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RCB0987 : C2C12  update : 2019/12/11
CommentSaid differentiate to myotubes, but need confirmation. Since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ECA91031101 prior to order.
Comment from the depositor
Terms and conditionsBasically, there is no restriction regarding academic use. However, since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ECA91031101 prior to order.
Remarks
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor ECACC
Year of deposit 1994
Animal mouse < Mammals
Strain name C3H
Tissue muscle
Classification other
History overseas, ECACC
Lifespan infinite
Morphology other
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives DMEM (low glucose) + 10% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 10 split
SC frequency Subculture : once/2-3 days
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Animal PCR OK
SSLP (mouse) OK
Images
deposit info
lot info
Reference information Reference 3
User's Publication 148


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Reference
1832  Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle.  Yaffe D, Saxel O  Nature  1977  270:725-7  PubMed ID: 563524
4920  Plasticity of the differentiated state.  Blau HM, Pavlath GK, Hardeman EC, Chiu CP, Silberstein L, Webster SG, Miller SC, Webster C.  Science  1985  230(4727):758-66  PubMed ID: 2414846
4921  Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage.  atagiri T, Yamaguchi A, Komaki M, Abe E, Takahashi N, Ikeda T, Rosen V, Wozney JM, Fujisawa-Sehara A, Suda T.  J Cell Biol  1994  127(6 Pt 1):1755-66.  PubMed ID: 7798324

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User's Publication
3398  SOCS-2 interferes with myotube formation and potentiates osteoblast differentiation through upregulation of JunB in C2C12 cells.  Ouyang, Xinshou, Fujimoto, Minoru, Nakagawa, Reiko, Serada, Satoshi, Tanaka, Toshio, Nomura, Shintaro, Kawase, Ichiro, Kishimoto, Tadamitsu, Naka, Tetsuji  J Cell Physiol  2006  207:428-36  PubMed ID: 16419040
2644  Basic helix-loop-helix transcription factor epicardin/capsulin/Pod-1 suppresses differentiation by negative regulation of transcription  Funato N, Ohyama K, Kuroda T, Nakamura M  J Biol Chem  2002  278:7486-7493  PubMed ID: 12493738
2718  MFH-1 is required for bone morphogenetic protein-2-induced osteoblastic differentiation of C2C12 myoblasts.  Yang XL, Matsuura H, Fu Y, Sugiyama T, Miura N  FEBS Lett  2000  470:29-34  PubMed ID: 10722840
2871  Runx-2 is not essential for the vitamin D-regulated expression of RANKL and osteoprotegerin in osteoblastic cells.  Notoya M, Otsuka E, Yamaguchi A, Hagiwara H  Biochem Biophys Res Commun  2004  324:655-60  PubMed ID: 15474477
2873  Mechanical stretch inhibits myoblast-to-adipocyte differentiation through Wnt signaling.  Akimoto T, Ushida T, Miyaki S, Akaogi H, Tsuchiya K, Yan Z, Williams RS, Tateishi T  Biochem Biophys Res Commun  2005  329:381-5  PubMed ID: 15721317
2878  Molecular cloning and characterization of the murine gnathodiaphyseal dysplasia gene GDD1.  Tsutsumi S, Inoue H, Sakamoto Y, Mizuta K, Kamata N, Itakura M  Biochem Biophys Res Commun  2005  331:1099-106  PubMed ID: 15882990
2915  Critical regulation of bone morphogenetic protein-induced osteoblastic differentiation by Delta1/Jagged1-activated Notch1 signaling.  Nobta M, Tsukazaki T, Shibata Y, Xin C, Moriishi T, Sakano S, Shindo H, Yamaguchi A  J Biol Chem  2005  280:15842-8  PubMed ID: 15695512
2378  Differentiation-induced insulin secretion from nonendocrine cells with engineered human proinsulin cDNA.  Yamasaki K, Sasaki T, Nemoto M, Eto Y, Tajima N  Biochem Biophys Res Commun  1999  265:361-5  PubMed ID: 10558872
2425  Positive regulation of skeletal myogenesis by R-Ras.  Suzuki J, Kaziro Y, Koide H  Oncogene  2000  19:1138-46  PubMed ID: 10713701
2426  Involvement of Ras and Ral in chemotactic migration of skeletal myoblasts.  Suzuki J, Yamazaki Y, Li G, Kaziro Y, Koide H  Mol Cell Biol  2000  20:4658-65  PubMed ID: 10848592
2893  Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation.  Ichida, Fumitaka, Nishimura, Riko, Hata, Kenji, Matsubara, Takuma, Ikeda, Fumiyo, Hisada, Kunihiro, Yatani, Hirofumi, Cao, Xu, Komori, Toshihisa, Yamaguchi, Akira, Yoneda, Toshiyuki  J Biol Chem  2004  279:34015-22  PubMed ID: 15175325
3183  A CCAAT/enhancer binding protein beta isoform, liver-enriched inhibitory protein, regulates commitment of osteoblasts and adipocytes.  Hata, Kenji, Nishimura, Riko, Ueda, Mio, Ikeda, Fumiyo, Matsubara, Takuma, Ichida, Fumitaka, Hisada, Kunihiro, Nokubi, Takashi, Yamaguchi, Akira, Yoneda, Toshiyuki  Mol Cell Biol  2005  25:1971-9  PubMed ID: 15713650
