Back Back
RCB0565 : ATDC5  update : 2018/07/06
CommentDifferentiate to chondrocytes, unidentifiable pigment cells. Teratocarcinoma AT805 derived.
Comment from the depositor
Terms and conditionsBasically, there is no restriction regarding academic use.
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC( regarding any kind of for-profit use.
Basic information Depositor Atsumi, Tadao
Originator Atsumi, Tadao
Year of deposit 1991
Original cell AT805
Animal mouse < Mammals
Strain name 129
Gender Male
Age at sampling embryo
Tissue embryo
Case history Teratocarcinoma AT805 derived
Classification cancer
Lifespan infinite
Morphology epithelial-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives DMEM/HamF12 + 5% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture or Medium Renewal : once/2-3 days
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
SSLP (mouse) OK
Isozyme LD, NP
deposit info
lot info
Reference information Reference 5
User's Publication 377

To topTop
1688  A chondrogenic cell line derived from a differentiating culture of AT805 teratocarcinoma cells.  Atsumi T, Miwa Y, Kimata K, Ikawa Y  Cell Differ Dev  1990  30:109-16  PubMed ID: 2201423
2605  Selective adhesion of embryonal carcinoma cells and differentiated cells by Ca2+-dependent sites.  Takeichi M, Atsumi T, Yoshida C, Uno K, Okada, T S  Dev Growth Differ  1981  87:340-350  PubMed ID: 6793433
1687  Chondrogenic differentiation of clonal mouse embryonic cell line ATDC5 in vitro: differentiation-dependent gene expression of parathyroid hormone (PTH)/PTH-related peptide receptor.  Shukunami C, Shigeno C, Atsumi T, Ishizeki K, Suzuki F, Hiraki Y.  J Cell Biol  1996  133(2):457-68  PubMed ID: 8609176
1681  Cellular hypertrophy and calcification of embryonal carcinoma-derived chondrogenic cell line ATDC5 in vitro.  Shukunami C, Ishizeki K, Atsumi T, Ohta Y, Suzuki F, Hiraki Y.  J Bone Miner Res  1997  12(8):1174-88  PubMed ID: 9258747
1682  Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells.  Kondo S, Shukunami C, Morioka Y, Matsumoto N, Takahashi R, Oh J, Atsumi T, Umezawa A, Kudo A, Kitayama H, Hiraki Y, Noda M.  J Cell Sci  2007  120(Pt 5):849-57  PubMed ID: 17298979

To topTop
User's Publication
2874  The canonical Wnt signaling pathway promotes chondrocyte differentiation in a Sox9-dependent manner.  Yano F, Kugimiya F, Ohba S, Ikeda T, Chikuda H, Ogasawara T, Ogata N, Takato T, Nakamura K, Kawaguchi H, Chung UI  Biochem Biophys Res Commun  2005  333:1300-8  PubMed ID: 15979579
2272  Localization of clearance receptor in rat lung and trachea : association with chondrogenic differentiation  Fujishige K, Yanaka N, Akatsuka H, Omori K  Am J Physiol  1998  274(3 Pt 1):425-431  PubMed ID: 9530179
2487  Phosphate provides an extracellular signal that drives nuclear export of Runx2/Cbfa1 in bone cells.  Fujita T, Izumo N, Fukuyama R, Meguro T, Nakamuta H, Kohno T, Koida M  Biochem Biophys Res Commun  2001  280:348-52  PubMed ID: 11162521
2488  Phosphate stimulates differentiation and mineralization of the chondroprogenitor clone ATDC5.  Fujita T, Meguro T, Izumo N, Yasutomi C, Fukuyama R, Nakamuta H, Koida M  Jpn J Pharmacol  2001  85:278-81  PubMed ID: 11325020
2899  Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling.  Fujita, Takashi, Azuma, Yasutaka, Fukuyama, Ryo, Hattori, Yuji, Yoshida, Carolina, Koida, Masao, Ogita, Kiyokazu, Komori, Toshihisa  J Cell Biol  2004  166:85-95  PubMed ID: 15226309
2926  WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair.  French, Dorothy M, Kaul, Raji J, D'Souza, Aloma L, Crowley, Craig W, Bao, Min, Frantz, Gretchen D, Filvaroff, Ellen H, Desnoyers, Luc  Am J Pathol  2004  165:855-67  PubMed ID: 15331410
7079  Axial Spondylometaphyseal Dysplasia Is Caused by C21orf2 Mutations.  Wang Z, Iida A, Miyake N, Nishiguchi KM, Fujita K, Nakazawa T, Alswaid A, Albalwi MA, Kim OH, Cho TJ, Lim GY, Isidor B, David A, Rustad CF, Merckoll E, Westvik J, Stattin EL, Grigelioniene G, Kou I, Nakajima M, Ohashi H, Smithson S, Matsumoto N, Nishimura G, Ikegawa S.  PLoS ONE  2016  11:e0150555  PubMed ID: 26974433
7085  Robust Circadian Rhythm and Parathyroid Hormone-Induced Resetting during Hypertrophic Differentiation in ATDC5 Chondroprogenitor Cells.  Hosokawa T, Tsuchiya Y, Okubo N, Kunimoto T, Minami Y, Fujiwara H, Umemura Y, Koike N, Kubo T, Yagita K.  Acta Histochem Cytochem  2016  48:165-71  PubMed ID: 26855448
7086  Tranilast stimulates endochondral ossification by upregulating SOX9 and RUNX2 promoters.  Hasegawa S, Kitoh H, Ohkawara B, Mishima K, Matsushita M, Masuda A, Ishiguro N, Ohno K.  Biochem. Biophys. Res. Commun.  2016  470:356-361  PubMed ID: 26777999
7124  E11/Podoplanin Protein Stabilization Through Inhibition of the Proteasome Promotes Osteocyte Differentiation in Murine in Vitro Models.  Staines KA, Prideaux M, Allen S, Buttle DJ, Pitsillides AA, Farquharson C.  J. Cell. Physiol.  2015  231:1392-404  PubMed ID: 26639105
7151  Synthetic PAMPS gel activates BMP/Smad signaling pathway in ATDC5 cells, which plays a significant role in the gel-induced chondrogenic differentiation.  Goto K, Kimura T, Kitamura N, Semba S, Ohmiya Y, Aburatani S, Matsukura S, Tsuda M, Kurokawa T, Ping Gong J, Tanaka S, Yasuda K.  J Biomed Mater Res A  2015  104:734-746  PubMed ID: 26566602
7185  Expression of Sulf1 and Sulf2 in cartilage, bone and endochondral fracture healing.  Zaman G, Staines KA, Farquharson C, Newton PT, Dudhia J, Chenu C, Pitsillides AA, Dhoot GK.  Histochem. Cell Biol.  2015  145:67-79  PubMed ID: 26464246
7192  Promyelocytic leukemia zinc finger mediates glucocorticoid-induced cell cycle arrest in the chondroprogenitor cell line ATDC5.  Naito M, Vongsa S, Tsukune N, Ohashi A, Takahashi T.  Mol. Cell. Endocrinol.  2015  417:114-23  PubMed ID: 26419928
7217  Suppression of Nkx3.2 by phosphatidylinositol-3-kinase signaling regulates cartilage development by modulating chondrocyte hypertrophy.  Kim JA, Im S, Cantley LC, Kim DW.  Cell. Signal.  2015  27:2389-400  PubMed ID: 26363466
7248  Smad3 deficiency leads to mandibular condyle degradation via the sphingosine 1-phosphate (S1P)/S1P3 signaling axis.  Mori H, Izawa T, Tanaka E.  Am. J. Pathol.  2015  185:2742-56  PubMed ID: 26272361
7279  The Role of MicroRNA-381 in Chondrogenesis and Interleukin-1-β Induced Chondrocyte Responses.  Hou C, Meng F, Zhang Z, Kang Y, Chen W, Huang G, Fu M, Sheng P, Zhang Z, Liao W.  Cell. Physiol. Biochem.  2015  36:1753-66  PubMed ID: 26184031
7291  Presence and function of microRNA-92a in chondrogenic ATDC5 and adipose-derived mesenchymal stem cells.  Hou C, Zhang Z, Zhang Z, Wu P, Zhao X, Fu M, Sheng P, Kang Y, Liao W.  Mol Med Rep  2015  12:4877-86  PubMed ID: 26135269
7329  Choosing the right chondrocyte cell line: Focus on nitric oxide.  Santoro A, Conde J, Scotece M, Abella V, Lopez V, Pino J, Gomez R, Gomez-Reino JJ, Gualillo O.  J. Orthop. Res.  2015  33:1784-8  PubMed ID: 26016689
7367  Inhibition of hyaluronan synthesis alters sulfated glycosaminoglycans deposition during chondrogenic differentiation in ATDC5 cells.  Yoshioka Y, Kozawa E, Urakawa H, Arai E, Futamura N, Zhuo L, Kimata K, Ishiguro N, Nishida Y.  Histochem. Cell Biol.  2015  144:167-77  PubMed ID: 25929745
7433  MicroRNA-200a Regulates the Development of Mandibular Condylar Cartilage.  Umeda M, Terao F, Miyazaki K, Yoshizaki K, Takahashi I.  J. Dent. Res.  2015  94:795-802  PubMed ID: 25784252
7450  Pregnane X receptor knockout mice display aging-dependent wearing of articular cartilage.  Azuma K, Casey SC, Urano T, Horie-Inoue K, Ouchi Y, Blumberg B, Inoue S.  PLoS ONE  2015  10:e0119177  PubMed ID: 25749104
7487  Non-dioxin-like polychlorinated biphenyls (PCB 101, PCB 153 and PCB 180) induce chondrocyte cell death through multiple pathways.  Abella V, Santoro A, Scotece M, Conde J, Lopez-Lopez V, Lazzaro V, Gomez-Reino JJ, Meli R, Gualillo O.  Toxicol. Lett.  2015  234:13-9  PubMed ID: 25659934
7506  High-Throughput Screening Assay for the Identification of Compounds Enhancing Collagenous Extracellular Matrix Production by ATDC5 Cells.  Le BQ, Fernandes H, Bouten CV, Karperien M, van Blitterswijk C, de Boer J.  Tissue Eng Part C Methods  2015  21:726-36  PubMed ID: 25604243
7669  Overexpression of hematopoietically expressed homeoprotein induces nonapoptotic cell death in mouse prechondrogenic ATDC5 cells.  Morimoto R, Obinata A.  Biol. Pharm. Bull.  2011  34:1589-95  PubMed ID: 21963500
7672  Thyroid-specific gene expression in chondrocytes.  Endo T, Kobayashi T.  Biochem. Biophys. Res. Commun.  2011  416:227-31  PubMed ID: 21945616
7711  3β-Hydroxysterol-Delta24 reductase plays an important role in long bone growth by protecting chondrocytes from reactive oxygen species.  Mirza R, Qiao S, Tateyama K, Miyamoto T, Xiuli L, Seo H.  J. Bone Miner. Metab.  2011  30:144-53  PubMed ID: 21845517
7760  Delta-like 1/fetal antigen-1 (Dlk1/FA1) is a novel regulator of chondrogenic cell differentiation via inhibition of the Akt kinase-dependent pathway.  Chen L, Qanie D, Jafari A, Taipaleenmaki H, Jensen CH, Saamanen AM, Sanz ML, Laborda J, Abdallah BM, Kassem M.  J. Biol. Chem.  2011  286:32140-9  PubMed ID: 21724852
7786  MicroRNA regulation associated chondrogenesis of mouse MSCs grown on polyhydroxyalkanoates.  Yan C, Wang Y, Shen XY, Yang G, Jian J, Wang HS, Chen GQ, Wu Q.  Biomaterials  2011  32:6435-44  PubMed ID: 21665270
7805  Nfatc2 is a primary response gene of Nell-1 regulating chondrogenesis in ATDC5 cells.  Chen W, Zhang X, Siu RK, Chen F, Shen J, Zara JN, Culiat CT, Tetradis S, Ting K, Soo C.  J. Bone Miner. Res.  2011  26:1230-41  PubMed ID: 21611965
7861  Homeoprotein Hex is expressed in mouse developing chondrocytes.  Morimoto R, Yamamoto A, Akimoto Y, Obinata A.  J. Biochem.  2011  150:61-71  PubMed ID: 21454303
7887  A novel fibrin gel derived from hyaluronic acid-grafted fibrinogen.  Yang CL, Chen HW, Wang TC, Wang YJ.  Biomed Mater  2011  6:025009  PubMed ID: 21393811
7902  Monocarboxylate transporter-1 is required for cell death in mouse chondrocytic ATDC5 cells exposed to interleukin-1beta via late phase activation of nuclear factor kappaB and expression of phagocyte-type NADPH oxidase.  Yoshimura K, Miyamoto Y, Yasuhara R, Maruyama T, Akiyama T, Yamada A, Takami M, Suzawa T, Tsunawaki S, Tachikawa T, Baba K, Kamijo R.  J. Biol. Chem.  2011  286:14744-52  PubMed ID: 21372137
7908  Senescence of chondrocytes in aging articular cartilage: GADD45β mediates p21 expression in association with C/EBPβ in senescence-accelerated mice.  Shimada H, Sakakima H, Tsuchimochi K, Matsuda F, Komiya S, Goldring MB, Ijiri K.  Pathol. Res. Pract.  2011  207:225-31  PubMed ID: 21353395
7912  Arid5a cooperates with Sox9 to stimulate chondrocyte-specific transcription.  Amano K, Hata K, Muramatsu S, Wakabayashi M, Takigawa Y, Ono K, Nakanishi M, Takashima R, Kogo M, Matsuda A, Nishimura R, Yoneda T.  Mol. Biol. Cell  2011  22:1300-11  PubMed ID: 21346191
7946  Alleviating effects of AS1892802, a Rho kinase inhibitor, on osteoarthritic disorders in rodents.  Takeshita N, Yoshimi E, Hatori C, Kumakura F, Seki N, Shimizu Y.  J. Pharmacol. Sci.  2011  115:481-9  PubMed ID: 21325780
7962  14-3-3 η inhibits chondrogenic differentiation of ATDC5 cell.  Yoon HE, Kim KS, Kim IY.  Biochem. Biophys. Res. Commun.  2011  406:59-63  PubMed ID: 21291861
7975  Stimulation of chondrogenesis in ATDC5 chondroprogenitor cells and hypertrophy in mouse by Genkwadaphnin.  Choi HJ, Nepal M, Park YR, Lee HK, Oh SR, Soh Y.  Eur. J. Pharmacol.  2011  655:9-15  PubMed ID: 21266170
8000  Expanding the adipokine network in cartilage: identification and regulation of novel factors in human and murine chondrocytes.  Conde J, Gomez R, Bianco G, Scotece M, Lear P, Dieguez C, Gomez-Reino J, Lago F, Gualillo O.  Ann. Rheum. Dis.  2011  70:551-9  PubMed ID: 21216818
