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RCB1001 : MKN45  update : 2018/07/06
CommentPoorly differentiated gastric adenocarcinoma. Producing high level of CEA.
Comment from the depositor
Terms and conditionsBasically, there is no restriction regarding academic use.
Remarks
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor Motoyama, Teiichi
Originator Hojo, Haruto
Year of deposit 1994
Animal human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Female
Age at sampling 62 years
Tissue stomach, liver meta
Case history Gastric adenocarcinoma
Metastastatic ability Yes
Metastatsd tissue liver
Classification cancer
Year of origin 1975
History Hojo, Haruto - Motoyama, Teiichi
Lifespan infinite
Morphology epithelial-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : once/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR (human) OK
Virus (HIV) (-)
Virus (HBV) (-)
Virus (HCV) (-)
Isozyme LD, NP
Chromosome mode 40-44(50) : 40(1),41(1),42(7),43(36),44(5)
Images
deposit info
lot info
Reference information Reference 9
User's Publication 197


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Reference
3128  Takeshima E, Hamaguchi M, Watanabe T, Akiyama S, Kataoka M, Ohnishi Y, Xiao, H Y, Nagai Y, Takagi H  Aberrant elevation of tyrosine-specific phosphorylation in human gastric cancer cells.  Jpn J Cancer Res.  1991  82:1428-35  PubMed ID: 1778766
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1889  Motoyama T, Hojo H, Watanabe H  Comparison of seven cell lines derived from human gastric carcinomas.  Acta Pathol Jpn  1986  36:65-83  PubMed ID: 3962675
5050  Koyama K, Akiyama K, Kawahara H, Egashira A, Murakami H.  Alloimmunization with cultured human stomach cancer cell lines and the establishment of human-human hybridomas producing monoclonal antibodies.  Jpn J Cancer Res  1990  81(10):967-70  PubMed ID: 2121682
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1858  Yanagawa N, Tamura G, Honda T, Endoh M, Nishizuka S, Motoyama T.  Demethylation of the synuclein gamma gene CpG island in primary gastric cancers and gastric cancer cell lines.  Clin Cancer Res  2004  10(7):2447-51  PubMed ID: 15073123
1860  Ogose A, Motoyama T, Hotta T, Watanabe H.  Expression of bone morphogenetic proteins in human osteogenic and epithelial tumor cells.  Pathol Int.   1996  46(1):9-14  PubMed ID: 10846544
1861  Motoyama T, Watanabe H.  Carcinoembryonic antigen production in human gastric cancer cell lines in vitro and in nude mice.  Gan  1983  74(5):679-86  PubMed ID: 6642141
1863  Homma N, Tamura G, Honda T, Matsumoto Y, Nishizuka S, Kawata S, Motoyama T.  Spreading of methylation within RUNX3 CpG island in gastric cancer.  Cancer Sci  2006  97(1):51-6  PubMed ID: 16367921

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User's Publication
3430  Wu, Jeng Yih, Lu, Hong, Sun, Yubo, Graham, David Y, Cheung, Herman S, Yamaoka, Yoshio  Balance between polyoma enhancing activator 3 and activator protein 1 regulates Helicobacter pylori-stimulated matrix metalloproteinase 1 expression.  Cancer Res  2006  66:5111-20  PubMed ID: 16707434
2807  Shida D, Kitayama J, Yamaguchi H, Hama K, Aoki J, Arai H, Yamashita H, Mori K, Sako A, Konishi T, Watanabe T, Sakai T, Suzuki R, Ohta H, Takuwa Y, Nagawa H  Dual mode regulation of migration by lysophosphatidic acid in human gastric cancer cells.  Exp Cell Res  2004  301:168-78  PubMed ID: 15530853
1783  Fujiwara T, Motoyama T, Ishihara N, Watanabe H, Kumanishi T, Kato K, Ichinose H, Nagatsu T  Characterization of four new cell lines derived from small-cell gastrointestinal carcinoma.  Int J Cancer  1993  54:965-71  PubMed ID: 8392984
3102  Osaki M, Miyata H, Hayashi A, Gomyo Y, Tatebe S, Ito H  Lack of rearranged Tpr-met mRNA expression in human gastric cancer cell lines and gastric mucosa and carcinoma.  Anticancer Res  1996  16:2881-4  PubMed ID: 8917402
2177  Tamura G, Sakata K, Nishizuka S, Maesawa C, Suzuki Y, Iwaya T, Terashima M, Saito K, Satodate R  Inactivation of the E-cadherin gene in primary gastric carcinomas and gastric carcinoma cell lines  Jpn J Cancer Res  1996  87:1153-1159  PubMed ID: 9045944
2194  Nishizuka S, Tamura G, Maesawa C, Sakata K, Suzuki Y, Iwaya T, Terashima M, Saito K, Satodate R  Analysis of the DPC4 gene in gastric carcinoma  Jpn J Cancer Res  1997  88:335-339  PubMed ID: 9197522
3103  Adachi, Keiko, Osaki, Mitsuhiko, Kase, Satoru, Takeda, Ami, Ito, Hisao  Anti-Fas antibody-induced apoptosis and its signal transduction in human gastric carcinoma cell lines.  Int J Oncol  2003  23:713-9  PubMed ID: 12888908
