T, Asaoka Y, Tada M, Mohri D, Kudo Y, Ijichi H, Tateishi K, Otsuka M, Hirata Y, Maeda S, Koike K, Omata M.  Reduced expression of RAS protein activator like-1 in gastric cancer.  Int. J. Cancer  2010  128:1293-302  PubMed ID: 20473946
8325  Otani K, Kitayama J, Kamei T, Soma D, Miyato H, Yamauchi T, Kadowaki T, Nagawa H.  Adiponectin receptors are downregulated in human gastric cancer.  J. Gastroenterol.  2010  45:918-27  PubMed ID: 20336470
8416  Nakamura J, Kitajima Y, Kai K, Hashiguchi K, Hiraki M, Noshiro H, Miyazaki K.  HIF-1alpha is an unfavorable determinant of relapse in gastric cancer patients who underwent curative surgery followed by adjuvant 5-FU chemotherapy.  Int. J. Cancer  2009  127:1158-71  PubMed ID: 20020496
8520  Kim JC, Shin ES, Kim CW, Roh SA, Cho DH, Na YS, Kim TW, Kim MB, Hyun YL, Ro S, Kim SY, Kim YS.  In vitro evaluation of histone deacetylase inhibitors as combination agents for colorectal cancer.  Anticancer Res.  2009  29:3027-34  PubMed ID: 19661311
8590  Miyato H, Kitayama J, Yamashita H, Souma D, Asakage M, Yamada J, Nagawa H.  Pharmacological synergism between cannabinoids and paclitaxel in gastric cancer cell lines.  J. Surg. Res.  2009  155:40-7  PubMed ID: 19394652
8930  Ohta M, Tateishi K, Kanai F, Watabe H, Kondo S, Guleng B, Tanaka Y, Asaoka Y, Jazag A, Imamura J, Ijichi H, Ikenoue T, Sata M, Miyagishi M, Taira K, Tada M, Kawabe T, Omata M.  p53-Independent negative regulation of p21/cyclin-dependent kinase-interacting protein 1 by the sonic hedgehog-glioma-associated oncogene 1 pathway in gastric carcinoma cells.  Cancer Res.  2005  65:10822-9  PubMed ID: 16322228
9573  Maeda Y, Echizen K, Oshima H, Yu L, Sakulsak N, Hirose O, Yamada Y, Taniguchi T, Jenkins BJ, Saya H, Oshima M.  Myeloid Differentiation Factor 88 Signaling in Bone Marrow-Derived Cells Promotes Gastric Tumorigenesis by Generation of Inflammatory Microenvironment.  Cancer Prev Res (Phila)  2016  9:253-63  PubMed ID: 26888865
9610  Saju P, Murata-Kamiya N, Hayashi T, Senda Y, Nagase L, Noda S, Matsusaka K, Funata S, Kunita A, Urabe M, Seto Y, Fukayama M, Kaneda A, Hatakeyama M.  Host SHP1 phosphatase antagonizes Helicobacter pylori CagA and can be downregulated by Epstein-Barr virus.  Nat Microbiol  2016  1:16026  PubMed ID: 27572445
9678  Kayamori K, Katsube K, Sakamoto K, Ohyama Y, Hirai H, Yukimori A, Ohata Y, Akashi T, Saitoh M, Harada K, Harada H, Yamaguchi A.  NOTCH3 Is Induced in Cancer-Associated Fibroblasts and Promotes Angiogenesis in Oral Squamous Cell Carcinoma.  PLoS ONE  2016  11:e0154112  PubMed ID: 27124156
9679  Narukawa Y, Komatsu C, Yamauchi R, Shibayama S, Hachisuka M, Kiuchi F.  Two new lignans and melanogenesis inhibitors from Schisandra nigra.  J Nat Med  2016  70:460-6  PubMed ID: 27142263
9680  Suto N, Mieda T, Iizuka A, Nakamura K, Hirai H.  Morphological and Functional Attenuation of Degeneration of Peripheral Neurons by Mesenchymal Stem Cell-Conditioned Medium in Spinocerebellar Ataxia Type 1-Knock-in Mice.  CNS Neurosci Ther  2016  22:670-6  PubMed ID: 27140210
9681  Widyowati R, Sugimoto S, Yamano Y, Sukardiman , Otsuka H, Matsunami K.  New Isolinariins C, D and E, Flavonoid Glycosides from Linaria japonica.  Chem. Pharm. Bull.  2016  64:517-21  PubMed ID: 27150486
9682  Shang X, Wang J, Luo Z, Wang Y, Morandi MM, Marymont JV, Hilton MJ, Dong Y.  Notch signaling indirectly promotes chondrocyte hypertrophy via regulation of BMP signaling and cell cycle arrest.  Sci Rep  2016  6:25594  PubMed ID: 27146698
9683  Tamura K, Naraba H, Hara T, Nakamura K, Yoshie M, Kogo H, Tachikawa E.  A positive feedback loop between progesterone and microsomal prostaglandin E synthase-1-mediated PGE2 promotes production of both in mouse granulosa cells.  Prostaglandins Other Lipid Mediat.  2016  123:56-62  PubMed ID: 27174800
9684  Isono T, Chano T, Yonese J, Yuasa T.  Therapeutic inhibition of mitochondrial function induces cell death in starvation-resistant renal cell carcinomas.  Sci Rep  2016  6:25669  PubMed ID: 27157976
9685  Gao J, Fu S, Zeng Z, Li F, Niu Q, Jing D, Feng X.  Cyclic stretch promotes osteogenesis-related gene expression in osteoblast-like cells through a cofilin-associated mechanism.  Mol Med Rep  2016  14:218-24  PubMed ID: 27177232
