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RCB1001 : MKN45  update : 2018/07/06
CommentPoorly differentiated gastric adenocarcinoma. Producing high level of CEA.
Comment from the depositor
Restriction (Category)a
Terms and conditionsBasically, there is no restriction regarding academic use.
Remarks
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor Motoyama, Teiichi
Originator Hojo, Haruto
Year of deposit 1994
Animal human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Female
Age at sampling 62 years
Tissue stomach, liver meta
Case history Gastric adenocarcinoma
Metastastatic ability Yes
Metastatsd tissue liver
Classification cancer
Year of origin 1975
History Hojo, Haruto - Motoyama, Teiichi
Lifespan infinite
Morphology epithelial-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : once/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR (human) OK
Virus (HIV) (-)
Virus (HBV) (-)
Virus (HCV) (-)
Isozyme LD, NP
Chromosome mode 40-44(50) : 40(1),41(1),42(7),43(36),44(5)
Images
deposit info
lot info
Reference information Reference 3
User's Publication 90


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Reference
Takeshima E, Hamaguchi M, Watanabe T, Akiyama S, Kataoka M, Ohnishi Y, Xiao, H Y, Nagai Y, Takagi H  Aberrant elevation of tyrosine-specific phosphorylation in human gastric cancer cells.  Jpn J Cancer Res (--> Cancer Sci)  1991  82:1428-35 
Yokoyama I, Watanabe T, Nishikimi M, Ichihashi H, Kondo T, Takagi H, Sakuma S  Radioimmunoscintigraphy of human gastric carcinoma xenografts with 125I-labeled monoclonal antibody.  Jpn J Cancer Res (--> Cancer Sci)  1986  77:1114-21 
Motoyama T, Hojo H, Watanabe H  Comparison of seven cell lines derived from human gastric carcinomas.  Acta Pathol Jpn  1986  36:65-83 

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User's Publication
Wu, Jeng Yih, Lu, Hong, Sun, Yubo, Graham, David Y, Cheung, Herman S, Yamaoka, Yoshio  Balance between polyoma enhancing activator 3 and activator protein 1 regulates Helicobacter pylori-stimulated matrix metalloproteinase 1 expression.  Cancer Res  2006  66:5111-20  PubMed ID: 16707434
Shida D, Kitayama J, Yamaguchi H, Hama K, Aoki J, Arai H, Yamashita H, Mori K, Sako A, Konishi T, Watanabe T, Sakai T, Suzuki R, Ohta H, Takuwa Y, Nagawa H  Dual mode regulation of migration by lysophosphatidic acid in human gastric cancer cells.  Exp Cell Res  2004  301:168-78  PubMed ID: 15530853
Fujiwara T, Motoyama T, Ishihara N, Watanabe H, Kumanishi T, Kato K, Ichinose H, Nagatsu T  Characterization of four new cell lines derived from small-cell gastrointestinal carcinoma.  Int J Cancer  1993  54:965-71 
Osaki M, Miyata H, Hayashi A, Gomyo Y, Tatebe S, Ito H  Lack of rearranged Tpr-met mRNA expression in human gastric cancer cell lines and gastric mucosa and carcinoma.  Anticancer Res  1996  16:2881-4 
Tamura G, Sakata K, Nishizuka S, Maesawa C, Suzuki Y, Iwaya T, Terashima M, Saito K, Satodate R  Inactivation of the E-cadherin gene in primary gastric carcinomas and gastric carcinoma cell lines  Jpn J Cancer Res  1996  87:1153-1159 
Nishizuka S, Tamura G, Maesawa C, Sakata K, Suzuki Y, Iwaya T, Terashima M, Saito K, Satodate R  Analysis of the DPC4 gene in gastric carcinoma  Jpn J Cancer Res  1997  88:335-339 
Adachi, Keiko, Osaki, Mitsuhiko, Kase, Satoru, Takeda, Ami, Ito, Hisao  Anti-Fas antibody-induced apoptosis and its signal transduction in human gastric carcinoma cell lines.  Int J Oncol  2003  23:713-9  PubMed ID: 12888908