3104  Osaki, Mitsuhiko, Kase, Satoru, Adachi, Keiko, Takeda, Ami, Hashimoto, Kiyoshi, Ito, Hisao  Inhibition of the PI3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45.  J Cancer Res Clin Oncol  2004  130:8-14  PubMed ID: 14605879
2921  Ishihara, Shunji, Rumi, Mohammad Azharul Karim, Kadowaki, Yasunori, Ortega-Cava, Cesar Francisco, Yuki, Takafumi, Yoshino, Nagisa, Miyaoka, Youichi, Kazumori, Hideaki, Ishimura, Norihisa, Amano, Yuji, Kinoshita, Yoshikazu  Essential role of MD-2 in TLR4-dependent signaling during Helicobacter pylori-associated gastritis.  J Immunol  2004  173:1406-16  PubMed ID: 15240737
3105  Osaki M, Moriyama M, Adachi K, Nakada C, Takeda A, Inoue Y, Adachi H, Sato K, Oshimura M, Ito H  Expression of RUNX3 protein in human gastric mucosa, intestinal metaplasia and carcinoma.  Eur J Clin Invest  2004  34:605-12  PubMed ID: 15379759
3109  Honjo, Soichiro, Osaki, Mitsuhiko, Ardyanto, Tonang Dwi, Hiramatsu, Toshiki, Maeta, Noritaka, Ito, Hisao  COX-2 inhibitor, NS398, enhances Fas-mediated apoptosis via modulation of the PTEN-Akt pathway in human gastric carcinoma cell lines.  DNA Cell Biol  2005  24:141-7  PubMed ID: 15767780
3167  Horie, Nobuyuki, Hirabayashi, Naomi, Takahashi, Yoshie, Miyauchi, Yuko, Taguchi, Hiroko, Takeishi, Keiichi  Synergistic effect of green tea catechins on cell growth and apoptosis induction in gastric carcinoma cells.  Biol Pharm Bull  2005  28:574-9  PubMed ID: 15802789
7097  Otsuka S, Matsumoto K, Nakajima M, Tanaka T, Ogura S.  Oxygen Availability for Porphyrin Biosynthesis Enzymes Determines the Production of Protoporphyrin IX (PpIX) during Hypoxia.  PLoS ONE  2015  10:e0146026  PubMed ID: 26717566
7206  Sawamura T, Tanaka T, Ishige H, Iizuka M, Murayama Y, Otsuji E, Ohkubo A, Ogura S, Yuasa H.  The Effect of Coatings on the Affinity of Lanthanide Nanoparticles to MKN45 and HeLa Cancer Cells and Improvement in Photodynamic Therapy Efficiency.  Int J Mol Sci  2015  16:22415-24  PubMed ID: 26389895
7233  Nakamura S, Kahyo T, Tao H, Shibata K, Kurabe N, Yamada H, Shinmura K, Ohnishi K, Sugimura H.  Novel roles for LIX1L in promoting cancer cell proliferation through ROS1-mediated LIX1L phosphorylation.  Sci Rep  2015  5:13474  PubMed ID: 26310847
7277  Yoshimoto M, Higaki K, Nanba E, Ikeguchi M.  Anti-Proliferation Activity of Fucoidan in MKN45 Gastric Cancer Cells and Downregulation of Phosphorylated ASK1, a Cell Cycle-Regulated Kinase.  Yonago Acta Med  2015  58:1-7  PubMed ID: 26190891
7297  Zhu S, Chen Z, Katsha A, Hong J, Belkhiri A, El-Rifai W.  Regulation of CD44E by DARPP-32-dependent activation of SRp20 splicing factor in gastric tumorigenesis.  Oncogene  2015  35:1847-56  PubMed ID: 26119931
7334  Ito H, Hasegawa K, Hasegawa Y, Nishimaki T, Hosomichi K, Kimura S, Ohba M, Yao H, Onimaru M, Inoue I, Inoue H.  Silver Nanoscale Hexagonal Column Chips for Detecting Cell-free DNA and Circulating Nucleosomes in Cancer Patients.  Sci Rep  2015  5:10455  PubMed ID: 25994878
7470  Sakimura S, Sugimachi K, Kurashige J, Ueda M, Hirata H, Nambara S, Komatsu H, Saito T, Takano Y, Uchi R, Sakimura E, Shinden Y, Iguchi T, Eguchi H, Oba Y, Hoka S, Mimori K.  The miR-506-Induced Epithelial-Mesenchymal Transition is Involved in Poor Prognosis for Patients with Gastric Cancer.  Ann. Surg. Oncol.  2015  22 Suppl 3:S1436-43  PubMed ID: 25707493
7512  Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N.  Gastric cancer cell proliferation is suppressed by frizzled-2 short hairpin RNA.  Int. J. Oncol.  2015  46:1018-24  PubMed ID: 25586465
7529  H Niwa, Y Maeyama, S Kikuchi, H Kawaguchi, T Daimon, Y Furuya, H Ito, N Mizuno, M Otsu, H Yasuhara, M Sasako  Impacts of Cancer-Associated Stromal Cells on Growth of Human Gastric Cancer Cell Lines.  Cancer Cell & Microenvironment  2015  2:e921 
7742  Sun PH, Zhu LM, Qiao MM, Zhang YP, Jiang SH, Wu YL, Tu SP.  The XAF1 tumor suppressor induces autophagic cell death via upregulation of Beclin-1 and inhibition of Akt pathway.  Cancer Lett.  2011  310:170-80  PubMed ID: 21788101
7753  Tabassam FH, Graham DY, Yamaoka Y.  Paxillin is a novel cellular target for converging Helicobacter pylori-induced cellular signaling.  Am. J. Physiol. Gastrointest. Liver Physiol.  2011  301:G601-11  PubMed ID: 21757638
7767  Miyamoto M, Ojima H, Iwasaki M, Shimizu H, Kokubu A, Hiraoka N, Kosuge T, Yoshikawa D, Kono T, Furukawa H, Shibata T.  Prognostic significance of overexpression of c-Met oncoprotein in cholangiocarcinoma.  Br. J. Cancer  2011  105:131-8  PubMed ID: 21673683
7869  Yang YM, Feng AL, Zhou CJ, Liang XH, Mao HT, Deng BP, Yan S, Sun JT, Du LT, Liu J, Wang QJ, Neckenig MR, Yang QF, Qu X.  Aberrant expression of chemokine receptor CCR4 in human gastric cancer contributes to tumor-induced immunosuppression.  Cancer Sci.  2011  102:1264-71  PubMed ID: 21443538
