CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB0658 : HHUA]

257 Withanage GS, Murata H, Koyama T, Ishiwata I. Agonistic and antagonistic effects of zearalenone, an etrogenic mycotoxin, on SKN, HHUA, and HepG2 human cancer cell lines Vet Hum Toxicol 2001 43(1):6-10 PubMed ID: 11205083

41 Ishiwata I, Ishiwata C, Nozawa S, Ishikawa H. CA125 production by gynecologic tumors in vitro and its modulation induced by dibutyl cyclic adenosine monophosphate Asia Oceania J Obstet Gynaecol 1996 12(2):285-90 PubMed ID: 2429643 DOI: 10.1111/j.1447-0756.1986.tb00192.x

268 Wake N, Yamada H, Fujita H, Kato H, Ishiwata I. Isolation of clones resistant to 6-thioguanine and G418 from HHUA endometrial carcinoma cells and their application to cell hybridization Cancer Genet Cytogenet 1990 49(1):117-23 PubMed ID: 2397465 DOI: 10.1016/0165-4608(90)90172-7

42 Ishiwata I, Ishiwata C, Soma M, Naik DR, Hashimoto H, Sudo T, Ishikawa H. Effect of tumour angiogenesis factor on proliferation of endothelial cell and tube formation Virchows Arch A Pathol Anat Histopathol 1990 417(6):473-6 PubMed ID: 2125385

43 Yamada H, Wake N, Fujino T, Aihara T, Tanaka S, Tanaka T, Fujimoto S, Ishiwata I. Somatic cell hybrids used in cytogenetic analysis of transformation mechanism of uterine endometrial cell Nihon Sanka Fujinka Gakkai Zasshi 1989 41(2):122-8 PubMed ID: 2723479

1521 Ishiwata I, Ishiwata C, Ishikawa H Effects of estradiol-17 beta and progesterone on cell proliferation and differentiation of the human endometrial carcinoma cell line (HHUA) in vitro. Asia Oceania J Obstet Gynaecol 1984 10:531-8 PubMed ID: 6532401 DOI: 10.1111/j.1447-0756.1984.tb00721.x

1519 Ishiwata I, Ishiwata C, Soma M, Arai J, Ishikawa H Establishment of human endometrial adenocarcinoma cell line containing estradiol-17 beta and progesterone receptors. Gynecol Oncol 1984 17:281-90 PubMed ID: 6706228 DOI: 10.1016/0090-8258(84)90212-9

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21711 Yusuke Hanaki, Rintaro Abe, Yasunori Sugiyama, Yasumasa Hara, Ryo C. Yanagita A new labdane-type diterpenoid from leaves of Vitex rotundifolia Results in Chemistry 2024 7:101512 DOI: 10.1016/j.rechem.2024.101512

22059 Hagiyama M, Yoneshige A, Otani T, Wada A, Takeuchi F, Shoya Y, Inoue T, Ito A. An antibody-drug conjugate for endometrioid carcinoma based on the expression of cell adhesion molecule 1. Mol Cell Oncol 2024 11(1):2399379 PubMed ID: 39252827 DOI: 10.1080/23723556.2024.2399379

18065 Yusuke Hanaki, Nichika Iwase, Yasunori Sugiyama, Sena Miyoshi, Ryo C. Yanagita Cell Morphology-Based Screening Identified Vitetrifolin D from Vitex Rotundifolia as an Inhibitor of Phorbol Ester–Induced Downregulation of E-Cadherin in HHUA Endometrial Cells BPB Reports 2023 6:103-107 DOI: 10.1248/bpbreports.6.3_103

18120 Bai H, Kawahara M, Takahashi M. Identification of menaquinone-4 (vitamin K2) target genes in bovine endometrial epithelial cells in vitro Theriogenology 2023 198:183-193 PubMed ID: 36592516 DOI: 10.1016/j.theriogenology.2022.12.033

17618 Dong P, Wang F, Taheri M, Xiong Y, Ihira K, Kobayashi N, Konno Y, Yue J, Watari H. Long Non-Coding RNA TMPO-AS1 Promotes GLUT1-Mediated Glycolysis and Paclitaxel Resistance in Endometrial Cancer Cells by Interacting With miR-140 and miR-143 Front Oncol 2022 12:912935 PubMed ID: 35712514 DOI: 10.3389/fonc.2022.912935

