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RCB0988 : CACO-2  update : 2018/07/31
CommentHuman colon carcinoma. Backup of ECA86010202 . Application consideration
Comment from the depositor
Use conditiona
Use condition descriptionBasically, there is no restriction regarding academic use.
Remarks
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor ECACC
Year of deposit 1994
Animal human < Mammals
Genus Homo
Species sapiens
Gender Male
Age at sampling 72 years
Tissue colon
Case history adenocarcinoma
Classification cancer
History overseas, ECACC
Lifespan infinite
Morphology epithelial-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives MEM + 20% FBS + 0.1mM NEAA
Antibiotics Free
Passage method 0.25% trypsin + 0.02% EDTA
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR (human) OK
Virus (HIV) (-)
Isozyme LD, NP
Chromosome mode 85-99(50) : /90(3),91(8),92(4),93(5),94(6)/
Images
deposit info
lot info
Reference information Reference 1
User's Publication 114


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Reference
Fogh J, Wright, W C, Loveless, J D  Absence of HeLa cell contamination in 169 cell lines derived from human tumors.  J Natl Cancer Inst  1977  58:209-14 

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User's Publication
Nakamura, Masato, Kawakita, Yasunori, Yasuhara, Akito, Fukasawa, Yoshiki, Yoshida, Koji, Sakagami, Kazunari, Nakazato, Atsuro  In vitro and in vivo evaluation of the metabolism and bioavailability of ester prodrugs of mgs0039 (3-(3,4-dichlorobenzyloxy)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarb oxylic Acid), a potent metabotropic glutamate receptor antagonist.  Drug Metab Dispos  2006  34:369-74  PubMed ID: 16326817
Yoshida, Naoko, Takagi, Akiyoshi, Kitazawa, Hidenori, Kawakami, Junichi, Adachi, Isao  Effects of citronellal, a monoterpenoid in Zanthoxyli Fructus, on the intestinal absorption of digoxin in vitro and in vivo.  J Pharm Sci  2006  95:552-60  PubMed ID: 16419049
Yamashita, Satoko, Katayama, Hideki, Saitoh, Hiroyuki, Akao, Tetsuyuki, Park, Yu Shin, Mizuki, Eiichi, Ohba, Michio, Ito, Akio  Typical Three-Domain Cry Proteins of Bacillus thuringiensis Strain A1462 Exhibit Cytocidal Activity on Limited Human Cancer Cells.  J Biochem  2005  138:663-72  PubMed ID: 16428294
Tamura, H., and Matsui, M.  Effects of Phenolic Enviromental Estrogens on the Sulfotransferase Activity of the Mouse Intestine and a Human Colon Carcinoma Cell Line, Caco-2  J Health Science  2001  47:468-472 
Aida, K. et al  Apoptosis Inducement by plant and fungus sphingoid beses in human colon cancer cells  J Oleo Sci  2004  53:503-510 
Katayama H, Yokota H, Akao T, Nakamura O, Ohba M, Mekada E, Mizuki E  Parasporin-1, a novel cytotoxic protein to human cells from non-insecticidal parasporal inclusions of Bacillus thuringiensis  J Biochem (Tokyo)  2005  137:17-25  PubMed ID: 15713879
Aiba T, Susa M, Fukumori S, Hashimoto Y  The effects of culture conditions on CYP3A4 and MDR1 mRNA induction by 1alpha,25-dihydroxyvitamin D(3) in human intestinal cell lines, Caco-2 and LS180  Drug Metab Pharmacokinet  2000  20:268-274 
Saegusa S, Totsuka M, Kaminogawa S, Hosoi T  Candida albicans and Saccharomyces cerevisiae induce interleukin-8 production from intestinal epithelial-like Caco-2 cells in the presence of butyric acid.  FEMS Immunol Med Microbiol  2004  41:227-35  PubMed ID: 15196572
Kanda T, Foucand L, Nakamura Y, Niot I, Besnard P, Fujita M, Sakai Y, Hatakeyama K, Ono T, Fujii H  Regulation of expression of human intestinal bile acid-binding protein in Caco-2 cells  Biochem J  1998  330:261-265 
