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RCB0999 : MKN7  update : 2018/07/06
Commentc-erbB-2 expressing gastric adenocarcinoma. Differentiated type.
Comment from the depositor
Restriction (Category)a
Terms and conditionsBasically, there is no restriction regarding academic use.
Remarks
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor Motoyama, Teiichi
Originator Hojo, Haruto
Year of deposit 1994
Animal human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Male
Age at sampling 39 years
Tissue stomach, lymph node meta
Metastastatic ability Yes
Metastatsd tissue lymph node
Genetics Gastric adenocarcinoma
Classification cancer
Year of origin 1975
History Hojo, Haruto - Motoyama, Teiichi
Lifespan infinite
Morphology epithelial-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : once/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR (human) OK
Virus (HIV) (-)
Isozyme LD, NP
Chromosome mode 51-71(50) : /64(1),65(3),66(4),67(6),68(7),69(14)/
Images
deposit info
lot info
Reference information Reference 1
User's Publication 26


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Reference
Motoyama T, Hojo H, Watanabe H  Comparison of seven cell lines derived from human gastric carcinomas.  Acta Pathol Jpn  1986  36:65-83 

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User's Publication
Nishizuka S, Tamura G, Maesawa C, Sakata K, Suzuki Y, Iwaya T, Terashima M, Saito K, Satodate R  Analysis of the DPC4 gene in gastric carcinoma  Jpn J Cancer Res  1997  88:335-339 
Adachi, Keiko, Osaki, Mitsuhiko, Kase, Satoru, Takeda, Ami, Ito, Hisao  Anti-Fas antibody-induced apoptosis and its signal transduction in human gastric carcinoma cell lines.  Int J Oncol  2003  23:713-9  PubMed ID: 12888908
Ishihara, Shunji, Rumi, Mohammad Azharul Karim, Kadowaki, Yasunori, Ortega-Cava, Cesar Francisco, Yuki, Takafumi, Yoshino, Nagisa, Miyaoka, Youichi, Kazumori, Hideaki, Ishimura, Norihisa, Amano, Yuji, Kinoshita, Yoshikazu  Essential role of MD-2 in TLR4-dependent signaling during Helicobacter pylori-associated gastritis.  J Immunol  2004  173:1406-16  PubMed ID: 15240737
Osaki M, Moriyama M, Adachi K, Nakada C, Takeda A, Inoue Y, Adachi H, Sato K, Oshimura M, Ito H  Expression of RUNX3 protein in human gastric mucosa, intestinal metaplasia and carcinoma.  Eur J Clin Invest  2004  34:605-12  PubMed ID: 15379759
Honjo, Soichiro, Osaki, Mitsuhiko, Ardyanto, Tonang Dwi, Hiramatsu, Toshiki, Maeta, Noritaka, Ito, Hisao  COX-2 inhibitor, NS398, enhances Fas-mediated apoptosis via modulation of the PTEN-Akt pathway in human gastric carcinoma cell lines.  DNA Cell Biol  2005  24:141-7  PubMed ID: 15767780
Joosten M, Linden S, Rossi M, Tay AC, Skoog E, Padra M, Peters F, Perkins T, Vandamme P, Van Nieuwerburgh F, D'Herde K, Van den Broeck W, Flahou B, Deforce D, Ducatelle R, Marshall B, Haesebrouck F, Smet A.  Divergence between the Highly Virulent Zoonotic Pathogen Helicobacter heilmannii and Its Closest Relative, the Low-Virulence "Helicobacter ailurogastricus" sp. nov.  Infect. Immun.  2015  84:293-306  PubMed ID: 26527212
