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RCB0987 : C2C12  update : 2019/12/11
細胞特性(Comment:英)Said differentiate to myotubes, but need confirmation. Since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ECA91031101 prior to order.
細胞特性(日)マウス筋芽細胞株で条件により急速に筋肉細胞(myotube)に分化する 。ECACC由来株。使用条件等がECACCによって随時変更となる可能性があります。ご購入前に、 ECA91031101 を必ずご参照ください。
使用条件(英)Basically, there is no restriction regarding academic use. However, since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ECA91031101 prior to order.
使用条件(日)学術研究における利用につきましては原則として使用制限はありません。しかし、使用条件等がECACCによって随時変更となる可能性があります。ご購入前に、ECA91031101 を必ずご参照ください。
提供申込書類 依頼書C-0001.pdf   同意書(非営利)C-0003.pdf   同意書(営利)C-0003p.pdf  
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 ECACC
寄託日 1994
動物種 mouse < Mammals
動物系統名 C3H
採取組織 muscle
細胞分類 other
入手歴 overseas, ECACC
細胞寿命 infinite
細胞形態 other
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 DMEM (low glucose) + 10% FBS
抗生物質 Free
継代方法 0.25% trypsin
継代密度 1 : 10 split
継代・培地交換頻度 Subculture : once/2-3 days
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ (-)
マウス系統検査 OK
文献情報 Reference(英) 3件
Reference(日) 0件
利用者成果(英) 127件
利用者成果(日) 2件

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7250  Otani M, Furukawa S, Wakisaka S, Maeda T.  A novel adipokine C1q/TNF-related protein 3 is expressed in developing skeletal muscle and controls myoblast proliferation and differentiation.  Mol. Cell. Biochem.  2015  409:271-82  PubMed ID: 26272338
7284  Ayabe T, Mizushige T, Ota W, Kawabata F, Hayamizu K, Han L, Tsuji T, Kanamoto R, Ohinata K.  A novel Alaska pollack-derived peptide, which increases glucose uptake in skeletal muscle cells, lowers the blood glucose level in diabetic mice.  Food Funct  2015  6:2749-57  PubMed ID: 26152190
7311  Ichimura T, Chiu LD, Fujita K, Machiyama H, Kawata S, Watanabe TM, Fujita H.  Visualizing the appearance and disappearance of the attractor of differentiation using Raman spectral imaging.  Sci Rep  2015  5:11358  PubMed ID: 26079396
7323  Minami K, Kasuya Y, Yamazaki T, Ji Q, Nakanishi W, Hill JP, Sakai H, Ariga K.  Highly Ordered 1D Fullerene Crystals for Concurrent Control of Macroscopic Cellular Orientation and Differentiation toward Large-Scale Tissue Engineering.  Adv. Mater. Weinheim  2015  27:4020-6  PubMed ID: 26033774
7416  Wu S, Zhang J, Huang C, Jia H, Wang Y, Xu Z, Yang L, Miyagishi M, Kasim V.  Prolyl hydroxylase domain-2 silencing induced by hydrodynamic limb vein injection enhances vascular regeneration in critical limb ischemia mice through activation of multiple genes.  Curr Gene Ther  2015  15:313-25  PubMed ID: 25832622
7454  Takeda I, Kawanabe M, Kaneko A.  Autonomous patterning of cells on microstructured fine particles.  Mater Sci Eng C Mater Biol Appl  2015  50:173-8  PubMed ID: 25746259
7465  Takemoto K, Ishihara S, Mizutani T, Kawabata K, Haga H.  Compressive stress induces dephosphorylation of the myosin regulatory light chain via RhoA phosphorylation by the adenylyl cyclase/protein kinase A signaling pathway.  PLoS ONE  2015  10:e0117937  PubMed ID: 25734240