Tamura H, Matsui M  Inhibitory effects of green tea and grape juice on the phenol sulfotransferase activity of mouse intestines and human colon carcinoma cell line, Caco-2.  Biol Pharm Bull  2000  23:695-9 
Satoh T, Matsui M, Tamura H  Sulfotransferases in a human colon carcinoma cell line, Caco-2.  Biol Pharm Bull  2000  23:810-4 
Todoriki K, Mukai T, Sato S, Toba T  Inhibition of adhesion of food-borne pathogens to Caco-2 cells by Lactobacillus strains.  J Appl Microbiol  2001  91:154-9 
Isozaki T, Tamura H  Epigallocatechin gallate (EGCG) inhibits the sulfation of 1-naphthol in a human colon carcinoma cell line, Caco-2.  Biol Pharm Bull  2001  24:1076-8 
Tamura, H O, Taniguchi K, Hayashi E, Hiyoshi Y, Nagai F  Expression profiling of sulfotransferases in human cell lines derived from extra-hepatic tissues.  Biol Pharm Bull  2001  24:1258-62 
Watanabe, Kazuhiro, Sawano, Tetsuya, Terada, Kazuaya, Endo, Tetsuya, Sakata, Masakatsu, Sato, Juichi  Studies on intestinal absorption of sulpiride (1): carrier-mediated uptake of sulpiride in the human intestinal cell line Caco-2.  Biol Pharm Bull  2002  25:885-90  PubMed ID: 12132663
Ohama, Tohru, Hirano, Ken-ichi, Zhang, Zhongyan, Aoki, Ryo, Tsujii, Ken-ichi, Nakagawa-Toyama, Yumiko, Tsukamoto, Kosuke, Ikegami, Chiaki, Matsuyama, Akifumi, Ishigami, Masato, Sakai, Naohiko, Hiraoka, Hisatoyo, Ueda, Kazumitsu, Yamashita, Shizuya, Matsuzawa, Yuji  Dominant expression of ATP-binding cassette transporter-1 on basolateral surface of Caco-2 cells stimulated by LXR/RXR ligands.  Biochem Biophys Res Commun  2002  296:625-30  PubMed ID: 12176027
Watanabe, Kazuhiro, Sawano, Tetsuya, Endo, Tetsuya, Sakata, Masakatsu, Sato, Juichi  Studies on intestinal absorption of sulpiride (2): transepithelial transport of sulpiride across the human intestinal cell line Caco-2.  Biol Pharm Bull  2002  25:1345-50  PubMed ID: 12392092
Hosoi, Tomohiro, Hirose, Rieko, Saegusa, Shizue, Ametani, Akio, Kiuchi, Kan, Kaminogawa, Shuichi  Cytokine responses of human intestinal epithelial-like Caco-2 cells to the nonpathogenic bacterium Bacillus subtilis (natto).  Int J Food Microbiol  2003  82:255-64  PubMed ID: 12593928
Shimizu, Takeshi, Hamabata, Takashi, Yoshiki, Akemi, Hori, Takeya, Ito, Satoru, Takeda, Yoshifumi, Hayashi, Hideo  An association of 27- and 40-kDa molecules with glycolipids that bind A-B bacterial enterotoxins to cultured cells.  Biochim Biophys Acta  2003  1612:186-94  PubMed ID: 12787937
Watanabe, Kazuhiro, Terada, Kazuaya, Jinriki, Toshiya, Sato, Juichi  Effect of insulin on cephalexin uptake and transepithelial transport in the human intestinal cell line Caco-2.  Eur J Pharm Sci  2004  21:87-95  PubMed ID: 14706815
Ito, Akio, Sasaguri, Yasuyuki, Kitada, Sakae, Kusaka, Yoshitomo, Kuwano, Kyoko, Masutomi, Kenjiro, Mizuki, Eiichi, Akao, Tetsuyuki, Ohba, Michio  A Bacillus thuringiensis crystal protein with selective cytocidal action to human cells.  J Biol Chem  2004  279:21282-6  PubMed ID: 15026424
Watanabe, Kazuhiro, Jinriki, Toshiya, Sato, Juichi  Effects of progesterone and norethisterone on cephalexin uptake in the human intestinal cell line Caco-2.  Biol Pharm Bull  2004  27:559-63  PubMed ID: 15056866
Nanda K, Miyoshi N, Nakamura Y, Shimoji Y, Tamura Y, Nishikawa Y, Uenakai K, Kohno H, Tanaka T  Extract of vinegar &quot;Kurosu&quot; from unpolished rice inhibits the proliferation of human cancer cells.  J Exp Clin Cancer Res  2004  23:69-75 