7896  Goto K, Tatsumi K, Nagata T, Komizu Y, Ueoka R.  Specific interaction between Ca2+ and anionic lipids in cancer cells along with apoptosis.  Biol. Pharm. Bull.  2011  34:439-42  PubMed ID: 21372400
7906  Takenouchi M, Hirai S, Sakuragi N, Yagita H, Hamada H, Kato K.  Epigenetic modulation enhances the therapeutic effect of anti-IL-13R(alpha)2 antibody in human mesothelioma xenografts.  Clin. Cancer Res.  2011  17:2819-29  PubMed ID: 21357681
7978  Shin VY, Jin HC, Ng EK, Cho CH, Leung WK, Sung JJ, Chu KM.  4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone promoted gastric cancer growth through prostaglandin E receptor (EP2 and EP4) in vivo and in vitro.  Cancer Sci.  2011  102:926-33  PubMed ID: 21261791
7990  Aoki M, Ishigami S, Uenosono Y, Arigami T, Uchikado Y, Kita Y, Kurahara H, Matsumoto M, Ueno S, Natsugoe S.  Expression of BMP-7 in human gastric cancer and its clinical significance.  Br. J. Cancer  2011  104:714-8  PubMed ID: 21224856
8006  Bachleitner-Hofmann T, Sun MY, Chen CT, Liska D, Zeng Z, Viale A, Olshen AB, Mittlboeck M, Christensen JG, Rosen N, Solit DB, Weiser MR.  Antitumor activity of SNX-2112, a synthetic heat shock protein-90 inhibitor, in MET-amplified tumor cells with or without resistance to selective MET Inhibition.  Clin. Cancer Res.  2011  17:122-33  PubMed ID: 21208906
8007  Endo S, Yamato K, Hirai S, Moriwaki T, Fukuda K, Suzuki H, Abei M, Nakagawa I, Hyodo I.  Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells.  Cancer Sci.  2011  102:605-13  PubMed ID: 21205074
8042  Coombs N, Sompallae R, Olbermann P, Gastaldello S, Goppel D, Masucci MG, Josenhans C.  Helicobacter pylori affects the cellular deubiquitinase USP7 and ubiquitin-regulated components TRAF6 and the tumour suppressor p53.  Int. J. Med. Microbiol.  2010  301:213-24  PubMed ID: 21131231
8148  Nakaya K, Ayaori M, Uto-Kondo H, Hisada T, Ogura M, Yakushiji E, Takiguchi S, Terao Y, Ozasa H, Sasaki M, Komatsu T, Ohsuzu F, Ikewaki K.  Cilostazol enhances macrophage reverse cholesterol transport in vitro and in vivo.  Atherosclerosis  2010  213:135-41  PubMed ID: 20723893
8164  Makiyama T, Nagasaka N, Houjyo Y, Yamaura E, Nakamura H, Koide Y, Nishida A, Murayama T.  Newly synthetic ceramide-1-phosphate analogs; their uptake, intracellular localization, and roles as an inhibitor of cytosolic phospholipase A(2)α and inducer of cell toxicity.  Biochem. Pharmacol.  2010  80:1396-406  PubMed ID: 20688048
8242  Chong PK, Lee H, Zhou J, Liu SC, Loh MC, Wang TT, Chan SP, Smoot DT, Ashktorab H, So JB, Lim KH, Yeoh KG, Lim YP.  ITIH3 is a potential biomarker for early detection of gastric cancer.  J. Proteome Res.  2010  9:3671-9  PubMed ID: 20515073
8253  Seto M, Ohta M, Ikenoue T, Sugimoto T, Asaoka Y, Tada M, Mohri D, Kudo Y, Ijichi H, Tateishi K, Otsuka M, Hirata Y, Maeda S, Koike K, Omata M.  Reduced expression of RAS protein activator like-1 in gastric cancer.  Int. J. Cancer  2010  128:1293-302  PubMed ID: 20473946
8290  Chong PK, Lee H, Zhou J, Liu SC, Loh MC, So JB, Lim KH, Yeoh KG, Lim YP.  Reduced plasma APOA1 level is associated with gastric tumor growth in MKN45 mouse xenograft model.  J Proteomics  2010  73:1632-40  PubMed ID: 20399916
8315  Saito Y, Sekine W, Sano R, Komatsu S, Mizuno H, Katabami K, Shimada K, Oku T, Tsuji T.  Potentiation of cell invasion and matrix metalloproteinase production by alpha3beta1 integrin-mediated adhesion of gastric carcinoma cells to laminin-5.  Clin. Exp. Metastasis  2010  27:197-205  PubMed ID: 20352300
8319  Takeuchi M, Inoue T, Otani T, Yamasaki F, Nakamura S, Kibata M.  Cell-in-cell structures formed between human cancer cell lines and the cytotoxic regulatory T-cell line HOZOT.  J Mol Cell Biol  2010  2:139-51  PubMed ID: 20348186
8395  Shin VY, Jin HC, Ng EK, Sung JJ, Chu KM, Cho CH.  Activation of 5-lipoxygenase is required for nicotine mediated epithelial-mesenchymal transition and tumor cell growth.  Cancer Lett.  2010  292:237-45  PubMed ID: 20061081
8416  Nakamura J, Kitajima Y, Kai K, Hashiguchi K, Hiraki M, Noshiro H, Miyazaki K.  HIF-1alpha is an unfavorable determinant of relapse in gastric cancer patients who underwent curative surgery followed by adjuvant 5-FU chemotherapy.  Int. J. Cancer  2009  127:1158-71  PubMed ID: 20020496
8439  Zhang DX, Zhao PT, Xia L, Liu LL, Liang J, Zhai HH, Zhang HB, Guo XG, Wu KC, Xu YM, Jia LT, Yang AG, Chen SY, Fan DM.  Potent inhibition of human gastric cancer by HER2-directed induction of apoptosis with anti-HER2 antibody and caspase-3 fusion protein.  Gut  2009  59:292-9  PubMed ID: 19951902
