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細胞番号 : 細胞名
RCB0980 : Sa3  update : 2022/07/07
細胞特性(Comment:英)Squamous carcinoma cells derived from human oral cancer.
細胞特性(日)上顎歯肉由来の扁平上皮癌。日本人由来。
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
使用条件(日)基礎的研究につきましては、使用制限はありません。商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。
備考(英)
備考(日)
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 Harada, Masakazu
樹立者 Harada, Masakazu
寄託日 1994
動物種 _human < Mammals
属名 Homo
種名 sapiens
人種 Japanese
性別 Male
63 years
採取組織 upper gingiva
病名 squamous cell carcinoma
転移 Yes
転移巣 lung, lymph node
細胞分類 cancer
初代培養日 1989
細胞寿命 infinite
細胞形態 epithelial-like
Cellosaurus(Expasy) CVCL_8063
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 BME (2mM L-Glutamine) + 20% NBS
抗生物質 Free
継代方法 0.25% Trypsin
継代密度 1 : 8 split
継代・培地交換頻度 Subculture : 1-2 times/week, Medium Renewal : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ (-)
アイソザイム検査 LD, NP
染色体検査 63-71(50) : /64(4),65(5),66(10),67(15),68(4),69(8)/
個体識別検査 OK
画像情報
寄託時情報
ロット情報
文献情報 Reference(英) 0件
Reference(日) 2件
利用者成果(英) 75件
利用者成果(日) 0件

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Reference(英)

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Reference(日)
2052  原田昌和  ヒト口腔癌由来培養細胞の温熱効果に関する細胞生物学的研究  和歌山医学  1994  45:239-258   
2053  原田昌和、宮田和幸、和田健、大亦哲司、森田展雄、坂本忠幸  ヒト歯肉扁平上皮癌由来細胞株 (Sa3) の樹立とその性状  Jpn J Oral Maxillofac Surg  1993  39:965-971    DOI: 10.5794/jjoms.39.965

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利用者成果(英)
17696  Minemura C, Asai S, Koma A, Kase-Kato I, Tanaka N, Kikkawa N, Kasamatsu A, Yokoe H, Hanazawa T, Uzawa K, Seki N.  Identification of Tumor-Suppressive miR-30e-3p Targets: Involvement of SERPINE1 in the Molecular Pathogenesis of Head and Neck Squamous Cell Carcinoma  Int J Mol Sci  2022  23(7):3808  PubMed ID: 35409173   DOI: 10.3390/ijms23073808
20513  Kono M, Komatsuda H, Yamaki H, Kumai T, Hayashi R, Wakisaka R, Nagato T, Ohkuri T, Kosaka A, Ohara K, Kishibe K, Takahara M, Katada A, Hayashi T, Kobayashi H, Harabuchi Y.  Immunomodulation via FGFR inhibition augments FGFR1 targeting T-cell based antitumor immunotherapy for head and neck squamous cell carcinoma.  Oncoimmunology  2022  11(1):2021619  PubMed ID: 35003900   DOI: 10.1080/2162402X.2021.2021619
20559  Komatsu M, Saito K, Miyamoto I, Koike K, Iyoda M, Nakashima D, Kasamatsu A, Shiiba M, Tanzawa H, Uzawa K.  Aberrant GIMAP2 expression affects oral squamous cell carcinoma progression by promoting cell cycle and inhibiting apoptosis.  Oncol Lett  2022  23(2):49  PubMed ID: 34992682   DOI: 10.3892/ol.2021.13167
20817  Minemura C, Asai S, Koma A, Kikkawa N, Kato M, Kasamatsu A, Uzawa K, Hanazawa T, Seki N.  Identification of Antitumor miR-30e-5p Controlled Genes; Diagnostic and Prognostic Biomarkers for Head and Neck Squamous Cell Carcinoma.  Genes (Basel)  2022  13(7)  PubMed ID: 35886008   DOI: 10.3390/genes13071225
21140  Asai S, Koma A, Nohata N, Kinoshita T, Kikkawa N, Kato M, Minemura C, Uzawa K, Hanazawa T, Seki N.  Impact of miR-1/miR-133 Clustered miRNAs: PFN2 Facilitates Malignant Phenotypes in Head and Neck Squamous Cell Carcinoma.  Biomedicines  2022  10(3)  PubMed ID: 35327465   DOI: 10.3390/biomedicines10030663