7142  Propolis Ethanol Extract Stimulates Cytokine and Chemokine Production through NF-κB Activation in C2C12 Myoblasts.  Washio K, Kobayashi M, Saito N, Amagasa M, Kitamura H.  Evid Based Complement Alternat Med  2015  2015:349751  PubMed ID: 26604971
7146  Enhancement of energy production by black ginger extract containing polymethoxy flavonoids in myocytes through improving glucose, lactic acid and lipid metabolism.  Toda K, Takeda S, Hitoe S, Nakamura S, Matsuda H, Shimoda H.  J Nat Med  2015  70:163-72  PubMed ID: 26581843
7184  A novel in vitro model of sarcopenia using BubR1 hypomorphic C2C12 myoblasts.  Nozaki T, Nikai S, Okabe R, Nagahama K, Eto N.  Cytotechnology  2015  68:1705-15  PubMed ID: 26464273
7249  A Comparison of Ci/Gli Activity as Regulated by Sufu in Drosophila and Mammalian Hedgehog Response.  Oh S, Kato M, Zhang C, Guo Y, Beachy PA.  PLoS ONE  2015  10:e0135804  PubMed ID: 26271100
7250  A novel adipokine C1q/TNF-related protein 3 is expressed in developing skeletal muscle and controls myoblast proliferation and differentiation.  Otani M, Furukawa S, Wakisaka S, Maeda T.  Mol. Cell. Biochem.  2015  409:271-82  PubMed ID: 26272338
7284  A novel Alaska pollack-derived peptide, which increases glucose uptake in skeletal muscle cells, lowers the blood glucose level in diabetic mice.  Ayabe T, Mizushige T, Ota W, Kawabata F, Hayamizu K, Han L, Tsuji T, Kanamoto R, Ohinata K.  Food Funct  2015  6:2749-57  PubMed ID: 26152190
7311  Visualizing the appearance and disappearance of the attractor of differentiation using Raman spectral imaging.  Ichimura T, Chiu LD, Fujita K, Machiyama H, Kawata S, Watanabe TM, Fujita H.  Sci Rep  2015  5:11358  PubMed ID: 26079396
7323  Highly Ordered 1D Fullerene Crystals for Concurrent Control of Macroscopic Cellular Orientation and Differentiation toward Large-Scale Tissue Engineering.  Minami K, Kasuya Y, Yamazaki T, Ji Q, Nakanishi W, Hill JP, Sakai H, Ariga K.  Adv. Mater. Weinheim  2015  27:4020-6  PubMed ID: 26033774
7416  Prolyl hydroxylase domain-2 silencing induced by hydrodynamic limb vein injection enhances vascular regeneration in critical limb ischemia mice through activation of multiple genes.  Wu S, Zhang J, Huang C, Jia H, Wang Y, Xu Z, Yang L, Miyagishi M, Kasim V.  Curr Gene Ther  2015  15:313-25  PubMed ID: 25832622
7454  Autonomous patterning of cells on microstructured fine particles.  Takeda I, Kawanabe M, Kaneko A.  Mater Sci Eng C Mater Biol Appl  2015  50:173-8  PubMed ID: 25746259
7465  Compressive stress induces dephosphorylation of the myosin regulatory light chain via RhoA phosphorylation by the adenylyl cyclase/protein kinase A signaling pathway.  Takemoto K, Ishihara S, Mizutani T, Kawabata K, Haga H.  PLoS ONE  2015  10:e0117937  PubMed ID: 25734240
7472  Proliferative effect of Hachimijiogan, a Japanese herbal medicine, in C2C12 skeletal muscle cells.  Takeda T, Tsuiji K, Li B, Tadakawa M, Yaegashi N.  Clin Interv Aging  2015  10:445-51  PubMed ID: 25709418
7483  Transient Ca2+ depletion from the endoplasmic reticulum is critical for skeletal myoblast differentiation.  Nakanishi K, Kakiguchi K, Yonemura S, Nakano A, Morishima N.  FASEB J.  2015  29:2137-49  PubMed ID: 25678623
7488  Optogenetic induction of contractile ability in immature C2C12 myotubes.  Asano T, Ishizuka T, Morishima K, Yawo H.  Sci Rep  2015  5:8317  PubMed ID: 25661648
7509  Hyaluronan inhibits BMP-induced osteoblast differentiation.  Kaneko K, Higuchi C, Kunugiza Y, Yoshida K, Sakai T, Yoshikawa H, Nakata K.  FEBS Lett.  2015  589:447-54  PubMed ID: 25592835
7576  Oxygen consumption of contractile C2C12 myotubes investigated by scanning electrochemical microscopy.  Yuki Igaki, Fumio Mizutani, Tomoyuki Yasukawa  Chemistry Letters  2015  44:1031-1032 
7663  17β-estradiol represses myogenic differentiation by increasing ubiquitin-specific peptidase 19 through estrogen receptor α.  Ogawa M, Yamaji R, Higashimura Y, Harada N, Ashida H, Nakano Y, Inui H.  J. Biol. Chem.  2011  286:41455-65  PubMed ID: 21971047
7665  Canonical Wnt signaling is involved in switching from cell proliferation to myogenic differentiation of mouse myoblast cells.  Tanaka S, Terada K, Nohno T.  J Mol Signal  2011  6:12  PubMed ID: 21970630
7705  Bone morphogenetic protein 4 accelerates the establishment of bovine trophoblastic cell lines.  Suzuki Y, Koshi K, Imai K, Takahashi T, Kizaki K, Hashizume K.  Reproduction  2011  142:733-43  PubMed ID: 21862694
7712  Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via induction of WW domain binding protein 1.  Morishima N, Nakanishi K, Nakano A.  J. Biol. Chem.  2011  286:35227-35  PubMed ID: 21841196