8062  Cloning and characterization of the osteoarthritis-associated gene DVWA.  Nakajima M, Miyamoto Y, Ikegawa S.  J. Bone Miner. Metab.  2010  29:300-8  PubMed ID: 21057832
8122  Cell behavior on extracellular matrix mimic materials based on mussel adhesive protein fused with functional peptides.  Choi BH, Choi YS, Kang DG, Kim BJ, Song YH, Cha HJ.  Biomaterials  2010  31:8980-8  PubMed ID: 20832110
8185  Inhibition of Src impairs the growth of met-addicted gastric tumors.  Bertotti A, Bracco C, Girolami F, Torti D, Gastaldi S, Galimi F, Medico E, Elvin P, Comoglio PM, Trusolino L.  Clin. Cancer Res.  2010  16:3933-43  PubMed ID: 20628031
8222  Stage-specific control of connective tissue growth factor (CTGF/CCN2) expression in chondrocytes by Sox9 and beta-catenin.  Huang BL, Brugger SM, Lyons KM.  J. Biol. Chem.  2010  285:27702-12  PubMed ID: 20571031
8241  The mechanism of ascorbic acid-induced differentiation of ATDC5 chondrogenic cells.  Temu TM, Wu KY, Gruppuso PA, Phornphutkul C.  Am. J. Physiol. Endocrinol. Metab.  2010  299:E325-34  PubMed ID: 20530736
8308  Identification of oxytetracycline as a chondrogenic compound using a cell-based screening system.  Hojo H, Yano F, Ohba S, Igawa K, Nakajima K, Komiyama Y, Kan A, Ikeda T, Yonezawa T, Woo JT, Takato T, Nakamura K, Kawaguchi H, Chung UI.  J. Bone Miner. Metab.  2010  28:627-33  PubMed ID: 20376510
8343  Effect of oleocanthal and its derivatives on inflammatory response induced by lipopolysaccharide in a murine chondrocyte cell line.  Iacono A, Gomez R, Sperry J, Conde J, Bianco G, Meli R, Gomez-Reino JJ, Smith AB 3rd, Gualillo O.  Arthritis Rheum.  2010  62:1675-82  PubMed ID: 20201078
8347  Akt1 in murine chondrocytes controls cartilage calcification during endochondral ossification under physiologic and pathologic conditions.  Fukai A, Kawamura N, Saito T, Oshima Y, Ikeda T, Kugimiya F, Higashikawa A, Yano F, Ogata N, Nakamura K, Chung UI, Kawaguchi H.  Arthritis Rheum.  2010  62:826-36  PubMed ID: 20187155
8353  Activation of the hypoxia-inducible factor-1 in overloaded temporomandibular joint, and induction of osteoclastogenesis.  Shirakura M, Tanimoto K, Eguchi H, Miyauchi M, Nakamura H, Hiyama K, Tanimoto K, Tanaka E, Takata T, Tanne K.  Biochem. Biophys. Res. Commun.  2010  393:800-5  PubMed ID: 20171183
8355  Chondrogenic mRNA expression in prechondrogenic cells after blue laser irradiation.  Kushibiki T, Tajiri T, Ninomiya Y, Awazu K.  J. Photochem. Photobiol. B, Biol.  2010  98:211-5  PubMed ID: 20163967
8363  Increased expression of the hedgehog signaling pathway in pediatric solid malignancies.  Oue T, Yoneda A, Uehara S, Yamanaka H, Fukuzawa M.  J. Pediatr. Surg.  2010  45:387-92  PubMed ID: 20152358
8399  A new chondrogenic differentiation initiator with the ability to up-regulate SOX trio expression.  Noguchi K, Watanabe Y, Fuse T, Takizawa M.  J. Pharmacol. Sci.  2010  112:89-97  PubMed ID: 20051655
8425  Fibulin-3 negatively regulates chondrocyte differentiation.  Wakabayashi T, Matsumine A, Nakazora S, Hasegawa M, Iino T, Ota H, Sonoda H, Sudo A, Uchida A.  Biochem. Biophys. Res. Commun.  2009  391:1116-21  PubMed ID: 20005202
8450  Cytokine receptor-like factor 1 is highly expressed in damaged human knee osteoarthritic cartilage and involved in osteoarthritis downstream of TGF-beta.  Tsuritani K, Takeda J, Sakagami J, Ishii A, Eriksson T, Hara T, Ishibashi H, Koshihara Y, Yamada K, Yoneda Y.  Calcif. Tissue Int.  2009  86:47-57  PubMed ID: 19921088
8500  Chondrocyte p21(WAF1/CIP1) expression is increased by dexamethasone but does not contribute to dexamethasone-induced growth retardation in vivo.  Owen HC, Ahmed SF, Farquharson C.  Calcif. Tissue Int.  2009  85:326-34  PubMed ID: 19727539
8545  Chondrogenesis on BMP-6 loaded chitosan scaffolds in stationary and dynamic cultures.  Ti?li RS, Gumu?derelio?lu M.  Biotechnol. Bioeng.  2009  104:601-10  PubMed ID: 19575410
8555  Interleukin-6 inhibits early differentiation of ATDC5 chondrogenic progenitor cells.  Nakajima S, Naruto T, Miyamae T, Imagawa T, Mori M, Nishimaki S, Yokota S.  Cytokine  2009  47:91-7  PubMed ID: 19535264
8559  Stimulation of the side population fraction of ATDC5 chondroprogenitors by hypoxia.  Kishimoto KN, Oxford CL, Reddi AH.  Cell Biol. Int.  2009  33:1222-9  PubMed ID: 19524690
8568  Expression and modulation of ghrelin O-acyltransferase in cultured chondrocytes.  Gomez R, Lago F, Gomez-Reino JJ, Dieguez C, Gualillo O.  Arthritis Rheum.  2009  60:1704-9  PubMed ID: 19479831
8608  Regulation of rapid signal transducer and activator of transcription-5 phosphorylation in the resting cells of the growth plate and in the liver by growth hormone and feeding.  Gevers EF, Hannah MJ, Waters MJ, Robinson IC.  Endocrinology  2009  150:3627-36  PubMed ID: 19359380
8636  Predominant promotion by tacrolimus of chondrogenic differentiation to proliferating chondrocytes.  Nakamura Y, Takarada T, Kodama A, Hinoi E, Yoneda Y.  J. Pharmacol. Sci.  2009  109:413-23  PubMed ID: 19270431
8646  CCAAT/enhancer binding protein beta mediates expression of matrix metalloproteinase 13 in human articular chondrocytes in inflammatory arthritis.  Hayashida M, Okazaki K, Fukushi J, Sakamoto A, Iwamoto Y.  Arthritis Rheum.  2009  60:708-16  PubMed ID: 19248099
8651  Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity.  Kotzsch A, Nickel J, Seher A, Sebald W, Muller TD.  EMBO J.  2009  28:937-47  PubMed ID: 19229295
8678  A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9) expression by chondrocytes during endochondral ossification.  Kumagishi K, Nishida K, Yamaai T, Momota R, Miyaki S, Hirohata S, Naito I, Asahara H, Ninomiya Y, Ohtsuka A.  Arch. Histol. Cytol.  2009  72:175-85  PubMed ID: 20513980
8706  A novel double-network hydrogel induces spontaneous articular cartilage regeneration in vivo in a large osteochondral defect.  Yasuda K, Kitamura N, Gong JP, Arakaki K, Kwon HJ, Onodera S, Chen YM, Kurokawa T, Kanaya F, Ohmiya Y, Osada Y.  Macromol Biosci  2008  9:307-16  PubMed ID: 19031389
8713  Evaluation of alginate-chitosan semi IPNs as cartilage scaffolds.  Ti?li RS, Gumu?derelio?lu M.  J Mater Sci Mater Med  2008  20:699-709  PubMed ID: 18987950
8784  Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand.  Saremba S, Nickel J, Seher A, Kotzsch A, Sebald W, Mueller TD.  FEBS J.  2007  275:172-83  PubMed ID: 18070108
3120  Expression of GABA(A) and GABA(B) receptors in rat growth plate chondrocytes: activation of the GABA receptors promotes proliferation of mouse chondrogenic ATDC5 cells.  Tamayama T, Maemura K, Kanbara K, Hayasaki H, Yabumoto Y, Yuasa M, Watanabe M.  Mol. Cell. Biochem.  2005  273:117-26  PubMed ID: 16013446
3194  Functional expression of particular isoforms of excitatory amino acid transporters by rodent cartilage.  Hinoi E, Wang L, Takemori A, Yoneda Y.  Biochem. Pharmacol.  2005  70:70-81  PubMed ID: 15894296
2900  p21(Cip-1/SDI-1/WAF-1) expression via the mitogen-activated protein kinase signaling pathway in insulin-induced chondrogenic differentiation of ATDC5 cells.  Nakajima M, Negishi Y, Tanaka H, Kawashima K.  Biochem. Biophys. Res. Commun.  2004  320:1069-75  PubMed ID: 15249198
3330  Molecular recognition of BMP-2 and BMP receptor IA.  Keller S, Nickel J, Zhang JL, Sebald W, Mueller TD.  Nat. Struct. Mol. Biol.  2004  11:481-8  PubMed ID: 15064755
9530  MicroRNA-320 regulates matrix metalloproteinase-13 expression in chondrogenesis and interleukin-1β-induced chondrocyte responses.  Meng F, Zhang Z, Chen W, Huang G, He A, Hou C, Long Y, Yang Z, Zhang Z, Liao W.  Osteoarthr. Cartil.  2016  24:932-41  PubMed ID: 26774733
9538  Role of the Wnt/β-catenin signaling pathway in the response of chondrocytes to mechanical loading.  Niu Q, Li F, Zhang L, Xu X, Liu Y, Gao J, Feng X.  Int. J. Mol. Med.  2016  37:755-62  PubMed ID: 26821383
9563  The novel adipokine progranulin counteracts IL-1 and TLR4-driven inflammatory response in human and murine chondrocytes via TNFR1.  Abella V, Scotece M, Conde J, López V, Pirozzi C, Pino J, Gómez R, Lago F, González-Gay MÁ, Gualillo O.  Sci Rep  2016  6:20356  PubMed ID: 26853108
9567  The Indispensable Role of Cyclin-Dependent Kinase 1 in Skeletal Development.  Saito M, Mulati M, Talib SZ, Kaldis P, Takeda S, Okawa A, Inose H.  Sci Rep  2016  6:20622  PubMed ID: 26860366
9645  The Role of Prostaglandins and COX-Enzymes in Chondrogenic Differentiation of ATDC5 Progenitor Cells.  Caron MM, Emans PJ, Sanen K, Surtel DA, Cremers A, Ophelders D, van Rhijn LW, Welting TJ.  PLoS ONE  2016  11:e0153162  PubMed ID: 27050768
9648  Serum of patients with active rheumatoid arthritis inhibits differentiation of osteochondrogenic precursor cells.  Pathak JL, Verschueren P, Lems WF, Bravenboer N, Klein-Nulend J, Bakker AD, Luyten FP.  Connect. Tissue Res.  2016  57:226-35  PubMed ID: 27050327
9704  E74-like factor 3 and nuclear factor-κB regulate lipocalin-2 expression in chondrocytes.  Conde J, Otero M, Scotece M, Abella V, López V, Pino J, Gómez R, Lago F, Goldring MB, Gualillo O.  J. Physiol. (Lond.)  2016  594:6133-6146  PubMed ID: 27222093
9705  Magnetic field-responsive release of transforming growth factor beta 1 from heparin-modified alginate ferrogels.  Kim H, Park H, Lee JW, Lee KY.  Carbohydr Polym  2016  151:467-473  PubMed ID: 27474590
9721  A post-translational modification cascade employing HDAC9-PIASy-RNF4 axis regulates chondrocyte hypertrophy by modulating Nkx3.2 protein stability.  Choi HJ, Kwon S, Kim DW.  Cell. Signal.  2016  28:1336-48  PubMed ID: 27312341
9746  Identification and Functional Characterization of RSPO2 as a Susceptibility Gene for Ossification of the Posterior Longitudinal Ligament of the Spine.  Nakajima M, Kou I, Ohashi H, , Ikegawa S.  Am. J. Hum. Genet.  2016  99:202-7  PubMed ID: 27374772
9754  Fundamental biomaterial properties of tough glycosaminoglycan-containing double network hydrogels newly developed using the molecular stent method.  Higa K, Kitamura N, Kurokawa T, Goto K, Wada S, Nonoyama T, Kanaya F, Sugahara K, Gong JP, Yasuda K.  Acta Biomater  2016  43:38-49  PubMed ID: 27427226
9768  Crucial Role of Elovl6 in Chondrocyte Growth and Differentiation during Growth Plate Development in Mice.  Kikuchi M, Shimada M, Matsuzaka T, Ishii K, Nakagawa Y, Takayanagi M, Yamada N, Shimano H.  PLoS ONE  2016  11:e0159375  PubMed ID: 27467521
9812  Molecular hydrogen suppresses activated Wnt/β-catenin signaling.  Lin Y, Ohkawara B, Ito M, Misawa N, Miyamoto K, Takegami Y, Masuda A, Toyokuni S, Ohno K.  Sci Rep  2016  6:31986  PubMed ID: 27558955
9829  mTORC1 Signaling Promotes Limb Bud Cell Growth and Chondrogenesis.  Jiang M, Fu X, Yang H, Long F, Chen J.  J. Cell. Biochem.  2017  118:748-753  PubMed ID: 27606668
9831  MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylation.  Chen W, Chen L, Zhang Z, Meng F, Huang G, Sheng P, Zhang Z, Liao W.  Biochim. Biophys. Acta  2016  1863:2881-2891  PubMed ID: 27638301
9852  Polyamines release the let-7b-mediated suppression of initiation codon recognition during the protein synthesis of EXT2.  Imamura M, Higashi K, Yamaguchi K, Asakura K, Furihata T, Terui Y, Satake T, Maegawa J, Yasumura K, Ibuki A, Akase T, Nishimura K, Kashiwagi K, Linhardt RJ, Igarashi K, Toida T.  Sci Rep  2016  6:33549  PubMed ID: 27650265
9905  Regulation of Chondrocyte Survival in Mouse Articular Cartilage by p63.  Taniguchi Y, Kawata M, Ho Chang S, Mori D, Okada K, Kobayashi H, Sugita S, Hosaka Y, Inui H, Taketomi S, Yano F, Ikeda T, Akiyama H, Mills AA, Chung UI, Tanaka S, Kawaguchi H, Saito T.  Arthritis Rheumatol  2017  69:598-609  PubMed ID: 27792866
9927  Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes.  Kobayashi H, Chang SH, Mori D, Itoh S, Hirata M, Hosaka Y, Taniguchi Y, Okada K, Mori Y, Yano F, Chung UI, Akiyama H, Kawaguchi H, Tanaka S, Saito T.  Nat Commun  2016  7:13336  PubMed ID: 27830706