7472  Takeda T, Tsuiji K, Li B, Tadakawa M, Yaegashi N.  Proliferative effect of Hachimijiogan, a Japanese herbal medicine, in C2C12 skeletal muscle cells.  Clin Interv Aging  2015  10:445-51  PubMed ID: 25709418
7483  Nakanishi K, Kakiguchi K, Yonemura S, Nakano A, Morishima N.  Transient Ca2+ depletion from the endoplasmic reticulum is critical for skeletal myoblast differentiation.  FASEB J.  2015  29:2137-49  PubMed ID: 25678623
7488  Asano T, Ishizuka T, Morishima K, Yawo H.  Optogenetic induction of contractile ability in immature C2C12 myotubes.  Sci Rep  2015  5:8317  PubMed ID: 25661648
7509  Kaneko K, Higuchi C, Kunugiza Y, Yoshida K, Sakai T, Yoshikawa H, Nakata K.  Hyaluronan inhibits BMP-induced osteoblast differentiation.  FEBS Lett.  2015  589:447-54  PubMed ID: 25592835
7576  Yuki Igaki, Fumio Mizutani, Tomoyuki Yasukawa  Oxygen consumption of contractile C2C12 myotubes investigated by scanning electrochemical microscopy.  Chemistry Letters  2015  44:1031-1032 
7663  Ogawa M, Yamaji R, Higashimura Y, Harada N, Ashida H, Nakano Y, Inui H.  17β-estradiol represses myogenic differentiation by increasing ubiquitin-specific peptidase 19 through estrogen receptor α.  J. Biol. Chem.  2011  286:41455-65  PubMed ID: 21971047
7665  Tanaka S, Terada K, Nohno T.  Canonical Wnt signaling is involved in switching from cell proliferation to myogenic differentiation of mouse myoblast cells.  J Mol Signal  2011  6:12  PubMed ID: 21970630
7705  Suzuki Y, Koshi K, Imai K, Takahashi T, Kizaki K, Hashizume K.  Bone morphogenetic protein 4 accelerates the establishment of bovine trophoblastic cell lines.  Reproduction  2011  142:733-43  PubMed ID: 21862694
7712  Morishima N, Nakanishi K, Nakano A.  Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via induction of WW domain binding protein 1.  J. Biol. Chem.  2011  286:35227-35  PubMed ID: 21841196
7857  Akiyama K, Tone J, Okabe M, Nishimoto S, Sugahara T, Kakinuma Y.  Inhibition of myotube formation by paraquat in the myoblast cell line C2C12.  J Toxicol Sci  2011  36:243-6  PubMed ID: 21467752
7868  Zang L, Nishikawa M, Machida K, Ando M, Takahashi Y, Watanabe Y, Takakura Y.  Inhibition of nuclear delivery of plasmid DNA and transcription by interferon γ: hurdles to be overcome for sustained gene therapy.  Gene Ther.  2011  18:891-7  PubMed ID: 21451577
7982  Itoigawa Y, Kishimoto KN, Sano H, Kaneko K, Itoi E.  Molecular mechanism of fatty degeneration in rotator cuff muscle with tendon rupture.  J. Orthop. Res.  2011  29:861-6  PubMed ID: 21246616
8044  Fujita H, Hirano M, Shimizu K, Nagamori E.  Rapid decrease in active tension generated by C2C12 myotubes after termination of artificial exercise.  J. Muscle Res. Cell. Motil.  2010  31:279-88  PubMed ID: 21120590
8078  Fujita H, Van Dau T, Shimizu K, Hatsuda R, Sugiyama S, Nagamori E.  Designing of a Si-MEMS device with an integrated skeletal muscle cell-based bio-actuator.  Biomed Microdevices  2010  13:123-9  PubMed ID: 20957437
8092  Miyake M, Hayashi S, Iwasaki S, Uchida T, Watanabe K, Ohwada S, Aso H, Yamaguchi T.  TIEG1 negatively controls the myoblast pool indispensable for fusion during myogenic differentiation of C2C12 cells.  J. Cell. Physiol.  2010  226:1128-36  PubMed ID: 20945337