20554 Sendo K, Seino M, Ohta T, Nagase S. Impact of the glutathione synthesis pathway on sulfasalazine-treated endometrial cancer. Oncotarget 2022 13:224-236 PubMed ID: 35106124 DOI: 10.18632/oncotarget.28185

20722 Takao T, Masuda H, Kajitani T, Miki F, Miyazaki K, Yoshimasa Y, Katakura S, Tomisato S, Uchida S, Uchida H, Tanaka M, Maruyama T. Sorafenib targets and inhibits the oncogenic properties of endometrial cancer stem cells via the RAF/ERK pathway. Stem Cell Res Ther 2022 13(1):225 PubMed ID: 35659728 DOI: 10.1186/s13287-022-02888-y

17174 Hanaki Y, Miyoshi S, Sugiyama Y, Yanagita RC, Sato M. 12-O-Tetradecanoylphorbol 13-acetate promotes proliferation and epithelial-mesenchymal transition in HHUA cells cultured on collagen type I gel: A feasible model to find new therapies for endometrial diseases Biosci Biotechnol Biochem 2022 86(10):1417-1422 PubMed ID: 35973688 DOI: 10.1093/bbb/zbac136

13789 Kojima M, Sugimoto K, Kobayashi M, Ichikawa-Tomikawa N, Kashiwagi K, Watanabe T, Soeda S, Fujimori K, Chiba H. Aberrant claudin-6-adhesion signaling promotes endometrial cancer progression via estrogen receptor α Mol Cancer Res 2021 molcanres.0835.2020 PubMed ID: 33727343 DOI: 10.1158/1541-7786.MCR-20-0835

14469 Yusuke Hanaki, Yusuke Araki, Toshio Nishikawa, Ryo C. Yanagita Evaluation of the in vitro cytotoxicity of oscillatoxins E and F under nutrient-starvation culture conditions Fundamental Toxicological Sciences 2021 8:69-73 DOI: 10.2131/fts.8.69

20209 Dong P, Xiong Y, Konno Y, Ihira K, Kobayashi N, Yue J, Watari H. Long non-coding RNA DLEU2 drives EMT and glycolysis in endometrial cancer through HK2 by competitively binding with miR-455 and by modulating the EZH2/miR-181a pathway. J Exp Clin Cancer Res 2021 40(1):216 PubMed ID: 34174908 DOI: 10.1186/s13046-021-02018-1

13321 Kato M, Onoyama I, Kawakami M, Yoshida S, Kawamura K, Kodama K, Hori E, Cui L, Matsumura Y, Yagi H, Asanoma K, Yahata H, Itakura A, Takeda S, Kato K. Downregulation of 5-hydroxymethylcytosine is associated with the progression of cervical intraepithelial neoplasia. PLoS One 2020 PubMed ID: 33141854 DOI: 10.1371/journal.pone.0241482

13779 Kato M, Onoyama I, Yoshida S, Cui L, Kawamura K, Kodama K, Hori E, Matsumura Y, Yagi H, Asanoma K, Yahata H, Itakura A, Takeda S, Kato K. Dual-specificity phosphatase 6 plays a critical role in the maintenance of a cancer stem-like cell phenotype in human endometrial cancer Int J Cancer 2020 147(7):1987-1999 PubMed ID: 32159851 DOI: 10.1002/ijc.32965

10248 Osanai K, Kobayashi Y, Otsu M, Izawa T, Sakai K, Iwashita M. Ramelteon, a selective MT1/MT2 receptor agonist, suppresses the proliferation and invasiveness of endometrial cancer cells. Hum. Cell 2017 30:209-215 PubMed ID: 28382516 DOI: 10.1007/s13577-017-0169-7

10315 Ando H, Miyamoto T, Kashima H, Higuchi S, Ida K, Mvunta DH, Shiozawa T. Panobinostat Enhances Growth Suppressive Effects of Progestin on Endometrial Carcinoma by Increasing Progesterone Receptor and Mitogen-Inducible Gene-6. Horm Cancer 2017 8:257-267 PubMed ID: 28516379 DOI: 10.1007/s12672-017-0295-4