7857  Inhibition of myotube formation by paraquat in the myoblast cell line C2C12.  Akiyama K, Tone J, Okabe M, Nishimoto S, Sugahara T, Kakinuma Y.  J Toxicol Sci  2011  36:243-6  PubMed ID: 21467752
7868  Inhibition of nuclear delivery of plasmid DNA and transcription by interferon γ: hurdles to be overcome for sustained gene therapy.  Zang L, Nishikawa M, Machida K, Ando M, Takahashi Y, Watanabe Y, Takakura Y.  Gene Ther.  2011  18:891-7  PubMed ID: 21451577
7982  Molecular mechanism of fatty degeneration in rotator cuff muscle with tendon rupture.  Itoigawa Y, Kishimoto KN, Sano H, Kaneko K, Itoi E.  J. Orthop. Res.  2011  29:861-6  PubMed ID: 21246616
8044  Rapid decrease in active tension generated by C2C12 myotubes after termination of artificial exercise.  Fujita H, Hirano M, Shimizu K, Nagamori E.  J. Muscle Res. Cell. Motil.  2010  31:279-88  PubMed ID: 21120590
8078  Designing of a Si-MEMS device with an integrated skeletal muscle cell-based bio-actuator.  Fujita H, Van Dau T, Shimizu K, Hatsuda R, Sugiyama S, Nagamori E.  Biomed Microdevices  2010  13:123-9  PubMed ID: 20957437
8092  TIEG1 negatively controls the myoblast pool indispensable for fusion during myogenic differentiation of C2C12 cells.  Miyake M, Hayashi S, Iwasaki S, Uchida T, Watanabe K, Ohwada S, Aso H, Yamaguchi T.  J. Cell. Physiol.  2010  226:1128-36  PubMed ID: 20945337
8128  VAMP2 marks quiescent satellite cells and myotubes, but not activated myoblasts.  Tajika Y, Takahashi M, Hino M, Murakami T, Yorifuji H.  Acta Histochem Cytochem  2010  43:107-14  PubMed ID: 20824121
8147  Characterization of HACD1 K64Q mutant found in arrhythmogenic right ventricular dysplasia patients.  Konishi H, Okuda A, Ohno Y, Kihara A.  J. Biochem.  2010  148:617-22  PubMed ID: 20724468
8161  Hypoxia induces adipogenic differentitation of myoblastic cell lines.  Itoigawa Y, Kishimoto KN, Okuno H, Sano H, Kaneko K, Itoi E.  Biochem. Biophys. Res. Commun.  2010  399:721-6  PubMed ID: 20692234
8162  Dominant-negative effects of a novel mutation in the filamin myopathy.  Kono S, Nishio T, Takahashi Y, Goto-Inoue N, Kinoshita M, Zaima N, Suzuki H, Fukutoku-Otsuji A, Setou M, Miyajima H.  Neurology  2010  75:547-54  PubMed ID: 20697107
8166  Heavy ion irradiation induces autophagy in irradiated C2C12 myoblasts and their bystander cells.  Hino M, Hamada N, Tajika Y, Funayama T, Morimura Y, Sakashita T, Yokota Y, Fukamoto K, Mutou Y, Kobayashi Y, Yorifuji H.  J Electron Microsc (Tokyo)  2010  59:495-501  PubMed ID: 20685830
8182  Epinephrine accelerates osteoblastic differentiation by enhancing bone morphogenetic protein signaling through a cAMP/protein kinase A signaling pathway.  Uemura T, Ohta Y, Nakao Y, Manaka T, Nakamura H, Takaoka K.  Bone  2010  47:756-65  PubMed ID: 20637325
8184  Evaluation of serum-free differentiation conditions for C2C12 myoblast cells assessed as to active tension generation capability.  Fujita H, Endo A, Shimizu K, Nagamori E.  Biotechnol. Bioeng.  2010  107:894-901  PubMed ID: 20635352
8231  Enhancement of C2C12 differentiation by perfluorocarbon-mediated oxygen delivery.  Fujita H, Shimizu K, Morioka Y, Nagamori E.  J. Biosci. Bioeng.  2010  110:359-62  PubMed ID: 20547328
8259  Proliferation and differentiation potential of pluripotent mesenchymal precursor C2C12 cells on resin-based restorative materials.  Imazato S, Horikawa D, Takeda K, Kiba W, Izutani N, Yoshikawa R, Hayashi M, Ebisu S, Nakano T.  Dent Mater J  2010  29:341-6  PubMed ID: 20467157
8264  Hydroxy monounsaturated fatty acids as agonists for peroxisome proliferator-activated receptors.  Yokoi H, Mizukami H, Nagatsu A, Tanabe H, Inoue M.  Biol. Pharm. Bull.  2010  33:854-61  PubMed ID: 20460766
8351  Novel method for measuring active tension generation by C2C12 myotube using UV-crosslinked collagen film.  Fujita H, Shimizu K, Nagamori E.  Biotechnol. Bioeng.  2010  106:482-9  PubMed ID: 20178119
8352  Possible role of TIEG1 as a feedback regulator of myostatin and TGF-beta in myoblasts.  Miyake M, Hayashi S, Iwasaki S, Chao G, Takahashi H, Watanabe K, Ohwada S, Aso H, Yamaguchi T.  Biochem. Biophys. Res. Commun.  2010  393:762-6  PubMed ID: 20171187
8371  Micropatterning of single myotubes on a thermoresponsive culture surface using elastic stencil membranes for single-cell analysis.  Shimizu K, Fujita H, Nagamori E.  J. Biosci. Bioeng.  2010  109:174-8  PubMed ID: 20129103
8385  Oxygen plasma-treated thermoresponsive polymer surfaces for cell sheet engineering.  Shimizu K, Fujita H, Nagamori E.  Biotechnol. Bioeng.  2010  106:303-10  PubMed ID: 20091737
8387  The cathepsin L gene is a direct target of FOXO1 in skeletal muscle.  Yamazaki Y, Kamei Y, Sugita S, Akaike F, Kanai S, Miura S, Hirata Y, Troen BR, Kitamura T, Nishino I, Suganami T, Ezaki O, Ogawa Y.  Biochem. J.  2010  427:171-8  PubMed ID: 20088826