9788  Deguchi Y, Okabe H, Oshima N, Hisamori S, Minamiguchi S, Muto M, Sakai Y.  PTEN loss is associated with a poor response to trastuzumab in HER2-overexpressing gastroesophageal adenocarcinoma.  Gastric Cancer  2017  20:416-427  PubMed ID: 27517839
10177  Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N.  Introduction of plasmids into gastric cancer cells by endoscopic ultrasound.  Oncol Lett  2017  13:3127-3130  PubMed ID: 28521417
10253  Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N.  CCAAT/enhancer-binding protein α decreases the viability of gastric cancer cells.  Oncol Lett  2017  13:4322-4326  PubMed ID: 28599433
10258  Gen Y, Yasui K, Kitaichi T, Iwai N, Terasaki K, Dohi O, Hashimoto H, Fukui H, Inada Y, Fukui A, Jo M, Moriguchi M, Nishikawa T, Umemura A, Yamaguchi K, Konishi H, Naito Y, Itoh Y.  ASPP2 suppresses invasion and TGF-β1-induced epithelial-mesenchymal transition by inhibiting Smad7 degradation mediated by E3 ubiquitin ligase ITCH in gastric cancer.  Cancer Lett.  2017  398:52-61  PubMed ID: 28400336
10437  Yanoma T, Ogata K, Yokobori T, Ide M, Mochiki E, Toyomasu Y, Yanai M, Kogure N, Kimura A, Suzuki M, Nakazawa N, Bai T, Oyama T, Asao T, Shirabe K, Kuwano H.  Heat shock-induced HIKESHI protects cell viability via nuclear translocation of heat shock protein 70.  Oncol. Rep.  2017  38:1500-1506  PubMed ID: 28731175
10586  Ishii S, Yamashita K, Harada H, Ushiku H, Tanaka T, Nishizawa N, Yokoi K, Washio M, Ema A, Mieno H, Moriya H, Hosoda K, Waraya M, Katoh H, Watanabe M.  The H19-PEG10/IGF2BP3 axis promotes gastric cancer progression in patients with high lymph node ratios.  Oncotarget  2017  8:74567-74581  PubMed ID: 29088808
10686  Imamura T, Komatsu S, Ichikawa D, Miyamae M, Okajima W, Ohashi T, Kiuchi J, Nishibeppu K, Kosuga T, Konishi H, Shiozaki A, Okamoto K, Fujiwara H, Otsuji E.  Low plasma levels of miR-101 are associated with tumor progression in gastric cancer.  Oncotarget  2017  8:106538-106550  PubMed ID: 29290969
10787  Shimada S, Akiyama Y, Mogushi K, Ishigami-Yuasa M, Kagechika H, Nagasaki H, Fukamachi H, Yuasa Y, Tanaka S.  Identification of selective inhibitors for diffuse-type gastric cancer cells by screening of annotated compounds in preclinical models.  Br. J. Cancer  2018  118:972-984  PubMed ID: 29527007
10796  Matsuoka K, Nakagawa F, Kobunai T, Takechi T.  Trifluridine/tipiracil overcomes the resistance of human gastric 5-fluorouracil-refractory cells with high thymidylate synthase expression.  Oncotarget  2018  9:13438-13450  PubMed ID: 29568368
11095  Kim M, Pyo S, Kang CH, Lee CO, Lee HK, Choi SU, Park CH.  Folate receptor 1 (FOLR1) targeted chimeric antigen receptor (CAR) T cells for the treatment of gastric cancer.  PLoS ONE  2018    PubMed ID: 29874279
11219  Kato R, Iwamuro M, Shiraha H, Horiguchi S, Tanaka E, Matsumoto K, Ohyama A, Sawahara H, Nagahara T, Uchida D, Tsutsumi K, Okada H.  Dipeptide γ-secretase inhibitor treatment enhances the anti-tumor effects of cisplatin against gastric cancer by suppressing cancer stem cell properties.  Oncol Lett  2018    PubMed ID: 30250614
11202  Shiozaki A, Ariyoshi Y, Iitaka D, Kosuga T, Shimizu H, Kudou M, Konishi T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Ichikawa D, Otsuji E.  Functional analysis and clinical significance of sodium iodide symporter expression in gastric cancer.  Gastric Cancer  2018    PubMed ID: 30191346
11231  Wang Z, Qu H, Gong W, Liu A.  Up-regulation and tumor-promoting role of SPHK1 were attenuated by miR-330-3p in gastric cancer.  IUBMB Life  2018    PubMed ID: 30281914
4426    Biological activity of intervenolin analogs with a phenyl substituent  The Journal of Antibiotics  2018  71, 86–90 
4303  Afroz S, Yagi A, Fujikawa K, Rahman MM, Morito K, Fukuta T, Watanabe S, Kiyokage E, Toida K, Shimizu T, Ishida T, Kogure K, Tokumura A, Tanaka T.  Lysophosphatidic acid in medicinal herbs enhances prostaglandin E2 and protects against indomethacin-induced gastric cell damage in vivo and in vitro.  Prostaglandins Other Lipid Mediat.  2018    PubMed ID: 29462674
4304  Zhang N, Xu J, Wang Y, Heng X, Yang L, Xing X.  Loss of opioid binding protein/cell adhesion molecule-like gene expression in gastric cancer.  Oncol Lett  2018    PubMed ID: 29805691



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