9667 Chuwa AH, Sone K, Oda K, Ikeda Y, Fukuda T, Wada-Hiraike O, Inaba K, Makii C, Takeuchi M, Oki S, Miyasaka A, Kashiyama T, Arimoto T, Kuramoto H, Kawana K, Yano T, Osuga Y, Fujii T. Significance of survivin as a prognostic factor and a therapeutic target in endometrial cancer. Gynecol. Oncol. 2016 141:564-569 PubMed ID: 27079211 DOI: 10.1016/j.ygyno.2016.04.003

9687 Miyamoto T, Kashima H, Yamada Y, Kobara H, Asaka R, Ando H, Higuchi S, Ida K, Mvunta DH, Shiozawa T. Lipocalin 2 Enhances Migration and Resistance against Cisplatin in Endometrial Carcinoma Cells. PLoS ONE 2016 11:e0155220 PubMed ID: 27168162 DOI: 10.1371/journal.pone.0155220

12617 Nakayama K, Rahman MT, Rahman M, Nakamura K, Ishikawa M, Katagiri H, Sato E, Ishibashi T, Iida K, Ishikawa N, Kyo S. CCNE1 amplification is associated with aggressive potential in endometrioid endometrial carcinomas Int J Oncol 2016 48(2):506-16 PubMed ID: 26647729 DOI: 10.3892/ijo.2015.3268

12648 Zou J, Hong L, Luo C, Li Z, Zhu Y, Huang T, Zhang Y, Yuan H, Hu Y, Wen T, Zhuang W, Cai B, Zhang X, Huang J, Cheng J. Metformin inhibits estrogen-dependent endometrial cancer cell growth by activating the AMPK-FOXO1 signal pathway Cancer Sci 2016 107(12):1806-1817 PubMed ID: 27636742 DOI: 10.1111/cas.13083

7200 Asanoma K, Liu G, Yamane T, Miyanari Y, Takao T, Yagi H, Ohgami T, Ichinoe A, Sonoda K, Wake N, Kato K. Regulation of the Mechanism of TWIST1 Transcription by BHLHE40 and BHLHE41 in Cancer Cells. Mol. Cell. Biol. 2015 35:4096-109 PubMed ID: 26391953 DOI: 10.1128/MCB.00678-15

7212 Asaka R, Miyamoto T, Yamada Y, Ando H, Mvunta DH, Kobara H, Shiozawa T. Sirtuin 1 promotes the growth and cisplatin resistance of endometrial carcinoma cells: a novel therapeutic target. Lab. Invest. 2015 95:1363-73 PubMed ID: 26367491 DOI: 10.1038/labinvest.2015.119

13788 Kajitani K, Honda K, Terada H, Yasui T, Sumi T, Koyama M, Ishiko O. Human Papillomavirus E6 Knockdown Restores Adenovirus Mediated-estrogen Response Element Linked p53 Gene Transfer in HeLa Cells Asian Pac J Cancer Prev 2015 16(18):8239-45 PubMed ID: 26745067 DOI: 10.7314/apjcp.2015.16.18.8239

18133 Dong P, Kaneuchi M, Xiong Y, Cao L, Cai M, Liu X, Guo SW, Ju J, Jia N, Konno Y, Watari H, Hosaka M, Sudo S, Sakuragi N. Identification of KLF17 as a novel epithelial to mesenchymal transition inducer via direct activation of TWIST1 in endometrioid endometrial cancer Carcinogenesis 2014 35(4):760-8 PubMed ID: 24220291 DOI: 10.1093/carcin/bgt369

13796 Koyama N, Nishida Y, Ishii T, Yoshida T, Furukawa Y, Narahara H. Telmisartan induces growth inhibition, DNA double-strand breaks and apoptosis in human endometrial cancer cells PLoS One 2014 9(3):e93050 PubMed ID: 24667764 DOI: 10.1371/journal.pone.0093050