20085  Kase Y, Uzawa K, Wagai S, Yoshimura S, Yamamoto JI, Toeda Y, Okubo M, Eizuka K, Ando T, Nobuchi T, Kawasaki K, Saito T, Iyoda M, Nakashima D, Kasamatsu A, Tanzawa H.  Engineered exosomes delivering specific tumor-suppressive RNAi attenuate oral cancer progression.  Sci Rep  2021  11(1):5897  PubMed ID: 33723306   DOI: 10.1038/s41598-021-85242-1
14341  Kono M, Kumai T, Hayashi R, Yamaki H, Komatsuda H, Wakisaka R, Nagato T, Ohkuri T, Kosaka A, Ohara K, Kishibe K, Takahara M, Katada A, Hayashi T, Celis E, Kobayashi H, Harabuchi Y.  Interruption of MDM2 signaling augments MDM2-targeted T cell-based antitumor immunotherapy through antigen-presenting machinery  Cancer Immunol Immunother  2021    PubMed ID: 33866408   DOI: 10.1007/s00262-021-02940-5
20509  Tanaka N, Minemura C, Asai S, Kikkawa N, Kinoshita T, Oshima S, Koma A, Kasamatsu A, Hanazawa T, Uzawa K, Seki N.  Identification of miR-199-5p and miR-199-3p Target Genes: Paxillin Facilities Cancer Cell Aggressiveness in Head and Neck Squamous Cell Carcinoma.  Genes (Basel)  2021  12(12)  PubMed ID: 34946859   DOI: 10.3390/genes12121910
16138  Ando T, Kasamatsu A, Kawasaki K, Hiroshima K, Fukushima R, Iyoda M, Nakashima D, Endo-Sakamoto Y, Uzawa K.  Tumor Suppressive Circular RNA-102450: Development of a Novel Diagnostic Procedure for Lymph Node Metastasis from Oral Cancer  Cancers (Basel)  2021  13(22):5708  PubMed ID: 34830863   DOI: 10.3390/cancers13225708
16139  Kase-Kato I, Asai S, Minemura C, Tsuneizumi K, Oshima S, Koma A, Kasamatsu A, Hanazawa T, Uzawa K, Seki N.  Molecular Pathogenesis of the Coronin Family: CORO2A Facilitates Migration and Invasion Abilities in Oral Squamous Cell Carcinoma  Int J Mol Sci   2021  22(23):12684  PubMed ID: 34884487   DOI: 10.3390/ijms222312684
16206  Koma A, Asai S, Minemura C, Oshima S, Kinoshita T, Kikkawa N, Koshizuka K, Moriya S, Kasamatsu A, Hanazawa T, Uzawa K, Seki N.  Impact of Oncogenic Targets by Tumor-Suppressive miR-139-5p and miR-139-3p Regulation in Head and Neck Squamous Cell Carcinoma  Int J Mol Sci  2021  22(18):9947  PubMed ID: 34576110   DOI: 10.3390/ijms22189947
16975  Hotta H, Hamamura K, Shibuya H, Ohmi Y, Furukawa K, Furukawa K.  Lewis y Expressed in Oral Squamous Cell Carcinoma Attenuates Malignant Properties via Down-regulation of EGF Signaling  Anticancer Res  2021  41(4):1821-1830  PubMed ID: 33813387   DOI: 10.21873/anticanres.14948
12061  Ohara M, Ohara K, Kumai T, Ohkuri T, Nagato T, Hirata-Nozaki Y, Kosaka A, Nagata M, Hayashi R, Harabuchi S, Yajima Y, Oikawa K, Harabuchi Y, Sumi Y, Furukawa H, Kobayashi H.  Phosphorylated vimentin as an immunotherapeutic target against metastatic colorectal cancer.  Cancer Immunol. Immunother.  2020    PubMed ID: 32086539   DOI: 10.1007/s00262-020-02524-9
12083  Hashimura S, Kido J, Matsuda R, Yokota M, Matsui H, Inoue-Fujiwara M, Inagaki Y, Hidaka M, Tanaka T, Tsutsumi T, Nagata T, Tokumura A.  A low level of lysophosphatidic acid in human gingival crevicular fluid from patients with periodontitis due to high soluble lysophospholipase activity: Its potential protective role on alveolar bone loss by periodontitis.  Biochim Biophys Acta Mol Cell Biol Lipids  2020    PubMed ID: 32179099   DOI: 10.1016/j.bbalip.2020.158698
13172  Li XH, Li D, Liu C, Zhang MM, Guan XJ, Fu YP.  p33ING1b regulates acetylation of p53 in oral squamous cell carcinoma via SIR2.  Cancer Cell Int  2020    PubMed ID: 32831651   DOI: 10.1186/s12935-020-01489-0