9987  AntimiR-30b Inhibits TNF-α Mediated Apoptosis and Attenuated Cartilage Degradation through Enhancing Autophagy.  Chen Z, Jin T, Lu Y.  Cell. Physiol. Biochem.  2016  40:883-894  PubMed ID: 27941314
10022  Central suspension technique of the midface.  Hagerty RC.  Plast. Reconstr. Surg.  1995  96:728-30  PubMed ID: 7638301
10062  Extracellular matrix loss in chondrocytes after exposure to interleukin-1β in NADPH oxidase-dependent manner.  Funato S, Yasuhara R, Yoshimura K, Miyamoto Y, Kaneko K, Suzawa T, Chikazu D, Mishima K, Baba K, Kamijo R.  Cell Tissue Res.  2017  368:135-144  PubMed ID: 28070636
10105  Micro-Topographies Promote Late Chondrogenic Differentiation Markers in the ATDC5 Cell Line.  Le BQ, Vasilevich A, Vermeulen S, Hulshof F, Stamatialis DF, van Blitterswijk CA, de Boer J.  Tissue Eng Part A  2017  23:458-469  PubMed ID: 28152670
10119  Corticoids synergize with IL-1 in the induction of LCN2.  Conde J, Lazzaro V, Scotece M, Abella V, Villar R, López V, Gonzalez-Gay MÁ, Pino J, Gómez R, Mera A, Gualillo O.  Osteoarthr. Cartil.  2017  25:1172-1178  PubMed ID: 28185846
10131  Cyclic compressive stress-induced scinderin regulates progress of developmental dysplasia of the hip.  Wang CL, Wang H, Xiao F, Wang CD, Hu GL, Zhu JF, Shen C, Zuo B, Cui YM, Li , Yuan-Gao , Zhang XL, Chen XD.  Biochem. Biophys. Res. Commun.  2017  485:400-408  PubMed ID: 28213129
10273  An Approach to In Vitro Manufacturing of Hypertrophic Cartilage Matrix for Bone Repair.  Quang Le B, Van Blitterswijk C, De Boer J.  Bioengineering (Basel)  2017  4:  PubMed ID: 28952514
10295  Nkx3.2 induces oxygen concentration-independent and lysosome-dependent degradation of HIF-1α to modulate hypoxic responses in chondrocytes.  Im S, Kim DW.  Cell. Signal.  2017  36:127-138  PubMed ID: 28479297
10306  Fabrication of chitosan/graphene oxide polymer nanofiber and its biocompatibility for cartilage tissue engineering.  Cao L, Zhang F, Wang Q, Wu X.  Mater Sci Eng C Mater Biol Appl  2017  79:697-701  PubMed ID: 28629070
10434  Osthole Promotes Bone Fracture Healing through Activation of BMP Signaling in Chondrocytes.  Wang P, Ying J, Luo C, Jin X, Zhang S, Xu T, Zhang L, Mi M, Chen D, Tong P, Jin H.  Int. J. Biol. Sci.  2017  13:996-1007  PubMed ID: 28924381
10505  Krüppel-Like Factor 2 Regulates Degradation of Type II Collagen by Suppressing the Expression of Matrix Metalloproteinase (MMP)-13.  Yuan Y, Tan H, Dai P.  Cell. Physiol. Biochem.  2017  42:2159-2168  PubMed ID: 28873368
10534  Halofuginone attenuates articular cartilage degeneration by inhibition of elevated TGF‑β1 signaling in articular cartilage in a rodent osteoarthritis model.  Mu W, Xu B, Ma H, Ji B, Zhang Z, Li J, Amat A, Cao L.  Mol Med Rep  2017  16:7679-7684  PubMed ID: 28944864
10547  Isoliquiritigenin suppresses IL-1β induced apoptosis and inflammation in chondrocyte-like ATDC5 cells by inhibiting NF-κB and exerts chondroprotective effects on a mouse model of anterior cruciate ligament transection.  Ji B, Guo W, Ma H, Xu B, Mu W, Zhang Z, Amat A, Cao L.  Int. J. Mol. Med.  2017  40:1709-1718  PubMed ID: 29039445
10570  Angiopoietin-like protein 2 promotes chondrogenic differentiation during bone growth as a cartilage matrix factor.  Tanoue H, Morinaga J, Yoshizawa T, Yugami M, Itoh H, Nakamura T, Uehara Y, Masuda T, Odagiri H, Sugizaki T, Kadomatsu T, Miyata K, Endo M, Terada K, Ochi H, Takeda S, Yamagata K, Fukuda T, Mizuta H, Oike Y.  Osteoarthr. Cartil.  2018  26:108-117  PubMed ID: 29074299
10631  Supplemented Chondroitin Sulfate and Hyaluronic Acid Suppress Mineralization of the Chondrogenic Cell Line, ATDC5, via Direct Inhibition of Alkaline Phosphatase.  Kudo T, Nakatani S, Kakizaki M, Arai A, Ishida K, Wada M, Kobata K.  Biol. Pharm. Bull.  2017  40:2075-2080  PubMed ID: 29199232
10636  Lysophosphatidylcholine acyltransferase 4 is involved in chondrogenic differentiation of ATDC5 cells.  Tabe S, Hikiji H, Ariyoshi W, Hashidate-Yoshida T, Shindou H, Shimizu T, Okinaga T, Seta Y, Tominaga K, Nishihara T.  Sci Rep  2017  7:16701  PubMed ID: 29196633
10651  Functional polymorphisms in asporin and CILP together with joint loading predispose to hand osteoarthritis.  Taipale M, Solovieva S, Leino-Arjas P, Männikkö M.  BMC Genet.  2017  18:108  PubMed ID: 29233086
10670  Rubbery Chitosan/Carrageenan Hydrogels Constructed through an Electroneutrality System and Their Potential Application as Cartilage Scaffolds.  Liang X, Wang X, Xu Q, Lu Y, Zhang Y, Xia H, Lu A, Zhang L.  Biomacromolecules  2018  19:340-352  PubMed ID: 29253344
10707  Nfatc1 Is a Functional Transcriptional Factor Mediating Nell-1-Induced Runx3 Upregulation in Chondrocytes.  Li C, Zheng Z, Zhang X, Asatrian G, Chen E, Song R, Culiat C, Ting K, Soo C.  Int J Mol Sci  2018  19:  PubMed ID: 29316655
10715  Blocking PI3K/AKT signaling inhibits bone sclerosis in subchondral bone and attenuates post-traumatic osteoarthritis.  Lin C, Shao Y, Zeng C, Zhao C, Fang H, Wang L, Pan J, Liu L, Qi W, Feng X, Qiu H, Zhang H, Chen Y, Wang H, Cai D, Xian CJ.  J. Cell. Physiol.  2018  233:6135-6147  PubMed ID: 29323710
10732  SIRT7 is an important regulator of cartilage homeostasis and osteoarthritis development.  Korogi W, Yoshizawa T, Karim MF, Tanoue H, Yugami M, Sobuz SU, Hinoi E, Sato Y, Oike Y, Mizuta H, Yamagata K.  Biochem. Biophys. Res. Commun.  2018    PubMed ID: 29402405
10752  LncRNA GAS5 Overexpression Reverses LPS-Induced Inflammatory Injury and Apoptosis Through Up-Regulating KLF2 Expression in ATDC5 Chondrocytes.  Li F, Sun J, Huang S, Su G, Pi G.  Cell. Physiol. Biochem.  2018  45:1241-1251  PubMed ID: 29448248
10779  Loss of Mob1a/b in mice results in chondrodysplasia due to YAP1/TAZ-TEAD-dependent repression of SOX9.  Goto H, Nishio M, To Y, Oishi T, Miyachi Y, Maehama T, Nishina H, Akiyama H, Mak TW, Makii Y, Saito T, Yasoda A, Tsumaki N, Suzuki A.  Development  2018  145:  PubMed ID: 29511023
10791  Bushenhuoxue formula attenuates cartilage degeneration in an osteoarthritic mouse model through TGF-β/MMP13 signaling.  Wang PE, Zhang L, Ying J, Jin X, Luo C, Xu S, Dong R, Xiao L, Tong P, Jin H.  J Transl Med  2018  16:72  PubMed ID: 29554973
10793  Treacher Collins syndrome 3 (TCS3)-associated POLR1C mutants are localized in the lysosome and inhibits chondrogenic differentiation.  Matsumoto N, Kaneko M, Watanabe N, Itaoka M, Seki Y, Morimoto T, Torii T, Miyamoto Y, Keiichi Homma , Yamauchi J.  Biochem. Biophys. Res. Commun.  2018  499:78-85  PubMed ID: 29567474
10823  Emodin attenuates apoptosis and inflammation induced by LPS through up-regulating lncRNA TUG1 in murine chondrogenic ATDC5 cells.  Liang Z, Ren C.  Biomed. Pharmacother.  2018  103:897-902  PubMed ID: 29710506
10843  Cyclic Tensile Strain Upregulates Pro-Inflammatory Cytokine Expression Via FAK-MAPK Signaling in Chondrocytes.  Yanoshita M, Hirose N, Okamoto Y, Sumi C, Takano M, Nishiyama S, Asakawa-Tanne Y, Horie K, Onishi A, Yamauchi Y, Mitsuyoshi T, Kunimatsu R, Tanimoto K.  Inflammation  2018  41(5):1621-1630  PubMed ID: 29737477
10870  High throughput screening for modulators of ACVR1 transcription potentially applicable to the treatment of Fibrodysplasia Ossificans Progressiva    Disease Models & Mechanisms  2016  9, 1067 
10918  Effects of a Chemically Synthesized Leucine-Rich Amelogenin Peptide (csLRAP) on Chondrogenic and Osteogenic Cells    Journal of Hard Tissue Biology  2017  26, 51- 60 
10986  The role of Tsukushi (TSK), a small leucine-rich repeat proteoglycan, in bone growth  Yano K, Washio K, Tsumanuma Y, Yamato M, Ohta K, Okano T, Izumi Y.  Regen Ther  2017  7:98-107  PubMed ID: 30271858
11046  Semaphorin 3A inhibits inflammation in chondrocytes under excessive mechanical stress    Mediators of Inflammation  2018  2018, 9  PubMed ID: 29849491
11154  MicroRNA-136 promotes lipopolysaccharide-induced ATDC5 cell injury and inflammatory cytokine expression by targeting myeloid cell leukemia 1.  Wang Y, Kong D.  J. Cell. Biochem.  2018  119(11):9316-9326  PubMed ID: 30074264
11185  Long noncoding RNA MALAT1 alleviates lipopolysaccharide-induced inflammatory injury by upregulating microRNA-19b in murine chondrogenic ATDC5 cells.  Pan L, Liu D, Zhao L, Wang L, Xin M, Li X.  J. Cell. Biochem.  2018  119(12):10165-10175  PubMed ID: 30145831
11286  Bushenhuoxue Formula Facilitates Articular Cartilage Repair and Attenuates Matrix Degradation by Activation of TGF-β Signaling Pathway.  Dong R, Ying J, Xu T, Hu S, Zhang P, Xia C, Fang L, Jin H, Wang P.  Evid Based Complement Alternat Med  2018    PubMed ID: 30402118
11264  In Vitro Screening of Molecularly Engineered Polyethylene Glycol Hydrogels for Cartilage Tissue Engineering using Periosteum-Derived and ATDC5 Cells.  Kudva AK, Luyten FP, Patterson J.  Int J Mol Sci  2018    PubMed ID: 30373138
11274  SLIT3 regulates endochondral ossification by β-catenin suppression in chondrocytes.  Kim H, Choi YJ, Lee YS, Park SY, Baek JE, Kim HK, Kim BJ, Lee SH, Koh JM.  Biochem. Biophys. Res. Commun.  2018    PubMed ID: 30389141
11305  Butyrate Modulates Inflammation in Chondrocytes via GPR43 Receptor.  Pirozzi C, Francisco V, Guida FD, Gómez R, Lago F, Pino J, Meli R, Gualillo O.  Cell. Physiol. Biochem.  2018    PubMed ID: 30448827
11328  Long non-coding RNA THRIL promotes LPS-induced inflammatory injury by down-regulating microRNA-125b in ATDC5 cells.  Liu G, Wang Y, Zhang M, Zhang Q.  Int. Immunopharmacol.  2019    PubMed ID: 30521964
11356  Retinoic Receptor Signaling Regulates Hypertrophic Chondrocyte-specific Gene Expression.  Shimo T, Koyama E, Okui T, Masui M, Kunisada Y, Ibaragi S, Yoshioka N, Kurio N, Yoshida S, Sasaki A, Iwamoto M.  In Vivo  2019    PubMed ID: 30587607
11403  Nutritional supplementation with myo-inositol in growing mice specifically augments mandibular endochondral growth.  Yamaguchi Y, Kanzaki H, Miyamoto Y, Itohiya K, Fukaya S, Katsumata Y, Nakamura Y.  Bone  2019    PubMed ID: 30682567
11417  The antiviral protein viperin regulates chondrogenic differentiation via CXCL10 protein secretion.  Steinbusch MMF, Caron MMJ, Surtel DAM, van den Akker GGH, van Dijk PJ, Friedrich F, Zabel B, van Rhijn LW, Peffers MJ, Welting TJM.  J. Biol. Chem.  2019    PubMed ID: 30718282
11438  Long non-coding RNA activated by transforming growth factor beta alleviates lipopolysaccharide-induced inflammatory injury via regulating microRNA-223 in ATDC5 cells.  Ying H, Wang Y, Gao Z, Zhang Q.  Int. Immunopharmacol.  2019    PubMed ID: 30771739
11449  Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12.  Lin C, Liu L, Zeng C, Cui ZK, Chen Y, Lai P, Wang H, Shao Y, Zhang H, Zhang R, Zhao C, Fang H, Cai D, Bai X.  Bone Res  2019    PubMed ID: 30792936
11478  Collagen type II suppresses articular chondrocyte hypertrophy and osteoarthritis progression by promoting integrin β1-SMAD1 interaction.  Lian C, Wang X, Qiu X, Wu Z, Gao B, Liu L, Liang G, Zhou H, Yang X, Peng Y, Liang A, Xu C, Huang D, Su P.  Bone Res  2019    PubMed ID: 30854241
4055  Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-κB pathway.  Chang SH, Mori D, Kobayashi H, Mori Y, Nakamoto H, Okada K, Taniguchi Y, Sugita S, Yano F, Chung UI, Kim-Kaneyama JR, Yanagita M, Economides A, Canalis E, Chen D, Tanaka S, Saito T.  Nat Commun  2019  10:1442  PubMed ID: 30926814
4144  Delta-like 2 negatively regulates chondrogenic differentiation.  Xu W, Wang Y, Zhao H, Fan B, Guo K, Cai M, Zhang S.  J. Cell. Physiol.  2018    PubMed ID: 29057471
4145  Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice.  Hirota Y, Nakagawa K, Isomoto K, Sakaki T, Kubodera N, Kamao M, Osakabe N, Suhara Y, Okano T.  PLoS ONE  2018    PubMed ID: 30281599
4146  Inclusion Body Expression and Refolding of Recombinant Bone Morphogenetic Protein-2.  Nasrabadi D, Rezaeiani S, Sayadmanesh A, Baghaban Eslaminejad M, Shabani A.  Avicenna J Med Biotechnol  2018    PubMed ID: 30555651