8457  Zaidi SF, Yamamoto T, Refaat A, Ahmed K, Sakurai H, Saiki I, Kondo T, Usmanghani K, Kadowaki M, Sugiyama T.  Modulation of activation-induced cytidine deaminase by curcumin in Helicobacter pylori-infected gastric epithelial cells.  Helicobacter  2009  14:588-95  PubMed ID: 19889077
8460  Zaidi SF, Ahmed K, Yamamoto T, Kondo T, Usmanghani K, Kadowaki M, Sugiyama T.  Effect of resveratrol on Helicobacter pylori-induced interleukin-8 secretion, reactive oxygen species generation and morphological changes in human gastric epithelial cells.  Biol. Pharm. Bull.  2009  32:1931-5  PubMed ID: 19881312
8590  Miyato H, Kitayama J, Yamashita H, Souma D, Asakage M, Yamada J, Nagawa H.  Pharmacological synergism between cannabinoids and paclitaxel in gastric cancer cell lines.  J. Surg. Res.  2009  155:40-7  PubMed ID: 19394652
8601  Auyeung KK, Cho CH, Ko JK.  A novel anticancer effect of Astragalus saponins: Transcriptional activation of NSAID-activated gene.  Int. J. Cancer  2009  125:1082-91  PubMed ID: 19384947
8916  Hitoshi KAWAMOTO, Yasunari MIKI, Takayuki KIMURA, Katsunori TANAKA, Tsuyoshi NAKAGAWA, Makoto KAWAMUKAI and Hideyuki MATSUDA  Effects of fucoidan from Mozuku on human stomach cell lines  Food Sci Technol Res  2006  12:218-222 
8930  Ohta M, Tateishi K, Kanai F, Watabe H, Kondo S, Guleng B, Tanaka Y, Asaoka Y, Jazag A, Imamura J, Ijichi H, Ikenoue T, Sata M, Miyagishi M, Taira K, Tada M, Kawabe T, Omata M.  p53-Independent negative regulation of p21/cyclin-dependent kinase-interacting protein 1 by the sonic hedgehog-glioma-associated oncogene 1 pathway in gastric carcinoma cells.  Cancer Res.  2005  65:10822-9  PubMed ID: 16322228
9517  Lin CJ, Liao WC, Lin HJ, Hsu YM, Lin CL, Chen YA, Feng CL, Chen CJ, Kao MC, Lai CH, Kao CH.  Statins Attenuate Helicobacter pylori CagA Translocation and Reduce Incidence of Gastric Cancer: In Vitro and Population-Based Case-Control Studies.  PLoS ONE  2016  11:e0146432  PubMed ID: 26730715
9541  Ito K, Mitsunaga M, Arihiro S, Saruta M, Matsuoka M, Kobayashi H, Tajiri H.  Molecular targeted photoimmunotherapy for HER2-positive human gastric cancer in combination with chemotherapy results in improved treatment outcomes through different cytotoxic mechanisms.  BMC Cancer  2016  16:37  PubMed ID: 26810644
9542  Shida M, Kitajima Y, Nakamura J, Yanagihara K, Baba K, Wakiyama K, Noshiro H.  Impaired mitophagy activates mtROS/HIF-1α interplay and increases cancer aggressiveness in gastric cancer cells under hypoxia.  Int. J. Oncol.  2016  48:1379-90  PubMed ID: 26820502
9548  Mu J, Liu T, Jiang L, Wu X, Cao Y, Li M, Dong Q, Liu Y, Xu H.  The Traditional Chinese Medicine Baicalein Potently Inhibits Gastric Cancer Cells.  J Cancer  2016  7:453-61  PubMed ID: 26918059
9625  Shiraishi K, Mimura K, Kua LF, Koh V, Siang LK, Nakajima S, Fujii H, Shabbir A, Yong WP, So J, Takenoshita S, Kono K.  Inhibition of MMP activity can restore NKG2D ligand expression in gastric cancer, leading to improved NK cell susceptibility.  J. Gastroenterol.  2016  51:1101-1111  PubMed ID: 27002316
9652  Lan H, Tang Z, Jin H, Sun Y.  Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells.  Sci Rep  2016  6:24218  PubMed ID: 27063292
9672  Zhu L, Cheng X, Shi J, Jiacheng L, Chen G, Jin H, Liu AB, Pyo H, Ye J, Zhu Y, Wang H, Chen H, Fang J, Cai L, Wang TC, Yang CS, Tu SP.  Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis.  Oncogene  2016  35:5388-5399  PubMed ID: 27109105
9673  Okahashi N, Nakata M, Kuwata H, Kawabata S.  Streptococcus oralis Induces Lysosomal Impairment of Macrophages via Bacterial Hydrogen Peroxide.  Infect. Immun.  2016  84:2042-2050  PubMed ID: 27113357
9675  Izawa T, Mori H, Shinohara T, Mino-Oka A, Hutami IR, Iwasa A, Tanaka E.  Rebamipide Attenuates Mandibular Condylar Degeneration in a Murine Model of TMJ-OA by Mediating a Chondroprotective Effect and by Downregulating RANKL-Mediated Osteoclastogenesis.  PLoS ONE  2016  11:e0154107  PubMed ID: 27123995
9760  Zhou J, You W, Sun G, Li Y, Chen B, Ai J, Jiang H.  The Marine-Derived Oligosaccharide Sulfate MS80, a Novel Transforming Growth Factor β1 Inhibitor, Reverses Epithelial Mesenchymal Transition Induced by Transforming Growth Factor-β1 and Suppresses Tumor Metastasis.  J. Pharmacol. Exp. Ther.  2016  359:54-61  PubMed ID: 27432893
9788  Deguchi Y, Okabe H, Oshima N, Hisamori S, Minamiguchi S, Muto M, Sakai Y.  PTEN loss is associated with a poor response to trastuzumab in HER2-overexpressing gastroesophageal adenocarcinoma.  Gastric Cancer  2017  20:416-427  PubMed ID: 27517839