13401  Hayashi R, Nagato T, Kumai T, Ohara K, Ohara M, Ohkuri T, Hirata-Nozaki Y, Harabuchi S, Kosaka A, Nagata M, Yajima Y, Yasuda S, Oikawa K, Kono M, Kishibe K, Takahara M, Katada A, Hayashi T, Celis E, Harabuchi Y, Kobayashi H.  Expression of placenta-specific 1 and its potential for eliciting anti-tumor helper T-cell responses in head and neck squamous cell carcinoma.  Oncoimmunology  2020    PubMed ID: 33457076   DOI: 10.1080/2162402X.2020.1856545
13903  Aika Tanzawa et al.  Comprehensive gene expression analysis of semaphorins in oral squamous cell carcinoma  Oral Science International  2020  17(2):67-72    DOI: 10.1002/osi2.1044
11354  Nakamura Y, Nakahata S, Kondo Y, Izumi A, Yamamoto K, Ichikawa T, Tamura T, Noumi K, Yamashita Y, Morishita K.  Overexpression of absent in melanoma 2 in oral squamous cell carcinoma contributes to tumor progression.  Biochem. Biophys. Res. Commun.  2019    PubMed ID: 30587341   DOI: 10.1016/j.bbrc.2018.12.066
11405  Uzawa K, Kasamatsu A, Saito T, Kita A, Sawai Y, Toeda Y, Koike K, Nakashima D, Endo Y, Shiiba M, Takiguchi Y, Tanzawa H.  Growth suppression of human oral cancer cells by candidate agents for cetuximab-side effects.  Exp. Cell Res.  2019    PubMed ID: 30690028   DOI: 10.1016/j.yexcr.2019.01.016
11497  Yasukochi A, Kawakubo-Yasukochi T, Morioka M, Hazekawa M, Nishinakagawa T, Ono K, Nakashima M, Nakamura S.  Regulation of collagen type XVII expression by miR203a-3p in oral squamous cell carcinoma cells.  J. Biochem.  2019    PubMed ID: 30918974   DOI: 10.1093/jb/mvz024
11759  Uzawa K, Amelio AL, Kasamatsu A, Saito T, Kita A, Fukamachi M, Sawai Y, Toeda Y, Eizuka K, Hayashi F, Kato-Kase I, Sunohara M, Iyoda M, Koike K, Nakashima D, Ogawara K, Endo-Sakamoto Y, Shiiba M, Takiguchi Y, Yamauchi M, Tanzawa H.  Resveratrol Targets Urokinase-Type Plasminogen Activator Receptor Expression to Overcome Cetuximab-Resistance in Oral Squamous Cell Carcinoma.  Sci Rep  2019    PubMed ID: 31434965   DOI: 10.1038/s41598-019-48717-w
9696  Kazuya Hiroshima, Masashi Shiiba, Noritoshi Oka, Fumihiko Hayashi, Sho Ishida, Reo Fukushima, Kazuyuki Koike, Manabu Iyoda, Dai Nakashima, Hideki Tanzawa, Katsuhiro Uzawa  Tspan15 Plays a Crucial Role in Metastasis in Oral Squamous Cell Carcinoma  Exp Cell Res  2019  384(2):111622  PubMed ID: 31518558   DOI: 10.1016/j.yexcr.2019.111622
11907  Cervino G, Fiorillo L, Herford AS, Romeo U, Bianchi A, Crimi S, D'Amico C, De Stefano R, Troiano G, Santoro R, Laino L, Laino G, Cicciù M.  Molecular Biomarkers Related to Oral Carcinoma: Clinical Trial Outcome Evaluation in a Literature Review.  Dis. Markers  2019    PubMed ID: 31019584   DOI: 10.1155/2019/8040361
12366  Zhang C, Qiao H, Guo W, Liu Y, Yang L, Liu Y, Jin B, Fu M, Wang G, Li W.  CD100-plexin-B1 induces epithelial-mesenchymal transition of head and neck squamous cell carcinoma and promotes metastasis  Cancer Lett  2019  455:1-13  PubMed ID: 30981760   DOI: 10.1016/j.canlet.2019.04.013
12457  Eizuka K, Nakashima D, Oka N, Wagai S, Takahara T, Saito T, Koike K, Kasamatsu A, Shiiba M, Tanzawa H, Uzawa K.  SYT12 plays a critical role in oral cancer and may be a novel therapeutic target  J Cancer  2019  10(20):4913-4920  PubMed ID: 31598163   DOI: 10.7150/jca.32582