13828 Miyasaka A, Oda K, Ikeda Y, Wada-Hiraike O, Kashiyama T, Enomoto A, Hosoya N, Koso T, Fukuda T, Inaba K, Sone K, Uehara Y, Kurikawa R, Nagasaka K, Matsumoto Y, Arimoto T, Nakagawa S, Kuramoto H, Miyagawa K, Yano T, Kawana K, Osuga Y, Fujii T. Anti-tumor activity of olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, in cultured endometrial carcinoma cells BMC Cancer 2014 14:179 PubMed ID: 24625059 DOI: 10.1186/1471-2407-14-179

18134 Dong P, Karaayvaz M, Jia N, Kaneuchi M, Hamada J, Watari H, Sudo S, Ju J, Sakuragi N. Mutant p53 gain-of-function induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis Oncogene 2013 32(27):3286-95 PubMed ID: 22847613 DOI: 10.1038/onc.2012.334

6463 Li H, Narahara H. 15-Deoxy-Δ(12,14)-prostaglandin J(2) induces growth inhibition, cell cycle arrest and apoptosis in human endometrial cancer cell lines. Int J Mol Med. 2013 31(4):778-88 PubMed ID: 23403520 DOI: 10.3892/ijmm.2013.1268

13830 Ishii T, Kira N, Yoshida T, Narahara H. Cucurbitacin D induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial and ovarian cancer cells Tumour Biol 2013 34(1):285-91 PubMed ID: 23150173 DOI: 10.1007/s13277-012-0549-2

7588 Mitsuhashi Y, Horiuchi A, Miyamoto T, Kashima H, Suzuki A, Shiozawa T. Prognostic significance of Notch signalling molecules and their involvement in the invasiveness of endometrial carcinoma cells. Histopathology 2012 60:826-37 PubMed ID: 22348356 DOI: 10.1111/j.1365-2559.2011.04158.x

13801 Tanaka T, Bai T, Toujima S, Utsunomiya T, Utsunomiya H, Yukawa K, Tanaka J. Impaired death-associated protein kinase-mediated survival signals in 5-fluorouracil-resistant human endometrial adenocarcinoma cells Oncol Rep 2012 28(1):330-6 PubMed ID: 22552543 DOI: 10.3892/or.2012.1774

18135 Tsuruta T, Kozaki K, Uesugi A, Furuta M, Hirasawa A, Imoto I, Susumu N, Aoki D, Inazawa J. miR-152 is a tumor suppressor microRNA that is silenced by DNA hypermethylation in endometrial cancer Cancer Res 2011 71(20):6450-62 PubMed ID: 21868754 DOI: 10.1158/0008-5472.CAN-11-0364

7708 Dong P, Kaneuchi M, Watari H, Hamada J, Sudo S, Ju J, Sakuragi N. MicroRNA-194 inhibits epithelial to mesenchymal transition of endometrial cancer cells by targeting oncogene BMI-1. Mol. Cancer 2011 10:99 PubMed ID: 21851624 DOI: 10.1186/1476-4598-10-99

7925 Miyamoto T, Kashima H, Suzuki A, Kikuchi N, Konishi I, Seki N, Shiozawa T. Laser-captured microdissection-microarray analysis of the genes involved in endometrial carcinogenesis: stepwise up-regulation of lipocalin2 expression in normal and neoplastic endometria and its functional relevance. Hum. Pathol. 2011 42:1265-74 PubMed ID: 21334721 DOI: 10.1016/j.humpath.2010.07.027

13786 Honda K, Kajitani K, Nobeyama H, Kira Y, Yabunaka Y, Egami M, Zhi X, Fukuda T, Yoshida H, Matsumoto Y, Ichimura T, Yaui T, Sumi T, Ishiko O. An upstream estrogen response element linked to exogenous p53 tumor suppressor gene expression differentiates effects of the codon 72 polymorphism Asian Pac J Cancer Prev 2011 12(4):865-8 PubMed ID: 21790217

13815 Tanaka T, Bai T, Yukawa K. Specific downregulation of death-associated protein kinase enhances Fas-mediated apoptosis in the human differentiated endometrial adenocarcinoma cell line, HHUA Eur J Gynaecol Oncol 2011 32(3):293-6 PubMed ID: 21797120