8562  Subtilisin-like proprotein convertase PACE4 is required for skeletal muscle differentiation.  Yuasa K, Masuda T, Yoshikawa C, Nagahama M, Matsuda Y, Tsuji A.  J. Biochem.  2009  146:407-15  PubMed ID: 19520771
8609  Novel method for fabrication of skeletal muscle construct from the C2C12 myoblast cell line using serum-free medium AIM-V.  Fujita H, Shimizu K, Nagamori E.  Biotechnol. Bioeng.  2009  103:1034-41  PubMed ID: 19350625
8643  RNA interference for noggin enhances the biological activity of bone morphogenetic proteins in vivo and in vitro.  Takayama K, Suzuki A, Manaka T, Taguchi S, Hashimoto Y, Imai Y, Wakitani S, Takaoka K.  J. Bone Miner. Metab.  2009  27:402-11  PubMed ID: 19252814
8652  Osteoinductive capacity and heat stability of recombinant human bone morphogenetic protein-2 produced by Escherichia coli and dimerized by biochemical processing.  Yano K, Hoshino M, Ohta Y, Manaka T, Naka Y, Imai Y, Sebald W, Takaoka K.  J. Bone Miner. Metab.  2009  27:355-63  PubMed ID: 19229473
8683  Live-Cell-Driven Insertion of a Nanoneedle  Takayuki Hoshino, Tomohiro Konno, Kazuhiko Ishihara, and Keisuke Morishima  Jpn J Appl Phys.  2009  48:107002-1-107002-6 
8684  Displacement of Actin Filament and Actin Binding Proteins under Local Deformation Processed by Digital Image Correlation Method in a Myoblast  Takeomi MIZUTANI, Kenichi DOI, Yasuyuki MORITA, Masakazu UCHINO, Mitsugu TODO, Hisashi HAGA and Kazushige KAWABATA  J Biomechanical Science and Engineering  2009  4:415-422 
8694  Effects of lactoferrin on the differentiation of pluripotent mesenchymal cells.  Yagi M, Suzuki N, Takayama T, Arisue M, Kodama T, Yoda Y, Otsuka K, Ito K.  Cell Biol. Int.  2009  33:283-9  PubMed ID: 19103298
8696  Specific knockdown of delta-sarcoglycan gene in C2C12 in vitro causes post-translational loss of other sarcoglycans without mechanical stress.  Honda M, Hosoda M, Kanzawa N, Tsuchiya T, Toyo-oka T.  Mol. Cell. Biochem.  2008  323:149-59  PubMed ID: 19083155
8727  Odd-skipped related 1 gene expression is regulated by Runx2 and Ikzf1 transcription factors.  Yamauchi M, Kawai S, Kato T, Ooshima T, Amano A.  Gene  2008  426:81-90  PubMed ID: 18804520
8741  Branched-chain amino acids and arginine suppress MaFbx/atrogin-1 mRNA expression via mTOR pathway in C2C12 cell line.  Herningtyas EH, Okimura Y, Handayaningsih AE, Yamamoto D, Maki T, Iida K, Takahashi Y, Kaji H, Chihara K.  Biochim. Biophys. Acta  2008  1780:1115-20  PubMed ID: 18616983
8766  Immobilized recombinant human bone morphogenetic protein-2 enhances the phosphorylation of receptor-activated Smads.  Yamachika E, Tsujigiwa H, Shirasu N, Ueno T, Sakata Y, Fukunaga J, Mizukawa N, Yamada M, Sugahara T.  J Biomed Mater Res A  2008  88:599-607  PubMed ID: 18314893
8803  Zinc-finger transcription factor odd-skipped related 2 is one of the regulators in osteoblast proliferation and bone formation.  Kawai S, Yamauchi M, Wakisaka S, Ooshima T, Amano A.  J. Bone Miner. Res.  2007  22:1362-72  PubMed ID: 17547533
8855  Notch2 negatively regulates myofibroblastic differentiation of myoblasts.  Ono Y, Sensui H, Okutsu S, Nagatomi R.  J. Cell. Physiol.  2006  210:358-69  PubMed ID: 17044085
2914  Translocation of Bim to the endoplasmic reticulum (ER) mediates ER stress signaling for activation of caspase-12 during ER stress-induced apoptosis.  Morishima N, Nakanishi K, Tsuchiya K, Shibata T, Seiwa E.  J. Biol. Chem.  2004  279:50375-81  PubMed ID: 15452118
3044  An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12.  Morishima N, Nakanishi K, Takenouchi H, Shibata T, Yasuhiko Y.  J. Biol. Chem.  2002  277:34287-94  PubMed ID: 12097332
9797  Indoxyl sulfate potentiates skeletal muscle atrophy by inducing the oxidative stress-mediated expression of myostatin and atrogin-1.  Enoki Y, Watanabe H, Arake R, Sugimoto R, Imafuku T, Tominaga Y, Ishima Y, Kotani S, Nakajima M, Tanaka M, Matsushita K, Fukagawa M, Otagiri M, Maruyama T.  Sci Rep  2016  6:32084  PubMed ID: 27549031
9803  The collagen derived dipeptide hydroxyprolyl-glycine promotes C2C12 myoblast differentiation and myotube hypertrophy.  Kitakaze T, Sakamoto T, Kitano T, Inoue N, Sugihara F, Harada N, Yamaji R.  Biochem. Biophys. Res. Commun.  2016  478:1292-7  PubMed ID: 27553280
9859  Effect of platelet-rich plasma on degeneration change of rotator cuff muscles: In vitro and in vivo evaluations.  Takase F, Inui A, Mifune Y, Sakata R, Muto T, Harada Y, Ueda Y, Kokubu T, Kurosaka M.  J. Orthop. Res.  2017  35:1806-1815  PubMed ID: 27684960
