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Cell No. : Cell Name
RCB0999 : MKN7  update : 2024/12/09
Commentc-erbB-2 expressing gastric adenocarcinoma. Differentiated type.
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Motoyama, Teiichi
Originator Hojo, Haruto
Year of deposit 1994
Animal _human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Male
Age at sampling 39 years
Tissue stomach, lymph node meta
Metastatic ability Yes
Metastatic tissue lymph node
Genetics Gastric adenocarcinoma
Classification cancer
Year of origin 1975
History Hojo, Haruto - Motoyama, Teiichi
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_1417
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : once/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma/Acholeplasma (-)
Virus (HIV) (-)
Isozyme LD, NP
Chromosome mode 51-71(50) : /64(1),65(3),66(4),67(6),68(7),69(14)/
STR(human) OK
Images
deposit info
lot info
Reference information Reference 6
User's Publication 127


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Reference
4399  Homma N, Tamura G, Honda T, Matsumoto Y, Nishizuka S, Kawata S, Motoyama T.  Spreading of methylation within RUNX3 CpG island in gastric cancer.  Cancer Sci  2006  97(1):51-6  PubMed ID: 16367921   DOI: 10.1111/j.1349-7006.2005.00133.x
4501  Yanagawa N, Tamura G, Honda T, Endoh M, Nishizuka S, Motoyama T.  Demethylation of the synuclein gamma gene CpG island in primary gastric cancers and gastric cancer cell lines.  Clin Cancer Res  2004  10(7):2447-51  PubMed ID: 15073123   DOI: 10.1158/1078-0432.ccr-03-0107
5050  Koyama K, Akiyama K, Kawahara H, Egashira A, Murakami H.  Alloimmunization with cultured human stomach cancer cell lines and the establishment of human-human hybridomas producing monoclonal antibodies.  Jpn J Cancer Res  1990  81(10):967-70  PubMed ID: 2121682   DOI: 10.1111/j.1349-7006.1990.tb03332.x
1889  Motoyama T, Hojo H, Watanabe H  Comparison of seven cell lines derived from human gastric carcinomas.  Acta Pathol Jpn  1986  36:65-83  PubMed ID: 3962675   DOI: 10.1111/j.1440-1827.1986.tb01461.x
5075  Nakatani H, Tahara E, Yoshida T, Sakamoto H, Suzuki T, Watanabe H, Sekiguchi M, Kaneko Y, Sakurai M, Terada M, et al.  Detection of amplified DNA sequences in gastric cancers by a DNA renaturation method in gel.  Jpn J Cancer Res  1986  77(9):849-53  PubMed ID: 3095279  
1861  Motoyama T, Watanabe H.  Carcinoembryonic antigen production in human gastric cancer cell lines in vitro and in nude mice.  Gan  1983  74(5):679-86  PubMed ID: 6642141  

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User's Publication
21570  Shirasaka Y, Yamada K, Etoh T, Noguchi K, Hasegawa T, Ogawa K, Kobayashi T, Nishizono A, Inomata M.  Cytocidal Effect of Irradiation on Gastric Cancer Cells Infected with a Recombinant Mammalian Orthoreovirus Expressing a Membrane-Targeted KillerRed.  Pharmaceuticals (Basel)  2024  17(1)  PubMed ID: 38256912   DOI: 10.3390/ph17010079
19687  Mori Y, Nishikawa SG, Fratiloiu AR, Tsutsui M, Kataoka H, Joh T, Johnston RN.  Modulation of Reoviral Cytolysis (I): Combination Therapeutics  Viruses  2023  15(7):1472  PubMed ID: 37515160   DOI: 10.3390/v15071472
19729  Sato T, Saito M, Nakajima S, Saito K, Katagata M, Fukai S, Okayama H, Sakamoto W, Saze Z, Momma T, Mimura K, Kono K.  ARID1A deficiency is targetable by AKT inhibitors in HER2-negative gastric cancer  Gastric Cancer  2023  26(3):379-392  PubMed ID: 36811690   DOI: 10.1007/s10120-023-01373-6
19939  hiozaki A, Fukami T, Shimizu H, Kosuga T, Kudou M, Takemoto K, Katsurahara K, Nishibeppu K, Ohashi T, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Otsuji E.  Effects of TRPV2 on the Expression of PD-L1 and Its Binding Ability to PD-1 in Gastric Cancer  Ann Surg Oncol  2023  30(13):8704-8716  PubMed ID: 37599296   DOI: 10.1245/s10434-023-14084-0
19973  Fukai S, Nakajima S, Saito M, Saito K, Kase K, Nakano H, Sato T, Sakuma M, Kaneta A, Okayama H, Mimura K, Sakamoto W, Saze Z, Momma T, Kono K.  Down-regulation of stimulator of interferon genes (STING) expression and CD8+ T-cell infiltration depending on HER2 heterogeneity in HER2-positive gastric cancer  Gastric Cancer  2023  26(6):878-890  PubMed ID: 37542528   DOI: 10.1007/s10120-023-01417-x