8128  Tajika Y, Takahashi M, Hino M, Murakami T, Yorifuji H.  VAMP2 marks quiescent satellite cells and myotubes, but not activated myoblasts.  Acta Histochem Cytochem  2010  43:107-14  PubMed ID: 20824121
8147  Konishi H, Okuda A, Ohno Y, Kihara A.  Characterization of HACD1 K64Q mutant found in arrhythmogenic right ventricular dysplasia patients.  J. Biochem.  2010  148:617-22  PubMed ID: 20724468
8161  Itoigawa Y, Kishimoto KN, Okuno H, Sano H, Kaneko K, Itoi E.  Hypoxia induces adipogenic differentitation of myoblastic cell lines.  Biochem. Biophys. Res. Commun.  2010  399:721-6  PubMed ID: 20692234
8162  Kono S, Nishio T, Takahashi Y, Goto-Inoue N, Kinoshita M, Zaima N, Suzuki H, Fukutoku-Otsuji A, Setou M, Miyajima H.  Dominant-negative effects of a novel mutation in the filamin myopathy.  Neurology  2010  75:547-54  PubMed ID: 20697107
8166  Hino M, Hamada N, Tajika Y, Funayama T, Morimura Y, Sakashita T, Yokota Y, Fukamoto K, Mutou Y, Kobayashi Y, Yorifuji H.  Heavy ion irradiation induces autophagy in irradiated C2C12 myoblasts and their bystander cells.  J Electron Microsc (Tokyo)  2010  59:495-501  PubMed ID: 20685830
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8259  Imazato S, Horikawa D, Takeda K, Kiba W, Izutani N, Yoshikawa R, Hayashi M, Ebisu S, Nakano T.  Proliferation and differentiation potential of pluripotent mesenchymal precursor C2C12 cells on resin-based restorative materials.  Dent Mater J  2010  29:341-6  PubMed ID: 20467157
8264  Yokoi H, Mizukami H, Nagatsu A, Tanabe H, Inoue M.  Hydroxy monounsaturated fatty acids as agonists for peroxisome proliferator-activated receptors.  Biol. Pharm. Bull.  2010  33:854-61  PubMed ID: 20460766
8351  Fujita H, Shimizu K, Nagamori E.  Novel method for measuring active tension generation by C2C12 myotube using UV-crosslinked collagen film.  Biotechnol. Bioeng.  2010  106:482-9  PubMed ID: 20178119
8352  Miyake M, Hayashi S, Iwasaki S, Chao G, Takahashi H, Watanabe K, Ohwada S, Aso H, Yamaguchi T.  Possible role of TIEG1 as a feedback regulator of myostatin and TGF-beta in myoblasts.  Biochem. Biophys. Res. Commun.  2010  393:762-6  PubMed ID: 20171187
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8385  Shimizu K, Fujita H, Nagamori E.  Oxygen plasma-treated thermoresponsive polymer surfaces for cell sheet engineering.  Biotechnol. Bioeng.  2010  106:303-10  PubMed ID: 20091737
8387  Yamazaki Y, Kamei Y, Sugita S, Akaike F, Kanai S, Miura S, Hirata Y, Troen BR, Kitamura T, Nishino I, Suganami T, Ezaki O, Ogawa Y.  The cathepsin L gene is a direct target of FOXO1 in skeletal muscle.  Biochem. J.  2010  427:171-8  PubMed ID: 20088826
8562  Yuasa K, Masuda T, Yoshikawa C, Nagahama M, Matsuda Y, Tsuji A.  Subtilisin-like proprotein convertase PACE4 is required for skeletal muscle differentiation.  J. Biochem.  2009  146:407-15  PubMed ID: 19520771
8609  Fujita H, Shimizu K, Nagamori E.  Novel method for fabrication of skeletal muscle construct from the C2C12 myoblast cell line using serum-free medium AIM-V.  Biotechnol. Bioeng.  2009  103:1034-41  PubMed ID: 19350625