9910  Functional loss of DHRS7C induces intracellular Ca2+ overload and myotube enlargement in C2C12 cells via calpain activation.  Arai S, Ikeda M, Ide T, Matsuo Y, Fujino T, Hirano K, Sunagawa K, Tsutsui H.  Am. J. Physiol., Cell Physiol.  2017  312:C29-C39  PubMed ID: 27806939
10095  Macrophage ubiquitin-specific protease 2 modifies insulin sensitivity in obese mice.  Saito N, Kimura S, Miyamoto T, Fukushima S, Amagasa M, Shimamoto Y, Nishioka C, Okamoto S, Toda C, Washio K, Asano A, Miyoshi I, Takahashi E, Kitamura H.  Biochem Biophys Rep  2017  9:322-329  PubMed ID: 28956020
10179  Hypoxia-responsive transgene expression system using RTP801 promoter and synthetic transactivator fused with oxygen-dependent degradation domain.  Ono A, Ito A, Sato T, Yamaguchi M, Suzuki T, Kawabe Y, Kamihira M.  J. Biosci. Bioeng.  2017  124:115-124  PubMed ID: 28284789
10180  Altered expression of ganglioside GM3 molecular species and a potential regulatory role during myoblast differentiation.  Go S, Go S, Veillon L, Ciampa MG, Mauri L, Sato C, Kitajima K, Prinetti A, Sonnino S, Inokuchi JI.  J. Biol. Chem.  2017  292:7040-7051  PubMed ID: 28275055
10348  Potential therapeutic interventions for chronic kidney disease-associated sarcopenia via indoxyl sulfate-induced mitochondrial dysfunction.  Enoki Y, Watanabe H, Arake R, Fujimura R, Ishiodori K, Imafuku T, Nishida K, Sugimoto R, Nagao S, Miyamura S, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Maruyama T.  J Cachexia Sarcopenia Muscle  2017  8:735-747  PubMed ID: 28608457
10375  Enzyme-free cell detachment mediated by resonance vibration with temperature modulation.  Kurashina Y, Hirano M, Imashiro C, Totani K, Komotori J, Takemura K.  Biotechnol. Bioeng.  2017  114:2279-2288  PubMed ID: 28627736
10413  Effect of everolimus on the glucose metabolic pathway in mouse skeletal muscle cells (C2C12).  Yoshida K, Imamura CK, Hara K, Mochizuki M, Tanigawara Y.  Metabolomics  2017  13:98  PubMed ID: 28781589
10442  Lipopolysaccharide inhibits myogenic differentiation of C2C12 myoblasts through the Toll-like receptor 4-nuclear factor-κB signaling pathway and myoblast-derived tumor necrosis factor-α.  Ono Y, Sakamoto K.  PLoS ONE  2017  12:e0182040  PubMed ID: 28742154
10462  Daidzein down-regulates ubiquitin-specific protease 19 expression through estrogen receptor β and increases skeletal muscle mass in young female mice.  Ogawa M, Kitano T, Kawata N, Sugihira T, Kitakaze T, Harada N, Yamaji R.  J. Nutr. Biochem.  2017  49:63-70  PubMed ID: 28886438
10476  Suppression of Myogenic Differentiation of Mammalian Cells Caused by Fluidity of a Liquid-Liquid Interface.  Minami K, Mori T, Nakanishi W, Shigi N, Nakanishi J, Hill JP, Komiyama M, Ariga K.  ACS Appl Mater Interfaces  2017  9:30553-30560  PubMed ID: 28836758
10477  Myogenic Maturation by Optical-Training in Cultured Skeletal Muscle Cells.  Asano T, Ishizuka T, Yawo H.  Methods Mol. Biol.  2017  1668:135-145  PubMed ID: 28842907
10479  Glucose-mediated inactivation of AMP-activated protein kinase reduces the levels of L-type amino acid transporter 1 mRNA in C2C12 cells.  Yamamoto Y, Sawa R, Wake I, Morimoto A, Okimura Y.  Nutr Res  2017  47:13-20  PubMed ID: 29241574
10511  Directed cell migration in co-cultures by topographic curvature for heterogeneous tissue engineering.  Okutani C, Wagatsuma A, Mabuchi K, Hoshino T.  Conf Proc IEEE Eng Med Biol Soc  2017  2017:1607-1610  PubMed ID: 29060190
10536  Oleuropein improves insulin resistance in skeletal muscle by promoting the translocation of GLUT4.  Fujiwara Y, Tsukahara C, Ikeda N, Sone Y, Ishikawa T, Ichi I, Koike T, Aoki Y.  J Clin Biochem Nutr  2017  61:196-202  PubMed ID: 29203961
10657  Zinc-finger transcription factor Odd-skipped related 1 regulates cranial bone formation.  Kawai S, Yamauchi M, Amano A.  J. Bone Miner. Metab.  2018  36(6):640-647  PubMed ID: 29234951
10659  Pharmacological targeting of HSP90 with 17-AAG induces apoptosis of myogenic cells through activation of the intrinsic pathway.  Wagatsuma A, Takayama Y, Hoshino T, Shiozuka M, Yamada S, Matsuda R, Mabuchi K.  Mol. Cell. Biochem.  2018  445(1-2):45-58  PubMed ID: 29248972
10712  PGC-1α regulates alanine metabolism in muscle cells.  Hatazawa Y, Qian K, Gong DW, Kamei Y.  PLoS ONE  2018  13:e0190904  PubMed ID: 29315328
10731  Cell type-specific suppression of mechanosensitive genes by audible sound stimulation.  Kumeta M, Takahashi D, Takeyasu K, Yoshimura SH.  PLoS ONE  2018  13:e0188764  PubMed ID: 29385174
10756  Lactoferrin promotes murine C2C12 myoblast proliferation and differentiation and myotube hypertrophy.  Kitakaze T, Oshimo M, Kobayashi Y, Ryu M, Suzuki YA, Inui H, Harada N, Yamaji R.  Mol Med Rep  2018  17:5912-5920  PubMed ID: 29436684