21486  Lou M, Iwatsuki M, Wu X, Zhang W, Matsumoto C, Baba H.  Cancer-Associated Fibroblast-Derived IL-8 Upregulates PD-L1 Expression in Gastric Cancer Through the NF-κB Pathway.  Ann Surg Oncol  2023    PubMed ID: 38006530   DOI: 10.1245/s10434-023-14586-x
17567  Takashima Y, Komatsu S, Ohashi T, Kiuchi J, Kamiya H, Shimizu H, Arita T, Konishi H, Shiozaki A, Kubota T, Okamoto K, Fujiwara H, Tsuda H, Otsuji E.  Overexpression of Tetraspanin31 contributes to malignant potential and poor outcomes in gastric cancer  Cancer Sci  2022  113(6):1984-1998  PubMed ID: 35307915   DOI: 10.1111/cas.15342
20459  Kato S, Shiozaki A, Kudou M, Shimizu H, Kosuga T, Ohashi T, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  TRPV2 Promotes Cell Migration and Invasion in Gastric Cancer via the Transforming Growth Factor-β Signaling Pathway.  Ann Surg Oncol  2022    PubMed ID: 34855064   DOI: 10.1245/s10434-021-11132-5
20571  Fu L, Yonemura A, Yasuda-Yoshihara N, Umemoto T, Zhang J, Yasuda T, Uchihara T, Akiyama T, Kitamura F, Yamashita K, Okamoto Y, Bu L, Wei F, Hu X, Liu Y, Ajani JA, Tan P, Baba H, Ishimoto T.  Intracellular MUC20 variant 2 maintains mitochondrial calcium homeostasis and enhances drug resistance in gastric cancer.  Gastric Cancer  2022    PubMed ID: 35166958   DOI: 10.1007/s10120-022-01283-z
20622  Takaki W, Konishi H, Matsubara D, Shoda K, Arita T, Kataoka S, Shibamoto J, Furuke H, Takabatake K, Shimizu H, Komatsu S, Shiozaki A, Kubota T, Okamoto K, Otsuji E.  Role of Extracellular High-Mobility Group Box-1 as a Therapeutic Target of Gastric Cancer.  Int J Mol Sci  2022  23(6)  PubMed ID: 35328684   DOI: 10.3390/ijms23063264
20627  Soda T, Gen Y, Terasaki K, Iwai N, Kitaichi T, Dohi O, Taketani H, Seko Y, Umemura A, Nishikawa T, Yamaguchi K, Moriguchi M, Konishi H, Naito Y, Itoh Y, Yasui K.  Loss of KAP3 decreases intercellular adhesion and impairs intracellular transport of laminin in signet ring cell carcinoma of the stomach.  Sci Rep  2022  12(1):5050  PubMed ID: 35322078   DOI: 10.1038/s41598-022-08904-8
20661  Inoue H, Shiozaki A, Kosuga T, Shimizu H, Kudou M, Ohashi T, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  Functions and Clinical Significance of CACNA2D1 in Gastric Cancer.  Ann Surg Oncol  2022    PubMed ID: 35445337   DOI: 10.1245/s10434-022-11752-5
21996  Fukami T, Shiozaki A, Kosuga T, Kudou M, Shimizu H, Ohashi T, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Morinaga Y, Konishi E, Otsuji E.  Anoctamin 5 regulates the cell cycle and affects prognosis in gastric cancer  World J Gastroenterol  2022  28(32):4649-4667.  PubMed ID: 36157935   DOI: 10.3748/wjg.v28.i32.4649
13323  Nishibeppu K, Komatsu S, Kiuchi J, Kishimoto T, Takashima Y, Shoda K, Arita T, Kosuga T, Konishi H, Shiozaki A, Kubota T, Okamoto K, Fujiwara H, Tsuda H, Otsuji E.  TRIM37 contributes to malignant outcomes and CDDP resistance in gastric cancer.  J Cancer  2021    PubMed ID: 33391428   DOI: 10.7150/jca.47577
20005  Iwata Y, Yasufuku I, Saigo C, Kito Y, Takeuchi T, Yoshida K.  Anti-fibrotic properties of an adiponectin paralog protein, C1q/TNF-related protein 6 (CTRP6), in diffuse gastric adenocarcinoma.  J Cancer  2021  12(4):1161-1168  PubMed ID: 33442414   DOI: 10.7150/jca.46765
20116  Kurashima K, Shiozaki A, Kudou M, Shimizu H, Arita T, Kosuga T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  LRRC8A influences the growth of gastric cancer cells via the p53 signaling pathway.  Gastric Cancer  2021    PubMed ID: 33864161   DOI: 10.1007/s10120-021-01187-4
14345  Katsurahara K, Shiozaki A, Kosuga T, Shimizu H, Kudou M, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  ANO9 regulates PD-L2 expression and binding ability to PD-1 in gastric cancer  Cancer Sci  2021  112(3):1026-1037.   PubMed ID: 33404124   DOI: 10.1111/cas.14796
16126  Nakamura K, Shiozaki A, Kosuga T, Shimizu H, Kudou M, Ohashi T, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  The expression of the alpha1 subunit of Na +/K +-ATPase is related to tumor development and clinical outcomes in gastric cancer  Gastric Cancer  2021  24(6):1278-1292  PubMed ID: 34251542   DOI: 10.1007/s10120-021-01212-6