4147  Tanshinone IIA protects murine chondrogenic ATDC5 cells from lipopolysaccharide-induced inflammatory injury by down-regulating microRNA-203a.  Luan L, Liang Z.  Biomed. Pharmacother.  2018    PubMed ID: 29679904
4863  Use of the SST-REX method for the identification of genes expressed at the condensation stage of chondrogenic cell line ATDC5.  Noguchi A, Watanabe N, Fujimaki R, Kitamura T, Hayashizaki Y, Miyaki S, Tezuka K, Hozumi N.  J Bone Miner Metab  2006  24(2):153-7  PubMed ID: 16502123
5399  Expression of GABAAand GABABreceptorsin rat growth plate chondrocytes: Activationof the GABA receptors promotes proliferationof mouse chondrogenic ATDC5 cells  Takumi Tamayama, Kentaro Maemura, Kiyoto Kanbara,Hana Hayasaki, Yasuaki Yabumoto, Masayoshi Yuasa,and Masahito Watanabe  Molecular and Cellular Biochemistry  2005  273:117–126 
3584  Functional gene screening system identified TRPV4 as a regulator of chondrogenic differentiation.  Muramatsu S, Wakabayashi M, Ohno T, Amano K, Ooishi R, Sugahara T, Shiojiri S, Tashiro K, Suzuki Y, Nishimura R, Kuhara S, Sugano S, Yoneda T, Matsuda A.  J Biol Chem  2007  282(44):32158-67  PubMed ID: 17804410
3917  Prostacyclin regulates bone growth via the Epac/Rap1 pathway.  Hutchison MR, White PC.  Endocrinology  2015  156(2):499-510  PubMed ID: 25406016
3957  p38 mitogen-activated protein kinase functionally contributes to chondrogenesis induced by growth/differentiation factor-5 in ATDC5 cells.  Nakamura K, Shirai T, Morishita S, Uchida S, Saeki-Miura K, Makishima F.  Exp Cell Res  1999  250(2):351-63  PubMed ID: 10413589
3971  Alteration of cGMP metabolism during chondrogenic differentiation of chondroprogenitor-like EC cells, ATDC5.  Fujishige K, Kotera J, Yanaka N, Akatsuka H, Omori K.  Biochim Biophys Acta.   1999  1452(3):219-27  PubMed ID: 10590311
3998  Inhibition of chondrocyte differentiation in vitro by constitutive and inducible overexpression of the c-fos proto-oncogene.  Thomas DP, Sunters A, Gentry A, Grigoriadis AE.  J Cell Sci.  2000  113 ( Pt 3):439-50  PubMed ID: 10639331
5978  Induction of basic helix-loop-helix protein DEC1 (BHLHB2)/Stra13/Sharp2 in response to the cyclic adenosine monophosphate pathway.  Shen M, Kawamoto T, Teramoto M, Makihira S, Fujimoto K, Yan W, Noshiro M, Kato Y.  Eur J Cell Biol  2001  80(5):329-34  PubMed ID: 11432722
6167  Expression profile of Papss2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2) during cartilage formation and skeletal development in the mouse embryo.  Stelzer C, Brimmer A, Hermanns P, Zabel B, Dietz UH.  Dev Dyn  2007  236(5):1313-8  PubMed ID: 17436279
6430  Metabolomic analysis of differential changes in metabolites during ATP oscillations in chondrogenesis.  Kwon HJ, Ohmiya Y.  Biomed Res Int  2013  2013:213972  PubMed ID: 23878799
6461  Adiponectin and leptin induce VCAM-1 expression in human and murine chondrocytes.  Conde J, Scotece M, López V, Gómez R, Lago F, Pino J, Gómez-Reino JJ, Gualillo O.  PLoS One  2012  7(12):e52533  PubMed ID: 23285079
6464  Nitric oxide boosts TLR-4 mediated lipocalin 2 expression in chondrocytes.  Gómez R, Scotece M, Conde J, Lopez V, Pino J, Lago F, Gómez-Reino JJ, Gualillo O.  J Orthop Res  2013  31(7):1046-52  PubMed ID: 23483583
6465  Transcriptional induction of ADAMTS5 protein by nuclear factor-κB (NF-κB) family member RelA/p65 in chondrocytes during osteoarthritis development.  Kobayashi H, Hirata M, Saito T, Itoh S, Chung UI, Kawaguchi H.  J Biol Chem  2013  288(40):28620-9  PubMed ID: 23963448
6469  6-Shogaol inhibits chondrocytes' innate immune responses and cathepsin-K activity.  Villalvilla A, da Silva JA, Largo R, Gualillo O, Vieira PC, Herrero-Beaumont G, Gómez R.  Mol Nutr Food Res  2014  58(2):256-66  PubMed ID: 24039109
3517  RAGE, receptor of advanced glycation endoproducts, negatively regulates chondrocytes differentiation.  Kosaka T, Fukui R, Matsui M, Kurosaka Y, Nishimura H, Tanabe M, Takakura Y, Iwai K, Waki T, Fujita T.  PLoS One  2014  9(9):e108819  PubMed ID: 25275461
3591  The importance to chondrocyte differentiation of changes in expression of the multiple inositol polyphosphate phosphatase.  Hidaka K, Kanematsu T, Caffrey JJ, Takeuchi H, Shears SB, Hirata M.  Exp Cell Res  2003  290(2):254-64  PubMed ID: 14567985
3545  Inhibition of insulin-induced chondrogenic differentiation of embryonic carcinoma cells by a teratogenic compound YM9429.  Shibata M, Fujino E, Sato Y, Numazawa S, Yoshida T, Kuroiwa Y.  Biochem Biophys Res Commun  1996  225(2):593-9  PubMed ID: 8753805
3547  Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation.  Fujii M, Takeda K, Imamura T, Aoki H, Sampath TK, Enomoto S, Kawabata M, Kato M, Ichijo H, Miyazono K.  Mol Biol Cell  1999  10(11):3801-13  PubMed ID: 10564272
3548  Midkine is expressed during repair of bone fracture and promotes chondrogenesis.  Ohta S, Muramatsu H, Senda T, Zou K, Iwata H, Muramatsu T.  J Bone Miner Res  1999  14(7):1132-44  PubMed ID: 10404013
3550  Cbfa1 is a positive regulatory factor in chondrocyte maturation.  Enomoto H, Enomoto-Iwamoto M, Iwamoto M, Nomura S, Himeno M, Kitamura Y, Kishimoto T, Komori T.  J Biol Chem  2000  275(12):8695-702  PubMed ID: 10722711
3540  Characterization of a bone morphogenetic protein-responsive Smad-binding element.  Kusanagi K, Inoue H, Ishidou Y, Mishima HK, Kawabata M, Miyazono K.  Mol Biol Cell  2000  11(2):555-65  PubMed ID: 10679014
3541  Involvement of the phosphoinositide 3-kinase/protein kinase B signaling pathway in insulin/IGF-I-induced chondrogenesis of the mouse embryonal carcinoma-derived cell line ATDC5.  Hidaka K, Kanematsu T, Takeuchi H, Nakata M, Kikkawa U, Hirata M.  Int J Biochem Cell Biol  2001  33(11):1094-103  PubMed ID: 11551825
3543  Structure and promoter analysis of the mouse membrane-bound transferrin-like protein (MTf) gene.  Nakamasu K, Kawamoto T, Yoshida E, Noshiro M, Matsuda Y, Kato Y.  Eur J Biochem  2001  268(5):1468-76  PubMed ID: 11231300
3555  FK506 induces chondrogenic differentiation of clonal mouse embryonic carcinoma cells, ATDC5.  Nishigaki F, Sakuma S, Ogawa T, Miyata S, Ohkubo T, Goto T.  Eur J Pharmacol  2002  437(3):123-8  PubMed ID: 11890899
3556  C-type natriuretic peptide/guanylate cyclase B system in ATDC5 cells, a chondrogenic cell line.  Suda M, Tanaka K, Yasoda A, Komatsu Y, Chusho H, Miura M, Tamura N, Ogawa Y, Nakao K.  J Bone Miner Metab  2002  20(3):136-41 
3557  Stimulation of osteoblastic cell differentiation by Notch.  Tezuka K, Yasuda M, Watanabe N, Morimura N, Kuroda K, Miyatani S, Hozumi N.  J Bone Miner Res  2002  17(2):231-9  PubMed ID: 11811553
3558  Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages.  Shen M, Yoshida E, Yan W, Kawamoto T, Suardita K, Koyano Y, Fujimoto K, Noshiro M, Kato Y.  J Biol Chem  2002  277(51):50112-20  PubMed ID: 12384505
3560  New signaling pathway for parathyroid hormone and cyclic AMP action on extracellular-regulated kinase and cell proliferation in bone cells. Checkpoint of modulation by cyclic AMP.  Fujita T, Meguro T, Fukuyama R, Nakamuta H, Koida M.  J Biol Chem  2002  277(25):22191-200  PubMed ID: 11956184
3561  Material Properties of Cells Can Be Determined From Compression Experiments of Cell-Gel Constructs  Jayendran Srinivasan , Vincent Kish , Vidyashankar Venkatesan , Sydha Salihu , Madhavi Ayyalasomayajula , Nilay Mukherjee  ASME 2002 International Mechanical Engineering Congress and Exposition  2002  47-48 
3563  Regulation of osteoblast, chondrocyte, and osteoclast functions by fibroblast growth factor (FGF)-18 in comparison with FGF-2 and FGF-10.  Shimoaka T, Ogasawara T, Yonamine A, Chikazu D, Kawano H, Nakamura K, Itoh N, Kawaguchi H.  J Biol Chem  2002  277(9):7493-500  PubMed ID: 11741978
3566  Effects of overexpression of membrane-bound transferrin-like protein (MTf) on chondrogenic differentiation in Vitro.  Suardita K, Fujimoto K, Oda R, Shimazu A, Miyazaki K, Kawamoto T, Kato Y.  J Biol Chem  2002  277(50):48579-86  PubMed ID: 12374788
3568  The zinc finger transcription factor Zfp60 is a negative regulator of cartilage differentiation.  Ganss B, Kobayashi H.  J Bone Miner Res  2002  17(12):2151-60  PubMed ID: 12469909
3569  Development of a cellular model to study alternative splicing of type II collagen gene.  Hatano H, Sarkar G, Bolander ME.  J Orthop Res  2002  0(3):516-9  PubMed ID: 12038625
3570  Internal ribosome entry site-mediated translation of Smad5 in vivo: requirement for a nuclear event.  Shiroki K, Ohsawa C, Sugi N, Wakiyama M, Miura K, Watanabe M, Suzuki Y, Sugano S.  Nucleic Acids Res  2002  30(13):2851-61  PubMed ID: 12087169
3549  PTHrP rescues ATDC5 cells from apoptosis induced by FGF receptor 3 mutation.  Yamanaka Y, Tanaka H, Koike M, Nishimura R, Seino Y.  J Bone Miner Res  2003  18(8):1395-403  PubMed ID: 12929929
4777  BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression.  Lee MH, Kim YJ, Kim HJ, Park HD, Kang AR, Kyung HM, Sung JH, Wozney JM, Kim HJ, Ryoo HM.  J Biol Chem  2003  278(36):34387-94. Epub 2003 Jun 18  PubMed ID: 12815054
4820  Suppression of differentiation and proliferation of early chondrogenic cells by Notch.  Watanabe N, Tezuka Y, Matsuno K, Miyatani S, Morimura N, Yasuda M, Fujimaki R, Kuroda K, Hiraki Y, Hozumi N, Tezuka K.  J Bone Miner Metab  2003  21(6):344-52  PubMed ID: 14586790
4874  Cis-acting intronic elements that regulate cartilage-specific alternative splicing of the type II collagen (Col2) pre-mRNA lie at or near splice site junction sequences flanking exon 2 of the gene.  Nishiyama T, Hatano H, Kurosaka M, Bolander ME, Sarkar G.  J Bone Miner Res  2003  18(9):1716-22  PubMed ID: 12968682
4908  A new approach to an artificial joint based on bio-cartilage/porous β-tricalcium phosphate system  Shinsuke Aoki et al  Journal of the European Ceramic Society  2003  23:2939-2946 
4937  Cystatin 10, a novel chondrocyte-specific protein, may promote the last steps of the chondrocyte differentiation pathway.  Koshizuka Y, Yamada T, Hoshi K, Ogasawara T, Chung UI, Kawano H, Nakamura Y, Nakamura K, Ikegawa S, Kawaguchi H.  J Biol Chem  2003  278(48):48259-66  PubMed ID: 13679380
4944  Anti-membrane-bound transferrin-like protein antibodies induce cell-shape change and chondrocyte differentiation in the presence or absence of concanavalin A.  Oda R, Suardita K, Fujimoto K, Pan H, Yan W, Shimazu A, Shintani H, Kato Y.  J Cell Sci  2003  116(Pt 10):2029-38  PubMed ID: 12679380
4989  Effects of retinoic acid on the differentiation of chondrogenic progenitor cells, ATDC5.  Kirimoto A1, Takagi Y, Ohya K, Shimokawa H.  J Med Dent Sci  2005  52(3):153-62  PubMed ID: 16350840
5412  Quantitative transcriptional profiling of ATDC5 mouse progenitor cells during chondrogenesis.  Chen L, Fink T, Zhang XY, Ebbesen P, Zachar V.  Differentiation  2005  73(7):350-63  PubMed ID: 16219039
5972  Interleukin-1beta induces death in chondrocyte-like ATDC5 cells through mitochondrial dysfunction and energy depletion in a reactive nitrogen and oxygen species-dependent manner.  Yasuhara R, Miyamoto Y, Akaike T, Akuta T, Nakamura M, Takami M, Morimura N, Yasu K, Kamijo R.  Biochem J  2005  389(Pt 2):315-23  PubMed ID: 15784009
6221  A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese.  Mototani H, Mabuchi A, Saito S, Fujioka M, Iida A, Takatori Y, Kotani A, Kubo T, Nakamura K, Sekine A, Murakami Y, Tsunoda T, Notoya K, Nakamura Y, Ikegawa S.  Hum Mol Genet  2005  14(8):1009-17  PubMed ID: 15746150
6230  Inhibition of Cdk6 expression through p38 MAP kinase is involved in differentiation of mouse prechondrocyte ATDC5.  Moro T, Ogasawara T, Chikuda H, Ikeda T, Ogata N, Maruyama Z, Komori T, Hoshi K, Chung UI, Nakamura K, Okayama H, Kawaguchi H.  J Cell Physiol  2005  204(3):927-33  PubMed ID: 15795936