13821 Tanaka T, Bai T, Utsunomiya H, Fukumoto T, Yukawa K. STAT3 enhances intracellular Fas-mediated apoptotic signals in HHUA human endometrial epithelial cells Mol Med Rep 2011 4(2):307-12 PubMed ID: 21468569 DOI: 10.3892/mmr.2011.424

8350 Fakhry H, Miyamoto T, Kashima H, Suzuki A, Ke H, Konishi I, Shiozawa T. Immunohistochemical detection of histone deacetylases in endometrial carcinoma: involvement of histone deacetylase 2 in the proliferation of endometrial carcinoma cells. Hum. Pathol. 2010 41:848-58 PubMed ID: 20178884 DOI: 10.1016/j.humpath.2009.11.012

8539 Suzuki A, Horiuchi A, Ashida T, Miyamoto T, Kashima H, Nikaido T, Konishi I, Shiozawa T. Cyclin A2 confers cisplatin resistance to endometrial carcinoma cells via up-regulation of an Akt-binding protein, periplakin. J. Cell. Mol. Med. 2010 14:2305-17 PubMed ID: 19583808 DOI: 10.1111/j.1582-4934.2009.00839.x

13793 Bai T, Tanaka T, Yukawa K. Targeted knockdown of death-associated protein kinase expression induces TRAIL-mediated apoptosis in human endometrial adenocarcinoma cells Int J Oncol 2010 37(1):203-10 PubMed ID: 20514412 DOI: 10.3892/ijo_00000668

13794 Tanaka T, Bai T, Yukawa K. Suppressed protein expression of the death-associated protein kinase enhances 5-fluorouracil-sensitivity but not etoposide-sensitivity in human endometrial adenocarcinoma cells Oncol Rep 2010 24(5):1401-5 PubMed ID: 20878137 DOI: 10.3892/or_00000999

13827 Tanaka T, Bai T, Toujima S. Establishment and characterization of monoclonal 5-fluorouracil-resistant cell lines derived from human endometrial adenocarcinoma Int J Oncol 2010 37(3):731-6 PubMed ID: 20664942 DOI: 10.3892/ijo_00000722

13833 Takai N, Ueda T, Nishida M, Nasu K, Narahara H. PK11195 enhances chemosensitivity to cisplatin and paclitaxel in human endometrial and ovarian cancer cells Int J Mol Med 2010 25(1):97-103 PubMed ID: 19956907

13835 Takai N, Ueda T, Nishida M, Nasu K, Narahara H. Synergistic anti-neoplastic effect of AG1478 in combination with cisplatin or paclitaxel on human endometrial and ovarian cancer cells Mol Med Rep 2010 3(3):479-84 PubMed ID: 21472266 DOI: 10.3892/mmr_00000284

14016 Ishikawa M, Nakayama K, Yeasmin S, Katagiri A, Iida K, Nakayama N, Miyazaki K. NAC1, a potential stem cell pluripotency factor expression in normal endometrium, endometrial hyperplasia and endometrial carcinoma Int J Oncol 2010 36(5):1097-103 PubMed ID: 20372782 DOI: 10.3892/ijo_00000591

14017 Tanaka T, Bai T, Yukawa K. Death-associated protein kinase is essential for the survival of various types of uterine cancer cells Int J Oncol 2010 37(4):1017-22 PubMed ID: 20811724 DOI: 10.3892/ijo_00000753

14018 Li H, Takai N, Yuge A, Furukawa Y, Tsuno A, Tsukamoto Y, Kong S, Moriyama M, Narahara H. Novel target genes responsive to the anti-growth activity of triptolide in endometrial and ovarian cancer cells Cancer Lett 2010 297(2):198-206 PubMed ID: 20547442 DOI: 10.1016/j.canlet.2010.05.012

18119 Tanaka T, Umesaki N. Danazol enhances Fas-mediated apoptosis in human endometrial epithelial cells within normal physiology Int J Mol Med 2009 23(2):237-43 PubMed ID: 19148548

18136 The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas Br J Cancer 2009 101(1):145-8. PubMed ID: 19491896 DOI: 10.1038/sj.bjc.6605109