Osaki, Mitsuhiko, Kase, Satoru, Adachi, Keiko, Takeda, Ami, Hashimoto, Kiyoshi, Ito, Hisao  Inhibition of the PI3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45.  J Cancer Res Clin Oncol  2004  130:8-14  PubMed ID: 14605879
Ishihara, Shunji, Rumi, Mohammad Azharul Karim, Kadowaki, Yasunori, Ortega-Cava, Cesar Francisco, Yuki, Takafumi, Yoshino, Nagisa, Miyaoka, Youichi, Kazumori, Hideaki, Ishimura, Norihisa, Amano, Yuji, Kinoshita, Yoshikazu  Essential role of MD-2 in TLR4-dependent signaling during Helicobacter pylori-associated gastritis.  J Immunol  2004  173:1406-16  PubMed ID: 15240737
Osaki M, Moriyama M, Adachi K, Nakada C, Takeda A, Inoue Y, Adachi H, Sato K, Oshimura M, Ito H  Expression of RUNX3 protein in human gastric mucosa, intestinal metaplasia and carcinoma.  Eur J Clin Invest  2004  34:605-12  PubMed ID: 15379759
Honjo, Soichiro, Osaki, Mitsuhiko, Ardyanto, Tonang Dwi, Hiramatsu, Toshiki, Maeta, Noritaka, Ito, Hisao  COX-2 inhibitor, NS398, enhances Fas-mediated apoptosis via modulation of the PTEN-Akt pathway in human gastric carcinoma cell lines.  DNA Cell Biol  2005  24:141-7  PubMed ID: 15767780
Horie, Nobuyuki, Hirabayashi, Naomi, Takahashi, Yoshie, Miyauchi, Yuko, Taguchi, Hiroko, Takeishi, Keiichi  Synergistic effect of green tea catechins on cell growth and apoptosis induction in gastric carcinoma cells.  Biol Pharm Bull  2005  28:574-9  PubMed ID: 15802789
Otsuka S, Matsumoto K, Nakajima M, Tanaka T, Ogura S.  Oxygen Availability for Porphyrin Biosynthesis Enzymes Determines the Production of Protoporphyrin IX (PpIX) during Hypoxia.  PLoS ONE  2015  10:e0146026  PubMed ID: 26717566
Sawamura T, Tanaka T, Ishige H, Iizuka M, Murayama Y, Otsuji E, Ohkubo A, Ogura S, Yuasa H.  The Effect of Coatings on the Affinity of Lanthanide Nanoparticles to MKN45 and HeLa Cancer Cells and Improvement in Photodynamic Therapy Efficiency.  Int J Mol Sci  2015  16:22415-24  PubMed ID: 26389895
Nakamura S, Kahyo T, Tao H, Shibata K, Kurabe N, Yamada H, Shinmura K, Ohnishi K, Sugimura H.  Novel roles for LIX1L in promoting cancer cell proliferation through ROS1-mediated LIX1L phosphorylation.  Sci Rep  2015  5:13474  PubMed ID: 26310847
Yoshimoto M, Higaki K, Nanba E, Ikeguchi M.  Anti-Proliferation Activity of Fucoidan in MKN45 Gastric Cancer Cells and Downregulation of Phosphorylated ASK1, a Cell Cycle-Regulated Kinase.  Yonago Acta Med  2015  58:1-7  PubMed ID: 26190891
Zhu S, Chen Z, Katsha A, Hong J, Belkhiri A, El-Rifai W.  Regulation of CD44E by DARPP-32-dependent activation of SRp20 splicing factor in gastric tumorigenesis.  Oncogene  2015  35:1847-56  PubMed ID: 26119931
Ito H, Hasegawa K, Hasegawa Y, Nishimaki T, Hosomichi K, Kimura S, Ohba M, Yao H, Onimaru M, Inoue I, Inoue H.  Silver Nanoscale Hexagonal Column Chips for Detecting Cell-free DNA and Circulating Nucleosomes in Cancer Patients.  Sci Rep  2015  5:10455  PubMed ID: 25994878
Sakimura S, Sugimachi K, Kurashige J, Ueda M, Hirata H, Nambara S, Komatsu H, Saito T, Takano Y, Uchi R, Sakimura E, Shinden Y, Iguchi T, Eguchi H, Oba Y, Hoka S, Mimori K.  The miR-506-Induced Epithelial-Mesenchymal Transition is Involved in Poor Prognosis for Patients with Gastric Cancer.  Ann. Surg. Oncol.  2015  22 Suppl 3:S1436-43  PubMed ID: 25707493
Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N.  Gastric cancer cell proliferation is suppressed by frizzled-2 short hairpin RNA.  Int. J. Oncol.  2015  46:1018-24  PubMed ID: 25586465
H Niwa, Y Maeyama, S Kikuchi, H Kawaguchi, T Daimon, Y Furuya, H Ito, N Mizuno, M Otsu, H Yasuhara, M Sasako  Impacts of Cancer-Associated Stromal Cells on Growth of Human Gastric Cancer Cell Lines.  Cancer Cell & Microenvironment  2015  2:e921 
Sun PH, Zhu LM, Qiao MM, Zhang YP, Jiang SH, Wu YL, Tu SP.  The XAF1 tumor suppressor induces autophagic cell death via upregulation of Beclin-1 and inhibition of Akt pathway.  Cancer Lett.  2011  310:170-80  PubMed ID: 21788101
Tabassam FH, Graham DY, Yamaoka Y.  Paxillin is a novel cellular target for converging Helicobacter pylori-induced cellular signaling.  Am. J. Physiol. Gastrointest. Liver Physiol.  2011  301:G601-11  PubMed ID: 21757638
Miyamoto M, Ojima H, Iwasaki M, Shimizu H, Kokubu A, Hiraoka N, Kosuge T, Yoshikawa D, Kono T, Furukawa H, Shibata T.  Prognostic significance of overexpression of c-Met oncoprotein in cholangiocarcinoma.  Br. J. Cancer  2011  105:131-8  PubMed ID: 21673683
Yang YM, Feng AL, Zhou CJ, Liang XH, Mao HT, Deng BP, Yan S, Sun JT, Du LT, Liu J, Wang QJ, Neckenig MR, Yang QF, Qu X.  Aberrant expression of chemokine receptor CCR4 in human gastric cancer contributes to tumor-induced immunosuppression.  Cancer Sci.  2011  102:1264-71  PubMed ID: 21443538
Hiraki M, Kitajima Y, Koga Y, Tanaka T, Nakamura J, Hashiguchi K, Noshiro H, Miyazaki K.  Aberrant gene methylation is a biomarker for the detection of cancer cells in peritoneal wash samples from advanced gastric cancer patients.  Ann. Surg. Oncol.  2011  18:3013-9  PubMed ID: 21409489
Takenouchi M, Hirai S, Sakuragi N, Yagita H, Hamada H, Kato K.  Epigenetic modulation enhances the therapeutic effect of anti-IL-13R(alpha)2 antibody in human mesothelioma xenografts.  Clin. Cancer Res.  2011  17:2819-29  PubMed ID: 21357681
Shin VY, Jin HC, Ng EK, Cho CH, Leung WK, Sung JJ, Chu KM.  4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone promoted gastric cancer growth through prostaglandin E receptor (EP2 and EP4) in vivo and in vitro.  Cancer Sci.  2011  102:926-33  PubMed ID: 21261791
Aoki M, Ishigami S, Uenosono Y, Arigami T, Uchikado Y, Kita Y, Kurahara H, Matsumoto M, Ueno S, Natsugoe S.  Expression of BMP-7 in human gastric cancer and its clinical significance.  Br. J. Cancer  2011  104:714-8  PubMed ID: 21224856
Bachleitner-Hofmann T, Sun MY, Chen CT, Liska D, Zeng Z, Viale A, Olshen AB, Mittlboeck M, Christensen JG, Rosen N, Solit DB, Weiser MR.  Antitumor activity of SNX-2112, a synthetic heat shock protein-90 inhibitor, in MET-amplified tumor cells with or without resistance to selective MET Inhibition.  Clin. Cancer Res.  2011  17:122-33  PubMed ID: 21208906
Endo S, Yamato K, Hirai S, Moriwaki T, Fukuda K, Suzuki H, Abei M, Nakagawa I, Hyodo I.  Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells.  Cancer Sci.  2011  102:605-13  PubMed ID: 21205074
Coombs N, Sompallae R, Olbermann P, Gastaldello S, Goppel D, Masucci MG, Josenhans C.  Helicobacter pylori affects the cellular deubiquitinase USP7 and ubiquitin-regulated components TRAF6 and the tumour suppressor p53.  Int. J. Med. Microbiol.  2010  301:213-24  PubMed ID: 21131231