6245  Laminin-5 suppresses chondrogenic differentiation of murine teratocarcinoma cell line ATDC5.  Hashimoto J, Ogawa T, Tsubota Y, Miyazaki K.  Exp Cell Res  2005  310(2):256-69  PubMed ID: 16165127
4968  Phenytoin stimulates chondrogenic differentiation in mouse clonal chondrogenic EC cells, ATDC5.  Okada A, Shiomi T, Aoki Y, Fujiwara M.  J Toxicol Sci  2005  30(3):145-56  PubMed ID: 16141649
6222  GPI-specific phospholipase D (GPI-PLD) is expressed during mouse development and is localized to the extracellular matrix of the developing mouse skeleton.  Gregory P, Kraemer E, Zürcher G, Gentinetta R, Rohrbach V, Brodbeck U, Andres AC, Ziemiecki A, Bütikofer P.  Bone  2005  37(2):139-47  PubMed ID: 15946906
6247  Dexamethasone inhibits insulin-induced chondrogenesis of ATDC5 cells by preventing PI3K-Akt signaling and DNA binding of Runx2.  Fujita T, Fukuyama R, Enomoto H, Komori T.  J Cell Biochem  2004  93(2):374-83  PubMed ID: 1536836
6294  Oligonucleotide decoy mimicking alphaA-crystallin-binding protein 1 binding site on mouse Col2a1 enhancer stimulates transcription from the adjacent Col2a1 promoter in chondrogenic ATDC5 cell.  Yamagiwa H, Yamada Y, Bolander ME, Sarkar G.  Mol Biotechnol  2004  28(1):1-8  PubMed ID: 15456958
6345  Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins.  Binnerts ME, Wen X, Canté-Barrett K, Bright J, Chen HT, Asundi V, Sattari P, Tang T, Boyle B, Funk W, Rupp F.  Biochem Biophys Res Commun  2004  315(2):272-80  PubMed ID: 14766204
6373  Evaluation of different conditions for ligating dumbbell-shaped oligonucleotides.  Yamagiwa H, Bolander ME, Sarkar G.  Mol Biotechnol  2004  26(2):111-6  PubMed ID: 14764936
6478  Excess magnesium inhibits excess calcium-induced matrix-mineralization and production of matrix gla protein (MGP) by ATDC5 cells.  Nakatani S, Mano H, Ryanghyok IM, Shimizu J, Wada M.  Biochem Biophys Res Commun  2006  348(3):1157-62  PubMed ID: 16904632
6479  The nitric oxide donor sodium nitroprusside inhibits mineralization in ATDC5 cells.  Huitema LF, Vaandrager AB, van Weeren PR, Barneveld A, Helms JB, van de Lest CH.  Calcif Tissue Int  2006  78(3):171-7  PubMed ID: 16523220
6481  The Wnt-inducible transcription factor Twist1 inhibits chondrogenesis.  Reinhold MI, Kapadia RM, Liao Z, Naski MC.  J Biol Chem  2006  281(3):1381-8  PubMed ID: 16293629
6482  Milk growth factor (MGF) induces transformation into ATDC5 cells, prechondrocytes, and cooperates with retinoic acid to transform the cells into new forms.  Kanda Y1, Hisayasu S, Fukai F, Takase B.  Life Sci  2006  78(6):640-8  PubMed ID: 16111716
6484  Iron ions derived from the nitric oxide donor sodium nitroprusside inhibit mineralization.  Huitema LF, van Weeren PR, Barneveld A, van de Lest CH, Helms JB, Vaandrager AB.  Eur J Pharmacol  2006  542(1-3):48-53  PubMed ID: 16828741
6485  Elevated expression of hypoxia inducible factor-2alpha in terminally differentiating growth plate chondrocytes.  Stewart AJ, Houston B, Farquharson C.  J Cell Physiol  2006  206(2):435-40  PubMed ID: 16155924
6486  The role of insulin in chondrogenesis.  Phornphutkul C, Wu KY, Gruppuso PA.  Mol Cell Endocrinol  2006  249(1-2):107-15  PubMed ID: 1653093
6487  Up-regulation of per mRNA expression by parathyroid hormone through a protein kinase A-CREB-dependent mechanism in chondrocytes.  Hinoi E, Ueshima T, Hojo H, Iemata M, Takarada T, Yoneda Y.  J Biol Chem  2006  281(33):23632-42  PubMed ID: 16777848
6488  Optimized chondrogenesis of ATCD5 cells through sequential regulation of oxygen conditions.  Chen L, Fink T, Ebbesen P, Zachar V.  Tissue Eng  2006  12(3):559-67  PubMed ID: 16579689
6489  TWEAK/Fn14 interaction regulates RANTES production, BMP-2-induced differentiation, and RANKL expression in mouse osteoblastic MC3T3-E1 cells.  Ando T, Ichikawa J, Wako M, Hatsushika K, Watanabe Y, Sakuma M, Tasaka K, Ogawa H, Hamada Y, Yagita H, Nakao A.  Arthritis Res Ther  2006  8(5):R146  PubMed ID: 16945157
6490  Pro-inflammatory cytokine tumor necrosis factor-alpha induces bone morphogenetic protein-2 in chondrocytes via mRNA stabilization and transcriptional up-regulation.  Fukui N, Ikeda Y, Ohnuki T, Hikita A, Tanaka S, Yamane S, Suzuki R, Sandell LJ, Ochi T.  J Biol Chem  2006  281(37):27229-41  PubMed ID: 16835229
6491  The restricted potential for recovery of growth plate chondrogenesis and longitudinal bone growth following exposure to pro-inflammatory cytokines.  MacRae VE, Farquharson C, Ahmed SF.  J Endocrinol  2006  189(2):319-28  PubMed ID: 16648299
6492  Ceramide inhibition of chondrocyte proliferation and bone growth is IGF-I independent.  MacRae VE, Burdon T, Ahmed SF, Farquharson C.  J Endocrinol  2006  191(2):369-77  PubMed ID: 17088406
6494  Glucosamine regulates differentiation of a chondrogenic cell line, ATDC5.  Nakatani S, Mano H, Im R, Shimizu J, Wada M.  Biol Pharm Bull  2007  30(3):433-8  PubMed ID: 17329833
6495  The MR tracking of transplanted ATDC5 cells using fluorinated poly-L-lysine-CF3.  Maki J, Masuda C, Morikawa S, Morita M, Inubushi T, Matsusue Y, Taguchi H, Tooyama I.  Biomaterials  2007  28(3):434-40  PubMed ID: 16978693
6496  Enamel matrix derivative stimulates chondrogenic differentiation of ATDC5 cells.  Narukawa M, Suzuki N, Takayama T, Shoji T, Otsuka K, Ito K.  J Periodontal Res  2007  42(2):131-7  PubMed ID: 17305871
6497  Soluble factors released by ATDC5 cells affect the formation of calcium phosphate crystals.  Huitema LF, van Weeren PR, van Balkom BW, Visser T, van de Lest CH, Barneveld A, Helms JB, Vaandrager AB.  Biochim Biophys Acta  2007  1774(9):1108-17  PubMed ID: 17669701
6498  Mechanisms for asporin function and regulation in articular cartilage.  Nakajima M, Kizawa H, Saitoh M, Kou I, Miyazono K, Ikegawa S.  J Biol Chem  2007  282(44):32185-92  PubMed ID: 17827158
6499  IGF-I signalling in bone growth: inhibitory actions of dexamethasone and IL-1beta.  Macrae VE, Ahmed SF, Mushtaq T, Farquharson C.  Growth Horm IGF Res  2007  17(5):435-9  PubMed ID: 17590365
6500  Nuclear factor E2 p45-related factor 2 negatively regulates chondrogenesis.  Hinoi E, Takarada T, Fujimori S, Wang L, Iemata M, Uno K, Yoneda Y.  Bone  2007  40(2):337-44  PubMed ID: 17029980
6501  Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling.  Suemoto H, Muragaki Y, Nishioka K, Sato M, Ooshima A, Itoh S, Hatamura I, Ozaki M, Braun A, Gustafsson E, Fässler R.  Dev Biol  2007  312(2):572-81  PubMed ID: 17997399
6502  Novel function of TWEAK in inducing intervertebral disc degeneration.  Wako M, Haro H, Ando T, Hatsushika K, Ohba T, Iwabuchi S, Nakao A, Hamada Y.  J Orthop Res  2007  25(11):1438-46  PubMed ID: 17568422
6503  Regulation of the human SOX9 promoter by Sp1 and CREB.  Piera-Velazquez S, Hawkins DF, Whitecavage MK, Colter DC, Stokes DG, Jimenez SA.  Exp Cell Res  2007  313(6):1069-79  PubMed ID: 17289023
6504  The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438.  Owen HC, Miner JN, Ahmed SF, Farquharson C.  Mol Cell Endocrinol  2007  264(1-2):164-70  PubMed ID: 17182172
6505  Identification and characterization of the human SOX6 promoter.  Ikeda T, Saito T, Ushita M, Yano F, Kan A, Itaka K, Moro T, Nakamura K, Kawaguchi H, Chung UI.  Biochem Biophys Res Commun  2007  357(2):383-90  PubMed ID: 17433257
6506  The 5' untranslated regions (UTRs) of CCN1, CCN2, and CCN4 exhibit cryptic promoter activity.  Huang BL, Dornbach LM, Lyons KM.  J Cell Commun Signal  2007  1(1):17-32  PubMed ID: 18481207
6507  Production of sex steroid hormones from DHEA in articular chondrocyte of rats.  Takeuchi S, Mukai N, Tateishi T, Miyakawa S.  Am J Physiol Endocrinol Metab  2007  293(1):E410-5  PubMed ID: 17473054
6509  Healing of full-thickness defects of the articular cartilage in rabbits using fibroblast growth factor-2 and a fibrin sealant.  Ishii I, Mizuta H, Sei A, Hirose J, Kudo S, Hiraki Y.  J Bone Joint Surg Br  2007  89(5):693-700  PubMed ID: 17540759
6510  Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells.  Itoh S, Kanno S, Gai Z, Suemoto H, Kawakatsu M, Tanishima H, Morimoto Y, Nishioka K, Hatamura I, Yoshida M, Muragaki Y.  Genes Cells  2008  13(4):355-63  PubMed ID: 18363966
6511  A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7.  Sengle G, Ono RN, Lyons KM, Bächinger HP, Sakai LY.  J Mol Biol  2008  381(4):1025-39  PubMed ID: 18621057
6512  Development of a cell culture system loading cyclic mechanical strain to chondrogenic cells.  Masuda T, Takahashi I, Anada T, Arai F, Fukuda T, Takano-Yamamoto T, Suzuki O.  J Biotechnol  2008  133(2):231-8  PubMed ID: 17904677
6513  Effect of estrogen on bone resorption and inflammation in the temporomandibular joint cellular elements.  Galal N, El Beialy W, Deyama Y, Yoshimura Y, Yoshikawa T, Suzuki K, Totsuka Y.  Int J Mol Med  2008  21(6):785-90  PubMed ID: 18506373
6514  Pivotal role of Bcl-2 family proteins in the regulation of chondrocyte apoptosis.  Oshima Y, Akiyama T, Hikita A, Iwasawa M, Nagase Y, Nakamura M, Wakeyama H, Kawamura N, Ikeda T, Chung UI, Hennighausen L, Kawaguchi H, Nakamura K, Tanaka S.  J Biol Chem  2008  283(39):26499-508  PubMed ID: 18632667
6515  Expression and activity of Runx2 mediated by hyaluronan during chondrocyte differentiation.  Tanne Y, Tanimoto K, Tanaka N, Ueki M, Lin YY, Ohkuma S, Kamiya T, Tanaka E, Tanne K.  Arch Oral Biol  2008  53(5):478-87  PubMed ID: 18242579
6516  Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model.  Nasu Y, Nishida K, Miyazawa S, Komiyama T, Kadota Y, Abe N, Yoshida A, Hirohata S, Ohtsuka A, Ozaki T.  Osteoarthritis Cartilage  2008  16(6):723-32  PubMed ID: 18226559
6517  Serine racemase suppresses chondrogenic differentiation in cartilage in a Sox9-dependent manner.  Takarada T, Hinoi E, Takahata Y, Yoneda Y.  J Cell Physiol  2008  215(2):320-8  PubMed ID: 17929246
6518  Identification of a novel splice variant of the haloacid dehalogenase: PHOSPHO1.  Roberts SJ, Owen HC, Farquharson C.  Biochem Biophys Res Commun  2008  371(4):872-6  PubMed ID: 18471996
6519  Paraspeckle protein p54nrb links Sox9-mediated transcription with RNA processing during chondrogenesis in mice.  Hata K, Nishimura R, Muramatsu S, Matsuda A, Matsubara T, Amano K, Ikeda F, Harley VR, Yoneda T.  J Clin Invest  2008  118(9):3098-108  PubMed ID: 18677406
6520  Leucine restriction inhibits chondrocyte proliferation and differentiation through mechanisms both dependent and independent of mTOR signaling.  Kim MS, Wu KY, Auyeung V, Chen Q, Gruppuso PA, Phornphutkul C.  Am J Physiol Endocrinol Metab  2009  296(6):E1374-82  PubMed ID: 19401455
6521  Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9.  Shinoda Y, Ogata N, Higashikawa A, Manabe I, Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung UI, Kawaguchi H.  J Biol Chem  2008  283(36):24682-9  PubMed ID: 18617520
6522  Small molecules in stem cell self-renewal and differentiation.  Schugar RC, Robbins PD, Deasy BM.  Gene Ther  2008  15(2):126-35  PubMed ID: 17989703
6523  Evaluation of RGD- or EGF-immobilized chitosan scaffolds for chondrogenic activity.  Tiğli RS, Gümüşderelioğlu M.  Int J Biol Macromol  2008  43(2):121-8  PubMed ID: 18485469
6524  Dexamethasone-induced expression of the glucocorticoid response gene lipocalin 2 in chondrocytes.  Owen HC, Roberts SJ, Ahmed SF, Farquharson C.  Am J Physiol Endocrinol Metab  2008  294(6):E1023-34  PubMed ID: 18381927
6531  Screening of chondrogenic factors with a real-time fluorescence-monitoring cell line ATDC5-C2ER: identification of sorting nexin 19 as a novel factor.  Kan A, Ikeda T, Saito T, Yano F, Fukai A, Hojo H, Ogasawara T, Ogata N, Nakamura K, Chung UI, Kawaguchi H.  Arthritis Rheum  2009  60(11):3314-23  PubMed ID: 19877062
6532  Transcriptional induction of SOX9 by NF-kappaB family member RelA in chondrogenic cells.  Ushita M, Saito T, Ikeda T, Yano F, Higashikawa A, Ogata N, Chung U, Nakamura K, Kawaguchi H.  Osteoarthritis Cartilage  2009  17(8):1065-75  PubMed ID: 19254740