Saraiva-Pava K, Navabi N, Skoog EC, Linden SK, Oleastro M, Roxo-Rosa M.  New NCI-N87-derived human gastric epithelial line after human telomerase catalytic subunit over-expression.  World J. Gastroenterol.  2015  21:6526-42  PubMed ID: 26074691
Sakimura S, Sugimachi K, Kurashige J, Ueda M, Hirata H, Nambara S, Komatsu H, Saito T, Takano Y, Uchi R, Sakimura E, Shinden Y, Iguchi T, Eguchi H, Oba Y, Hoka S, Mimori K.  The miR-506-Induced Epithelial-Mesenchymal Transition is Involved in Poor Prognosis for Patients with Gastric Cancer.  Ann. Surg. Oncol.  2015  22 Suppl 3:S1436-43  PubMed ID: 25707493
Hiraki M, Kitajima Y, Koga Y, Tanaka T, Nakamura J, Hashiguchi K, Noshiro H, Miyazaki K.  Aberrant gene methylation is a biomarker for the detection of cancer cells in peritoneal wash samples from advanced gastric cancer patients.  Ann. Surg. Oncol.  2011  18:3013-9  PubMed ID: 21409489
Aoki M, Ishigami S, Uenosono Y, Arigami T, Uchikado Y, Kita Y, Kurahara H, Matsumoto M, Ueno S, Natsugoe S.  Expression of BMP-7 in human gastric cancer and its clinical significance.  Br. J. Cancer  2011  104:714-8  PubMed ID: 21224856
Seto M, Ohta M, Ikenoue T, Sugimoto T, Asaoka Y, Tada M, Mohri D, Kudo Y, Ijichi H, Tateishi K, Otsuka M, Hirata Y, Maeda S, Koike K, Omata M.  Reduced expression of RAS protein activator like-1 in gastric cancer.  Int. J. Cancer  2010  128:1293-302  PubMed ID: 20473946
Ohta M, Tateishi K, Kanai F, Watabe H, Kondo S, Guleng B, Tanaka Y, Asaoka Y, Jazag A, Imamura J, Ijichi H, Ikenoue T, Sata M, Miyagishi M, Taira K, Tada M, Kawabe T, Omata M.  p53-Independent negative regulation of p21/cyclin-dependent kinase-interacting protein 1 by the sonic hedgehog-glioma-associated oncogene 1 pathway in gastric carcinoma cells.  Cancer Res.  2005  65:10822-9  PubMed ID: 16322228
Cheng L, Mirko R, Sara L, Medea P, Caroline B, Eva B, Myrthe J, Bram F, Wim VD, Richard D, Freddy H, Annemieke S.  The Helicobacter heilmannii hofE and hofF Genes are Essential for Colonization of the Gastric Mucosa and Play a Role in IL-1β-Induced Gastric MUC13 Expression.  Helicobacter  2016  21:504-522  PubMed ID: 26935145
Saju P, Murata-Kamiya N, Hayashi T, Senda Y, Nagase L, Noda S, Matsusaka K, Funata S, Kunita A, Urabe M, Seto Y, Fukayama M, Kaneda A, Hatakeyama M.  Host SHP1 phosphatase antagonizes Helicobacter pylori CagA and can be downregulated by Epstein-Barr virus.  Nat Microbiol  2016  1:16026  PubMed ID: 27572445
Deguchi Y, Okabe H, Oshima N, Hisamori S, Minamiguchi S, Muto M, Sakai Y.  PTEN loss is associated with a poor response to trastuzumab in HER2-overexpressing gastroesophageal adenocarcinoma.  Gastric Cancer  2017  20:416-427  PubMed ID: 27517839
Diaz-Lagares A, Crujeiras AB, Lopez-Serra P, Soler M, Setien F, Goyal A, Sandoval J, Hashimoto Y, Martinez-Cardús A, Gomez A, Heyn H, Moutinho C, Espada J, Vidal A, Paúles M, Galán M, Sala N, Akiyama Y, Martínez-Iniesta M, Farré L, Villanueva A, Gross M, Diederichs S, Guil S, Esteller M.  Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer.  Proc. Natl. Acad. Sci. U.S.A.  2016  113:E7535-E7544  PubMed ID: 27821766