10769  Buffering roles of (pro)renin receptor in starvation-induced autophagy of skeletal muscles.  Mizuguchi Y, Yatabe M, Morishima N, Morimoto S, Ichihara A.  Physiol Rep  2018  6:  PubMed ID: 29488348
10874  Electron beam induced fine virtual electrode for mechanical strain microscopy of living cell    Sensors and Actuators B: Chemical   2016  236, 659-667 
10886  Improvement of Mitochondrial Function and Lipid Utilization by 3,5-dihydroxy-4-methoxybenzyl Alcohol, an Oyster-derived polyphenol, in Oleate-loaded C2C12 Myotubes    Journal of Food and Nutrition Research  2016  4, 498 
10942  Fine virtual cathode display for biomolecules control and cell nano surgery  Takayuki Hoshino ; Moto Yoshioka ; Akira Wagatsuma ; Hiroki Miyazako ; Kunihiko Mabuchi  IEEE Xplore  2017   
10943  On-chip internalization process of an intracellular nanobot into a single cell    IEEE Xplore  2017   
10963  Cell descent caused by boundary curvature of a high topographical structure for a device that changes cell density    Japanese Journal of Applied Physics  2017  56:06GM03 
11134  Corticosterone biosynthesis in mouse clonal myoblastic C2C12 cells.  Fujiki J, Maeda N, Sato M, Ieko T, Inoue H, Iwasaki T, Iwano H, Yokota H.  Steroids  2018  138:64-71  PubMed ID: 30018003
11094  Vaccinium ashei leaves extract alleviates insulin resistance via AMPK independent pathway in C2C12 myotube model.  Yamasaki M, Hamada K, Fujii K, Nishiyama K, Yamasaki Y, Tari H, Araki K, Arakawa T.  Biochem Biophys Rep  2018  14:182-187  PubMed ID: 29872751
11104  Targeted ablation of p38α MAPK suppresses denervation-induced muscle atrophy.  Yuasa K, Okubo K, Yoda M, Otsu K, Ishii Y, Nakamura M, Itoh Y, Horiuchi K.  Sci Rep  2018  8(1):9037  PubMed ID: 29899565
11127  Monocarboxylate transporter-1 promotes osteoblast differentiation via suppression of p53, a negative regulator of osteoblast differentiation.  Sasa K, Yoshimura K, Yamada A, Suzuki D, Miyamoto Y, Imai H, Nagayama K, Maki K, Yamamoto M, Kamijo R.  Sci Rep  2018  8(1):10579  PubMed ID: 30002387
11181  Muscle-dominant wild-type TDP-43 expression induces myopathological changes featuring tubular aggregates and TDP-43-positive inclusions.  Tawara N, Yamashita S, Kawakami K, Kurashige T, Zhang Z, Tasaki M, Yamamoto Y, Nishikami T, Doki T, Zhang X, Matsuo Y, Kimura E, Tawara A, Maeda Y, Hauschka SD, Maruyama H, Ando Y.  Exp. Neurol.  2018  309:169-180  PubMed ID: 30130494
11188  Enzymatic digest of whey protein and wheylin-1, a dipeptide released in the digest, increase insulin sensitivity in an Akt phosphorylation-dependent manner.  Ogiwara M, Ota W, Mizushige T, Kanamoto R, Ohinata K.  Food Funct  2018  9(9):4635-4641  PubMed ID: 30151525
11183  Dexamethasone exacerbates cisplatin-induced muscle atrophy.  Sakai H, Kimura M, Tsukimura Y, Yabe S, Isa Y, Kai Y, Sato F, Kon R, Ikarashi N, Narita M, Chiba Y, Kamei J.  Clin. Exp. Pharmacol. Physiol.  2019  46(1):19-28  PubMed ID: 30137654
11227  Growth hormone and Insulin-like growth factor-I (IGF-I) modulate the expression of L-type amino acid transporters in the muscles of spontaneous dwarf rats and L6 and C2C12 myocytes.  Sawa R, Nishida H, Yamamoto Y, Wake I, Kai N, Kikkawa U, Okimura Y.  Growth Horm. IGF Res.  2018    PubMed ID: 30273774
11239  Reduction of Real-Time Imaging of M1 Macrophage Chemotaxis toward Damaged Muscle Cells is PI3K-Dependent.  Yano H, Uchida M, Saito T, Aoki T, Kremenik MJ, Oyanagi E.  Antioxidants (Basel)  2018    PubMed ID: 30297636
11302  Liver-type of tissue non-specific alkaline phosphatase is induced during mouse bone and tooth cell differentiation.  Baba TT, Terashima T, Oida S.  Arch. Oral Biol.  2019    PubMed ID: 30439569
11284  Baicalein stimulates fibroblast growth factor 21 expression by up-regulating retinoic acid receptor-related orphan receptor α in C2C12 myotubes.  Hirai T, Nomura K, Ikai R, Nakashima KI, Inoue M.  Biomed. Pharmacother.  2019    PubMed ID: 30399586
11285  Granulocyte-colony stimulating factor enhances load-induced muscle hypertrophy in mice.  Ohashi M, Okubo K, Mizuno S, Yoda M, Shirasawa H, Chiba K, Horiuchi K, Matsumoto M, Nakamura M.  Biochem. Biophys. Res. Commun.  2018    PubMed ID: 30401566
11385  Heat induces myogenic transcription factors of myoblast cells via transient receptor potential vanilloid 1 (Trpv1).  Obi S, Nakajima T, Hasegawa T, Nakamura F, Sakuma M, Toyoda S, Tei C, Inoue T.  FEBS Open Bio  2019    PubMed ID: 30652078
11401  5-Hydroxy-7-methoxyflavone derivatives from Kaempferia parviflora induce skeletal muscle hypertrophy.  Ono S, Yoshida N, Maekawa D, Kitakaze T, Kobayashi Y, Kitano T, Fujita T, Okuwa-Hayashi H, Harada N, Nakano Y, Yamaji R.  Food Sci Nutr  2019    PubMed ID: 30680186