6533  Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type X collagen gene.  Arthritis Rheum  Higashikawa A, Saito T, Ikeda T, Kamekura S, Kawamura N, Kan A, Oshima Y, Ohba S, Ogata N, Takeshita K, Nakamura K, Chung UI, Kawaguchi H.  2009  60(1):166-78  PubMed ID: 19116917
6534  Transcriptional regulation of fibrillin-2 gene by E2F family members in chondrocyte differentiation.  Yanagino T, Yuasa K, Nagahama M, Matsuda Y, Tsuji A.  J Cell Biochem  2009  106(4):580-8  PubMed ID: 19142862
6535  Receptor oligomerization and beyond: a case study in bone morphogenetic proteins.  Heinecke K, Seher A, Schmitz W, Mueller TD, Sebald W, Nickel J.  BMC Biol  2009  7:59  PubMed ID: 19735544
6536  Isolation and characterization of a novel plasma membrane protein, osteoblast induction factor (obif), associated with osteoblast differentiation.  Kanamoto T, Mizuhashi K, Terada K, Minami T, Yoshikawa H, Furukawa T.  BMC Dev Biol  2009  9:70  PubMed ID: 20025746
6537  Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis.  Saito A, Hino S, Murakami T, Kanemoto S, Kondo S, Saitoh M, Nishimura R, Yoneda T, Furuichi T, Ikegawa S, Ikawa M, Okabe M, Imaizumi K. Author information  Nat Cell Biol  2009  11(10):1197-204  PubMed ID: 19767744
6538  Sox9 family members negatively regulate maturation and calcification of chondrocytes through up-regulation of parathyroid hormone-related protein.  Amano K, Hata K, Sugita A, Takigawa Y, Ono K, Wakabayashi M, Kogo M, Nishimura R, Yoneda T.  Mol Biol Cell  2009  20(21):4541-51  PubMed ID: 19759178
6539  Increased bone mass, altered trabecular architecture and modified growth plate organization in the growing skeleton of SOCS2 deficient mice.  Macrae VE, Horvat S, Pells SC, Dale H, Collinson RS, Pitsillides AA, Ahmed SF, Farquharson C.  J Cell Physiol  2009  218(2):276-84  PubMed ID: 18803233
11510  CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth.  Choi S, Kim HY, Cha PH, Seo SH, Lee C, Choi Y, Shin W, Heo Y, Han G, Lee W, Choi KY.  Life Sci Alliance  2019    PubMed ID: 30971423
11512  Long non-coding RNA highly up-regulated in liver cancer protects tumor necrosis factor-alpha-induced inflammatory injury by down-regulation of microRNA-101 in ATDC5 cells.  Chu P, Wang Q, Wang Z, Gao C.  Int. Immunopharmacol.  2019    PubMed ID: 30981080
11519  Involvement of ADAM12 in Chondrocyte Differentiation by Regulation of TGF-β1-Induced IGF-1 and RUNX-2 Expressions.  Horita M, Nishida K, Hasei J, Furumatsu T, Sakurai M, Onodera Y, Fukuda K, Salter DM, Ozaki T.  Calcif. Tissue Int.  2019    PubMed ID: 30993375
11532  Long noncoding RNA CHRF exacerbates IL-6-induced inflammatory damages by downregulating microRNA-146a in ATDC5 cells.  Yu C, Shi D, Li Z, Wan G, Shi X.  J. Cell. Physiol.  2019    PubMed ID: 31026064
11564  Green tea polyphenols attenuate LPS-induced inflammation through upregulating microRNA-9 in murine chondrogenic ATDC5 cells.  Zhang Q, Wang Y, Zhang M, Ying H.  J. Cell. Physiol.  2019    PubMed ID: 31102286
11588  METTL3 promotes experimental osteoarthritis development by regulating inflammatory response and apoptosis in chondrocyte.  Liu Q, Li M, Jiang L, Jiang R, Fu B.  Biochem. Biophys. Res. Commun.  2019    PubMed ID: 31186141
11592  Exogenous C-type natriuretic peptide therapy for impaired skeletal growth in a murine model of glucocorticoid treatment.  Ueda Y, Yasoda A, Hirota K, Yamauchi I, Yamashita T, Kanai Y, Sakane Y, Fujii T, Inagaki N.  Sci Rep  2019    PubMed ID: 31189976
11597  LINC00305 represses miR-124 expression to trigger inflammatory insults in the presence of lipopolysaccharide.  Li X, Yu M, Han L, Chen L, Zhang D, Zhou G, Zhao Q, Sun T.  Artif Cells Nanomed Biotechnol  2019    PubMed ID: 31190561
11605  Loss of autophagy in chondrocytes causes severe growth retardation.  Horigome Y, Ida-Yonemochi H, Waguri S, Shibata S, Endo N, Komatsu M.  Autophagy  2019    PubMed ID: 31203752
11606  MiR-19b-3p attenuates IL-1β induced extracellular matrix degradation and inflammatory injury in chondrocytes by targeting GRK6.  Duan L, Duan D, Wei W, Sun Z, Xu H, Guo L, Wu X.  Mol. Cell. Biochem.  2019    PubMed ID: 31227976
11650  Artesunate alleviates interleukin‑1β‑induced inflammatory response and apoptosis by inhibiting the NF‑κB signaling pathway in chondrocyte‑like ATDC5 cells, and delays the progression of osteoarthritis in a mouse model.  Li Y, Mu W, Ren J, Wuermanbieke S, Wahafu T, Ji B, Ma H, Amat A, Zhang K, Cao L.  Int. J. Mol. Med.  2019    PubMed ID: 31364719
11680  Nanocarrier systems assembled from PEGylated hyperbranched poly(arylene oxindole)  Al HalifaSoultan, Dennis Lambrechts, Thomas Verheyen, Hans Van Gorp, Maarten B.J. Roeffaers, Mario Smet, Wim M. De Borggraeve, Jennifer Patterson  European Polymer Journal  2019   
11741  Hyaluronan promotes TRPV4-induced chondrogenesis in ATDC5 cells.  Ogawa Y, Takahashi N, Takemoto T, Nishiume T, Suzuki M, Ishiguro N, Kojima T.  PLoS ONE  2019    PubMed ID: 31393869
11785  In Vitro Release of Bioactive Bone Morphogenetic Proteins (GDF5, BB-1, and BMP-2) from a PLGA Fiber-Reinforced, Brushite-Forming Calcium Phosphate Cement.  Gunnella F, Kunisch E, Horbert V, Maenz S, Bossert J, Jandt KD, Plöger F, Kinne RW.  Pharmaceutics  2019    PubMed ID: 31484306
11789  lncRNA‑NR024118 overexpression reverses LPS‑induced inflammatory injury and apoptosis via NF‑κB/Nrf2 signaling in ATDC5 chondrocytes.  Mei X, Tong J, Zhu W, Zhu Y.  Mol Med Rep  2019    PubMed ID: 31485657
11803  Indirubin-3'-oxime stimulates chondrocyte maturation and longitudinal bone growth via activation of the Wnt/β-catenin pathway.  Choi S, Cha PH, Kim HY, Choi KY.  Exp. Mol. Med.  2019    PubMed ID: 31515471
11843  FOXO1 transcription factor regulates chondrogenic differentiation through transforming growth factor β1 signaling.  Kurakazu I, Akasaki Y, Hayashida M, Tsushima H, Goto N, Sueishi T, Toya M, Kuwahara M, Okazaki K, Duffy T, Lotz MK, Nakashima Y.  J. Biol. Chem.  2019    PubMed ID: 31601652
11853  Neural EGFL like 1 as a potential pro-chondrogenic, anti-inflammatory dual-functional disease-modifying osteoarthritis drug.  Li C, Zheng Z, Ha P, Jiang W, Berthiaume EA, Lee S, Mills Z, Pan H, Chen EC, Jiang J, Culiat CT, Zhang X, Ting K, Soo C.  Biomaterials  2020    PubMed ID: 31634652
4605  In vitro differentiation of chondrogenic ATDC5 cells is enhanced by culturing on synthetic hydrogels with various charge densities.  Kwon HJ, Yasuda K, Ohmiya Y, Honma K, Chen YM, Gong JP.  Acta Biomater  2010  6(2):494-501  PubMed ID: 19651251
4608  Inhibitory effect of lactoferrin on hypertrophic differentiation of ATDC5 mouse chondroprogenitor cells.  Takayama Y, Mizumachi K.  Biometals  2010  23(3):477-84  PubMed ID: 20094900
4655  Activation of epidermal growth factor receptor gene is involved in transforming growth factor-beta-mediated fibronectin expression in a chondrocyte progenitor cell line.  Takeda H, Inoue H, Kutsuna T, Matsushita N, Takahashi T, Watanabe S, Higashiyama S, Yamamoto H.  Int J Mol Med  2010  25(4):593-600  PubMed ID: 20198308
4669  The cleavage of N-cadherin is essential for chondrocyte differentiation.  Nakazora S, Matsumine A, Iino T, Hasegawa M, Kinoshita A, Uemura K, Niimi R, Uchida A, Sudo A.  Biochem Biophys Res Commun  2010  400(4):493-9  PubMed ID: 20735983
4678  SCF, BDNF, and Gas6 are regulators of growth plate chondrocyte proliferation and differentiation.  Hutchison MR1, Bassett MH, White PC.  Mol Endocrinol  2010  24(1):193-203  PubMed ID: 19897599
4679  The transcription factor Znf219 regulates chondrocyte differentiation by assembling a transcription factory with Sox9.  Takigawa Y, Hata K, Muramatsu S, Amano K, Ono K, Wakabayashi M, Matsuda A, Takada K, Nishimura R, Yoneda T.  J Cell Sci  2010  123(Pt 21):3780-8  PubMed ID: 20940257
4790  Controlled release of NELL-1 protein from chitosan/hydroxyapatite-modified TCP particles.  Zhang Y, Dong R2, Park Y1, Bohner M3, Zhang X4, Ting K5, Soo C5, Wu BM6.  Int J Pharm  2016  511(1):79-89  PubMed ID: 27349789
4791  RB1CC1 protein suppresses type II collagen synthesis in chondrocytes and causes dwarfism.  Nishimura I, Chano T, Kita H, Matsusue Y, Okabe H.  J Biol Chem  2011  286(51):43925-32  PubMed ID: 22049074
4864  Fibronectin regulates proteoglycan production balance in transforming growth factor-β1-induced chondrogenesis.  Kutsuna T, Inoue H, Takeda H, Takahashi T, Yamamoto H, Miura H, Higashiyama S.  Int J Mol Med.  2011  28(5):829-34  PubMed ID: 21822533
4882  C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes.  Hirata M, Kugimiya F, Fukai A, Saito T, Yano F, Ikeda T, Mabuchi A, Sapkota BR, Akune T, Nishida N, Yoshimura N, Nakagawa T, Tokunaga K, Nakamura K, Chung UI, Kawaguchi H.  Hum Mol Genet.   2012  21(5):1111-23  PubMed ID: 22095691
4922  Chondrogenic ATDC5 cells: an optimised model for rapid and physiological matrix mineralisation.  Newton PT, Staines KA, Spevak L, Boskey AL, Teixeira CC, Macrae VE, Canfield AE, Farquharson C.  Int J Mol Med  2012  30(5):1187-93  PubMed ID: 22941229
4939  FGF-2 inhibits TNF-α mediated apoptosis through upregulation of Bcl2-A1 and Bcl-xL in ATDC5 cells.  Kim HR1, Heo YM, Jeong KI Kim YM, Jang HL, Lee KY, Yeo CY, Kim SH, Lee HK, Kim SR, Kim EG, Choi JK.  BMB Rep  2012  ;45(5):287-92  PubMed ID: 22617452
4943  Increased expression of the histamine H4 receptor subtype in hypertrophic differentiation of chondrogenic ATDC5 cells.  Yamaura K, Akiyama S, Ueno K.  J Cell Biochem  2012  113(3):1054-60  PubMed ID: 22065367
4965  Chondroregulatory action of prolactin on proliferation and differentiation of mouse chondrogenic ATDC5 cells in 3-dimensional micromass cultures.  Seriwatanachai D, Krishnamra N, Charoenphandhu N.  Biochem Biophys Res Commun  2012  420(1):108-13  PubMed ID: 22405773
5029  Adhesive force behavior of single ATDC5 cells in chondrogenic culture.  Kambe Y, Hayashi N, Tomita N.  Biochem Biophys Res Commun  2012  420(2):241-6  PubMed ID: 22425987
5270  Isopsoralen Induces Differentiation of Prechondrogenic ATDC5 Cells via Activation of MAP Kinases and BMP-2 Signaling Pathways.  Li L, Eun JS, Nepal M, Ryu JH, Cho HK, Choi BY, Soh Y.  Biomol Ther (Seoul)  2012  20(3):299-305  PubMed ID: 24130927
5310  Biocompatibility and bone tissue compatibility of alumina ceramics reinforced with carbon nanotubes.  Ogihara N, Usui Y, Aoki K, Shimizu M, Narita N, Hara K, Nakamura K, Ishigaki N, Takanashi S, Okamoto M, Kato H, Haniu H, Ogiwara N, Nakayama N, Taruta  Nanomedicine (Lond).  2012  7(7):981-93  PubMed ID: 22401267
5318  Basic helix-loop-helix transcription factor Twist1 inhibits transactivator function of master chondrogenic regulator Sox9.  Gu S, Boyer TG, Naski MC.  J Biol Chem.   2012  287(25):21082-92  PubMed ID: 22532563
5341  A semi-autonomous model of endochondral ossification for developmental tissue engineering.  Weiss HE, Roberts SJ, Schrooten J, Luyten FP.  Tissue Eng Part A  2012  18(13-14):1334-43  PubMed ID: 22394057
5433  GSK-3α and GSK-3β proteins are involved in early stages of chondrocyte differentiation with functional redundancy through RelA protein phosphorylation.  Itoh S, Saito T, Hirata M, Ushita M, Ikeda T, Woodgett JR, Algül H, Schmid RM, Chung UI, Kawaguchi H.  J Biol Chem  2012  287(35):29227-36  PubMed ID: 22761446
6232  A microfabricated platform to form three-dimensional toroidal multicellular aggregate.  Masuda T, Takei N, Nakano T, Anada T, Suzuki O, Arai F.  Biomed Microdevices  2012  14(6):1085-93  PubMed ID: 22996697
6233  Chondrocyte-intrinsic Smad3 represses Runx2-inducible matrix metalloproteinase 13 expression to maintain articular cartilage and prevent osteoarthritis.  Chen CG, Thuillier D, Chin EN, Alliston T.  Arthritis Rheum  2012  64(10):3278-89  PubMed ID: 22674505