9795  Xie P, Fujii I, Zhao J, Shinohara M, Matsukura M.  A novel polysaccharide derived from algae extract induces apoptosis and cell cycle arrest in human gastric carcinoma MKN45 cells via ROS/JNK signaling pathway.  Int. J. Oncol.  2016  49:1561-1568  PubMed ID: 27633119
9902  Hayashi N, Kataoka H, Yano S, Kikuchi JI, Tanaka M, Nishie H, Kinoshita Y, Hatano M, Nomoto A, Ogawa A, Inoue M, Mizoshita T, Shimura T, Mori Y, Kubota E, Tanida S, Joh T.  Anticancer Effects of a New Aminosugar-conjugated Platinum Complex Agent Against Cisplatin-resistant Gastric Cancer.  Anticancer Res.  2016  36:6005-6009  PubMed ID: 27793927
9919  Chang HR, Nam S, Lee J, Kim JH, Jung HR, Park HS, Park S, Ahn YZ, Huh I, Balch C, Ku JL, Powis G, Park T, Jeong JH, Kim YH.  Systematic approach identifies RHOA as a potential biomarker therapeutic target for Asian gastric cancer.  Oncotarget  2016  7:81435-81451  PubMed ID: 27806312
9928  Diaz-Lagares A, Crujeiras AB, Lopez-Serra P, Soler M, Setien F, Goyal A, Sandoval J, Hashimoto Y, Martinez-Cardús A, Gomez A, Heyn H, Moutinho C, Espada J, Vidal A, Paúles M, Galán M, Sala N, Akiyama Y, Martínez-Iniesta M, Farré L, Villanueva A, Gross M, Diederichs S, Guil S, Esteller M.  Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer.  Proc. Natl. Acad. Sci. U.S.A.  2016  113:E7535-E7544  PubMed ID: 27821766
10088  Tanaka S, Nagashima H, Uotani T, Graham DY, Yamaoka Y.  Autophagy-related genes in Helicobacter pylori infection.  Helicobacter  2017  22:  PubMed ID: 28111844
10177  Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N.  Introduction of plasmids into gastric cancer cells by endoscopic ultrasound.  Oncol Lett  2017  13:3127-3130  PubMed ID: 28521417
10253  Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N.  CCAAT/enhancer-binding protein α decreases the viability of gastric cancer cells.  Oncol Lett  2017  13:4322-4326  PubMed ID: 28599433
10258  Gen Y, Yasui K, Kitaichi T, Iwai N, Terasaki K, Dohi O, Hashimoto H, Fukui H, Inada Y, Fukui A, Jo M, Moriguchi M, Nishikawa T, Umemura A, Yamaguchi K, Konishi H, Naito Y, Itoh Y.  ASPP2 suppresses invasion and TGF-β1-induced epithelial-mesenchymal transition by inhibiting Smad7 degradation mediated by E3 ubiquitin ligase ITCH in gastric cancer.  Cancer Lett.  2017  398:52-61  PubMed ID: 28400336
10328  Suzuki N, Nakagawa F, Takechi T.  Trifluridine/tipiracil increases survival rates in peritoneal dissemination mouse models of human colorectal and gastric cancer.  Oncol Lett  2017  14:639-646  PubMed ID: 28693216
10437  Yanoma T, Ogata K, Yokobori T, Ide M, Mochiki E, Toyomasu Y, Yanai M, Kogure N, Kimura A, Suzuki M, Nakazawa N, Bai T, Oyama T, Asao T, Shirabe K, Kuwano H.  Heat shock-induced HIKESHI protects cell viability via nuclear translocation of heat shock protein 70.  Oncol. Rep.  2017  38:1500-1506  PubMed ID: 28731175
10486  Shibaguchi H, Luo N, Shirasu N, Kuroki M, Kuroki M.  Enhancement of antitumor activity by using a fully human gene encoding a single-chain fragmented antibody specific for carcinoembryonic antigen.  Onco Targets Ther  2017  10:3979-3990  PubMed ID: 28860806
10652  Lin Z, Lai S, He X, Zhuo W, Wang L, Si J, Chen S.  Decreased long non-coding RNA MTM contributes to gastric cancer cell migration and invasion via modulating MT1F.  Oncotarget  2017  8:97371-97383  PubMed ID: 29228617
10686  Imamura T, Komatsu S, Ichikawa D, Miyamae M, Okajima W, Ohashi T, Kiuchi J, Nishibeppu K, Kosuga T, Konishi H, Shiozaki A, Okamoto K, Fujiwara H, Otsuji E.  Low plasma levels of miR-101 are associated with tumor progression in gastric cancer.  Oncotarget  2017  8:106538-106550  PubMed ID: 29290969
10722  Lan KH, Lee WP, Wang YS, Liao SX, Lan KH.  Helicobacter pylori CagA protein activates Akt and attenuates chemotherapeutics-induced apoptosis in gastric cancer cells.  Oncotarget  2017  8:113460-113471  PubMed ID: 29371922
10736  Zhu S, Chen Z, Wang L, Peng D, Belkhiri A, Lockhart AC, El-Rifai W.  A Combination of SAHA and Quinacrine Is Effective in Inducing Cancer Cell Death in Upper Gastrointestinal Cancers.  Clin. Cancer Res.  2018  24:1905-1916  PubMed ID: 29386219
10744  Xue M, Chen LY, Wang WJ, Su TT, Shi LH, Wang L, Zhang W, Si JM, Wang LJ, Chen SJ.  HOTAIR induces the ubiquitination of Runx3 by interacting with Mex3b and enhances the invasion of gastric cancer cells.  Gastric Cancer  2018    PubMed ID: 29417297
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11231  Wang Z, Qu H, Gong W, Liu A.  Up-regulation and tumor-promoting role of SPHK1 were attenuated by miR-330-3p in gastric cancer.  IUBMB Life  2018    PubMed ID: 30281914