Nakaya K, Ayaori M, Uto-Kondo H, Hisada T, Ogura M, Yakushiji E, Takiguchi S, Terao Y, Ozasa H, Sasaki M, Komatsu T, Ohsuzu F, Ikewaki K.  Cilostazol enhances macrophage reverse cholesterol transport in vitro and in vivo.  Atherosclerosis  2010  213:135-41  PubMed ID: 20723893
Makiyama T, Nagasaka N, Houjyo Y, Yamaura E, Nakamura H, Koide Y, Nishida A, Murayama T.  Newly synthetic ceramide-1-phosphate analogs; their uptake, intracellular localization, and roles as an inhibitor of cytosolic phospholipase A(2)α and inducer of cell toxicity.  Biochem. Pharmacol.  2010  80:1396-406  PubMed ID: 20688048
Chong PK, Lee H, Zhou J, Liu SC, Loh MC, Wang TT, Chan SP, Smoot DT, Ashktorab H, So JB, Lim KH, Yeoh KG, Lim YP.  ITIH3 is a potential biomarker for early detection of gastric cancer.  J. Proteome Res.  2010  9:3671-9  PubMed ID: 20515073
Seto M, Ohta M, Ikenoue T, Sugimoto T, Asaoka Y, Tada M, Mohri D, Kudo Y, Ijichi H, Tateishi K, Otsuka M, Hirata Y, Maeda S, Koike K, Omata M.  Reduced expression of RAS protein activator like-1 in gastric cancer.  Int. J. Cancer  2010  128:1293-302  PubMed ID: 20473946
Chong PK, Lee H, Zhou J, Liu SC, Loh MC, So JB, Lim KH, Yeoh KG, Lim YP.  Reduced plasma APOA1 level is associated with gastric tumor growth in MKN45 mouse xenograft model.  J Proteomics  2010  73:1632-40  PubMed ID: 20399916
Saito Y, Sekine W, Sano R, Komatsu S, Mizuno H, Katabami K, Shimada K, Oku T, Tsuji T.  Potentiation of cell invasion and matrix metalloproteinase production by alpha3beta1 integrin-mediated adhesion of gastric carcinoma cells to laminin-5.  Clin. Exp. Metastasis  2010  27:197-205  PubMed ID: 20352300
Takeuchi M, Inoue T, Otani T, Yamasaki F, Nakamura S, Kibata M.  Cell-in-cell structures formed between human cancer cell lines and the cytotoxic regulatory T-cell line HOZOT.  J Mol Cell Biol  2010  2:139-51  PubMed ID: 20348186
Shin VY, Jin HC, Ng EK, Sung JJ, Chu KM, Cho CH.  Activation of 5-lipoxygenase is required for nicotine mediated epithelial-mesenchymal transition and tumor cell growth.  Cancer Lett.  2010  292:237-45  PubMed ID: 20061081
Nakamura J, Kitajima Y, Kai K, Hashiguchi K, Hiraki M, Noshiro H, Miyazaki K.  HIF-1alpha is an unfavorable determinant of relapse in gastric cancer patients who underwent curative surgery followed by adjuvant 5-FU chemotherapy.  Int. J. Cancer  2009  127:1158-71  PubMed ID: 20020496
Zhang DX, Zhao PT, Xia L, Liu LL, Liang J, Zhai HH, Zhang HB, Guo XG, Wu KC, Xu YM, Jia LT, Yang AG, Chen SY, Fan DM.  Potent inhibition of human gastric cancer by HER2-directed induction of apoptosis with anti-HER2 antibody and caspase-3 fusion protein.  Gut  2009  59:292-9  PubMed ID: 19951902
Zaidi SF, Yamamoto T, Refaat A, Ahmed K, Sakurai H, Saiki I, Kondo T, Usmanghani K, Kadowaki M, Sugiyama T.  Modulation of activation-induced cytidine deaminase by curcumin in Helicobacter pylori-infected gastric epithelial cells.  Helicobacter  2009  14:588-95  PubMed ID: 19889077
Zaidi SF, Ahmed K, Yamamoto T, Kondo T, Usmanghani K, Kadowaki M, Sugiyama T.  Effect of resveratrol on Helicobacter pylori-induced interleukin-8 secretion, reactive oxygen species generation and morphological changes in human gastric epithelial cells.  Biol. Pharm. Bull.  2009  32:1931-5  PubMed ID: 19881312
Miyato H, Kitayama J, Yamashita H, Souma D, Asakage M, Yamada J, Nagawa H.  Pharmacological synergism between cannabinoids and paclitaxel in gastric cancer cell lines.  J. Surg. Res.  2009  155:40-7  PubMed ID: 19394652