8643  Takayama K, Suzuki A, Manaka T, Taguchi S, Hashimoto Y, Imai Y, Wakitani S, Takaoka K.  RNA interference for noggin enhances the biological activity of bone morphogenetic proteins in vivo and in vitro.  J. Bone Miner. Metab.  2009  27:402-11  PubMed ID: 19252814
8652  Yano K, Hoshino M, Ohta Y, Manaka T, Naka Y, Imai Y, Sebald W, Takaoka K.  Osteoinductive capacity and heat stability of recombinant human bone morphogenetic protein-2 produced by Escherichia coli and dimerized by biochemical processing.  J. Bone Miner. Metab.  2009  27:355-63  PubMed ID: 19229473
8683  Takayuki Hoshino, Tomohiro Konno, Kazuhiko Ishihara, and Keisuke Morishima  Live-Cell-Driven Insertion of a Nanoneedle  Jpn J Appl Phys.  2009  48:107002-1-107002-6 
8684  Takeomi MIZUTANI, Kenichi DOI, Yasuyuki MORITA, Masakazu UCHINO, Mitsugu TODO, Hisashi HAGA and Kazushige KAWABATA  Displacement of Actin Filament and Actin Binding Proteins under Local Deformation Processed by Digital Image Correlation Method in a Myoblast  J Biomechanical Science and Engineering  2009  4:415-422 
8694  Yagi M, Suzuki N, Takayama T, Arisue M, Kodama T, Yoda Y, Otsuka K, Ito K.  Effects of lactoferrin on the differentiation of pluripotent mesenchymal cells.  Cell Biol. Int.  2008  33:283-9  PubMed ID: 19103298
8696  Honda M, Hosoda M, Kanzawa N, Tsuchiya T, Toyo-oka T.  Specific knockdown of delta-sarcoglycan gene in C2C12 in vitro causes post-translational loss of other sarcoglycans without mechanical stress.  Mol. Cell. Biochem.  2008  323:149-59  PubMed ID: 19083155
8727  Yamauchi M, Kawai S, Kato T, Ooshima T, Amano A.  Odd-skipped related 1 gene expression is regulated by Runx2 and Ikzf1 transcription factors.  Gene  2008  426:81-90  PubMed ID: 18804520
8741  Herningtyas EH, Okimura Y, Handayaningsih AE, Yamamoto D, Maki T, Iida K, Takahashi Y, Kaji H, Chihara K.  Branched-chain amino acids and arginine suppress MaFbx/atrogin-1 mRNA expression via mTOR pathway in C2C12 cell line.  Biochim. Biophys. Acta  2008  1780:1115-20  PubMed ID: 18616983
8766  Yamachika E, Tsujigiwa H, Shirasu N, Ueno T, Sakata Y, Fukunaga J, Mizukawa N, Yamada M, Sugahara T.  Immobilized recombinant human bone morphogenetic protein-2 enhances the phosphorylation of receptor-activated Smads.  J Biomed Mater Res A  2008  88:599-607  PubMed ID: 18314893
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8855  Ono Y, Sensui H, Okutsu S, Nagatomi R.  Notch2 negatively regulates myofibroblastic differentiation of myoblasts.  J. Cell. Physiol.  2006  210:358-69  PubMed ID: 17044085
9165  Morishima N, Nakanishi K, Tsuchiya K, Shibata T, Seiwa E.  Translocation of Bim to the endoplasmic reticulum (ER) mediates ER stress signaling for activation of caspase-12 during ER stress-induced apoptosis.  J. Biol. Chem.  2004  279:50375-81  PubMed ID: 15452118
9428  Morishima N, Nakanishi K, Takenouchi H, Shibata T, Yasuhiko Y.  An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12.  J. Biol. Chem.  2002  277:34287-94  PubMed ID: 12097332