16229  Wenzhe Li, Atsushi Okabe, Genki Usui, Masaki Fukuyo, Keisuke Matsusaka, Bahityar Rahmutulla, Yasunobu Mano, Takayuki Hoshii, Sayaka Funata, Nobuhiro Hiura, Masashi Fukayama, Patrick Tan, Tetsuo Ushiku, Atsushi Kaneda  Activation of EHF via STAT3 phosphorylation by LMP2A in Epstein-Barr virus-positive gastric cancer  Cancer Sci  2021  112(8):3349-3362  PubMed ID: 34014591   DOI: 10.1111/cas.14978
16861  Kunzke T, Hölzl FT, Prade VM, Buck A, Huber K, Feuchtinger A, Ebert K, Zwingenberger G, Geffers R, Hauck SM, Haffner I, Luber B, Lordick F, Walch A.  Metabolomic therapy response prediction in pretherapeutic tissue biopsies for trastuzumab in patients with HER2-positive advanced gastric cancer  Clin Transl Med  2021  11(9):e547.  PubMed ID: 34586736   DOI: 10.1002/ctm2.547
12041  Hirano T, Shinsato Y, Tanabe K, Higa N, Kamil M, Kawahara K, Yamamoto M, Minami K, Shimokawa M, Arigami T, Yanagita S, Matushita D, Uenosono Y, Ishigami S, Kijima Y, Maemura K, Kitazono I, Tanimoto A, Furukawa T, Natsugoe S.  FARP1 boosts CDC42 activity from integrin αvβ5 signaling and correlates with poor prognosis of advanced gastric cancer.  Oncogenesis  2020    PubMed ID: 32029704   DOI: 10.1038/s41389-020-0190-7
13023  Berlamont H, De Witte C, Bauwens E, Min Jou H, Ducatelle R, De Meester E, Gansemans Y, Deforce D, Van Nieuwerburgh F, Haesebrouck F, Smet A.  Distinct transcriptome signatures of Helicobacter suis and Helicobacter heilmannii strains upon adherence to human gastric epithelial cells.  Vet Res  2020    PubMed ID: 32381076   DOI: 10.1186/s13567-020-00786-w
13131  Okabe A, Huang KK, Matsusaka K, Fukuyo M, Xing M, Ong X, Hoshii T, Usui G, Seki M, Mano Y, Rahmutulla B, Kanda T, Suzuki T, Rha SY, Ushiku T, Fukayama M, Tan P, Kaneda A.  Cross-species chromatin interactions drive transcriptional rewiring in Epstein-Barr virus-positive gastric adenocarcinoma.  Nat Genet  2020    PubMed ID: 32719515   DOI: 10.1038/s41588-020-0665-7
13315  Ebert K, Zwingenberger G, Barbaria E, Keller S, Heck C, Arnold R, Hollerieth V, Mattes J, Geffers R, Raimúndez E, Hasenauer J, Luber B.  Determining the effects of trastuzumab, cetuximab and afatinib by phosphoprotein, gene expression and phenotypic analysis in gastric cancer cell lines.  BMC Cancer  2020    PubMed ID: 33115415   DOI: 10.1186/s12885-020-07540-7
13344  Hinata M, Kunita A, Abe H, Morishita Y, Sakuma K, Yamashita H, Seto Y, Ushiku T, Fukayama M.  Exosomes of Epstein-Barr Virus-Associated Gastric Carcinoma Suppress Dendritic Cell Maturation.  Microorganisms  2020    PubMed ID: 33198173   DOI: 10.3390/microorganisms8111776
13504  Baatar S, Bai T, Yokobori T, Gombodorj N, Nakazawa N, Ubukata Y, Kimura A, Kogure N, Sano A, Sohda M, Sakai M, Tumenjargal A, Ogata K, Kuwano H, Shirabe K, Saeki H.  High RAD18 Expression is Associated with Disease Progression and Poor Prognosis in Patients with Gastric Cancer  Ann Surg Oncol  2020  27(11):4360-4368  PubMed ID: 32356270   DOI: 10.1245/s10434-020-08518-2
13525  Asakawa Y, Okabe A, Fukuyo M, Li W, Ikeda E, Mano Y, Funata S, Namba H, Fujii T, Kita K, Matsusaka K, Kaneda A.  Epstein-Barr virus-positive gastric cancer involves enhancer activation through activating transcription factor 3  Cancer Sci  2020  111(5):1818-1828  PubMed ID: 32119176   DOI: 10.1111/cas.14370
13600  Sano H, Futamura M, Gaowa S, Kamino H, Nakamura Y, Yamaguchi K, Tanaka Y, Yasufuku I, Nakakami A, Arakawa H, Yoshida K.  p53/Mieap-regulated mitochondrial quality control plays an important role as a tumor suppressor in gastric and esophageal cancers  Biochem Biophys Res Commun  2020  529(3):582-589.  PubMed ID: 32736677   DOI: 10.1016/j.bbrc.2020.05.168
14832  Saito S, Kitamura-Muramatsu Y, Komine F, Polat M, Takeshima SN, Takei M, Aida Y.  Absence of bovine leukemia virus proviral DNA in Japanese human blood cell lines and human cancer cell lines  Arch Virol  2020  165(1):207-214  PubMed ID: 31776677   DOI: 10.1007/s00705-019-04474-9