Auyeung KK, Cho CH, Ko JK.  A novel anticancer effect of Astragalus saponins: Transcriptional activation of NSAID-activated gene.  Int. J. Cancer  2009  125:1082-91  PubMed ID: 19384947
Hitoshi KAWAMOTO, Yasunari MIKI, Takayuki KIMURA, Katsunori TANAKA, Tsuyoshi NAKAGAWA, Makoto KAWAMUKAI and Hideyuki MATSUDA  Effects of fucoidan from Mozuku on human stomach cell lines  Food Sci Technol Res  2006  12:218-222 
Ohta M, Tateishi K, Kanai F, Watabe H, Kondo S, Guleng B, Tanaka Y, Asaoka Y, Jazag A, Imamura J, Ijichi H, Ikenoue T, Sata M, Miyagishi M, Taira K, Tada M, Kawabe T, Omata M.  p53-Independent negative regulation of p21/cyclin-dependent kinase-interacting protein 1 by the sonic hedgehog-glioma-associated oncogene 1 pathway in gastric carcinoma cells.  Cancer Res.  2005  65:10822-9  PubMed ID: 16322228
Lin CJ, Liao WC, Lin HJ, Hsu YM, Lin CL, Chen YA, Feng CL, Chen CJ, Kao MC, Lai CH, Kao CH.  Statins Attenuate Helicobacter pylori CagA Translocation and Reduce Incidence of Gastric Cancer: In Vitro and Population-Based Case-Control Studies.  PLoS ONE  2016  11:e0146432  PubMed ID: 26730715
Ito K, Mitsunaga M, Arihiro S, Saruta M, Matsuoka M, Kobayashi H, Tajiri H.  Molecular targeted photoimmunotherapy for HER2-positive human gastric cancer in combination with chemotherapy results in improved treatment outcomes through different cytotoxic mechanisms.  BMC Cancer  2016  16:37  PubMed ID: 26810644
Shida M, Kitajima Y, Nakamura J, Yanagihara K, Baba K, Wakiyama K, Noshiro H.  Impaired mitophagy activates mtROS/HIF-1α interplay and increases cancer aggressiveness in gastric cancer cells under hypoxia.  Int. J. Oncol.  2016  48:1379-90  PubMed ID: 26820502
Mu J, Liu T, Jiang L, Wu X, Cao Y, Li M, Dong Q, Liu Y, Xu H.  The Traditional Chinese Medicine Baicalein Potently Inhibits Gastric Cancer Cells.  J Cancer  2016  7:453-61  PubMed ID: 26918059
Shiraishi K, Mimura K, Kua LF, Koh V, Siang LK, Nakajima S, Fujii H, Shabbir A, Yong WP, So J, Takenoshita S, Kono K.  Inhibition of MMP activity can restore NKG2D ligand expression in gastric cancer, leading to improved NK cell susceptibility.  J. Gastroenterol.  2016  51:1101-1111  PubMed ID: 27002316
Lan H, Tang Z, Jin H, Sun Y.  Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells.  Sci Rep  2016  6:24218  PubMed ID: 27063292
Zhu L, Cheng X, Shi J, Jiacheng L, Chen G, Jin H, Liu AB, Pyo H, Ye J, Zhu Y, Wang H, Chen H, Fang J, Cai L, Wang TC, Yang CS, Tu SP.  Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis.  Oncogene  2016  35:5388-5399  PubMed ID: 27109105
Okahashi N, Nakata M, Kuwata H, Kawabata S.  Streptococcus oralis Induces Lysosomal Impairment of Macrophages via Bacterial Hydrogen Peroxide.  Infect. Immun.  2016  84:2042-2050  PubMed ID: 27113357
Yamada S, Asanagi M, Hirata N, Itagaki H, Sekino Y, Kanda Y.  Tributyltin induces mitochondrial fission through Mfn1 degradation in human induced pluripotent stem cells.  Toxicol In Vitro  2016  34:257-63  PubMed ID: 27133438
Izawa T, Mori H, Shinohara T, Mino-Oka A, Hutami IR, Iwasa A, Tanaka E.  Rebamipide Attenuates Mandibular Condylar Degeneration in a Murine Model of TMJ-OA by Mediating a Chondroprotective Effect and by Downregulating RANKL-Mediated Osteoclastogenesis.  PLoS ONE  2016  11:e0154107  PubMed ID: 27123995