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4304  Zhang N, Xu J, Wang Y, Heng X, Yang L, Xing X.  Loss of opioid binding protein/cell adhesion molecule-like gene expression in gastric cancer.  Oncol Lett  2018    PubMed ID: 29805691
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5808  Hughes PE et al  In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models.  Mol Cancer Ther  2016  15(7):1568-79  PubMed ID: 27196782
5809  Ninomiya K et al  Acylated oleanane-type triterpene saponins from the flowers of Bellis perennis show anti-proliferative activities against human digestive tract carcinoma cell lines.  J Nat Med   2016  0(3):435-51  PubMed ID: 27178360
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5813  Costa AM etal  Helicobacter pylori Activates Matrix Metalloproteinase 10 in Gastric Epithelial Cells via EGFR and ERK-mediated Pathways.  J Infect Dis  2016  213(11):1767-76  PubMed ID: 26802142
5819  Yoshida K, Tsujimoto H, Matsumura K, Kinoshita M, Takahata R, Matsumoto Y, Hiraki S, Ono S, Seki S, Yamamoto J, Hase K.  CD47 is an adverse prognostic factor and a therapeutic target in gastric cancer.  Cancer Med  2015  4(9):1322-33  PubMed ID: 26077800
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5822  Montiel-Eulefi, E. Jara, F. Toro, C. Garcés, M.& Leal, P.  Cytotoxic Effect of Double Emulsion (W/O/W) CuSO4Loaded PLA Nanoparticles on MKN-45 GastricAdenocarcinoma Cell Line  Int J Morphol  2014  32(1):61-69 
5823  Yoneda A, Taniguchi K, Torashima Y, Susumu S, Kanetaka K, Kuroki T, Eguchi S.  The detection of gastric cancer cells in intraoperative peritoneal lavage using the reverse transcription--loop-mediated isothermal amplification method.  J Surg Res  2014  187(1):e1-6  PubMed ID: 24360119
5824  Shen Q, Tang W, Sun J, Feng L, Jin H, Wang X.  Regulation of CRADD-caspase 2 cascade by histone deacetylase 1 in gastric cancer.  Am J Transl Res  2014  6(5):538-47  PubMed ID: 25360218
5830  Hirai S, Endo S, Saito R, Hirose M, Ueno T, Suzuki H, Yamato K, Abei M, Hyodo I.  Antitumor effects of a sirtuin inhibitor, tenovin-6, against gastric cancer cells via death receptor 5 up-regulation.  PLoS One  2014  9(7):e102831  PubMed ID: 25033286
5831  Montiel-Eulefi, E Jara, F. Toro, C. Garcés, M. & Leal, P.  Cytotoxic Effect of Double Emulsion (W/O/W) CuSO4 Loaded PLA Nanoparticles on MKN-45 Gastric Adenocarcinoma Cell Line  Int J Morphol  2014  32(1):61-69 
5832  Dong Z, Fu S, Xu X, Yang Y, Du L, Li W, Kan S, Li Z, Zhang X, Wang L, Li J, Liu H, Qu X, Wang C.  Leptin-mediated regulation of ICAM-1 is Rho/ROCK dependent and enhances gastric cancer cell migration.  Br J Cancer  2014  110(7):1801-10  PubMed ID: 24548863
5835  Funakoshi Y, Mukohara T, Ekyalongo RC, Tomioka H, Kataoka Y, Shimono Y, Chayahara N, Toyoda M, Kiyota N, Fujiwara Y, Minami H.  Regulation of MET kinase inhibitor resistance by copy number of MET in gastric carcinoma cells.  Oncol Res. 2  2013  21(6):287-93  PubMed ID: 25198658
5839  Ikawa-Yoshida A, Ando K, Oki E, Saeki H, Kumashiro R, Taketani K, Ida S, Tokunaga E, Kitao H, Morita M, Maehara Y.  Contribution of BubR1 to oxidative stress-induced aneuploidy in p53-deficient cells.  Cancer Med  2013  2(4):447-56  PubMed ID: 24156017
5841  Ye L, Ou X, Tian Y, Yu B, Luo Y, Feng B, Lin H, Zhang J, Wu S.  Indazoles as potential c-Met inhibitors: design, synthesis and molecular docking studies.  Eur J Med Chem  2013  65:112-8  PubMed ID: 23702473
5842  Dong Z, Xu X, Du L, Yang Y, Cheng H, Zhang X, Li Z, Wang L, Li J, Liu H, Qu X, Wang C.  Leptin-mediated regulation of MT1-MMP localization is KIF1B dependent and enhances gastric cancer cell invasion.  Carcinogenesis  2013  34(5):974-83  PubMed ID: 23354307
5846  Li M, Gao J, Feng R, Wang Y, Chen X, Sun J, Zhang D, Zhu Z, Ellis LM, Lu M, Lee JE, Feng Z, Liu B.  Generation of monoclonal antibody MS17-57 targeting secreted alkaline phosphatase ectopically expressed on the surface of gastrointestinal cancer cells.  PLoS One  2013  8(10):e77398  PubMed ID: 24143229
5848  Kataoka Y, Mukohara T, Tomioka H, Funakoshi Y, Kiyota N, Fujiwara Y, Yashiro M, Hirakawa K, Hirai M, Minami H.  Foretinib (GSK1363089), a multi-kinase inhibitor of MET and VEGFRs, inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks.  Invest New Drugs  2012  30(4):1352-60  PubMed ID: 21655918
5849  Tu SP, Jin H, Shi JD, Zhu LM, Suo Y, Lu G, Liu A, Wang TC, Yang CS.  Curcumin induces the differentiation of myeloid-derived suppressor cells and inhibits their interaction with cancer cells and related tumor growth.  Cancer Prev Res (Phila)  2012  5(2):205-15  PubMed ID: 22030090
5850  Miyato H, Tsuno NH, Kitayama J.  Semaphorin 3C is involved in the progression of gastric cancer.  Cancer Sci  2012  103(11):1961-6  PubMed ID: 22924992