9797  Enoki Y, Watanabe H, Arake R, Sugimoto R, Imafuku T, Tominaga Y, Ishima Y, Kotani S, Nakajima M, Tanaka M, Matsushita K, Fukagawa M, Otagiri M, Maruyama T.  Indoxyl sulfate potentiates skeletal muscle atrophy by inducing the oxidative stress-mediated expression of myostatin and atrogin-1.  Sci Rep  2016  6:32084  PubMed ID: 27549031
9803  Kitakaze T, Sakamoto T, Kitano T, Inoue N, Sugihara F, Harada N, Yamaji R.  The collagen derived dipeptide hydroxyprolyl-glycine promotes C2C12 myoblast differentiation and myotube hypertrophy.  Biochem. Biophys. Res. Commun.  2016  478:1292-7  PubMed ID: 27553280
9859  Takase F, Inui A, Mifune Y, Sakata R, Muto T, Harada Y, Ueda Y, Kokubu T, Kurosaka M.  Effect of platelet-rich plasma on degeneration change of rotator cuff muscles: In vitro and in vivo evaluations.  J. Orthop. Res.  2017  35:1806-1815  PubMed ID: 27684960
9910  Arai S, Ikeda M, Ide T, Matsuo Y, Fujino T, Hirano K, Sunagawa K, Tsutsui H.  Functional loss of DHRS7C induces intracellular Ca2+ overload and myotube enlargement in C2C12 cells via calpain activation.  Am. J. Physiol., Cell Physiol.  2017  312:C29-C39  PubMed ID: 27806939
10095  Saito N, Kimura S, Miyamoto T, Fukushima S, Amagasa M, Shimamoto Y, Nishioka C, Okamoto S, Toda C, Washio K, Asano A, Miyoshi I, Takahashi E, Kitamura H.  Macrophage ubiquitin-specific protease 2 modifies insulin sensitivity in obese mice.  Biochem Biophys Rep  2017  9:322-329  PubMed ID: 28956020
10179  Ono A, Ito A, Sato T, Yamaguchi M, Suzuki T, Kawabe Y, Kamihira M.  Hypoxia-responsive transgene expression system using RTP801 promoter and synthetic transactivator fused with oxygen-dependent degradation domain.  J. Biosci. Bioeng.  2017  124:115-124  PubMed ID: 28284789
10180  Go S, Go S, Veillon L, Ciampa MG, Mauri L, Sato C, Kitajima K, Prinetti A, Sonnino S, Inokuchi JI.  Altered expression of ganglioside GM3 molecular species and a potential regulatory role during myoblast differentiation.  J. Biol. Chem.  2017  292:7040-7051  PubMed ID: 28275055
10348  Enoki Y, Watanabe H, Arake R, Fujimura R, Ishiodori K, Imafuku T, Nishida K, Sugimoto R, Nagao S, Miyamura S, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Maruyama T.  Potential therapeutic interventions for chronic kidney disease-associated sarcopenia via indoxyl sulfate-induced mitochondrial dysfunction.  J Cachexia Sarcopenia Muscle  2017  8:735-747  PubMed ID: 28608457
10375  Kurashina Y, Hirano M, Imashiro C, Totani K, Komotori J, Takemura K.  Enzyme-free cell detachment mediated by resonance vibration with temperature modulation.  Biotechnol. Bioeng.  2017  114:2279-2288  PubMed ID: 28627736
10413  Yoshida K, Imamura CK, Hara K, Mochizuki M, Tanigawara Y.  Effect of everolimus on the glucose metabolic pathway in mouse skeletal muscle cells (C2C12).  Metabolomics  2017  13:98  PubMed ID: 28781589
10442  Ono Y, Sakamoto K.  Lipopolysaccharide inhibits myogenic differentiation of C2C12 myoblasts through the Toll-like receptor 4-nuclear factor-κB signaling pathway and myoblast-derived tumor necrosis factor-α.  PLoS ONE  2017  12:e0182040  PubMed ID: 28742154