11505  Kageyama-Yahara N, Yamamichi N, Takahashi Y, Takeuchi C, Matsumoto Y, Sakaguchi Y, Koike K.  Tandem repeats of the 5' flanking region of human MUC5AC have a role as a novel enhancer in MUC5AC gene expression.  Biochem Biophys Rep  2019  18:100632  PubMed ID: 30993217   DOI: 10.1016/j.bbrep.2019.100632
11568  De Witte C, Demeyere K, De Bruyckere S, Taminiau B, Daube G, Ducatelle R, Meyer E, Haesebrouck F.  Characterization of the non-glandular gastric region microbiota in Helicobacter suis-infected versus non-infected pigs identifies a potential role for Fusobacterium gastrosuis in gastric ulceration.  Vet. Res.  2019  50(1):39  PubMed ID: 31126330   DOI: 10.1186/s13567-019-0656-9
11499  S Zhang et al  Sensitization of Gastric Cancer Cells to Irinotecan by p53 Activation  BPB Reports  2019  2,130-133   
14935  Wu D, Yan J, Shen X, Sun Y, Thulin M, Cai Y, Wik L, Shen Q, Oelrich J, Qian X, Dubois KL, Ronquist KG, Nilsson M, Landegren U, Kamali-Moghaddam M.  Profiling surface proteins on individual exosomes using a proximity barcoding assay  Nat Commun  2019  10(1):3854  PubMed ID: 31451692   DOI: 10.1038/s41467-019-11486-1
10787  Shimada S, Akiyama Y, Mogushi K, Ishigami-Yuasa M, Kagechika H, Nagasaki H, Fukamachi H, Yuasa Y, Tanaka S.  Identification of selective inhibitors for diffuse-type gastric cancer cells by screening of annotated compounds in preclinical models.  Br. J. Cancer  2018  118:972-984  PubMed ID: 29527007   DOI: 10.1038/s41416-018-0008-y
11145  Li W, Wong CC, Zhang X, Kang W, Nakatsu G, Zhao Q, Chen H, Go MYY, Chiu PWY, Wang X, Ji J, Li X, Cai Z, Ng EKW, Yu J.  CAB39L elicited an anti-Warburg effect via a LKB1-AMPK-PGC1α axis to inhibit gastric tumorigenesis.  Oncogene  2018  37(50):6383-6398  PubMed ID: 30054562   DOI: 10.1038/s41388-018-0402-1
11095  Kim M, Pyo S, Kang CH, Lee CO, Lee HK, Choi SU, Park CH.  Folate receptor 1 (FOLR1) targeted chimeric antigen receptor (CAR) T cells for the treatment of gastric cancer.  PLoS ONE  2018  13(6):e0198347  PubMed ID: 29874279   DOI: 10.1371/journal.pone.0198347
11231  Wang Z, Qu H, Gong W, Liu A.  Up-regulation and tumor-promoting role of SPHK1 were attenuated by miR-330-3p in gastric cancer.  IUBMB Life  2018    PubMed ID: 30281914   DOI: 10.1002/iub.1934
4300  Keller S, Zwingenberger G, Ebert K, Hasenauer J, Wasmuth J, Maier D, Haffner I, Schierle K, Weirich G, Luber B.  Effects of trastuzumab and afatinib on kinase activity in gastric cancer cell lines.  Mol Oncol  2018    PubMed ID: 29325228   DOI: 10.1002/1878-0261.12170
4313  Kiuchi J, Komatsu S, Imamura T, Nishibeppu K, Shoda K, Arita T, Kosuga T, Konishi H, Shiozaki A, Kubota T, Okamoto K, Fujiwara H, Ichikawa D, Tsuda H, Otsuji E.  Overexpression of YEATS4 contributes to malignant outcomes in gastric carcinoma.  Am J Cancer Res  2018    PubMed ID: 30662802  
4380  Yoshioka T, Shien K, Namba K, Torigoe H, Sato H, Tomida S, Yamamoto H, Asano H, Soh J, Tsukuda K, Nagasaka T, Fujiwara T, Toyooka S.  Antitumor activity of pan-HER inhibitors in HER2-positive gastric cancer.  Cancer Sci.  2018  109(4):1166-1176  PubMed ID: 29465762   DOI: 10.1111/cas.13546
9788  Deguchi Y, Okabe H, Oshima N, Hisamori S, Minamiguchi S, Muto M, Sakai Y.  PTEN loss is associated with a poor response to trastuzumab in HER2-overexpressing gastroesophageal adenocarcinoma.  Gastric Cancer  2017  20:416-427  PubMed ID: 27517839   DOI: 10.1007/s10120-016-0627-z
9945  Ooi A, Oyama T, Nakamura R, Tajiri R, Ikeda H, Fushida S, Dobashi Y.  Gene amplification of CCNE1, CCND1, and CDK6 in gastric cancers detected by multiplex ligation-dependent probe amplification and fluorescence in situ hybridization.  Hum. Pathol.  2017  61:58-67  PubMed ID: 27864121   DOI: 10.1016/j.humpath.2016.10.025
9978  Kneissl J, Hartmann A, Pfarr N, Erlmeier F, Lorber T, Keller S, Zwingenberger G, Weichert W, Luber B.  Influence of the HER receptor ligand system on sensitivity to cetuximab and trastuzumab in gastric cancer cell lines.  J. Cancer Res. Clin. Oncol.  2017  143:573-600  PubMed ID: 27933395   DOI: 10.1007/s00432-016-2308-z