13787 Ishibashi M, Nakayama K, Yeasmin S, Katagiri A, Iida K, Nakayama N, Miyazaki K. Expression of a BTB/POZ protein, NAC1, is essential for the proliferation of normal cyclic endometrial glandular cells and is up-regulated by estrogen Clin Cancer Res 2009 15(3):804-11 PubMed ID: 19188150 DOI: 10.1158/1078-0432.CCR-08-2134

13803 Takai N, Ueda T, Nasu K, Yamashita S, Toyofuku M, Narahara H. Targeting calcium/calmodulin-dependence kinase I and II as a potential anti-proliferation remedy for endometrial carcinomas Cancer Lett 2009 277(2):235-43 PubMed ID: 19168280 DOI: 10.1016/j.canlet.2008.12.018

13822 Tanaka T, Wang C, Umesaki N. Remodeling of the human endometrial epithelium is regulated by laminin and type IV collagen Int J Mol Med 2009 23(2):173-80 PubMed ID: 19148540

8749 Matsumoto M, Yamaguchi Y, Seino Y, Hatakeyama A, Takei H, Niikura H, Ito K, Suzuki T, Sasano H, Yaegashi N, Hayashi S. Estrogen signaling ability in human endometrial cancer through the cancer-stromal interaction. Endocr. Relat. Cancer 2008 15:451-63 PubMed ID: 18508998 DOI: 10.1677/ERC-07-0227

13798 Yoshizaki T, Enomoto T, Fujita M, Ueda Y, Miyatake T, Fujiwara K, Miyake T, Kimura T, Yoshino K, Kimura T. Frequent inactivation of RUNX3 in endometrial carcinoma Gynecol Oncol 2008 110(3):439-44 PubMed ID: 18572225 DOI: 10.1016/j.ygyno.2008.05.004

13823 Tanaka T, Umesaki N. Leptin regulates the proliferation and apoptosis of human endometrial epithelial cells Int J Mol Med 2008 22(5):683-9. PubMed ID: 18949391

13829 Takai N, Ueda T, Nishida M, Nasu K, Narahara H. Bufalin induces growth inhibition, cell cycle arrest and apoptosis in human endometrial and ovarian cancer cells Int J Mol Med 2008 21(5):637-43 PubMed ID: 18425357

13834 Takai N, Ueda T, Nishida M, Nasu K, Narahara H. K252a is highly effective in suppressing the growth of human endometrial cancer cells, but has little effect on normal human endometrial epithelial cells Oncol Rep 2008 19(3):749-53 PubMed ID: 18288411

18130 Feng YZ, Shiozawa T, Miyamoto T, Kashima H, Kurai M, Suzuki A, Ying-Song J, Konishi I. Overexpression of hedgehog signaling molecules and its involvement in the proliferation of endometrial carcinoma cells Clin Cancer Res 2007 13(5):1389-98 PubMed ID: 17332280 DOI: 10.1158/1078-0432.CCR-06-1407

18131 Sato N, Ito K, Onogawa T, Akahira J, Unno M, Abe T, Niikura H, Yaegashi N. Expression of organic cation transporter SLC22A16 in human endometria Int J Gynecol Pathol 2007 26(1):53-60 PubMed ID: 17197897 DOI: 10.1097/01.pgp.0000225845.67245.b3

8772 Sugimoto T, Koizumi T, Sudo T, Yamaguchi S, Kojima A, Kumagai S, Nishimura R. Correlative expression of cyclooxygenase-1 (Cox-1) and human epidermal growth factor receptor type-2 (Her-2) in endometrial cancer. Kobe J Med Sci 2007 53:177-87 PubMed ID: 18204294

13785 Zhi X, Honda K, Sumi T, Yasui T, Nobeyama H, Yoshida H, Ishiko O. Estradiol-17beta regulates vascular endothelial growth factor and Bcl-2 expression in HHUA cells Int J Oncol 2007 31(6):1333-8 PubMed ID: 17982659

18617 Takai N, Ueda T, Nishida M, Nasu K, Narahara H. Anticancer activity of MS-275, a novel histone deacetylase inhibitor, against human endometrial cancer cells Anticancer Res 2006 26(2A):939-45 PubMed ID: 16619490