Minekawa, Ryoko, Takeda, Takashi, Sakata, Masahiro, Hayashi, Masami, Isobe, Aki, Yamamoto, Toshiya, Tasaka, Keiichi, Murata, Yuji  Human breast milk suppresses the transcriptional regulation of IL-1beta-induced NF-kappaB signaling in human intestinal cells.  Am J Physiol Cell Physiol  2004  287:C1404-11  PubMed ID: 15229109
Seike, Masahiro, Kondo, Tadashi, Fujii, Kazuyasu, Yamada, Tesshi, Gemma, Akihiko, Kudoh, Shoji, Hirohashi, Setsuo  Proteomic signature of human cancer cells.  Proteomics  2004  4:2776-88  PubMed ID: 15352251
Kaneda, Atsushi, Wakazono, Kuniko, Tsukamoto, Tetsuya, Watanabe, Naoko, Yagi, Yukiko, Tatematsu, Masae, Kaminishi, Michio, Sugimura, Takashi, Ushijima, Toshikazu  Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers.  Cancer Res  2004  64:6410-5  PubMed ID: 15374948
Aiba, Tetsuya, Ishida, Kazuya, Yoshinaga, Mariko, Okuno, Marie, Hashimoto, Yukiya  Pharmacokinetic characterization of transcellular transport and drug interaction of digoxin in Caco-2 cell monolayers.  Biol Pharm Bull  2005  28:114-9  PubMed ID: 15635174
Koyama, Yu, Suzuki, Takuji, Kajiya, Akane, Isemura, Mamoru  Stimulation of IL-8 production by Aralia cordate lectin in human colon carcinoma Caco-2 cells.  Biosci Biotechnol Biochem  2005  69:202-5  PubMed ID: 15665486
Kanno, Syu-Ichi, Tomizawa, Ayako, Hiura, Takako, Osanai, Yuu, Shouji, Ai, Ujibe, Mayuko, Ohtake, Takaharu, Kimura, Katsuhiko, Ishikawa, Masaaki  Inhibitory effects of naringenin on tumor growth in human cancer cell lines and sarcoma S-180-implanted mice.  Biol Pharm Bull  2005  28:527-30  PubMed ID: 15744083
Innami, Satoshi, Ishida, Hiroshi, Nakamura, Kahoru, Kondo, Mika, Tabata, Kimiko, Koguchi, Takashi, Shimizu, Jun, Furusho, Tadasu  Jew's mellow leaves (Corchorus olitorius) suppress elevation of postprandial blood glucose levels in rats and humans.  Int J Vitam Nutr Res  2005  75:39-46  PubMed ID: 15830920
Takamatsu, Shinji, Inoue, Noboru, Katsumata, Toshiyuki, Nakamura, Katsumi, Fujibayashi, Yasuhisa, Takeuchi, Makoto  The relationship between the branch-forming glycosyltransferases and cell surface sugar chain structures.  Biochemistry  2005  44:6343-9  PubMed ID: 15835923
Shimizu T, Ichimura K, Noda M.  The Surface Sensor NlpE of Enterohemorrhagic Escherichia coli Contributes to Regulation of the Type III Secretion System and Flagella by the Cpx Response to Adhesion.  Infect. Immun.  2015  84:537-49  PubMed ID: 26644384
Tanabe T, Miyamoto K, Tsujibo H, Yamamoto S, Funahashi T.  The small RNA Spot 42 regulates the expression of the type III secretion system 1 (T3SS1) chaperone protein VP1682 in Vibrio parahaemolyticus.  FEMS Microbiol. Lett.  2015  362:  PubMed ID: 26394644
Ogura J, Kuwayama K, Sasaki S, Kaneko C, Koizumi T, Yabe K, Tsujimoto T, Takeno R, Takaya A, Kobayashi M, Yamaguchi H, Iseki K.  Reactive oxygen species derived from xanthine oxidase interrupt dimerization of breast cancer resistance protein, resulting in suppression of uric acid excretion to the intestinal lumen.  Biochem. Pharmacol.  2015  97:89-98  PubMed ID: 26119820
Kaku Y, Tsuchiya A, Kanno T, Nishizaki T.  Irinotecan induces cell cycle arrest, but not apoptosis or necrosis, in Caco-2 and CW2 colorectal cancer cell lines.  Pharmacology  2015  95:154-9  PubMed ID: 25833236
Ibusuki K, Sakiyama T, Kanmura S, Maeda T, Iwashita Y, Nasu Y, Sasaki F, Taguchi H, Hashimoto S, Numata M, Uto H, Tsubouchi H, Ido A.  Human neutrophil peptides induce interleukin-8 in intestinal epithelial cells through the P2 receptor and ERK1/2 signaling pathways.  Int. J. Mol. Med.  2015  35:1603-9  PubMed ID: 25816245
Hsieh CY, Osaka T, Moriyama E, Date Y, Kikuchi J, Tsuneda S.  Strengthening of the intestinal epithelial tight junction by Bifidobacterium bifidum.  Physiol Rep  2015  3:  PubMed ID: 25780093