11314  Lactate Promotes Myoblast Differentiation and Myotube Hypertrophy via a Pathway Involving MyoD In Vitro and Enhances Muscle Regeneration In Vivo.  Tsukamoto S, Shibasaki A, Naka A, Saito H, Iida K.  Int J Mol Sci  2018    PubMed ID: 30463265
11327  Involvement of natriuretic peptide system in C2C12 myocytes.  Ishikawa K, Hara T, Kato K, Shimomura T, Omori K.  Mol. Cell. Biochem.  2018    PubMed ID: 30519782
11340  Caffeine-stimulated muscle IL-6 mediates alleviation of non-alcoholic fatty liver disease.  Fang C, Cai X, Hayashi S, Hao S, Sakiyama H, Wang X, Yang Q, Akira S, Nishiguchi S, Fujiwara N, Tsutsui H, Sheng J.  Biochim Biophys Acta Mol Cell Biol Lipids  2019    PubMed ID: 30553055
11452  Formation of Large Scaffold-Free 3-D Aggregates in a Cell Culture Dish by Ultrasound Standing Wave Trapping.  Nakao M, Imashiro C, Kuribara T, Kurashina Y, Totani K, Takemura K.  Ultrasound Med Biol  2019    PubMed ID: 30799124
11458  Insulin-Like Growth Factor-I Protects Against the Detrimental Effects of Advanced Glycation End Products and High Glucose in Myoblastic C2C12 Cells.  Adachi N, Kanazawa I, Tanaka KI, Takeno A, Notsu M, Tanaka S, Sugimoto T.  Calcif. Tissue Int.  2019    PubMed ID: 30809689
4077  Effects of diamond-like carbon thin film and wrinkle microstructure on cell proliferation  Masahito Ban, Satoshi Tobea, Louie Takeuchi  Diamond and Related Materials  2018  90:194-201 
4167  Organelle Optogenetics: Direct Manipulation of Intracellular Ca2+ Dynamics by Light.  Asano T, Igarashi H, Ishizuka T, Yawo H.  Front Neurosci  2018    PubMed ID: 30174581
4168  Nano Hydroxyapatite & Mineral Trioxide Aggregate Efficiently Promote Odontogenic Differentiation of Dental Pulp Stem Cells.  Hanafy AK, Shinaishin SF, Eldeen GN, Aly RM.  Open Access Maced J Med Sci  2018    PubMed ID: 30337999
4169  Efficacy of Prednisolone in Generated Myotubes Derived From Fibroblasts of Duchenne Muscular Dystrophy Patients.  Kameyama T, Ohuchi K, Funato M, Ando S, Inagaki S, Sato A, Seki J, Kawase C, Tsuruma K, Nishino I, Nakamura S, Shimazawa M, Saito T, Takeda S, Kaneko H, Hara H.  Front Pharmacol  2018    PubMed ID: 30559667
4170  A Method for Collecting Single Cell Suspensions Using an Ultrasonic Pump.  Nakao M, Kurashina Y, Imashiro C, Takemura K.  IEEE Trans Biomed Eng  2018    PubMed ID: 28463184
4171  A Closed System for Pico-Liter Order Substance Transport from a Giant Liposome to a Cell.  Miyakawa S, Uesugi K, Morishima K.  Micromachines (Basel)  2018    PubMed ID: 30424264
5402  Alignment of Skeletal Muscle Cells Cultured in Collagen Gel by Mechanical and Electrical Stimulation  Takara Tanaka, Noriko Hattori-Aramaki, Ayano Sunohara, Keisuke Okabe, Yoshiaki Sakamoto, Hiroko Ochiai, Ruka Hayashi, and Kazuo Kishi  International Journal of Tissue Engineering  2014  Article ID 621529, 5 pages 
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5450  Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2.  Sugita S1, Hosaka Y2, Okada K1, Mori D3, Yano F4, Kobayashi H1, Taniguchi Y1, Mori Y1, Okuma T1, Chang SH1, Kawata M1, Taketomi S1, Chikuda H, Akiyama H, Kageyama R, Chung UI, Tanaka S, Kawaguchi H, Ohba S, Saito T.  Proc Natl Acad Sci U S A  2015  112(10):3080-5  PubMed ID: 25733872
3649  Optically controlled contraction of photosensitive skeletal muscle cells.  Asano T, Ishizua T, Yawo H.  Biotechnol Bioeng  2012  109(1):199-204  PubMed ID: 21809334
3967  Screening for Bioactive Compounds that Induce the Differentiation of Bone Marrow-Derived Preadipocytic Cell Line, ST2, into the Cells of Osteoblastic Phenotype  Tomohiro ShimizuJe-Tae WooKazuo Nagai  Animal Cell Technology: Basic & Applied Aspects  1999  10:353–356 
5803  Cryoprotectant-free cryopreservation of mammalian cells by superflash freezing.  Akiyama Y, Shinose M, Watanabe H, Yamada S, Kanda Y.  Proc Natl Acad Sci U S A  2019  116(16):7738-7743  PubMed ID: 30936320
3542  Molecular cloning and biological activity of a novel lysyl oxidase-related gene expressed in cartilage.  Ito H, Akiyama H, Iguchi H, Iyama K, Miyamoto M, Ohsawa K, Nakamura T.  J Biol Chem  2001  276(26):24023-9  PubMed ID: 11292829
3560  New signaling pathway for parathyroid hormone and cyclic AMP action on extracellular-regulated kinase and cell proliferation in bone cells. Checkpoint of modulation by cyclic AMP.  Fujita T, Meguro T, Fukuyama R, Nakamuta H, Koida M.  J Biol Chem  2002  277(25):22191-200  PubMed ID: 11956184
7002  Direct visualization of human myosin II force generation using DNA origami-based thick filaments.  Fujita K, Ohmachi M, Ikezaki K, Yanagida T, Iwaki M.  Commun Biol  2019  2:437  PubMed ID: 31799438