10134  Qian Y, Wong CC, Xu J, Chen H, Zhang Y, Kang W, Wang H, Zhang L, Li W, Chu ESH, Go MYY, Chiu PWY, Ng EKW, Chan FKL, Sung JJY, Si J, Yu J.  Sodium Channel Subunit SCNN1B Suppresses Gastric Cancer Growth and Metastasis via GRP78 Degradation.  Cancer Res.  2017  77:1968-1982  PubMed ID: 28202509   DOI: 10.1158/0008-5472.CAN-16-1595
10258  Gen Y, Yasui K, Kitaichi T, Iwai N, Terasaki K, Dohi O, Hashimoto H, Fukui H, Inada Y, Fukui A, Jo M, Moriguchi M, Nishikawa T, Umemura A, Yamaguchi K, Konishi H, Naito Y, Itoh Y.  ASPP2 suppresses invasion and TGF-β1-induced epithelial-mesenchymal transition by inhibiting Smad7 degradation mediated by E3 ubiquitin ligase ITCH in gastric cancer.  Cancer Lett.  2017  398:52-61  PubMed ID: 28400336   DOI: 10.1016/j.canlet.2017.04.002
10437  Yanoma T, Ogata K, Yokobori T, Ide M, Mochiki E, Toyomasu Y, Yanai M, Kogure N, Kimura A, Suzuki M, Nakazawa N, Bai T, Oyama T, Asao T, Shirabe K, Kuwano H.  Heat shock-induced HIKESHI protects cell viability via nuclear translocation of heat shock protein 70.  Oncol. Rep.  2017  38:1500-1506  PubMed ID: 28731175   DOI: 10.3892/or.2017.5844
10460  Li HK, Morokoshi Y, Nagatsu K, Kamada T, Hasegawa S.  Locoregional therapy with α-emitting trastuzumab against peritoneal metastasis of human epidermal growth factor receptor 2-positive gastric cancer in mice.  Cancer Sci.  2017  108:1648-1656  PubMed ID: 28514062   DOI: 10.1111/cas.13282
10586  Ishii S, Yamashita K, Harada H, Ushiku H, Tanaka T, Nishizawa N, Yokoi K, Washio M, Ema A, Mieno H, Moriya H, Hosoda K, Waraya M, Katoh H, Watanabe M.  The H19-PEG10/IGF2BP3 axis promotes gastric cancer progression in patients with high lymph node ratios.  Oncotarget  2017  8:74567-74581  PubMed ID: 29088808   DOI: 10.18632/oncotarget.20209
5806  Shiroki T et al  Enhanced expression of the M2 isoform of pyruvate kinase is involved in gastric cancer development by regulating cancer-specific metabolism.  Cancer Sci  2017  108(5):931-940  PubMed ID: 28235245   DOI: 10.1111/cas.13211
14227  Okabe A, Funata S, Matsusaka K, Namba H, Fukuyo M, Rahmutulla B, Oshima M, Iwama A, Fukayama M, Kaneda A.  Regulation of tumour related genes by dynamic epigenetic alteration at enhancer regions in gastric epithelial cells infected by Epstein-Barr virus  Sci Rep  2017  7(1):7924   PubMed ID: 28801683   DOI: 10.1038/s41598-017-08370-7
14615  Nambara S, Masuda T, Nishio M, Kuramitsu S, Tobo T, Ogawa Y, Hu Q, Iguchi T, Kuroda Y, Ito S, Eguchi H, Sugimachi K, Saeki H, Oki E, Maehara Y, Suzuki A, Mimori K.  Antitumor effects of the antiparasitic agent ivermectin via inhibition of Yes-associated protein 1 expression in gastric cancer  Oncotarget   2017  8(64):107666-107677  PubMed ID: 29296196   DOI: 10.18632/oncotarget.22587
14631  Funata S, Matsusaka K, Yamanaka R, Yamamoto S, Okabe A, Fukuyo M, Aburatani H, Fukayama M, Kaneda A.  Histone modification alteration coordinated with acquisition of promoter DNA methylation during Epstein-Barr virus infection  Oncotarget  2017  8(33):55265-55279  PubMed ID: 28903418   DOI: 10.18632/oncotarget.19423
14663  Ito M, Migita K, Matsumoto S, Wakatsuki K, Tanaka T, Kunishige T, Nakade H, Nakatani M, Nakajima Y.  Overexpression of E3 ubiquitin ligase tripartite motif 32 correlates with a poor prognosis in patients with gastric cancer  Oncol Lett  2017  13(5):3131-3138  PubMed ID: 28521418   DOI: 10.3892/ol.2017.5806
14737  Baba K, Kitajima Y, Miyake S, Nakamura J, Wakiyama K, Sato H, Okuyama K, Kitagawa H, Tanaka T, Hiraki M, Yanagihara K, Noshiro H.  Hypoxia-induced ANGPTL4 sustains tumour growth and anoikis resistance through different mechanisms in scirrhous gastric cancer cell lines  Sci Rep  2017  7(1):11127  PubMed ID: 28894280   DOI: 10.1038/s41598-017-11769-x
7159  Joosten M, Linden S, Rossi M, Tay AC, Skoog E, Padra M, Peters F, Perkins T, Vandamme P, Van Nieuwerburgh F, D'Herde K, Van den Broeck W, Flahou B, Deforce D, Ducatelle R, Marshall B, Haesebrouck F, Smet A.  Divergence between the Highly Virulent Zoonotic Pathogen Helicobacter heilmannii and Its Closest Relative, the Low-Virulence "Helicobacter ailurogastricus" sp. nov.  Infect. Immun.  2016  84:293-306  PubMed ID: 26527212   DOI: 10.1128/IAI.01300-15