Zhou J, You W, Sun G, Li Y, Chen B, Ai J, Jiang H.  The Marine-Derived Oligosaccharide Sulfate MS80, a Novel Transforming Growth Factor β1 Inhibitor, Reverses Epithelial Mesenchymal Transition Induced by Transforming Growth Factor-β1 and Suppresses Tumor Metastasis.  J. Pharmacol. Exp. Ther.  2016  359:54-61  PubMed ID: 27432893
Deguchi Y, Okabe H, Oshima N, Hisamori S, Minamiguchi S, Muto M, Sakai Y.  PTEN loss is associated with a poor response to trastuzumab in HER2-overexpressing gastroesophageal adenocarcinoma.  Gastric Cancer  2017  20:416-427  PubMed ID: 27517839
Xie P, Fujii I, Zhao J, Shinohara M, Matsukura M.  A novel polysaccharide derived from algae extract induces apoptosis and cell cycle arrest in human gastric carcinoma MKN45 cells via ROS/JNK signaling pathway.  Int. J. Oncol.  2016  49:1561-1568  PubMed ID: 27633119
Hayashi N, Kataoka H, Yano S, Kikuchi JI, Tanaka M, Nishie H, Kinoshita Y, Hatano M, Nomoto A, Ogawa A, Inoue M, Mizoshita T, Shimura T, Mori Y, Kubota E, Tanida S, Joh T.  Anticancer Effects of a New Aminosugar-conjugated Platinum Complex Agent Against Cisplatin-resistant Gastric Cancer.  Anticancer Res.  2016  36:6005-6009  PubMed ID: 27793927
Chang HR, Nam S, Lee J, Kim JH, Jung HR, Park HS, Park S, Ahn YZ, Huh I, Balch C, Ku JL, Powis G, Park T, Jeong JH, Kim YH.  Systematic approach identifies RHOA as a potential biomarker therapeutic target for Asian gastric cancer.  Oncotarget  2016  7:81435-81451  PubMed ID: 27806312
Diaz-Lagares A, Crujeiras AB, Lopez-Serra P, Soler M, Setien F, Goyal A, Sandoval J, Hashimoto Y, Martinez-Cardús A, Gomez A, Heyn H, Moutinho C, Espada J, Vidal A, Paúles M, Galán M, Sala N, Akiyama Y, Martínez-Iniesta M, Farré L, Villanueva A, Gross M, Diederichs S, Guil S, Esteller M.  Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer.  Proc. Natl. Acad. Sci. U.S.A.  2016  113:E7535-E7544  PubMed ID: 27821766
Tanaka S, Nagashima H, Uotani T, Graham DY, Yamaoka Y.  Autophagy-related genes in Helicobacter pylori infection.  Helicobacter  2017  22:  PubMed ID: 28111844
Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N.  Introduction of plasmids into gastric cancer cells by endoscopic ultrasound.  Oncol Lett  2017  13:3127-3130  PubMed ID: 28521417
Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N.  CCAAT/enhancer-binding protein α decreases the viability of gastric cancer cells.  Oncol Lett  2017  13:4322-4326  PubMed ID: 28599433
Gen Y, Yasui K, Kitaichi T, Iwai N, Terasaki K, Dohi O, Hashimoto H, Fukui H, Inada Y, Fukui A, Jo M, Moriguchi M, Nishikawa T, Umemura A, Yamaguchi K, Konishi H, Naito Y, Itoh Y.  ASPP2 suppresses invasion and TGF-β1-induced epithelial-mesenchymal transition by inhibiting Smad7 degradation mediated by E3 ubiquitin ligase ITCH in gastric cancer.  Cancer Lett.  2017  398:52-61  PubMed ID: 28400336
Suzuki N, Nakagawa F, Takechi T.  Trifluridine/tipiracil increases survival rates in peritoneal dissemination mouse models of human colorectal and gastric cancer.  Oncol Lett  2017  14:639-646  PubMed ID: 28693216
Yanoma T, Ogata K, Yokobori T, Ide M, Mochiki E, Toyomasu Y, Yanai M, Kogure N, Kimura A, Suzuki M, Nakazawa N, Bai T, Oyama T, Asao T, Shirabe K, Kuwano H.  Heat shock-induced HIKESHI protects cell viability via nuclear translocation of heat shock protein 70.  Oncol. Rep.  2017  38:1500-1506  PubMed ID: 28731175