Kimura O, Tsukagoshi K, Hayasaka M, Endo T.  Transepithelial transport of 4-chloro-2-methylphenoxyacetic acid (MCPA) across human intestinal Caco-2 cell monolayers.  Basic Clin. Pharmacol. Toxicol.  2011  110:530-6  PubMed ID: 22181038
Miyata M, Sakaida Y, Matsuzawa H, Yoshinari K, Yamazoe Y.  Fibroblast growth factor 19 treatment ameliorates disruption of hepatic lipid metabolism in farnesoid X receptor (Fxr)-null mice.  Biol. Pharm. Bull.  2011  34:1885-9  PubMed ID: 22130247
Ito N, Ohtsubo T, Kusu F, Hakamata H.  An ultra performance liquid chromatographic method for determining phytosterol uptake by Caco-2 cells.  Anal. Biochem.  2011  421:86-91  PubMed ID: 22119071
Yasui K, Tanabe H, Miyoshi N, Suzuki T, Goto S, Taguchi K, Ishigami Y, Paeng N, Fukutomi R, Imai S, Isemura M.  Effects of (-)-epigallocatechin-3-O-gallate on expression of gluconeogenesis-related genes in the mouse duodenum.  Biomed. Res.  2011  32:313-20  PubMed ID: 22033300
Isshiki M, Umezawa K, Tamura H.  Coffee induces breast cancer resistance protein expression in Caco-2 cells.  Biol. Pharm. Bull.  2011  34:1624-7  PubMed ID: 21963506
Mitsuyama K, Niwa M, Masuda J, Kuwaki K, Yamasaki H, Takedatsu H, Kobayashi T, Sata M.  Isolation and characterization of a novel short peptide associated with Crohn's disease.  Clin. Exp. Immunol.  2011  166:72-9  PubMed ID: 21797848
Ashida N, Yanagihara S, Shinoda T, Yamamoto N.  Characterization of adhesive molecule with affinity to Caco-2 cells in Lactobacillus acidophilus by proteome analysis.  J. Biosci. Bioeng.  2011  112:333-7  PubMed ID: 21763196
Kimura O, Kotaki Y, Hamaue N, Haraguchi K, Endo T.  Transcellular transport of domoic acid across intestinal Caco-2 cell monolayers.  Food Chem. Toxicol.  2011  49:2167-71  PubMed ID: 21672599
Horie A, Sakata J, Nishimura M, Ishida K, Taguchi M, Hashimoto Y.  Mechanisms for membrane transport of metformin in human intestinal epithelial Caco-2 cells.  Biopharm Drug Dispos  2011  32:253-60  PubMed ID: 21567399
Yasuda A, Natsume M, Osakabe N, Kawahata K, Koga J.  Cacao polyphenols influence the regulation of apolipoprotein in HepG2 and Caco2 cells.  J. Agric. Food Chem.  2011  59:1470-6  PubMed ID: 21226458
Tsuruta H, Yagishita T, Shimizu M, Tamura H.  Megadose vitamin C suppresses sulfoconjugation in human colon carcinoma cell line Caco-2.  Toxicol In Vitro  2010  25:500-4  PubMed ID: 21144891
Sumitomo T, Nakata M, Higashino M, Jin Y, Terao Y, Fujinaga Y, Kawabata S.  Streptolysin S contributes to group A streptococcal translocation across an epithelial barrier.  J. Biol. Chem.  2010  286:2750-61  PubMed ID: 21084306
Nose S, Wasa M, Tazuke Y, Owari M, Fukuzawa M.  Cisplatin upregulates glutamine transport in human intestinal epithelial cells: the protective mechanism of glutamine on intestinal mucosa after chemotherapy.  JPEN J Parenter Enteral Nutr  2010  34:530-7  PubMed ID: 20852181
Wang C, Ho PC, Lim LY.  Wheat germ agglutinin-conjugated PLGA nanoparticles for enhanced intracellular delivery of paclitaxel to colon cancer cells.  Int J Pharm  2010  400:201-10  PubMed ID: 20804835
Yaguchi T, Saito M, Yasuda Y, Kanno T, Nakano T, Nishizaki T.  Higher concentrations of extracellular ATP suppress proliferation of Caco-2 human colonic cancer cells via an unknown receptor involving PKC inhibition.  Cell. Physiol. Biochem.  2010  26:125-34  PubMed ID: 20798496
Watanabe K, Kamata K, Sato J, Takahashi T.  Fundamental studies on the inhibitory action of Acanthopanax senticosus Harms on glucose absorption.  J Ethnopharmacol  2010  132:193-9  PubMed ID: 20713144