Ooi A, Oyama T, Nakamura R, Tajiri R, Ikeda H, Fushida S, Dobashi Y.  Gene amplification of CCNE1, CCND1, and CDK6 in gastric cancers detected by multiplex ligation-dependent probe amplification and fluorescence in situ hybridization.  Hum. Pathol.  2017  61:58-67  PubMed ID: 27864121
Kneissl J, Hartmann A, Pfarr N, Erlmeier F, Lorber T, Keller S, Zwingenberger G, Weichert W, Luber B.  Influence of the HER receptor ligand system on sensitivity to cetuximab and trastuzumab in gastric cancer cell lines.  J. Cancer Res. Clin. Oncol.  2017  143:573-600  PubMed ID: 27933395
Qian Y, Wong CC, Xu J, Chen H, Zhang Y, Kang W, Wang H, Zhang L, Li W, Chu ESH, Go MYY, Chiu PWY, Ng EKW, Chan FKL, Sung JJY, Si J, Yu J.  Sodium Channel Subunit SCNN1B Suppresses Gastric Cancer Growth and Metastasis via GRP78 Degradation.  Cancer Res.  2017  77:1968-1982  PubMed ID: 28202509
Gen Y, Yasui K, Kitaichi T, Iwai N, Terasaki K, Dohi O, Hashimoto H, Fukui H, Inada Y, Fukui A, Jo M, Moriguchi M, Nishikawa T, Umemura A, Yamaguchi K, Konishi H, Naito Y, Itoh Y.  ASPP2 suppresses invasion and TGF-β1-induced epithelial-mesenchymal transition by inhibiting Smad7 degradation mediated by E3 ubiquitin ligase ITCH in gastric cancer.  Cancer Lett.  2017  398:52-61  PubMed ID: 28400336
Yanoma T, Ogata K, Yokobori T, Ide M, Mochiki E, Toyomasu Y, Yanai M, Kogure N, Kimura A, Suzuki M, Nakazawa N, Bai T, Oyama T, Asao T, Shirabe K, Kuwano H.  Heat shock-induced HIKESHI protects cell viability via nuclear translocation of heat shock protein 70.  Oncol. Rep.  2017  38:1500-1506  PubMed ID: 28731175
Li HK, Morokoshi Y, Nagatsu K, Kamada T, Hasegawa S.  Locoregional therapy with α-emitting trastuzumab against peritoneal metastasis of human epidermal growth factor receptor 2-positive gastric cancer in mice.  Cancer Sci.  2017  108:1648-1656  PubMed ID: 28514062
Shimada S, Akiyama Y, Mogushi K, Ishigami-Yuasa M, Kagechika H, Nagasaki H, Fukamachi H, Yuasa Y, Tanaka S.  Identification of selective inhibitors for diffuse-type gastric cancer cells by screening of annotated compounds in preclinical models.  Br. J. Cancer  2018  118:972-984  PubMed ID: 29527007
Li W, Wong CC, Zhang X, Kang W, Nakatsu G, Zhao Q, Chen H, Go MYY, Chiu PWY, Wang X, Ji J, Li X, Cai Z, Ng EKW, Yu J.  CAB39L elicited an anti-Warburg effect via a LKB1-AMPK-PGC1α axis to inhibit gastric tumorigenesis.  Oncogene  2018    PubMed ID: 30054562
Kim M, Pyo S, Kang CH, Lee CO, Lee HK, Choi SU, Park CH.  Folate receptor 1 (FOLR1) targeted chimeric antigen receptor (CAR) T cells for the treatment of gastric cancer.  PLoS ONE  2018    PubMed ID: 29874279
Wang Z, Qu H, Gong W, Liu A.  Up-regulation and tumor-promoting role of SPHK1 were attenuated by miR-330-3p in gastric cancer.  IUBMB Life  2018    PubMed ID: 30281914



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