5852  Tomioka H, Mukohara T, Kataoka Y, Ekyalongo RC, Funakoshi Y, Imai Y, Kiyota N, Fujiwara Y, Minami H.  Inhibition of the mTOR/S6K signal is necessary to enhance fluorouracil-induced apoptosis in gastric cancer cells with HER2 amplification.  Int J Oncol  2012  41(2):551-8  PubMed ID: 22614071
5854  Lianbao Ye et al  Design, synthesis and molecular docking studies of some novel spiro[indoline-3, 4′-piperidine]-2-ones as potential c-Met inhibitors  European Journal of Medicinal Chemistry  2012  50:370-375 
5855  Yang Y, Toy W, Choong LY, Hou P, Ashktorab H, Smoot DT, Yeoh KG, Lim YP.  Discovery of SLC3A2 cell membrane protein as a potential gastric cancer biomarker: implications in molecular imaging.  J Proteome Res  2012  11(12):5736-47  PubMed ID: 23116296
5857  Mao W, Chen J, Peng TL, Yin XF, Chen LZ, Chen MH.  Downregulation of gastrokine-1 in gastric cancer tissues and restoration of its expression induced gastric cancer cells to apoptosis.  J Exp Clin Cancer Res  2012  31:49  PubMed ID: 22621392
5858  Kazuki Tatsumi, Hideaki Ichihara, YujiKomizu, Koichi Goto, and Ryuichi Ueoka  Therapeutic Effects of Ca2+ on Peritoneal Dissemination of Gastric Carcinoma in Vivo  Journal of Health Science  2011  57(2):210–214 
5860  Du L, Xiao X, Wang C, Zhang X, Zheng N, Wang L, Zhang X, Li W, Wang S, Dong Z.  Human leukocyte antigen-G is closely associated with tumor immune escape in gastric cancer by increasing local regulatory T cells.  Cancer Sci  2011  102(7):1272-80  PubMed ID: 21466615
5864  Mika Hoshino, Hiroyuki Suzuki, Seigo Kashimura, Norio Kanzaki, Hiroshi Yaginuma, Takeo Hasegawa, Atsushi Yonechi, Jun Ohsugi, Mitsunori Higuchi, Yutaka Shio, Kazuya Ise, Mitsukazu Gotoh  BRM cocktail treatment using PSK and OK432 significantly up-regulates the migration activity in human dendritic cells without losing effective CTL induction  Annals of Cancer Research and Therapy  2011  19:1-8 
5865  Nakata W, Hayakawa Y, Nakagawa H, Sakamoto K, Kinoshita H, Takahashi R, Hirata Y, Maeda S, Koike K.  Anti-tumor activity of the proteasome inhibitor bortezomib in gastric cancer.  Int J Oncol  2011  39(6):1529-36  PubMed ID: 21785822
5866  Nakamura J, Kitajima Y, Kai K, Hashiguchi K, Hiraki M, Noshiro H, Miyazaki K.  Expression of hypoxic marker CA IX is regulated by site-specific DNA methylation and is associated with the histology of gastric cancer.  Am J Pathol  2011  178(2):515-24  PubMed ID: 21281785
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5869  Tatsuya Nodagashira,Hiroki Odagiri,Shojiro-Kazunori Ikenaga,Masaki Maruyama, Toshiyuki Sato and Kenichi Hakamada  Efficient gene transduction in HER2-expressing cancer cells by two recombinant adenovirus vectors with HER2 promoter and Cre/loxP system  Hirosaki Med J  2010  61:26―34 
5873  Yu J, Cheng YY, Tao Q, Cheung KF, Lam CN, Geng H, Tian LW, Wong YP, Tong JH, Ying JM, Jin H, To KF, Chan FK, Sung JJ.  Methylation of protocadherin 10, a novel tumor suppressor, is associated with poor prognosis in patients with gastric cancer.  Gastroenterology  2009  136(2):640  PubMed ID: 19084528
5874  Tu SP, Chi AL, Ai W, Takaishi S, Dubeykovskaya Z, Quante M, Fox JG, Wang TC.  p53 inhibition of AP1-dependent TFF2 expression induces apoptosis and inhibits cell migration in gastric cancer cells.  Am J Physiol Gastrointest Liver Physiol  2009  297(2):G385-96  PubMed ID: 19541923
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5885  Bachleitner-Hofmann T, Sun MY, Chen CT, Tang L, Song L, Zeng Z, Shah M, Christensen JG, Rosen N, Solit DB, Weiser MR.  HER kinase activation confers resistance to MET tyrosine kinase inhibition in MET oncogene-addicted gastric cancer cells.  Mol Cancer Ther  2008  7(11):3499-508  PubMed ID: 18974395
5886  Inoue M, Matsumoto S, Saito H, Tsujitani S, Ikeguchi M.  Intraperitoneal administration of a small interfering RNA targeting nuclear factor-kappa B with paclitaxel successfully prolongs the survival of xenograft model mice with peritoneal metastasis of gastric cancer.  Int J Cancer.   2008  123(11):2696-701  PubMed ID: 18798274
5887  Hara M, Nakanishi H, Tsujimura K, Matsui M, Yatabe Y, Manabe T, Tatematsu M.  Interleukin-2 potentiation of cetuximab antitumor activity for epidermal growth factor receptor-overexpressing gastric cancer xenografts through antibody-dependent cellular cytotoxicity.  Cancer Sci  2008  99(7):1471-8  PubMed ID: 18422755
5889  Sakurai Y, Yoshida I, Kamoshida S, Inaba K, Isogaki J, Komori Y, Uyama I, Tsutsumi Y.  Changes of gene expression of thymidine phosphorylase, thymidylate synthase, dihydropyrimidine dehydrogenase after the administration of 5'-deoxy-5-fluorouridine, paclitaxel and its combination in human gastric cancer xenografts.  Anticancer Res  2008  28(3A):1593-602  PubMed ID: 18630517