Shibaguchi H, Luo N, Shirasu N, Kuroki M, Kuroki M.  Enhancement of antitumor activity by using a fully human gene encoding a single-chain fragmented antibody specific for carcinoembryonic antigen.  Onco Targets Ther  2017  10:3979-3990  PubMed ID: 28860806
Lin Z, Lai S, He X, Zhuo W, Wang L, Si J, Chen S.  Decreased long non-coding RNA MTM contributes to gastric cancer cell migration and invasion via modulating MT1F.  Oncotarget  2017  8:97371-97383  PubMed ID: 29228617
Imamura T, Komatsu S, Ichikawa D, Miyamae M, Okajima W, Ohashi T, Kiuchi J, Nishibeppu K, Kosuga T, Konishi H, Shiozaki A, Okamoto K, Fujiwara H, Otsuji E.  Low plasma levels of miR-101 are associated with tumor progression in gastric cancer.  Oncotarget  2017  8:106538-106550  PubMed ID: 29290969
Lan KH, Lee WP, Wang YS, Liao SX, Lan KH.  Helicobacter pylori CagA protein activates Akt and attenuates chemotherapeutics-induced apoptosis in gastric cancer cells.  Oncotarget  2017  8:113460-113471  PubMed ID: 29371922
Zhu S, Chen Z, Wang L, Peng D, Belkhiri A, Lockhart AC, El-Rifai W.  A Combination of SAHA and Quinacrine Is Effective in Inducing Cancer Cell Death in Upper Gastrointestinal Cancers.  Clin. Cancer Res.  2018  24:1905-1916  PubMed ID: 29386219
Xue M, Chen LY, Wang WJ, Su TT, Shi LH, Wang L, Zhang W, Si JM, Wang LJ, Chen SJ.  HOTAIR induces the ubiquitination of Runx3 by interacting with Mex3b and enhances the invasion of gastric cancer cells.  Gastric Cancer  2018    PubMed ID: 29417297
Shimada S, Akiyama Y, Mogushi K, Ishigami-Yuasa M, Kagechika H, Nagasaki H, Fukamachi H, Yuasa Y, Tanaka S.  Identification of selective inhibitors for diffuse-type gastric cancer cells by screening of annotated compounds in preclinical models.  Br. J. Cancer  2018  118:972-984  PubMed ID: 29527007
Emam SE, Ando H, Abu Lila AS, Shimizu T, Ukawa M, Okuhira K, Ishima Y, Mahdy MA, Ghazy FS, Ishida T.  A Novel Strategy to Increase the Yield of Exosomes (Extracellular Vesicles) for an Expansion of Basic Research.  Biol. Pharm. Bull.  2018  41:733-742  PubMed ID: 29709910
Kitayama J, Ishigami H, Yamaguchi H, Yamada J, Soma D, Miyato H, Kamei T, Lefor AK, Sata N.  Optimal drug delivery for intraperitoneal paclitaxel (PTX) in murine model  Pleura Peritoneum  2017  2:95-102  PubMed ID: 30911637
Guan SS, Wu CT, Chiu CY, Luo TY, Wu JY, Liao TZ, Liu SH.  Polyethylene glycol-conjugated HER2-targeted peptides as a nuclear imaging probe for HER2-overexpressed gastric cancer detection in vivo.  J Transl Med  2018    PubMed ID: 29921305
Nguyen PH, Touchefeu Y, Durand T, Aubert P, Duchalais E, Bruley des Varannes S, Varon C, Neunlist M, Matysiak-Budnik T.  Acetylcholine induces stem cell properties of gastric cancer cells of diffuse type.  Tumour Biol.  2018    PubMed ID: 30207200
Osanai-Sasakawa A, Hosomi K, Sumitomo Y, Takizawa T, Tomura-Suruki S, Imaizumi M, Kasai N, Poh TW, Yamano K, Yong WP, Kono K, Nakamura S, Ishii T, Nakai R.  An anti-ASCT2 monoclonal antibody suppresses gastric cancer growth by inducing oxidative stress and antibody dependent cellular toxicity in preclinical models.  Am J Cancer Res  2018    PubMed ID: 30210919
Kato R, Iwamuro M, Shiraha H, Horiguchi S, Tanaka E, Matsumoto K, Ohyama A, Sawahara H, Nagahara T, Uchida D, Tsutsumi K, Okada H.  Dipeptide γ-secretase inhibitor treatment enhances the anti-tumor effects of cisplatin against gastric cancer by suppressing cancer stem cell properties.  Oncol Lett  2018    PubMed ID: 30250614
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