Tsuji S, Tsuura Y, Morohoshi T, Shinohara T, Oshita F, Yamada K, Kameda Y, Ohtsu T, Nakamura Y, Miyagi Y.  Secretion of intelectin-1 from malignant pleural mesothelioma into pleural effusion.  Br. J. Cancer  2010  103:517-23  PubMed ID: 20628387
Takahashi T, Kaku T, Sato T, Watanabe K, Sato J.  Effects of Acanthopanax senticosus HARMS extract on drug transport in human intestinal cell line Caco-2.  J Nat Med  2010  64:55-62  PubMed ID: 20091240
Narita K, Kawate T, Kakinuma N, Takeda S.  Multiple primary cilia modulate the fluid transcytosis in choroid plexus epithelium.  Traffic  2009  11:287-301  PubMed ID: 19958467
Yamanashi Y, Takada T, Suzuki H.  In-vitro characterization of the six clustered variants of NPC1L1 observed in cholesterol low absorbers.  Pharmacogenet. Genomics  2009  19:884-92  PubMed ID: 19823104
Yoshimura S, Kawano K, Matsumura R, Sugihara N, Furuno K.  Inhibitory effect of flavonoids on the efflux of N-acetyl 5-aminosalicylic acid intracellularly formed in Caco-2 cells.  J. Biomed. Biotechnol.  2009  2009:467489  PubMed ID: 19688110
Kimura O, Tsukagoshi K, Endo T.  Uptake of phenoxyacetic acid derivatives into Caco-2 cells by the monocarboxylic acid transporters.  Toxicol. Lett.  2009  189:102-9  PubMed ID: 19465094
Yasuda Y, Saito M, Yamamura T, Yaguchi T, Nishizaki T.  Extracellular adenosine induces apoptosis in Caco-2 human colonic cancer cells by activating caspase-9/-3 via A(2a) adenosine receptors.  J. Gastroenterol.  2009  44:56-65  PubMed ID: 19159073
Ozawa T, Miyata M, Nishimura M, Ando T, Ouyang Y, Ohba T, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Nakao A.  Transforming growth factor-beta activity in commercially available pasteurized cow milk provides protection against inflammation in mice.  J. Nutr.  2008  139:69-75  PubMed ID: 19056655
Ishii S, Katsumura T, Shiozuka C, Ooyauchi K, Kawasaki K, Takigawa S, Fukushima T, Tokuji Y, Kinoshita M, Ohnishi M, Kawahara M, Ohba K.  Anti-inflammatory effect of buckwheat sprouts in lipopolysaccharide-activated human colon cancer cells and mice.  Biosci. Biotechnol. Biochem.  2008  72:3148-57  PubMed ID: 19060399
Kobori M, Ohnishi-Kameyama M, Akimoto Y, Yukizaki C, Yoshida M.  Alpha-eleostearic acid and its dihydroxy derivative are major apoptosis-inducing components of bitter gourd.  J. Agric. Food Chem.  2008  56:10515-20  PubMed ID: 18959405
Lee JS, Ma CM, Park DK, Yoshimi Y, Hatanaka M, Hattori M.  Transformation of ergosterol peroxide to cytotoxic substances by rat intestinal bacteria.  Biol. Pharm. Bull.  2008  31:949-54  PubMed ID: 18451525
Katsube T, Tsuji H, Onoda M.  Nitric oxide attenuates hydrogen peroxide-induced barrier disruption and protein tyrosine phosphorylation in monolayers of intestinal epithelial cell.  Biochim. Biophys. Acta  2007  1773:794-803  PubMed ID: 17451824
Kobori M, Yoshida M, Ohnishi-Kameyama M, Shinmoto H.  Ergosterol peroxide from an edible mushroom suppresses inflammatory responses in RAW264.7 macrophages and growth of HT29 colon adenocarcinoma cells.  Br. J. Pharmacol.  2006  150:209-19  PubMed ID: 17160010
Moriya Y, Nakamura T, Okamura N, Sakaeda T, Horinouchi M, Tamura T, Aoyama N, Kasuga M, Okumura K.  Comparison of synthetic DNA templates with authentic cDNA templates in terms of quantification by real-time quantitative reverse transcription polymerase chain reaction.  Biol. Pharm. Bull.  2006  29:535-8  PubMed ID: 16508161
Yamashita S, Katayama H, Saitoh H, Akao T, Park YS, Mizuki E, Ohba M, Ito A.  Typical three-domain cry proteins of Bacillus thuringiensis strain A1462 exhibit cytocidal activity on limited human cancer cells.  J. Biochem.  2006  138:663-72  PubMed ID: 16428294