6519  Paraspeckle protein p54nrb links Sox9-mediated transcription with RNA processing during chondrogenesis in mice.  Hata K, Nishimura R, Muramatsu S, Matsuda A, Matsubara T, Amano K, Ikeda F, Harley VR, Yoneda T.  J Clin Invest  2008  118(9):3098-108  PubMed ID: 18677406
6536  Isolation and characterization of a novel plasma membrane protein, osteoblast induction factor (obif), associated with osteoblast differentiation.  Kanamoto T, Mizuhashi K, Terada K, Minami T, Yoshikawa H, Furukawa T.  BMC Dev Biol  2009  9:70  PubMed ID: 20025746
11602  Effect of Cyclic Stretch on Tissue Maturation in Myoblast-Laden Hydrogel Fibers.  Bansai S, Morikura T, Onoe H, Miyata S.  Micromachines (Basel)  2019    PubMed ID: 31208059
11657  Influence of Intermittent Cold Stimulations on CREB and Its Targeting Genes in Muscle: Investigations into Molecular Mechanisms of Local Cryotherapy  Takehito Sugasawa, Tome Yoshiya, Yoshinori Takeuchi, Naoya Yahagi, Rahul Sharma, Yuichi Aita, Yasuko Yoshida, Katuyuki Tokinoya, Nanami Sekine, Kaoru Takeuchi, Haruna Ueda, Reina Maruyama, Shohei Morita, Yasushi Kawamai, Kazuhiro Takekoshi  molecular biology  2019   
11663  Method of localized removal of cells using a bolt‐clamped Langevin transducer with an ultrasonic horn  Takumi Inui, Yuta Kurashina, Chikahiro Imashiro, Kenjiro Takemura  Eng Life Sci  2019  19:575–583 
11692  Fabrication of arrayed microwells with wrinkle microstructure by ink-jet and diamond-like carbon thin film deposition process  Masahito Ban, Yuuya Kogi, Taichi Hirose  Materials Science and Engineering: B  2019   
11711  cis-Banglene, a bangle (Zingiber purpureum)-derived bioactive compound, promotes mitochondrial biogenesis and glucose uptake by activating the IL-6/AMPK signaling pathway in C2C12 skeletal muscle cells  Toshio Norikura, Shiori Kajiya, Mami Sugawara, Miwa Kubo, Yoshiyasu Fukuyama, Shin Sato  Journal of Functional Foods  2019   
11723  Inhibition of ubiquitin-specific protease 2 causes accumulation of reactive oxygen species, mitochondria dysfunction, and intracellular ATP decrement in C2C12 myoblasts.  Hashimoto M, Saito N, Ohta H, Yamamoto K, Tashiro A, Nakazawa K, Inanami O, Kitamura H.  Physiol Rep  2019    PubMed ID: 31353872
11749  CYLD dysregulation in pathogenesis of sporadic inclusion body myositis.  Yamashita S, Matsuo Y, Tawara N, Hara K, Yamamoto M, Nishikami T, Kawakami K, Zhang X, Zhang Z, Doki T, Ando Y.  Sci Rep  2019    PubMed ID: 31406156
11868  Native adiponectin in serum binds to mammalian cells expressing T-cadherin, but not AdipoRs or calreticulin.  Kita S, Fukuda S, Maeda N, Shimomura I.  Elife  2019    PubMed ID: 31647413
11874  An effective detachment system for human induced pluripotent stem cells cultured on multilayered cultivation substrates using resonance vibrations.  Terao Y, Kurashina Y, Tohyama S, Fukuma Y, Fukuda K, Fujita J, Takemura K.  Sci Rep  2019    PubMed ID: 31666563
4679  The transcription factor Znf219 regulates chondrocyte differentiation by assembling a transcription factory with Sox9.  Takigawa Y, Hata K, Muramatsu S, Amano K, Ono K, Wakabayashi M, Matsuda A, Takada K, Nishimura R, Yoneda T.  J Cell Sci  2010  123(Pt 21):3780-8  PubMed ID: 20940257
4978  BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2.  Lee MH, Kwon TG, Park HS, Wozney JM, Ryoo HM.  Biochem Biophys Res Commun  2003  309(3):689-94  PubMed ID: 12963046
6710  Treatment of myoblastic C2C12 cells with BMP-2 stimulates vitamin D-induced formation of osteoclasts.  Otsuka E, Notoya M, Hagiwara H.  Calcif Tissue Int  2003  3(1):72-7  PubMed ID: 14506957
6716  Homeobox protein MSX2 acts as a molecular defense mechanism for preventing ossification in ligament fibroblasts.  Yoshizawa T, Takizawa F, Iizawa F, Ishibashi O, Kawashima H, Matsuda A, Endo N, Kawashima H.  Mol Cell Biol  2004  24(8):3460-72  PubMed ID: 15060165
6964  Mariannamides A and B, new cyclic octapeptides isolated from Mariannaea elegans NBRC102301.  Ishiuchi K, Hirose D, Kondo T, Watanabe K, Terasaka K, Makino T.  Bioorg Med Chem Lett  2020    PubMed ID: 31928840
3357  Long-lasting in vitro hematopoiesis derived from primate embryonic stem cells.  Hiroyama, Takashi, Miharada, Kenichi, Aoki, Naoko, Fujioka, Tsuyoshi, Sudo, Kazuhiro, Danjo, Inaho, Nagasawa, Toshiro, Nakamura, Yukio  Exp Hematol  2006  34:760-9  PubMed ID: 16728281
3158  Lectins induce resistance to proteases and/or mechanical stimulus in all examined cells--including bone marrow mesenchymal stem cells--on various scaffolds.  Nishimura, Haruki, Nishimura, Masahiro, Oda, Ryo, Yamanaka, Katsuyuki, Matsubara, Takehiro, Ozaki, Yoshie, Sekiya, Kensuke, Hamada, Taizo, Kato, Yukio  Exp Cell Res  2004  295:119-27  PubMed ID: 15051495



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