13790 Abe H, Shibata MA, Otsuki Y. Caspase cascade of Fas-mediated apoptosis in human normal endometrium and endometrial carcinoma cells Mol Hum Reprod 2006 12(9):535-41 PubMed ID: 16870953 DOI: 10.1093/molehr/gah260

13820 Mochizuki T, Sakai K, Iwashita M. Effects of insulin-like growth factor (IGF) binding protein-3 (IGFBP-3) on endometrial cancer (HHUA) cell apoptosis and EGF stimulated cell proliferation in vitro Growth Horm IGF Res 2006 16(3):202-10 PubMed ID: 16844395 DOI: 10.1016/j.ghir.2006.05.002

3713 Taniguchi H, Yamamoto H, Hirata T, Miyamoto N, Oki M, Nosho K, Adachi Y, Endo T, Imai K, Shinomura Y. Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers. Oncogene 2005 24(53):7946-52 PubMed ID: 16007117 DOI: 10.1038/sj.onc.1208910

11007 Tetsuji Tanaka , Tao Bai, Kazunori Yukawa, Naohiko Umesaki Radiation-induced cell death is independent of the apoptotic signals mediated by death-associated protein kinase in human cervical squamous cell carcinoma cells Oncol Rep 2005 14(4):949-55 PubMed ID: 16142356

13825 Tanaka T. Effects of anti-endometriotic therapies on Fas-mediated endometrial epithelial apoptosis Oncol Rep 2005 13(6):1235-9 PubMed ID: 15870948

13795 Sugawara T, Nomura E, Fujimoto S. Expression of enzyme associated with steroid hormone synthesis and local production of steroid hormone in endometrial carcinoma cells J Endocrinol 2004 180(1):135-44 PubMed ID: 14709152 DOI: 10.1677/joe.0.1800135

13799 Enomoto M, Endo D, Kawashima S, Park MK. Human type II GnRH receptor mediates effects of GnRH on cell proliferation Zoolog Sci 2004 21(7):763-70 PubMed ID: 15277720 DOI: 10.2108/zsj.21.763

13800 Enomoto M, Seong JY, Kawashima S, Park MK. Proliferation of TSU-Pr1, a human prostatic carcinoma cell line is stimulated by gonadotropin-releasing hormone Life Sci . 2004 May 7;74(25):3141-52 2004 74(25):3141-52 PubMed ID: 15081579 DOI: 10.1016/j.lfs.2003.11.009

13826 Bai T, Tanaka T, Yukawa K, Maeda M, Umesaki N. Reduced expression of death-associated protein kinase in human uterine and ovarian carcinoma cells Oncol Rep 2004 11(3):661-5. PubMed ID: 14767518

14020 Tanaka T, Toujima S, Umesaki N. Activin A inhibits growth-inhibitory signals by TGF-beta1 in differentiated human endometrial adenocarcinoma cells Oncol Rep 2004 11(4):875-9 PubMed ID: 15010888

14021 Tanaka T, Toujima S, Umesaki N. Growth-inhibitory signals by activin A do not affect anticancer drug-sensitivity and acquired multi-drug-resistance in human ovarian endometrioid adenocarcinoma OVK-18 cells Oncol Rep 2004 11(3):667-71 PubMed ID: 14767519

13831 Unoki M, Nakamura Y. Methylation at CpG islands in intron 1 of EGR2 confers enhancer-like activity FEBS Lett 2003 554(1-2):67-72 PubMed ID: 14596916 DOI: 10.1016/s0014-5793(03)01092-5

13832 Tanaka T, Umesaki N. Fas antigen (CD95) mediates cell survival signals to regulate functional cellular subpopulations in normal human endometrial stromal cells Int J Mol Med 2003 11(6):757-62 PubMed ID: 12736718

14019 Tanaka T, Toujima S, Otani T, Minami S, Yamoto M, Umesaki N. Expression and function of activin receptors in human endometrial adenocarcinoma cells Int J Oncol 2003 23(3):657-63 PubMed ID: 12888901

2758 Harada, Hideki, Saijo, Kaoru, Watanabe, Satoru, Tsuboi, Koji, Nose, Tadao, Ishiwata, Isamu, Ohno, Tadao Selective expansion of human natural killer cells from peripheral blood mononuclear cells by the cell line, HFWT. Jpn J Cancer Res 2002 93:313-9 PubMed ID: 11927014 DOI: 10.1111/j.1349-7006.2002.tb02174.x