Nakamura M, Kawakita Y, Yasuhara A, Fukasawa Y, Yoshida K, Sakagami K, Nakazato A.  In vitro and in vivo evaluation of the metabolism and bioavailability of ester prodrugs of mgs0039 (3-(3,4-dichlorobenzyloxy)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid), a potent metabotropic glutamate receptor antagonist.  Drug Metab. Dispos.  2005  34:369-74  PubMed ID: 16326817
Inamura J, Ikuta K, Jimbo J, Shindo M, Sato K, Torimoto Y, Kohgo Y.  Upregulation of hepcidin by interleukin-1beta in human hepatoma cell lines.  Hepatol. Res.  2005  33:198-205  PubMed ID: 16198622
Katayama H, Yokota H, Akao T, Nakamura O, Ohba M, Mekada E, Mizuki E.  Parasporin-1, a novel cytotoxic protein to human cells from non-insecticidal parasporal inclusions of Bacillus thuringiensis.  J. Biochem.  2005  137:17-25  PubMed ID: 15713879
Piyawan Bunpo, B.Sc., Keiko Kataoka, Ph.D., Hideki Arimochi, Ph.D., Haruyuki Nakayama, M.Sc., Tomomi Kuwahara, Ph.D., Yoshinari Ohnishi, Ph.D., Usanee Vinitketkumnuen, Ph.D.  CENTELLA ASIATICA EXTRACT INDUCES CELL CYCLE ARREST IN CACO-2 HUMAN COLON CANCER CELLS  Chiang Mai Med Bull  2005  44:21-28 
Nanda K, Miyoshi N, Nakamura Y, Shimoji Y, Tamura Y, Nishikawa Y, Uenakai K, Kohno H, Tanaka T.  Extract of vinegar "Kurosu" from unpolished rice inhibits the proliferation of human cancer cells.  J. Exp. Clin. Cancer Res.  2004  23:69-75  PubMed ID: 15149153
Aida K. et al.  Apoptosis Inducement by plant and fungus sphingoid beses in human colon cancer cells.  J Oleo Sci.  2004  53:503-510 
Kaku Y, Tsuchiya A, Shimizu T, Tanaka A, Nishizaki T.  HUHS1015 Suppresses Colonic Cancer Growth by Inducing Necrosis and Apoptosis in Association with Mitochondrial Damage.  Anticancer Res.  2016  36:39-48  PubMed ID: 26722026
Ikai A, Watanabe M, Sowa Y, Kishimoto M, Yanagisawa A, Fujiwara H, Otsuji E, Sakai T.  Phosphorylated retinoblastoma protein is a potential predictive marker of irinotecan efficacy for colorectal cancer.  Int. J. Oncol.  2016  48:1297-304  PubMed ID: 26783196
Sumitomo T, Nakata M, Higashino M, Yamaguchi M, Kawabata S.  Group A Streptococcus exploits human plasminogen for bacterial translocation across epithelial barrier via tricellular tight junctions.  Sci Rep  2016  7:20069  PubMed ID: 26822058
Amen YM, Zhu Q, Tran HB, Afifi MS, Halim AF, Ashour A, Mira A, Shimizu K.  Lucidumol C, a new cytotoxic lanostanoid triterpene from Ganoderma lingzhi against human cancer cells.  J Nat Med  2016  70:661-6  PubMed ID: 26899240
Jdir H, Khemakham B, Najjaa H, Chakroun M, Jridi M, Ben Arfa A, Ben Ali Y, Zouari N.  Anti-inflammatory and anti-proliferative activities of the wild edible cruciferous: Diplotaxis simplex.  Pharm Biol  2016  54:2111-8  PubMed ID: 26916801
Kaze N, Watanabe Y, Sato H, Murota K, Kotaniguchi M, Yamamoto H, Inui H, Kitamura S.  Estimation of the Intestinal Absorption and Metabolism Behaviors of 2- and 3-Monochloropropanediol Esters.  Lipids  2016  51:913-22  PubMed ID: 27023203
Wakita M, Edamatsu H, Li M, Emi A, Kitazawa S, Kataoka T.  Phospholipase Cϵ Activates Nuclear Factor-κB Signaling by Causing Cytoplasmic Localization of Ribosomal S6 Kinase and Facilitating Its Phosphorylation of Inhibitor κB in Colon Epithelial Cells.  J. Biol. Chem.  2016  291:12586-600  PubMed ID: 27053111
Kimura O, Fujii Y, Haraguchi K, Ohta C, Koga N, Kato Y, Endo T.  Effect of quercetin on the uptake and efflux of aristolochic acid I from Caco-2 cell monolayers.  J. Pharm. Pharmacol.  2016  68:883-9  PubMed ID: 27166429