5891  Tozawa K, Oshima T, Kobayashi T, Yamamoto N, Hayashi C, Matsumoto T, Miwa H  Oxaliplatin in treatment of the cisplatin-resistant MKN45 cell line of gastric cancer.  Anticancer Res  2008  28(4B):2087-92  PubMed ID: 18751380
5892  Setoyama T, Natsugoe S, Okumura H, Matsumoto M, Uchikado Y, Aikou T.  Isolated tumour cells in blood and E-cadherin expression in oesophageal squamous cell cancer.  Br J Surg  2007  94(8):984-91  PubMed ID: 17410638
5893  Hara M, Nakanishi H, Jun Q, Kanemitsu Y, Ito S, Mochizuki Y, Yamamura Y, Kodera Y, Tatematsu M, Hirai T, Kato T.  Comparative analysis of intraperitoneal minimal free cancer cells between colorectal and gastric cancer patients using quantitative RT-PCR: possible reason for rare peritoneal recurrence in colorectal cancer.  Clin Exp Metastasis  2007  24(3):179-89  PubMed ID: 17487561
5894  Cheng YY, Yu J, Wong YP, Man EP, To KF, Jin VX, Li J, Tao Q, Sung JJ, Chan FK, Leung WK.  Frequent epigenetic inactivation of secreted frizzled-related protein 2 (SFRP2) by promoter methylation in human gastric cancer.  Br J Cancer  2007  97(7):895-901  PubMed ID: 17848950
5895  Yanagawa T, Funasaka T, Tsutsumi S, Hu H, Watanabe H, Raz A.  Regulation of phosphoglucose isomerase/autocrine motility factor activities by the poly(ADP-ribose) polymerase family-14.  Cancer Res  2007  67(18):8682-9  PubMed ID: 17875708
5897  Kanaji S, Saito H, Tsujitani S, Matsumoto S, Tatebe S, Kondo A, Ozaki M, Ito H, Ikeguchi M.  Expression of polo-like kinase 1 (PLK1) protein predicts the survival of patients with gastric carcinoma.  Oncology  2006  70(2):126-33  PubMed ID: 16645325
5898  Handa O, Yoshida N, Fujita N, Tanaka Y, Ueda M, Takagi T, Kokura S, Naito Y, Okanoue T, Yoshikawa T.  Molecular mechanisms involved in anti-inflammatory effects of proton pump inhibitors.  Inflamm Res  2006  55(11):476-80  PubMed ID: 17122965
5899  Yokoyama H, Ikehara Y, Kodera Y, Ikehara S, Yatabe Y, Mochizuki Y, Koike M, Fujiwara M, Nakao A, Tatematsu M, Nakanishi H.  Molecular basis for sensitivity and acquired resistance to gefitinib in HER2-overexpressing human gastric cancer cell lines derived from liver metastasis.  Br J Cancer  2006  95(11):1504-13  PubMed ID: 17088902
5900  Xia HH, He H, De Wang J, Gu Q, Lin MC, Zou B, Yu LF, Sun YW, Chan AO, Kung HF, Wong BC.  Induction of apoptosis and cell cycle arrest by a specific c-Jun NH2-terminal kinase (JNK) inhibitor, SP-600125, in gastrointestinal cancers.  Cancer Lett  2006  241(2):268-74  PubMed ID: 16337741
5904  Matsumoto S, Saito H, Tsujitani S, Ikeguchi M.  Allogeneic gastric cancer cell-dendritic cell hybrids induce tumor antigen (carcinoembryonic antigen) specific CD8(+) T cells.  Cancer Immunol Immunother  2006  55(2):131-9  PubMed ID: 15891883
5907  Sako A, Kitayama J, Shida D, Suzuki R, Sakai T, Ohta H, Nagawa H.  Lysophosphatidic acid (LPA)-induced vascular endothelial growth factor (VEGF) by mesothelial cells and quantification of host-derived VEGF in malignant ascites.  J Surg Res  2006  130(1):94-101  PubMed ID: 16171822
5908  Ohashi N, Kodera Y, Nakanishi H, Yokoyama H, Fujiwara M, Koike M, Hibi K, Nakao A, Tatematsu M.  Efficacy of intraperitoneal chemotherapy with paclitaxel targeting peritoneal micrometastasis as revealed by GFP-tagged human gastric cancer cell lines in nude mice.  nt J Oncol  2005  27(3):637-44  PubMed ID: 16077911
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5919  Shizue Yoshioka, Shigeru Tatebe, Naruo Tokuyasu, Kenjiro Taniguchi, Yoshimi Ogami, Osamu Yamamoto, Keigo Ashida, Yoshihito Gomyo, Akira Kondo, Shunichi Tsujitani and Masahide Ikeguchi  The PI3K-Akt Pathway in SN-38-Induced Apoptosis in Human Gastric Cancer Cell Lines  Yonago Acta medica  2005  48:7–16 
5920  Chang YJ, Wu MS, Lin JT, Chen CC.  Helicobacter pylori-Induced invasion and angiogenesis of gastric cells is mediated by cyclooxygenase-2 induction through TLR2/TLR9 and promoter regulation.  J Immunol  2005  175(12):8242-52  PubMed ID: 16339564
5922  Meng H, Lu C, Mabuchi H, Tanigawa N.  Prognostic significance and different properties of survivin splicing variants in gastric cancer.  Cancer Lett  2004  216(2):147-55  PubMed ID: 15533590
5923  Namiki Y, Namiki T, Date M, Yanagihara K, Yashiro M, Takahashi H.  Enhanced photodynamic antitumor effect on gastric cancer by a novel photosensitive stealth liposome.  Pharmacol Res.   2004  50(1):65-76  PubMed ID: 15082031
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