12586  Sato K, Shi L, Ito F, Ohara Y, Motooka Y, Tanaka H, Mizuno M, Hori M, Hirayama T, Hibi H, Toyokuni S.  Non-thermal plasma specifically kills oral squamous cell carcinoma cells in a catalytic Fe(II)-dependent manner  J Clin Biochem Nutr  2019  65(1):8-15  PubMed ID: 31379408   DOI: 10.3164/jcbn.18-91
10682  Yamamoto JI, Kasamatsu A, Okubo Y, Nakashima D, Fushimi K, Minakawa Y, Kasama H, Shiiba M, Tanzawa H, Uzawa K.  Evaluation of tryptophan-aspartic acid repeat-containing protein 34 as a novel tumor-suppressor molecule in human oral cancer.  Biochem. Biophys. Res. Commun.  2018  495:2469-2474  PubMed ID: 29278705   DOI: 10.1016/j.bbrc.2017.12.138
10806  Okubo Y, Kasamatsu A, Yamatoji M, Fushimi K, Ishigami T, Shimizu T, Kasama H, Shiiba M, Tanzawa H, Uzawa K.  Diacylglycerol lipase alpha promotes tumorigenesis in oral cancer by cell-cycle progression.  Exp. Cell Res.  2018  367:112-118  PubMed ID: 29614312   DOI: 10.1016/j.yexcr.2018.03.041
11226  Fukushima R, Kasamatsu A, Nakashima D, Higo M, Fushimi K, Kasama H, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Overexpression of Translocation Associated Membrane Protein 2 Leading to Cancer-Associated Matrix Metalloproteinase Activation as a Putative Metastatic Factor for Human Oral Cancer.  J Cancer  2018    PubMed ID: 30271493   DOI: 10.7150/jca.25666
4183  Ohara K, Ohkuri T, Kumai T, Nagato T, Nozaki Y, Ishibashi K, Kosaka A, Nagata M, Harabuchi S, Ohara M, Oikawa K, Aoki N, Harabuchi Y, Celis E, Kobayashi H.  Targeting phosphorylated p53 to elicit tumor-reactive T helper responses against head and neck squamous cell carcinoma.  Oncoimmunology  2018    PubMed ID: 30510853   DOI: 10.1080/2162402X.2018.1466771
16201  Sawai Y, Kasamatsu A, Nakashima D, Fushimi K, Kasama H, Iyoda M, Kouzu Y, Shiiba M, Tanzawa H, Uzawa K.  Critical role of deoxynucleotidyl transferase terminal interacting protein 1 in oral cancer  Lab Invest  2018  98(8):980-988  PubMed ID: 29855544   DOI: 10.1038/s41374-018-0070-3
10148  Takahara T, Kasamatsu A, Yamatoji M, Iyoda M, Kasama H, Saito T, Takeuchi S, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  SIPA1 promotes invasion and migration in human oral squamous cell carcinoma by ITGB1 and MMP7.  Exp. Cell Res.  2017  352:357-363  PubMed ID: 28237246   DOI: 10.1016/j.yexcr.2017.02.026
10155  Koide N, Kasamatsu A, Endo-Sakamoto Y, Ishida S, Shimizu T, Kimura Y, Miyamoto I, Yoshimura S, Shiiba M, Tanzawa H, Uzawa K.  Evidence for Critical Role of Lymphocyte Cytosolic Protein 1 in Oral Cancer.  Sci Rep  2017  7:43379  PubMed ID: 28230172   DOI: 10.1038/srep43379
10191  Takeuchi S, Kasamatsu A, Yamatoji M, Nakashima D, Endo-Sakamoto Y, Koide N, Takahara T, Shimizu T, Iyoda M, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  TEAD4-YAP interaction regulates tumoral growth by controlling cell-cycle arrest at the G1 phase.  Biochem. Biophys. Res. Commun.  2017  486:385-390  PubMed ID: 28315328   DOI: 10.1016/j.bbrc.2017.03.050
10418  Kita A, Kasamatsu A, Nakashima D, Endo-Sakamoto Y, Ishida S, Shimizu T, Kimura Y, Miyamoto I, Yoshimura S, Shiiba M, Tanzawa H, Uzawa K.  Activin B Regulates Adhesion, Invasiveness, and Migratory Activities in Oral Cancer: a Potential Biomarker for Metastasis.  J Cancer  2017  8:2033-2041  PubMed ID: 28819404   DOI: 10.7150/jca.18714
10958    Inactivation of dermatopontin via histone deacetylation in human oral cancer  Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   2017  29, 400-404    DOI: 10.1016/j.ajoms.2017.03.013