9606  Cheng L, Mirko R, Sara L, Medea P, Caroline B, Eva B, Myrthe J, Bram F, Wim VD, Richard D, Freddy H, Annemieke S.  The Helicobacter heilmannii hofE and hofF Genes are Essential for Colonization of the Gastric Mucosa and Play a Role in IL-1β-Induced Gastric MUC13 Expression.  Helicobacter  2016  21:504-522  PubMed ID: 26935145   DOI: 10.1111/hel.12307
9610  Saju P, Murata-Kamiya N, Hayashi T, Senda Y, Nagase L, Noda S, Matsusaka K, Funata S, Kunita A, Urabe M, Seto Y, Fukayama M, Kaneda A, Hatakeyama M.  Host SHP1 phosphatase antagonizes Helicobacter pylori CagA and can be downregulated by Epstein-Barr virus.  Nat Microbiol  2016  1:16026  PubMed ID: 27572445   DOI: 10.1038/nmicrobiol.2016.26
9928  Diaz-Lagares A, Crujeiras AB, Lopez-Serra P, Soler M, Setien F, Goyal A, Sandoval J, Hashimoto Y, Martinez-Cardús A, Gomez A, Heyn H, Moutinho C, Espada J, Vidal A, Paúles M, Galán M, Sala N, Akiyama Y, Martínez-Iniesta M, Farré L, Villanueva A, Gross M, Diederichs S, Guil S, Esteller M.  Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer.  Proc. Natl. Acad. Sci. U.S.A.  2016  113:E7535-E7544  PubMed ID: 27821766   DOI: 10.1073/pnas.1608585113
10867  P. Li, Chenghong Wang, Sen Guo, Z. Zhang  Neuropilin 2 could promote gastric adenocarcinoma lymphatic invasionwith VEGF-C stimulation   Int J Clin Exp Med  2016  9:2795-2803   
3733  Nishikawaji T, Akiyama Y, Shimada S, Kojima K, Kawano T, Eishi Y, Yuasa Y, Tanaka S.  Oncogenic roles of the SETDB2 histone methyltransferase in gastric cancer.  Oncotarget  2016  7(41):67251-67265  PubMed ID: 27572307   DOI: 10.18632/oncotarget.11625
12613  Takeda S, Tanigawa T, Watanabe T, Tatsuwaki H, Nadatani Y, Otani K, Nagami Y, Tanaka F, Kamata N, Yamagami H, Shiba M, Tominaga K, Fujiwara Y, Muguruma K, Ohira M, Hirakawa K, Arakawa T.  Reduction of prostaglandin transporter predicts poor prognosis associated with angiogenesis in gastric adenocarcinoma  J Gastroenterol Hepatol  2016  31(2):376-83  PubMed ID: 26250887   DOI: 10.1111/jgh.13079
12873  Liu X, Kwong A, Sihoe A, Chu KM.  Plasma miR-940 may serve as a novel biomarker for gastric cancer  Tumour Biol  2016  37(3):3589-97  PubMed ID: 26456959   DOI: 10.1007/s13277-015-4019-5
12874  Altan B, Yokobori T, Ide M, Mochiki E, Toyomasu Y, Kogure N, Kimura A, Hara K, Bai T, Bao P, Suzuki M, Ogata K, Asao T, Nishiyama M, Oyama T, Kuwano H.  Nuclear PRMT1 expression is associated with poor prognosis and chemosensitivity in gastric cancer patients  Gastric Cancer  2016  19(3):789-97.  PubMed ID: 26472729   DOI: 10.1007/s10120-015-0551-7
12891  Namba-Fukuyo H, Funata S, Matsusaka K, Fukuyo M, Rahmutulla B, Mano Y, Fukayama M, Aburatani H, Kaneda A.  TET2 functions as a resistance factor against DNA methylation acquisition during Epstein-Barr virus infection  Oncotarget  2016  7(49):81512-81526.  PubMed ID: 27829228   DOI: 10.18632/oncotarget.13130
12951  Kubo H, Kitajima Y, Kai K, Nakamura J, Miyake S, Yanagihara K, Morito K, Tanaka T, Shida M, Noshiro H.  Regulation and clinical significance of the hypoxia-induced expression of ANGPTL4 in gastric cancer  Oncol Lett   2016  11(2):1026-1034.  PubMed ID: 26893686   DOI: 10.3892/ol.2015.4011
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7470  Sakimura S, Sugimachi K, Kurashige J, Ueda M, Hirata H, Nambara S, Komatsu H, Saito T, Takano Y, Uchi R, Sakimura E, Shinden Y, Iguchi T, Eguchi H, Oba Y, Hoka S, Mimori K.  The miR-506-Induced Epithelial-Mesenchymal Transition is Involved in Poor Prognosis for Patients with Gastric Cancer.  Ann. Surg. Oncol.  2015  22 Suppl 3:S1436-43  PubMed ID: 25707493   DOI: 10.1245/s10434-015-4418-2
5817  Sun Q, Lin P, Zhang J, Li X, Yang L, Huang J, Zhou Z, Liu P, Liu N.  Expression of Fibroblast Growth Factor 10 Is Correlated with Poor Prognosis in Gastric Adenocarcinoma.  Tohoku J Exp Med  2015  236(4):311-8  PubMed ID: 26268776   DOI: 10.1620/tjem.236.311
5819  Yoshida K, Tsujimoto H, Matsumura K, Kinoshita M, Takahata R, Matsumoto Y, Hiraki S, Ono S, Seki S, Yamamoto J, Hase K.  CD47 is an adverse prognostic factor and a therapeutic target in gastric cancer.  Cancer Med  2015  4(9):1322-33  PubMed ID: 26077800   DOI: 10.1002/cam4.478