6415  Chitosan-based nanoparticles as a sustained protein release carrier for tissue engineering applications.  Hou Y, Hu J, Park H, Lee M.  J Biomed Mater Res A  2012  100(4):939-47  PubMed ID: 22275184
6416  SOCS2 is the critical regulator of GH action in murine growth plate chondrogenesis.  Pass C, MacRae VE, Huesa C, Faisal Ahmed S, Farquharson C.  J Bone Miner Res  2012  27(5):1055-66  PubMed ID: 22228213
6420  Beta-tricalcium phosphate particles as a controlled release carrier of osteogenic proteins for bone tissue engineering.  Hu J, Hou Y, Park H, Lee M.  J Biomed Mater Res A  2012  100(7):1680-6  PubMed ID: 22447727
6421  Osterix regulates calcification and degradation of chondrogenic matrices through matrix metalloproteinase 13 (MMP13) expression in association with transcription factor Runx2 during endochondral ossification.  Nishimura R, Wakabayashi M, Hata K, Matsubara T, Honma S, Wakisaka S, Kiyonari H, Shioi G, Yamaguchi A, Tsumaki N, Akiyama H, Yoneda T.  J Biol Chem  2012  287(40):33179-90  PubMed ID: 22869368
6472  Mechanisms involved in inhibition of chondrogenesis by activin-A.  Mitsugi S, Ariyoshi W, Okinaga T, Kaneuji T, Kataoka Y, Takahashi T, Nishihara T.  Biochem Biophys Res Commun  2012  420(2):380-4  PubMed ID: 22425773
6473  New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance.  Schwaerzer GK, Hiepen C, Schrewe H, Nickel J, Ploeger F, Sebald W, Mueller T, Knaus P.  J Bone Miner Res  2012  27(2):429-42  PubMed ID: 21976273
6540  MEPE is a novel regulator of growth plate cartilage mineralization.  Staines KA, Mackenzie NC, Clarkin CE, Zelenchuk L, Rowe PS, MacRae VE, Farquharson C.  Bone  2012  51(3):418-30  PubMed ID: 22766095
6541  Indian Hedgehog signalling triggers Nkx3.2 protein degradation during chondrocyte maturation.  Choi SW, Jeong DU, Kim JA, Lee B, Joeng KS, Long F, Kim DW.  Biochem J  2012  443(3):789-98  PubMed ID: 22507129
6542  Positive regulation by γ-aminobutyric acid B receptor subunit-1 of chondrogenesis through acceleration of nuclear translocation of activating transcription factor-4.  Takahata Y, Hinoi E, Takarada T, Nakamura Y, Ogawa S, Yoneda Y.  J Biol Chem  2012  287(40):33293-303  PubMed ID: 22879594
6543  SnoN suppresses maturation of chondrocytes by mediating signal cross-talk between transforming growth factor-β and bone morphogenetic protein pathways.  Kawamura I, Maeda S, Imamura K, Setoguchi T, Yokouchi M, Ishidou Y, Komiya S.  J Biol Chem  2012  287(34):29101-13  PubMed ID: 22767605
6544  Clock genes influence gene expression in growth plate and endochondral ossification in mice.  Takarada T, Kodama A, Hotta S, Mieda M, Shimba S, Hinoi E, Yoneda Y.  J Biol Chem  2012  287(43):36081-95  PubMed ID: 22936800
6545  TGF-β but not BMP signaling induces prechondrogenic condensation through ATP oscillations during chondrogenesis.  Kwon HJ.  Biochem Biophys Res Commun  2012  424(4):793-800  PubMed ID: 22814106
6546  Surface characterization of polyethylene terephthalate films treated by ammonia low-temperature plasma  Zhiwen Zheng et al  Applied Surface Science  2012  258:7207-7212 
6547  The increase in O-linked N-acetylglucosamine protein modification stimulates chondrogenic differentiation both in vitro and in vivo.  Andrés-Bergós J, Tardio L, Larranaga-Vera A, Gómez R, Herrero-Beaumont G, Largo R.  J Biol Chem  2012  287(40):33615-28  PubMed ID: 22859309
6548  Early stage structural evolution of PLLA porous scaffolds in thermally induced phase separation process and the corresponding biodegradability and biological property  Jundong Shao et al  Polymer Degradation and Stability  2012  97:955-963 
6549  ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation.  Allen JL, Cooke ME, Alliston T.  Mol Biol Cell  2012  23(18):3731-42  PubMed ID: 22833566
6550  BDNF alters ERK/p38 MAPK activity ratios to promote differentiation in growth plate chondrocytes.  Hutchison MR.  Mol Endocrinol  2012  26(8):1406-16  PubMed ID: 22700586
6551  Procyanidin B3 prevents articular cartilage degeneration and heterotopic cartilage formation in a mouse surgical osteoarthritis model.  Aini H, Ochi H, Iwata M, Okawa A, Koga D, Okazaki M, Sano A, Asou Y.  PLoS One  2012  7(5):e37728  PubMed ID: 22629448
6552  Osteoclastogenesis is negatively regulated by D-serine produced by osteoblasts.  Takarada T, Takarada-Iemata M, Takahata Y, Yamada D, Yamamoto T, Nakamura Y, Hinoi E, Yoneda Y.  J Cell Physiol  2012  227(10):3477-87  PubMed ID: 22252936
6553  Extracellular ATP signaling via P2X(4) receptor and cAMP/PKA signaling mediate ATP oscillations essential for prechondrogenic condensation.  Kwon HJ.  J Endocrinol  2012  214(3):337-48  PubMed ID: 22685336
6556  Kaempferol induces chondrogenesis in ATDC5 cells through activation of ERK/BMP-2 signaling pathway.  Nepal M, Li L, Cho HK, Park JK, Soh Y.  Food Chem Toxicol  2013  62:238-45  PubMed ID: 23989061
6557  Human YKL39 (chitinase 3-like protein 2), an osteoarthritis-associated gene, enhances proliferation and type II collagen expression in ATDC5 cells.  Miyatake K, Tsuji K, Yamaga M, Yamada J, Matsukura Y, Abula K, Sekiya I, Muneta T.  Biochem Biophys Res Commun  2013  431(1):52-7  PubMed ID: 23291184
6559  Octacalcium phosphate suppresses chondrogenic differentiation of ATDC5 cells.  Shibuya I, Yoshimura K, Miyamoto Y, Yamada A, Takami M, Suzawa T, Suzuki D, Ikumi N, Hiura F, Anada T, Suzuki O, Kamijo R.  Cell Tissue Res  2013  352(2):401-12  PubMed ID: 23274552
6560  Amelogenin splice isoforms stimulate chondrogenic differentiation of ATDC5 cells.  Mitani K1 Haruyama N, Hatakeyama J, Igarashi K.  Oral Dis  2013  19(2):169-79  PubMed ID: 22863294
6561  Double-stranded RNA-dependent protein kinase regulates insulin-stimulated chondrogenesis in mouse clonal chondrogenic cells, ATDC-5.  Morimoto H, Baba R, Haneji T, Doi Y.  Cell Tissue Res  2013  351(1):41-7  PubMed ID: 23180319
6562  Negative correlation between Per1 and Sox6 expression during chondrogenic differentiation in pre-chondrocytic ATDC5 cells.  Le NQ, Binh NT, Takarada T, Takarada-Iemata M, Hinoi E, Yoneda Y.  J Pharmacol Sci  2013  122(4):318-25  PubMed ID: 23883486
6563  Hyaluronic acid affects the in vitro induction effects of synthetic PAMPS and PDMAAm hydrogels on chondrogenic differentiation of ATDC5 cells, depending on the level of concentration.  Yoshikawa K, Kitamura N, Kurokawa T, Gong JP, Nohara Y, Yasuda K.  BMC Musculoskelet Disord  2013  14:56  PubMed ID: 23379610
6564  Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development.  Hosaka Y, Saito T, Sugita S, Hikata T, Kobayashi H, Fukai A, Taniguchi Y, Hirata M, Akiyama H, Chung UI, Kawaguchi H.  Proc Natl Acad Sci U S A  2013  110(5):1875-80  PubMed ID: 23319657
6565  β-catenin regulates parathyroid hormone/parathyroid hormone-related protein receptor signals and chondrocyte hypertrophy through binding to the intracellular C-terminal region of the receptor.  Yano F, Saito T, Ogata N, Yamazawa T, Iino M, Chung UI, Kawaguchi H.  Arthritis Rheum  2013  65(2):429-35  PubMed ID: 23124878
6566  ATP oscillations mediate inductive action of FGF and Shh signalling on prechondrogenic condensation.  Kwon HJ.  Cell Biochem Funct  2013  31(1):75-81  PubMed ID: 22886426
6567  Fluorescent oxygen sensitive microbead incorporation for measuring oxygen tension in cell aggregates.  Lambrechts D, Roeffaers M, Kerckhofs G, Roberts SJ, Hofkens J, Van de Putte T, Van Oosterwyck H, Schrooten J.  Biomaterials  2013  34(4):922-9  PubMed ID: 23122803
6568  CCN2/CTGF is required for matrix organization and to protect growth plate chondrocytes from cellular stress.  Hall-Glenn F, Aivazi A, Akopyan L, Ong JR, Baxter RR, Benya PD, Goldschmeding R, van Nieuwenhoven FA, Hunziker EB, Lyons KM.  J Cell Commun Signal  2013  7(3):219-30  PubMed ID: 23666466
6569  Surface modification on polyethylene terephthalate films with 2-methacryloyloxyethyl phosphorylcholine.  Zheng Z, Ren L, Zhai Z, Wang Y, Hang F.  Mater Sci Eng C Mater Biol Appl  2013  33(5):3041-6  PubMed ID: 23623130
6570  Activating types 1 and 2 angiotensin II receptors modulate the hypertrophic differentiation of chondrocytes.  Tsukamoto I, Inoue S, Teramura T, Takehara T, Ohtani K, Akagi M.  FEBS Open Bio  2013  3:279-84  PubMed ID: 23905010
6571  Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling.  Piao J, Tsuji K, Ochi H, Iwata M, Koga D, Okawa A, Morita S, Takeda S, Asou Y.  Sci Rep  2013  3:3022  PubMed ID: 24149372
6572  SOX11 contributes to the regulation of GDF5 in joint maintenance.  Kan A, Ikeda T, Fukai A, Nakagawa T, Nakamura K, Chung UI, Kawaguchi H, Tabin CJ.  BMC Dev Biol  2013  13:4  PubMed ID: 23356643
6573  Involvement of phospholipase A/acyltransferase-1 in N-acylphosphatidylethanolamine generation.  Uyama T, Inoue M, Okamoto Y, Shinohara N, Tai T, Tsuboi K, Inoue T, Tokumura A, Ueda N.  Biochim Biophys Acta  2013  1831(12):1690-701  PubMed ID: 23994608
6575  Arid5b facilitates chondrogenesis by recruiting the histone demethylase Phf2 to Sox9-regulated genes.  Hata K, Takashima R, Amano K, Ono K, Nakanishi M, Yoshida M, Wakabayashi M, Matsuda A, Maeda Y, Suzuki Y, Sugano S, Whitson RH, Nishimura R, Yoneda T.  Nat Commun  2013  4:2850  PubMed ID: 24276541
6576  Identification and characterization of regulatory elements in the promoter of ACVR1, the gene mutated in Fibrodysplasia Ossificans Progressiva.  Giacopelli F, Cappato S, Tonachini L, Mura M, Di Lascio S, Fornasari D, Ravazzolo R, Bocciardi R.  Orphanet J Rare Dis  2013  8:145  PubMed ID: 24047559
6579  Sulfation patterns of exogenous chondroitin sulfate affect chondrogenic differentiation of ATDC5 cells.  Kawamura D, Funakoshi T, Mizumoto S, Sugahara K, Iwasaki N.  J Orthop Sci  2014  19(6):1028-35  PubMed ID: 25209441
6580  Hyaluronic acid enhances the effect of the PAMPS/PDMAAm double-network hydrogel on chondrogenic differentiation of ATDC5 cells.  Kitamura N, Kurokawa T, Fukui T, Gong JP, Yasuda K.  BMC Musculoskelet Disord  2014  15:222  PubMed ID: 24997593
6581  High molecular weight hyaluronic acid increases the differentiation potential of the murine chondrocytic ATDC5 cell line.  Sato E, Ando T, Ichikawa J, Okita G, Sato N, Wako M, Ohba T, Ochiai S, Hagino T, Jacobson R, Haro H.  J Orthop Res  2014  32(12):1619-27  PubMed ID: 25196420
6582  The effect of growth differentiation factor-5, 6, 7 in chondrogenic cell differentiation of ATDC-5   Yuji Hatakeyama, Yuko Matsuda, Junko Hatakeyama, Kyoko Oka, Hisashi Anan, Eichi Tsuruga, Tetsuichiro Inai, Hiroyuki Ishikawa, Yoshihiko Sawa  American Journal of BioScience  2014  2(5):182-186  
6583  A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine.  Nakajima M et al  Nat Genet  2014  46(9):1012-6  PubMed ID: 25064007
6584  Teneurin-4, a transmembrane protein, is a novel regulator that suppresses chondrogenic differentiation.  Suzuki N, Mizuniwa C, Ishii K, Nakagawa Y, Tsuji K, Muneta T, Sekiya I, Akazawa C.  J Orthop Res  2014  32(7):915-22  PubMed ID: 24648313
6585  Significant increase in Young׳s modulus of ATDC5 cells during chondrogenic differentiation induced by PAMPS/PDMAAm double-network gel: Comparison with induction by insulin  Eijiro Maeda et al  Journal of Biomechanics  2014  47:3408-3414 
6586  Enhanced mechanical properties of a novel, injectable, fiber-reinforced brushite cement.  Maenz S, Kunisch E, Mühlstädt M, Böhm A, Kopsch V, Bossert J, Kinne RW, Jandt KD.  J Mech Behav Biomed Mater  2014  39:328-38  PubMed ID: 25171749
6587  NUCB2/nesfatin-1: a new adipokine expressed in human and murine chondrocytes with pro-inflammatory properties, an in vitro study.  Scotece M, Conde J, Abella V, López V, Lago F, Pino J, Gómez-Reino JJ, Gualillo O.  J Orthop Res  2014  32(5):653-60  PubMed ID: 24464950
6588  Nuclear factor Y (NF-Y) regulates the proximal promoter activity of the mouse collagen α1(XI) gene (Col11a1) in chondrocytes.  Hida M, Hamanaka R, Okamoto O, Yamashita K, Sasaki T, Yoshioka H, Matsuo N.  In Vitro Cell Dev Biol Anim  2014  50(4):358-66  PubMed ID: 24092017