13797 Enomoto M, Mori T, Park M. Influence of serum supplements in culture medium on gonadotropin-releasing hormone effects on colony formation Life Sci 2002 71(18):2153-60 PubMed ID: 12204773 DOI: 10.1016/s0024-3205(02)02015-5

3101 Matsushima-Nishiu M, Unoki M, Ono K, Tsunoda T, Minaguchi T, Kuramoto H, Nishida M, Satoh T, Tanaka T, Nakamura Y Growth and gene expression profile analyses of endometrial cancer cells expressing exogenous PTEN. Cancer Res 2001 61:3741-9 PubMed ID: 11325847

13816 Enomoto M, Mori T, Park MK. GnRH agonist Buserelin affects colony-forming efficiency of HHUA and Jurkat cells Biochem Biophys Res Commun 2001 289(5):1180-7 PubMed ID: 11741317 DOI: 10.1006/bbrc.2001.6131

13792 Tanaka T, Umesaki N. Cytokine regulation of apoptotic susceptibility in a human endometrial epithelial cell line J Reprod Immunol 2000 47(2):105-19 PubMed ID: 10924745 DOI: 10.1016/s0165-0378(00)00062-0

13819 Tauchi H, Komatsu K, Ishizaki K, Yatagai F, Kato T. Mutation spectrum of MSH3-deficient HHUA/chr.2 cells reflects in vivo activity of the MSH3 gene product in mismatch repair Mutat Res 2000 447(2):155-64 PubMed ID: 10751599 DOI: 10.1016/s0027-5107(99)00199-2

13824 Tanaka T, Mizuno K, Miyama M, Chang L, Chen H, Ohtaki S, Umesaki N, Ogita S. Enhanced Fas/CD95-mediated apoptosis by epidermal growth factor in human endometrial epithelial cells Eur J Obstet Gynecol Reprod Biol 1999 86(2):189-94 PubMed ID: 10509790 DOI: 10.1016/s0301-2115(99)00048-2

14015 Kunishige I, Samejima Y, Shiki Y, Moriyama A, Meruelo D, Saji F, Murata Y. Suicide gene therapy for human uterine adenocarcinoma cells using herpes simplex virus thymidine kinase Gynecol Oncol 1999 72(1):16-25 PubMed ID: 9889024 DOI: 10.1006/gyno.1998.5224

18137 Tanaka T, Mizuno K, Umesaki N, Ogita S. Suppressed apoptotic susceptibility in human endometrial epithelial cells pretreated with hepatocyte growth factor Clin Exp Obstet Gynecol 1998 25(4):125-8 PubMed ID: 9987568

13791 Chang L, Tanaka T, Umesaki N, Ogita S. Differential apoptotic susceptibility to anti-Fas IgM and anticancer drugs in a human endometrial adenocarcinoma cell line HHUA on laminin and type I collagen Osaka City Med J 1998 44(2):173-80 PubMed ID: 10097597

13817 Tanaka T, Umesaki N, Mizuno K, Chang L, Ohtaki S, Ogita S. Enhancement of apoptotic susceptibility by interleukin-1 beta in human endometrial epithelial cells Gynecol Endocrinol 1998 12(5):315-9 PubMed ID: 9859023 DOI: 10.3109/09513599809012832

1212 T. Tanaka, N. Umesaki, K. Mizuno, L. Chang, M. Miyama, S. Ohtaki, S. Ogita Enhancement of Apoptotic Susceptibility in Human Endometrial Epithelial Cell Line HHUA by Transforming Growth Factor-β1 Hormone and Metabolic Research 1998 30:61-65 DOI: 10.1055/s-2007-978835

17977 Kagami I, Mizunuma H, Miyamoto S, Ibuki Y, Uchida T. Quantification of estrogen receptor messenger RNA by quantitative polymerase chain reaction using internal standard fragment Biochem Biophys Res Commun 1996 228(2):358-64 PubMed ID: 8920919 DOI: 10.1006/bbrc.1996.1666