14961  Angiopoietin-like protein 2 is a potential biomarker for gastric cancer  Angiopoietin-like protein 2 is a potential biomarker for gastric cancer  Molecular Medicine Reports  2015  11:2653-2658  PubMed ID: 25484242   DOI: 10.3892/mmr.2014.3040
15000  Sakamoto A, Akiyama Y, Shimada S, Zhu WG, Yuasa Y, Tanaka S.  DNA Methylation in the Exon 1 Region and Complex Regulation of Twist1 Expression in Gastric Cancer Cells  PLoS One  2015  10(12):e0145630  PubMed ID: 26695186   DOI: 10.1371/journal.pone.0145630
15037  Toiyama Y, Tanaka K, Kitajima T, Shimura T, Imaoka H, Mori K, Okigami M, Yasuda H, Okugawa Y, Saigusa S, Ohi M, Inoue Y, Mohri Y, Goel A, Kusunoki M.  Serum angiopoietin-like protein 2 as a potential biomarker for diagnosis, early recurrence and prognosis in gastric cancer patients  Carcinogenesis  2015  36(12):1474-83  PubMed ID: 26420253   DOI: 10.1093/carcin/bgv139
15073  Banerjee D, Fernandez HR, Patil PB, Premaratne P, Quiding-Järbrink M, Lindén SK.  Epithelial MUC1 promotes cell migration, reduces apoptosis and affects levels of mucosal modulators during acetylsalicylic acid (aspirin)-induced gastropathy  Biochem J  2015  465(3):423-31  PubMed ID: 25387004   DOI: 10.1042/BJ20140617
18932  Kang W, Tong JH, Chan AW, Zhao J, Dong Y, Wang S, Yang W, Sin FM, Ng SS, Yu J, Cheng AS, To KF.  Yin Yang 1 contributes to gastric carcinogenesis and its nuclear expression correlates with shorter survival in patients with early stage gastric adenocarcinoma  J Transl Med  2014  12:80  PubMed ID: 24674326   DOI: 10.1186/1479-5876-12-80
5826  Zhu DY, Guo QS, Li YL, Cui B, Guo J, Liu JX, Li P.  Twist1 correlates with poor differentiation and progression in gastric adenocarcinoma via elevation of FGFR2 expression.  World J Gastroenterol  2014  28;20(48):18306-15  PubMed ID: 25561797   DOI: 10.3748/wjg.v20.i48.18306
5827  Ito T, Kajino K, Abe M, Sato K, Maekawa H, Sakurada M, Orita H, Wada R, Kajiyama Y, Hino O.  ERC/mesothelin is expressed in human gastric cancer tissues and cell lines.  Oncol Rep  2014  31(1):27-33  PubMed ID: 24146039   DOI: 10.3892/or.2013.2803
19058  Tanaka T, Nakamura J, Kitajima Y, Kai K, Miyake S, Hiraki M, Ide T, Koga Y, Noshiro H.  Loss of trefoil factor 1 is regulated by DNA methylation and is an independent predictive factor for poor survival in advanced gastric cancer  Int J Oncol  2013  42(3):894-902  PubMed ID: 23291975   DOI: 10.3892/ijo.2013.1759
5840  Kawada M, Inoue H, Ohba S, Hatano M, Amemiya M, Hayashi C, Usami I, Abe H, Watanabe T, Kinoshita N, Igarashi M, Masuda T, Ikeda D, Nomoto   Intervenolin, a new antitumor compound with anti-Helicobacter pylori activity, from Nocardia sp. ML96-86F2.  J Antibiot (Tokyo)  2013  66(9):543-8  PubMed ID: 23632919   DOI: 10.1038/ja.2013.42
5845  Konno-Shimizu M1, Yamamichi N, Inada K, Kageyama-Yahara N, Shiogama K, Takahashi Y, Asada-Hirayama I, Yamamichi-Nishina M, Nakayama C, Ono S, Kodashima S, Fujishiro M, Tsutsumi Y, Ichinose M, Koike K.  Cathepsin E is a marker of gastric differentiation and signet-ring cell carcinoma of stomach: a novel suggestion on gastric tumorigenesis.  PLoS One  2013  8(2):e56766  PubMed ID: 23451082   DOI: 10.1371/journal.pone.0056766
14202  Navabi N, McGuckin MA, Lindén SK.  Gastrointestinal cell lines form polarized epithelia with an adherent mucus layer when cultured in semi-wet interfaces with mechanical stimulation  PLoS One  2013  8(7):e68761  PubMed ID: 23869232   DOI: 10.1371/journal.pone.0068761
5848  Kataoka Y, Mukohara T, Tomioka H, Funakoshi Y, Kiyota N, Fujiwara Y, Yashiro M, Hirakawa K, Hirai M, Minami H.  Foretinib (GSK1363089), a multi-kinase inhibitor of MET and VEGFRs, inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks.  Invest New Drugs  2012  30(4):1352-60  PubMed ID: 21655918   DOI: 10.1007/s10637-011-9699-0
5852  Tomioka H, Mukohara T, Kataoka Y, Ekyalongo RC, Funakoshi Y, Imai Y, Kiyota N, Fujiwara Y, Minami H.  Inhibition of the mTOR/S6K signal is necessary to enhance fluorouracil-induced apoptosis in gastric cancer cells with HER2 amplification.  Int J Oncol  2012  41(2):551-8  PubMed ID: 22614071   DOI: 10.3892/ijo.2012.1485