10462  Ogawa M, Kitano T, Kawata N, Sugihira T, Kitakaze T, Harada N, Yamaji R.  Daidzein down-regulates ubiquitin-specific protease 19 expression through estrogen receptor β and increases skeletal muscle mass in young female mice.  J. Nutr. Biochem.  2017  49:63-70  PubMed ID: 28886438
10476  Minami K, Mori T, Nakanishi W, Shigi N, Nakanishi J, Hill JP, Komiyama M, Ariga K.  Suppression of Myogenic Differentiation of Mammalian Cells Caused by Fluidity of a Liquid-Liquid Interface.  ACS Appl Mater Interfaces  2017  9:30553-30560  PubMed ID: 28836758
10477  Asano T, Ishizuka T, Yawo H.  Myogenic Maturation by Optical-Training in Cultured Skeletal Muscle Cells.  Methods Mol. Biol.  2017  1668:135-145  PubMed ID: 28842907
10479  Yamamoto Y, Sawa R, Wake I, Morimoto A, Okimura Y.  Glucose-mediated inactivation of AMP-activated protein kinase reduces the levels of L-type amino acid transporter 1 mRNA in C2C12 cells.  Nutr Res  2017  47:13-20  PubMed ID: 29241574
10511  Okutani C, Wagatsuma A, Mabuchi K, Hoshino T.  Directed cell migration in co-cultures by topographic curvature for heterogeneous tissue engineering.  Conf Proc IEEE Eng Med Biol Soc  2017  2017:1607-1610  PubMed ID: 29060190
10536  Fujiwara Y, Tsukahara C, Ikeda N, Sone Y, Ishikawa T, Ichi I, Koike T, Aoki Y.  Oleuropein improves insulin resistance in skeletal muscle by promoting the translocation of GLUT4.  J Clin Biochem Nutr  2017  61:196-202  PubMed ID: 29203961
10657  Kawai S, Yamauchi M, Amano A.  Zinc-finger transcription factor Odd-skipped related 1 regulates cranial bone formation.  J. Bone Miner. Metab.  2018    PubMed ID: 29234951
10659  Wagatsuma A, Takayama Y, Hoshino T, Shiozuka M, Yamada S, Matsuda R, Mabuchi K.  Pharmacological targeting of HSP90 with 17-AAG induces apoptosis of myogenic cells through activation of the intrinsic pathway.  Mol. Cell. Biochem.  2018    PubMed ID: 29248972
10712  Hatazawa Y, Qian K, Gong DW, Kamei Y.  PGC-1α regulates alanine metabolism in muscle cells.  PLoS ONE  2018  13:e0190904  PubMed ID: 29315328
10731  Kumeta M, Takahashi D, Takeyasu K, Yoshimura SH.  Cell type-specific suppression of mechanosensitive genes by audible sound stimulation.  PLoS ONE  2018  13:e0188764  PubMed ID: 29385174
10756  Kitakaze T, Oshimo M, Kobayashi Y, Ryu M, Suzuki YA, Inui H, Harada N, Yamaji R.  Lactoferrin promotes murine C2C12 myoblast proliferation and differentiation and myotube hypertrophy.  Mol Med Rep  2018  17:5912-5920  PubMed ID: 29436684
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10942    Fine virtual cathode display for biomolecules control and cell nano surgery  IEEE Xplore  2017   
10943    On-chip internalization process of an intracellular nanobot into a single cell  IEEE Xplore  2017   
10963    Cell descent caused by boundary curvature of a high topographical structure for a device that changes cell density  Japanese Journal of Applied Physics  2017  06GM03 
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10899    マウス由来筋芽細胞の増殖におけるストレス応答ホルモン刺激の影響  秋田県立大学ウェブジャーナルB  2016  3, 118 - 123 
5662  村上 祐子, 足立 浩章, 田中 浩, 八代 洋一, 中田 悟  眼輪筋に着目した目もとの加齢変化のメカニズム解析  日本化粧品技術者会誌  2015  49:36-41 

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