Kudo M, Katayoshi T, Kobayashi-Nakamura K, Akagawa M, Tsuji-Naito K.  H(+)/peptide transporter (PEPT2) is expressed in human epidermal keratinocytes and is involved in skin oligopeptide transport.  Biochem. Biophys. Res. Commun.  2016  475:335-41  PubMed ID: 27216463
Takayama Y, Aoki R, Uchida R, Tajima A, Aoki-Yoshida A.  Role of CXC chemokine receptor type 4 as a lactoferrin receptor.  Biochem. Cell Biol.  2017  95:57-63  PubMed ID: 28075616
Zhao C, Sakaguchi T, Fujita K, Ito H, Nishida N, Nagatomo A, Tanaka-Azuma Y, Katakura Y.  Pomegranate-Derived Polyphenols Reduce Reactive Oxygen Species Production via SIRT3-Mediated SOD2 Activation.  Oxid Med Cell Longev  2016  2016:2927131  PubMed ID: 27840668
Kuroda K, Fukuda T, Krstic-Demonacos M, Demonacos C, Okumura K, Isogai H, Hayashi M, Saito K, Isogai E.  miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway.  BMC Cancer  2017  17:33  PubMed ID: 28061765
Imai S, Morishita Y, Hata T, Kondoh M, Yagi K, Gao JQ, Nagano K, Higashisaka K, Yoshioka Y, Tsutsumi Y.  Cellular internalization, transcellular transport, and cellular effects of silver nanoparticles in polarized Caco-2 cells following apical or basolateral exposure.  Biochem. Biophys. Res. Commun.  2017  484:543-549  PubMed ID: 28130106
Takahashi K, Suzuki N, Ogra Y.  Bioavailability Comparison of Nine Bioselenocompounds In Vitro and In Vivo.  Int J Mol Sci  2017  18:  PubMed ID: 28245633
Nakahara T, Nishitani Y, Nishiumi S, Yoshida M, Azuma T.  Astilbin from Engelhardtia chrysolepis enhances intestinal barrier functions in Caco-2 cell monolayers.  Eur. J. Pharmacol.  2017  804:46-51  PubMed ID: 28327343
Sugihara N, Kuroda N, Watanabe F, Choshi T, Kamishikiryo J, Seo M.  Effects of Catechins and Their Related Compounds on Cellular Accumulation and Efflux Transport of Mitoxantrone in Caco-2 Cell Monolayers.  J. Food Sci.  2017  82:1224-1230  PubMed ID: 28346686
Fujii K, Abe K, Kadooka K, Matsumoto T, Katakura Y.  Carnosine activates the CREB pathway in Caco-2 cells.  Cytotechnology  2017  69:523-527  PubMed ID: 28374107
Nakayama T, Funakoshi-Tago M, Tamura H.  Coffee reduces KRAS expression in Caco-2 human colon carcinoma cells via regulation of miRNAs.  Oncol Lett  2017  14:1109-1114  PubMed ID: 28693281
Kimura O, Fujii Y, Haraguchi K, Kato Y, Ohta C, Koga N, Endo T.  Uptake of perfluorooctanoic acid by Caco-2 cells: Involvement of organic anion transporting polypeptides.  Toxicol. Lett.  2017  277:18-23  PubMed ID: 28552774
Watanabe H, Sugimoto R, Ikegami K, Enoki Y, Imafuku T, Fujimura R, Bi J, Nishida K, Sakaguchi Y, Murata M, Maeda H, Hirata K, Jingami S, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Maruyama T.  Parathyroid hormone contributes to the down-regulation of cytochrome P450 3A through the cAMP/PI3K/PKC/PKA/NF-κB signaling pathway in secondary hyperparathyroidism.  Biochem. Pharmacol.  2017  145:192-201  PubMed ID: 28843775
Seike S, Takehara M, Takagishi T, Miyamoto K, Kobayashi K, Nagahama M.  Delta-toxin from Clostridium perfringens perturbs intestinal epithelial barrier function in Caco-2 cell monolayers.  Biochim. Biophys. Acta  2018  1860:428-433  PubMed ID: 28988777
Okubo S, Uto T, Goto A, Tanaka H, Nishioku T, Yamada K, Shoyama Y.  Berberine Induces Apoptotic Cell Death via Activation of Caspase-3 and -8 in HL-60 Human Leukemia Cells: Nuclear Localization and Structure-Activity Relationships.  Am. J. Chin. Med.  2017  45:1497-1511  PubMed ID: 29025293