5855  Yang Y, Toy W, Choong LY, Hou P, Ashktorab H, Smoot DT, Yeoh KG, Lim YP.  Discovery of SLC3A2 cell membrane protein as a potential gastric cancer biomarker: implications in molecular imaging.  J Proteome Res  2012  11(12):5736-47  PubMed ID: 23116296   DOI: 10.1021/pr300555y
15746  Hayakawa Y, Hirata Y, Sakitani K, Nakagawa H, Nakata W, Kinoshita H, Takahashi R, Takeda K, Ichijo H, Maeda S, Koike K.  Apoptosis signal-regulating kinase-1 inhibitor as a potent therapeutic drug for the treatment of gastric cancer  Cancer Sci  2012  103:2181-5  PubMed ID: 23110662   DOI: 10.1111/cas.12024
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7990  Aoki M, Ishigami S, Uenosono Y, Arigami T, Uchikado Y, Kita Y, Kurahara H, Matsumoto M, Ueno S, Natsugoe S.  Expression of BMP-7 in human gastric cancer and its clinical significance.  Br. J. Cancer  2011  104:714-8  PubMed ID: 21224856   DOI: 10.1038/sj.bjc.6606075
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5866  Nakamura J, Kitajima Y, Kai K, Hashiguchi K, Hiraki M, Noshiro H, Miyazaki K.  Expression of hypoxic marker CA IX is regulated by site-specific DNA methylation and is associated with the histology of gastric cancer.  Am J Pathol  2011  178(2):515-24  PubMed ID: 21281785   DOI: 10.1016/j.ajpath.2010.10.010
6115  Kakimoto T, Shiraishi R, Iwakiri R, Fujimoto K, Takahashi H, Hamajima H, Mizuta T, Ideguchi H, Toda S, Kitajima Y, Ozaki I, Matsuhashi S.  Expression patterns of the tumor suppressor PDCD4 and correlation with β-catenin expression in gastric cancers.  Oncol Rep  2011  26(6):1385-92  PubMed ID: 21894439   DOI: 10.3892/or.2011.1450
16164  Masateru Maruyama, Hiroki Odagiri, Shojiro-Kazunori Ikenaga, Tatsuya Nodagashira, Toshiyuki Sato, Kenichi Hakamada, Hirofumi Munakata  The suicide gene introduction using two recombinant adenovirus vectors with HER2 promoter and Cre/loxP system  Hirosaki Medical Journal  2011  61:150-158    DOI: 10.32216/hirosakiigaku.61.2-4_150
16560  Matsusaka K, Kaneda A, Nagae G, Ushiku T, Kikuchi Y, Hino R, Uozaki H, Seto Y, Takada K, Aburatani H, Fukayama M.  Classification of Epstein-Barr virus-positive gastric cancers by definition of DNA methylation epigenotypes  Cancer Res  2011  71(23):7187-97.  PubMed ID: 21990320   DOI: 10.1158/0008-5472.CAN-11-1349
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3109  Honjo, Soichiro, Osaki, Mitsuhiko, Ardyanto, Tonang Dwi, Hiramatsu, Toshiki, Maeta, Noritaka, Ito, Hisao  COX-2 inhibitor, NS398, enhances Fas-mediated apoptosis via modulation of the PTEN-Akt pathway in human gastric carcinoma cell lines.  DNA Cell Biol  2005  24:141-7  PubMed ID: 15767780   DOI: 10.1089/dna.2005.24.141
3375  Ohta M, Tateishi K, Kanai F, Watabe H, Kondo S, Guleng B, Tanaka Y, Asaoka Y, Jazag A, Imamura J, Ijichi H, Ikenoue T, Sata M, Miyagishi M, Taira K, Tada M, Kawabe T, Omata M.  p53-Independent negative regulation of p21/cyclin-dependent kinase-interacting protein 1 by the sonic hedgehog-glioma-associated oncogene 1 pathway in gastric carcinoma cells.  Cancer Res.  2005  65:10822-9  PubMed ID: 16322228   DOI: 10.1158/0008-5472.CAN-05-0777
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2921  Ishihara, Shunji, Rumi, Mohammad Azharul Karim, Kadowaki, Yasunori, Ortega-Cava, Cesar Francisco, Yuki, Takafumi, Yoshino, Nagisa, Miyaoka, Youichi, Kazumori, Hideaki, Ishimura, Norihisa, Amano, Yuji, Kinoshita, Yoshikazu  Essential role of MD-2 in TLR4-dependent signaling during Helicobacter pylori-associated gastritis.  J Immunol  2004  173:1406-16  PubMed ID: 15240737   DOI: 10.4049/jimmunol.173.2.1406
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5928  Kawashima R, Haisa M, Kimura M, Takaoka M, Shirakawa Y, Takeda H, Uetsuka H, Gunduz M, Nagai N, Tanaka N, Naomoto Y.  Cyclin A correlates with the sensitivity of human cancer cells to cytotoxic effects of 5-FU.  Int J Oncolo  2004  24(2):273-8  PubMed ID: 14719102  
3103  Adachi, Keiko, Osaki, Mitsuhiko, Kase, Satoru, Takeda, Ami, Ito, Hisao  Anti-Fas antibody-induced apoptosis and its signal transduction in human gastric carcinoma cell lines.  Int J Oncol  2003  23:713-9  PubMed ID: 12888908  
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