6589  LRP4 induces extracellular matrix productions and facilitates chondrocyte differentiation.  Asai N, Ohkawara B, Ito M, Masuda A, Ishiguro N, Ohno K.  Biochem Biophys Res Commun  2014  451(2):302-7  PubMed ID: 25091481
6590  Endogenous cannabinoid anandamide impairs cell growth and induces apoptosis in chondrocytes.  Gómez R, Conde J, Scotece M, López V, Lago F, Gómez Reino JJ, Gualillo O.  J Orthop Res  2014  32(9):1137-46  PubMed ID: 24902823
6591  S100A1 and S100B are dispensable for endochondral ossification during skeletal development.  Mori Y, Mori D, Chung UI, Tanaka S, Heierhorst J, Buchou T, Baudier J, Kawaguchi H, Saito T.  Biomed Res  2014  35(4):243-50  PubMed ID: 25152033
6592  Constitutive activation of IKK2/NF-κB impairs osteogenesis and skeletal development.  Swarnkar G, Zhang K, Mbalaviele G, Long F, Abu-Amer Y.  PLoS One  2014  9(3):e91421  PubMed ID: 24618907
6593  Master regulator for chondrogenesis, Sox9, regulates transcriptional activation of the endoplasmic reticulum stress transducer BBF2H7/CREB3L2 in chondrocytes.  Hino K, Saito A, Kido M, Kanemoto S, Asada R, Takai T, Cui M, Cui X, Imaizumi K  J Biol Chem  2014  289(20):13810-20  PubMed ID: 24711445
6594  Identification of novel regulators of osteoblast matrix mineralization by time series transcriptional profiling.  Staines KA, Zhu D, Farquharson C, MacRae VE.  J Bone Miner Metab  2014  32(3):240-51  PubMed ID: 23925391
6595  Calcium phosphate based three-dimensional cold plotted bone scaffolds for critical size bone defects.  Bergmann CJ1, Odekerken JC2, Welting TJ2, Jungwirth F, Devine D3, Bouré L3, Zeiter S3, van Rhijn LW2, Telle R4, Fischer H1, Emans PJ2.  Biomed Res Int  2014  2014:852610  PubMed ID: 24719891
6596  CCAAT/enhancer binding protein β regulates expression of Indian hedgehog during chondrocytes differentiation.  Ushijima T, Okazaki K, Tsushima H, Ishihara K, Doi T, Iwamoto Y.  PLoS One  2014  9(8):e104547  PubMed ID: 25105964
6597  Shear reversible cell/microsphere aggregate as an injectable for tissue regeneration.  Woo E, Park H, Lee KY.  Macromol Biosci  2014  14(5):740-8  PubMed ID: 24436180
6598  Palmitoyl acyltransferase, Zdhhc13, facilitates bone mass acquisition by regulating postnatal epiphyseal development and endochondral ossification: a mouse model.  Song IW, Li WR, Chen LY, Shen LF, Liu KM, Yen JJ, Chen YJ, Chen YJ, Kraus VB, Wu JY, Lee MT, Chen YT.  PLoS One  2014  9(3):e92194  PubMed ID: 24637783
6599  Verapamil protects against cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling.  Takamatsu A, Ohkawara B, Ito M, Masuda A, Sakai T, Ishiguro N, Ohno K.  PLoS One  2014  9(3):e92699  PubMed ID: 24658359
6600  Oxygen tension affects lubricin expression in chondrocytes.  Hatta T, Kishimoto KN, Okuno H, Itoi E.  Tissue Eng Part A  2014  20(19-20):2720-7  PubMed ID: 24712343
6601  Facile and rapid ruthenium mediated photo-crosslinking of Bombyx mori silk fibroin  Jasmin L. Whittaker a, Namita R. Choudhury, Naba K. Dutta and Andrew Zannettino  J Mater Chem B,  2014  2:6259-6270 
6602  Discovery of novel differentiation markers in the early stage of chondrogenesis by glycoform-focused reverse proteomics and genomics.  Ishihara T, Kakiya K, Takahashi K, Miwa H, Rokushima M, Yoshinaga T, Tanaka Y, Ito T, Togame H, Takemoto H, Amano M, Iwasaki N, Minami A, Nishimura S.  Biochim Biophys Acta  2014  1840(1):645-55  PubMed ID: 24161698
6603  Matrilin-3 chondrodysplasia mutations cause attenuated chondrogenesis, premature hypertrophy and aberrant response to TGF-β in chondroprogenitor cells.  Jayasuriya CT, Zhou FH, Pei M, Wang Z, Lemme NJ, Haines P, Chen Q.  Int J Mol Sci  2014  15(8):14555-73  PubMed ID: 25196597
6604  Human immunodeficiency virus type 1 enhancer-binding protein 3 is essential for the expression of asparagine-linked glycosylation 2 in the regulation of osteoblast and chondrocyte differentiation.  Imamura K, Maeda S, Kawamura I, Matsuyama K, Shinohara N, Yahiro Y, Nagano S, Setoguchi T, Yokouchi M, Ishidou Y, Komiya S.  J Biol Chem  2014  89(14):9865-79  PubMed ID: 24563464
6605  Effects of culture on PAMPS/PDMAAm double-network gel on chondrogenic differentiation of mouse C3H10T1/2 cells: in vitro experimental study.  Inagaki Y, Kitamura N, Kurokawa T, Tanaka Y, Gong JP, Yasuda K, Tohyama H.  BMC Musculoskelet Disord  2014  15:320  PubMed ID: 25262146
6606  Bone morphogenic protein (BMP) signaling up-regulates neutral sphingomyelinase 2 to suppress chondrocyte maturation via the Akt protein signaling pathway as a negative feedback mechanism.  Kakoi H, Maeda S, Shinohara N, Matsuyama K, Imamura K, Kawamura I, Nagano S, Setoguchi T, Yokouchi M, Ishidou Y, Komiya S.  J Biol Chem  2014  289(12):8135-50  PubMed ID: 24505141
6607  Constitutive and functional expression of runt-related transcription factor-2 by microglial cells.  Nakazato R, Takarada T, Watanabe T, Nguyen BT, Ikeno S, Hinoi E, Yoneda Y.  Neurochem Int  2014  74:24-35  PubMed ID: 24768841
6612  Regulation of mouse chondrocyte differentiation by CCAAT/enhancer-binding proteins.  Okuma T, Hirata M, Yano F, Mori D, Kawaguchi H, Chung UI, Tanaka S, Saito T.  Biomed Res  2015  36(1):21-9  PubMed ID: 25749148
6613  GDF-5 can act as a context-dependent BMP-2 antagonist.  Klammert U, Mueller TD, Hellmann TV, Wuerzler KK, Kotzsch A, Schliermann A, Schmitz W, Kuebler AC, Sebald W, Nickel J.  BMC Biol  2015  13:77  PubMed ID: 26385096
6614  MiR-455-3p regulates early chondrogenic differentiation via inhibiting Runx2.  Zhang Z, Hou C, Meng F, Zhao X, Zhang Z, Huang G, Chen W, Fu M, Liao W.  FEBS Lett  2015  589(23):3671-8  PubMed ID: 26474644
6615  A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis.  Liu Z, Chen J, Mirando AJ, Wang C, Zuscik MJ, O'Keefe RJ, Hilton MJ.  Sci Signal  2015  8(386):ra71  PubMed ID: 26198357
6616  Electrospun chitosan/poly(vinyl alcohol) reinforced with CaCO3 nanoparticles with enhanced mechanical properties and biocompatibility for cartilage tissue engineeringcccc  Nonni Soraya et al  Composites Science and Technology   2015  106:76-84 
6617  Discrete spatial organization of TGFβ receptors couples receptor multimerization and signaling to cellular tension.  Rys JP, DuFort CC, Monteiro DA, Baird MA, Oses-Prieto JA, Chand S, Burlingame AL, Davidson MW, Alliston TN.  Elife  2015  4:e09300  PubMed ID: 26652004
6620  AMP-activated protein kinase (AMPK) activity negatively regulates chondrogenic differentiation.  Bandow K, Kusuyama J, Kakimoto K, Ohnishi T, Matsuguchi T.  Bone  2015  74:125-33  PubMed ID: 25497570
6622  The Transcription Factor Hand1 Is Involved In Runx2-Ihh-Regulated Endochondral Ossification.  Laurie LE, Kokubo H, Nakamura M, Saga Y, Funato N.  PLoS One  2016  11(2):e0150263  PubMed ID: 26918743
6623  Aloe-Emodin Induces Chondrogenic Differentiation of ATDC5 Cells via MAP Kinases and BMP-2 Signaling Pathways.  Yang M, Li L, Heo SM, Soh Y.  Biomol Ther (Seoul)  2016  24(4):395-401  PubMed ID: 27350340
6624  R-spondin 2 facilitates differentiation of proliferating chondrocytes into hypertrophic chondrocytes by enhancing Wnt/β-catenin signaling in endochondral ossification.  Takegami Y, Ohkawara B, Ito M, Masuda A, Nakashima H, Ishiguro N, Ohno K.  Biochem Biophys Res Commun  2016  473(1):255-264  PubMed ID: 27012200
6625  Cordycepin inhibits chondrocyte hypertrophy of mesenchymal stem cells through PI3K/Bapx1 and Notch signaling pathway.  Cao Z, Dou C, Li J, Tang X, Xiang J, Zhao C2, Zhu L, Bai Y, Xiang Q, Dong S.  BMB Rep  2016  49(10):548-553  PubMed ID: 27439604
6630  mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation.  Yan B, Zhang Z, Jin D, Cai C, Jia C, Liu W, Wang T, Li S, Zhang H, Huang B, Lai P, Wang H, Liu A, Zeng C, Cai D, Jiang Y, Bai X.  Nat Commun  2016  7:11151  PubMed ID: 27039827
6631  HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development.  Rutkowski TP, Kohn A, Sharma D, Ren Y, Mirando AJ, Hilton MJ.  J Cell Sci  2016  129(11):2145-55  PubMed ID: 27160681
6632  Engineering DN hydrogels from regenerated silk fibroin and poly(N-vinylcaprolactam)  Jasmin L. Whittaker, Naba K. Dutta, Andrew Zannettino and Namita Roy Choudhury  J Mater Chem B  2016  4:5519-5533 
6633  Correction: High-throughput screening for modulators of ACVR1 transcription: discovery of potential therapeutics for fibrodysplasia ossificans progressiva.  Cappato S, Tonachini L, Giacopelli F, Tirone M, Galietta LJ, Sormani M, Giovenzana A, Spinelli AE, Canciani B, Brunelli S, Ravazzolo R, Bocciardi R.  Dis Model Mech  2016  Sep 1;9(9):1067  PubMed ID: 27604694
6635  Utilizing BMP-2 muteins for treatment of multiple myeloma.  Seher A, Lagler C, Stühmer T, Müller-Richter UDA, Kübler AC, Sebald W, Müller TD, Nickel J.  PLoS One  2017  12(5):e0174884  PubMed ID: 28489849
6636  Heterogeneous nuclear ribonucleoprotein A1 interacts with microRNA-34a to promote chondrogenic differentiation of mesenchymal stem cells.  Meng X, Cui J, Wang Y, Zhang X, Li D, Hai Y, Du H.  Am J Transl Res  2017  9(4):1774-1782  PubMed ID: 28469782
6637  Fibulin-4 reduces extracellular matrix production and suppresses chondrocyte differentiation via DKK1- mediated canonical Wnt/β-catenin signaling.  Shangguan L, Ning G, Luo Z, Zhou Y  Int J Biol Macromol  2017  99:293-299  PubMed ID: 28238906
6638  Suppression of cartilage degeneration by intra-articular injection of heparan sulfate 6-O endosulfatase in a mouse osteoarthritis model.  Otsuki S, Murakami T, Okamoto Y, Hoshiyama Y, Oda S, Neo M.  Histol Histopathol  2017  32(7):725-733  PubMed ID: 27808352
6639  Heat-stimuli-enhanced osteogenesis using clinically available biomaterials.  Ota T, Nishida Y, Ikuta K, Kato R, Kozawa E, Hamada S, Sakai T, Ishiguro N.  PLoS One  2017  12(7):e0181404  PubMed ID: 28719650
6644  Polyamines stimulate the CHSY1 synthesis through the unfolding of the RNA G-quadruplex at the 5'-untraslated region.  Yamaguchi K, Asakura K, Imamura M, Kawai G, Sakamoto T, Furihata T, Linhardt RJ, Igarashi K, Toida T, Higashi K.  Biochem J  2018  475(23):3797-3812  PubMed ID: 30401686
6643  Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia.  Wang C, Tan Z, Niu B, Tsang KY, Tai A, Chan WCW, Lo RLK, Leung KKH, Dung NWF, Itoh N, Zhang MQ, Chan D, Cheah KSE.  Elife  2018  7. pii: e37673  PubMed ID: 30024379
4978  BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2.  Lee MH, Kwon TG, Park HS, Wozney JM, Ryoo HM.  Biochem Biophys Res Commun  2003  309(3):689-94  PubMed ID: 12963046
6871  Regulation of the human Sox9 promoter by the CCAAT-binding factor.  Colter DC, Piera-Velazquez S, Hawkins DF, Whitecavage MK, Jimenez SA, Stokes DG.  Matrix Biol   2005  24(3):185-97  PubMed ID: 15908194
6878  Runx1 contributes to articular cartilage maintenance by enhancement of cartilage matrix production and suppression of hypertrophic differentiation.  Yano F, Ohba S, Murahashi Y, Tanaka S, Saito T, Chung UI.  Sci Rep  2019  9(1):7666  PubMed ID: 31113964
6910  Notoginsenoside R1 suppresses miR-301a via NF-κB pathway in lipopolysaccharide-treated ATDC5 cells.  Dong Y, Yan X, Yang X, Yu C, Deng Y, Song X, Zhang L.  Exp Mol Pathol  2019    PubMed ID: 31837326
6950  Secreted tyrosine kinase Vlk negatively regulates Hedgehog signaling by inducing lysosomal degradation of Smoothened.  Kim JM, Han H, Bahn M, Hur Y, Yeo CY, Kim DW.  Biochem J  2020  477(1):121-136  PubMed ID: 31845979
3158  Lectins induce resistance to proteases and/or mechanical stimulus in all examined cells--including bone marrow mesenchymal stem cells--on various scaffolds.  Nishimura, Haruki, Nishimura, Masahiro, Oda, Ryo, Yamanaka, Katsuyuki, Matsubara, Takehiro, Ozaki, Yoshie, Sekiya, Kensuke, Hamada, Taizo, Kato, Yukio  Exp Cell Res  2004  295:119-27  PubMed ID: 15051495

Back Back Return Top Page