Tsubaki M, Takeda T, Asano RT, Matsuda T, Fujimoto SI, Itoh T, Imano M, Satou T, Nishida S.  Rebamipide suppresses 5-fluorouracil-induced cell death via the activation of Akt/mTOR pathway and regulates the expression of Bcl-2 family proteins.  Toxicol In Vitro  2018  46:284-293  PubMed ID: 29054700
Mito A, Nakano Y, Saitoh T, Gouraud SSS, Yamaguchi Y, Sato T, Sasaki N, Kojima-Aikawa K.  Lectin ZG16p inhibits proliferation of human colorectal cancer cells via its carbohydrate-binding sites.  Glycobiology  2018  28:21-31  PubMed ID: 29069492
Yamashita S, Seino T, Aida K, Kinoshita M.  Effects of Plant Sphingolipids on Inflammatory Stress in Differentiated Caco-2 Cells.  J Oleo Sci  2017  66:1337-1342  PubMed ID: 29199207
Kaito Y, Kataoka R, Mihara T, Takechi K, Takahira A, Watanabe S, Han F, Tamura M.  Phosphorylation of Ser-525 in βPix impairs Nox1-activating ability in Caco-2 cells.  Arch. Biochem. Biophys.  2018  638:58-65  PubMed ID: 29242061
Omoto T, Kim-Kaneyama JR, Lei XF, Orimo A, Ohnishi K, Yoshihara K, Miyauchi A, Li S, Gao L, Umemoto T, Tanaka J, Nakahara K, Takeya M, Ishida F, Kudo SE, Haraguchi S, Miyazaki T, Miyazaki A.  The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling.  Oncogene  2018  37:1205-1219  PubMed ID: 29242607
Akiyama K, Warabi E, Okada K, Yanagawa T, Ishii T, Kose K, Tokushige K, Ishige K, Mizokami Y, Yamagata K, Onizawa K, Ariizumi SI, Yamamoto M, Shoda J.  Deletion of both p62 and Nrf2 spontaneously results in the development of nonalcoholic steatohepatitis.  Exp. Anim.  2018  67:201-218  PubMed ID: 29276215
Numata T, Sato-Numata K, Okada Y, Inoue R.  Cellular mechanism for herbal medicine Junchoto to facilitate intestinal Cl-/water secretion that involves cAMP-dependent activation of CFTR.  J Nat Med  2018  72:694-705  PubMed ID: 29569221
  Combining Biological and Chemical Screenings to Assess Cytotoxicity of Emerging Contaminants in Discharges into Surface Water        PubMed ID:
Zhao C, Sakaguchi T, Fujita K, Ito H, Nishida N, Nagatomo A, Tanaka-Azuma Y, Katakura Y.  Pomegranate-derived polyphenols reduce reactive oxygen species production via SIRT3-mediated SOD2 activation  Oxid Med Cell Longev  2016  2016:2927131  PubMed ID: 27840668
  Effects of Vitamin K2 on Activity and Gene Expression of Human Alkaline Phosphatase in the Human Intestinal Epithelial-like Cell Line Caco-2        PubMed ID:
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  1-alpha, 25-dihydroxyvitamin D3 up-regulates the expression of two types of human intestinal alkaline phosphatase alternative splicing variants in Caco-2 cells and may be an important regulator of their expression in gut homeostasis        PubMed ID:
  Major constituents of Cistanche tubulosa, echinacoside and acteoside, inhibit sodium-dependent glucose cotransporter 1-mediated glucose uptake by intestinal epithelial cells        PubMed ID:
  Hot Water Extract of Grifola gargal Possesses Anti-inflammatory Activity        PubMed ID:
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  nhancement of Intestinal Alkaline Phosphatase Expression by 1, 25 (OH) 2D3 in the Human Intestinal Epithelial-like Cell Line Caco-2        PubMed ID:
Yamada M, Takahashi N, Matsuda Y, Sato K, Yokoji M, Sulijaya B, Maekawa T, Ushiki T, Mikami Y, Hayatsu M, Mizutani Y, Kishino S, Ogawa J, Arita M, Tabeta K, Maeda T, Yamazaki K.  A bacterial metabolite ameliorates periodontal pathogen-induced gingival epithelial barrier disruption via GPR40 signaling.  Sci Rep  2018    PubMed ID: 29899364
Kawai K, Kamochi R, Oiki S, Murata K, Hashimoto W.  Probiotics in human gut microbiota can degrade host glycosaminoglycans.  Sci Rep  2018    PubMed ID: 30006634



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