11036    Increased Expression of CD44v9, A Cancer Stem Cell Marker, in Head And Neck Squamous Cell Carcinoma Cells after Irradiation  Int J Cancer Oncol  2017  4: 225- 230    DOI: 10.15436/2377-0902.17.1628
6029  Ishida S et al  Novel mechanism of aberrant ZIP4 expression with zinc supplementation in oral tumorigenesis.  Biochem Biophys Res Commun  2017  483(1):339-345  PubMed ID: 28017725   DOI: 10.1016/j.bbrc.2016.12.142
12679  Tamura T, Ichikawa T, Nakahata S, Kondo Y, Tagawa Y, Yamamoto K, Nagai K, Baba T, Yamaguchi R, Futakuchi M, Yamashita Y, Morishita K.  Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential  Cancer Res  2017  77(9):2363-2374  PubMed ID: 28209617   DOI: 10.1158/0008-5472.CAN-16-2114
14229  Shiiba M, Yamagami H, Yamamoto A, Minakawa Y, Okamoto A, Kasamatsu A, Sakamoto Y, Uzawa K, Takiguchi Y, Tanzawa H.  Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity  Oncol Rep  2017  37(4):2025-2032  PubMed ID: 28259989   DOI: 10.3892/or.2017.5480
14306  Noriko Komatsu, Kenichi Mitsui, Osamu Kusano-Arai, Hiroko Iwanari, Kazuto Hoshi, Tsuyoshi Takato, Takahiro Abe and Takao Hamakubo  Enhancement of anti-robo1 immunotoxin cytotoxicity to head and neck squamous cell carcinoma via photochemical internalization  Archives in Cancer Research  2017  5   
9616  Kitajima D, Kasamatsu A, Nakashima D, Miyamoto I, Kimura Y, Saito T, Suzuki T, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Tie2 Regulates Tumor Metastasis of Oral Squamous Cell Carcinomas.  J Cancer  2016  7:600-7  PubMed ID: 27053959   DOI: 10.7150/jca.13820
9630  Kimura Y, Kasamatsu A, Nakashima D, Yamatoji M, Minakawa Y, Koike K, Fushimi K, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  ARNT2 Regulates Tumoral Growth in Oral Squamous Cell Carcinoma.  J Cancer  2016  7:702-10  PubMed ID: 27076852   DOI: 10.7150/jca.14208
6036  Suzuki T, Kasamatsu A, Miyamoto I, Saito T, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Overexpression of TMOD1 is associated with enhanced regional lymph node metastasis in human oral cancer.  Int J Oncol.  2016  48(2):607-12  PubMed ID: 26718916   DOI: 10.3892/ijo.2015.3305
6044  Kasama H et al   Adenosine A2b receptor promotes progression of human oral cancer.  BMC Cancer  2015  15:563  PubMed ID: 26228921   DOI: 10.1186/s12885-015-1577-2
6051  Okamoto A et al  Down-Regulation of Nucleolar and Spindle-Associated Protein 1 (NUSAP1) Expression Suppresses Tumor and Cell Proliferation and Enhances Anti-Tumor Effect of Paclitaxel in Oral Squamous Cell Carcinoma.  PLoS One  2015  10(11):e0142252  PubMed ID: 26554377   DOI: 10.1371/journal.pone.0142252
6052  Saito T et al  Semaphorin7A Promotion of Tumoral Growth and Metastasis in Human Oral Cancer by Regulation of G1 Cell Cycle and Matrix Metalloproteases: Possible Contribution to Tumoral Angiogenesis.  PLoS One  2015  10(9):e0137923  PubMed ID: 26378920   DOI: 10.1371/journal.pone.0137923
6054  Baba T et al  Persephin: A potential key component in human oral cancer progression through the RET receptor tyrosine kinase-mitogen-activated protein kinase signaling pathway.  Mol Carcinog  2015  54(8):608-17  PubMed ID: 24375483   DOI: 10.1002/mc.22127
6058  Shida-Sakazume T et al  Lysophosphatidylcholine acyltransferase1 overexpression promotes oral squamous cell carcinoma progression via enhanced biosynthesis of platelet-activating factor.  PLoS One.  2015  10(3):e0120143  PubMed ID: 25803864   DOI: 10.1371/journal.pone.0120143
15042  Koyama T, Ogawara K, Kasamatsu A, Okamoto A, Kasama H, Minakawa Y, Shimada K, Yokoe H, Shiiba M, Tanzawa H, Uzawa K.  ANGPTL3 is a novel biomarker as it activates ERK/MAPK pathway in oral cancer  Cancer Med  2015  4(5):759-69  PubMed ID: 25644496   DOI: 10.1002/cam4.418
15186  Kumai T, Matsuda Y, Ohkuri T, Oikawa K, Ishibashi K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H.  c-Met is a novel tumor associated antigen for T-cell based immunotherapy against NK/T cell lymphoma  Oncoimmunology  2015  4(2):e976077  PubMed ID: 25949874   DOI: 10.4161/2162402X.2014.976077
10985  Kumai T, Ohkuri T, Nagato T, Matsuda Y, Oikawa K, Aoki N, Kimura S, Celis E, Harabuchi Y, Kobayashi H.  Targeting HER-3 to elicit antitumor helper T cells against head and neck squamous cell carcinoma  Sci Rep  2015  5:16280  PubMed ID: 26538233   DOI: 10.1038/srep16280
5585  Kasamatsu A, Uzawa K, Minakawa Y, Ishige S, Kasama H, Endo-Sakamoto Y, Ogawara K, Shiiba M, Takiguchi Y, Tanzawa H.  Decorin in human oral cancer: a promising predictive biomarker of S-1 neoadjuvant chemosensitivity  Biochem Biophys Res Commun  2015  457(1):71-6  PubMed ID: 25550184   DOI: 10.1016/j.bbrc.2014.12.093
5778  Ishige S, Kasamatsu A, Ogoshi K, Saito Y, Usukura K, Yokoe H, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  Decreased expression of kallikrein-related peptidase 13: possible contribution to metastasis of human oral cancer.  Mol Carcinog  2014  53(7):557-65  PubMed ID: 23371469   DOI: 10.1002/mc.22007
5307  Kumai T, Oikawa K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H.  Tumor-derived TGF-β and prostaglandin E2 attenuate anti-tumor immune responses in head and neck squamous cell carcinoma treated with EGFR inhibitor.  J Transl Med  2014  12:265  PubMed ID: 25240937   DOI: 10.1186/s12967-014-0265-3
16010  Fukumoto C, Nakashima D, Kasamatsu A, Unozawa M, Shida-Sakazume T, Higo M, Ogawara K, Yokoe H, Shiiba M, Tanzawa H, Uzawa K.  WWP2 is overexpressed in human oral cancer, determining tumor size and poor prognosis in patients: downregulation of WWP2 inhibits the AKT signaling and tumor growth in mice  Oncoscience  2014  1(12):807-20  PubMed ID: 25621296   DOI: 10.18632/oncoscience.101
5432  Taiyoji M, Yamanaka T, Tsuno T, Ohtsubo S.  Potential value of a rice protein extract, containing proteinaceous inhibitors against cysteine proteinases from Porphyromonas gingivalis, for managing periodontal diseases.  Biosci Biotechnol Biochem  2013  77(1):80-6  PubMed ID: 23291749   DOI: 10.1271/bbb.120585
5028  Saito Y, Kasamatsu A, Yamamoto A, Shimizu T, Yokoe H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  ALY as a potential contributor to metastasis in human oral squamous cell carcinoma.  J Cancer Res Clin Oncol  2013  139(4):585-94  PubMed ID: 23242234   DOI: 10.1007/s00432-012-1361-5
6067  Koike K, Kasamatsu A, Iyoda M, Saito Y, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Tanzawa H, Uzawa K.  High prevalence of epigenetic inactivation of the human four and a half LIM domains 1 gene in human oral cancer.  Int J Oncol  2013  42(1):141-50  PubMed ID: 23123766   DOI: 10.3892/ijo.2012.1677
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