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RCB0565 : ATDC5  update : 2018/07/06
CommentDifferentiate to chondrocytes, unidentifiable pigment cells. Teratocarcinoma AT805 derived.
Comment from the depositor
Restriction (Category)a
Terms and conditionsBasically, there is no restriction regarding academic use.
Remarks
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor Atsumi, Tadao
Originator Atsumi, Tadao
Year of deposit 1991
Original cell AT805
Animal mouse < Mammals
Strain name 129
Gender Male
Age at sampling embryo
Tissue embryo
Case history Teratocarcinoma AT805 derived
Classification cancer
Lifespan infinite
Morphology epithelial-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives DMEM/HamF12 + 5% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture or Medium Renewal : once/2-3 days
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
SSLP (mouse) OK
Isozyme LD, NP
Images
deposit info
lot info
Reference information Reference 2
User's Publication 133


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Reference
Atsumi T, Miwa Y, Kimata K, Ikawa Y  A chondrogenic cell line derived from a differentiating culture of AT805 teratocarcinoma cells.  Cell Differ Dev  1990  30:109-16 
Takeichi M, Atsumi T, Yoshida C, Uno K, Okada, T S    Dev Growth Differ  1981  87:340-350 

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User's Publication
Fujishige K, Yanaka N, Akatsuka H, Omori K  Localization of clearance receptor in rat lung and trachea : association with chondrogenic differentiation  Am J Physiol  1998  274(3 Pt 1):425-431 
Fujita T, Izumo N, Fukuyama R, Meguro T, Nakamuta H, Kohno T, Koida M  Phosphate provides an extracellular signal that drives nuclear export of Runx2/Cbfa1 in bone cells.  Biochem Biophys Res Commun  2001  280:348-52 
Fujita T, Meguro T, Izumo N, Yasutomi C, Fukuyama R, Nakamuta H, Koida M  Phosphate stimulates differentiation and mineralization of the chondroprogenitor clone ATDC5.  Jpn J Pharmacol  2001  85:278-81 
Wang Z, Iida A, Miyake N, Nishiguchi KM, Fujita K, Nakazawa T, Alswaid A, Albalwi MA, Kim OH, Cho TJ, Lim GY, Isidor B, David A, Rustad CF, Merckoll E, Westvik J, Stattin EL, Grigelioniene G, Kou I, Nakajima M, Ohashi H, Smithson S, Matsumoto N, Nishimura G, Ikegawa S.  Axial Spondylometaphyseal Dysplasia Is Caused by C21orf2 Mutations.  PLoS ONE  2016  11:e0150555  PubMed ID: 26974433
Hosokawa T, Tsuchiya Y, Okubo N, Kunimoto T, Minami Y, Fujiwara H, Umemura Y, Koike N, Kubo T, Yagita K.  Robust Circadian Rhythm and Parathyroid Hormone-Induced Resetting during Hypertrophic Differentiation in ATDC5 Chondroprogenitor Cells.  Acta Histochem Cytochem  2016  48:165-71  PubMed ID: 26855448
Hasegawa S, Kitoh H, Ohkawara B, Mishima K, Matsushita M, Masuda A, Ishiguro N, Ohno K.  Tranilast stimulates endochondral ossification by upregulating SOX9 and RUNX2 promoters.  Biochem. Biophys. Res. Commun.  2016  470:356-361  PubMed ID: 26777999
Staines KA, Prideaux M, Allen S, Buttle DJ, Pitsillides AA, Farquharson C.  E11/Podoplanin Protein Stabilization Through Inhibition of the Proteasome Promotes Osteocyte Differentiation in Murine in Vitro Models.  J. Cell. Physiol.  2015  231:1392-404  PubMed ID: 26639105
Goto K, Kimura T, Kitamura N, Semba S, Ohmiya Y, Aburatani S, Matsukura S, Tsuda M, Kurokawa T, Ping Gong J, Tanaka S, Yasuda K.  Synthetic PAMPS gel activates BMP/Smad signaling pathway in ATDC5 cells, which plays a significant role in the gel-induced chondrogenic differentiation.  J Biomed Mater Res A  2015  104:734-746  PubMed ID: 26566602
Zaman G, Staines KA, Farquharson C, Newton PT, Dudhia J, Chenu C, Pitsillides AA, Dhoot GK.  Expression of Sulf1 and Sulf2 in cartilage, bone and endochondral fracture healing.  Histochem. Cell Biol.  2015  145:67-79  PubMed ID: 26464246
Naito M, Vongsa S, Tsukune N, Ohashi A, Takahashi T.  Promyelocytic leukemia zinc finger mediates glucocorticoid-induced cell cycle arrest in the chondroprogenitor cell line ATDC5.  Mol. Cell. Endocrinol.  2015  417:114-23  PubMed ID: 26419928
Kim JA, Im S, Cantley LC, Kim DW.  Suppression of Nkx3.2 by phosphatidylinositol-3-kinase signaling regulates cartilage development by modulating chondrocyte hypertrophy.  Cell. Signal.  2015  27:2389-400  PubMed ID: 26363466
Mori H, Izawa T, Tanaka E.  Smad3 deficiency leads to mandibular condyle degradation via the sphingosine 1-phosphate (S1P)/S1P3 signaling axis.  Am. J. Pathol.  2015  185:2742-56  PubMed ID: 26272361
Hou C, Meng F, Zhang Z, Kang Y, Chen W, Huang G, Fu M, Sheng P, Zhang Z, Liao W.  The Role of MicroRNA-381 in Chondrogenesis and Interleukin-1-β Induced Chondrocyte Responses.  Cell. Physiol. Biochem.  2015  36:1753-66  PubMed ID: 26184031
Hou C, Zhang Z, Zhang Z, Wu P, Zhao X, Fu M, Sheng P, Kang Y, Liao W.  Presence and function of microRNA-92a in chondrogenic ATDC5 and adipose-derived mesenchymal stem cells.  Mol Med Rep  2015  12:4877-86  PubMed ID: 26135269
Santoro A, Conde J, Scotece M, Abella V, Lopez V, Pino J, Gomez R, Gomez-Reino JJ, Gualillo O.  Choosing the right chondrocyte cell line: Focus on nitric oxide.  J. Orthop. Res.  2015  33:1784-8  PubMed ID: 26016689
Yoshioka Y, Kozawa E, Urakawa H, Arai E, Futamura N, Zhuo L, Kimata K, Ishiguro N, Nishida Y.  Inhibition of hyaluronan synthesis alters sulfated glycosaminoglycans deposition during chondrogenic differentiation in ATDC5 cells.  Histochem. Cell Biol.  2015  144:167-77  PubMed ID: 25929745
Umeda M, Terao F, Miyazaki K, Yoshizaki K, Takahashi I.  MicroRNA-200a Regulates the Development of Mandibular Condylar Cartilage.  J. Dent. Res.  2015  94:795-802  PubMed ID: 25784252
Azuma K, Casey SC, Urano T, Horie-Inoue K, Ouchi Y, Blumberg B, Inoue S.  Pregnane X receptor knockout mice display aging-dependent wearing of articular cartilage.  PLoS ONE  2015  10:e0119177  PubMed ID: 25749104
Abella V, Santoro A, Scotece M, Conde J, Lopez-Lopez V, Lazzaro V, Gomez-Reino JJ, Meli R, Gualillo O.  Non-dioxin-like polychlorinated biphenyls (PCB 101, PCB 153 and PCB 180) induce chondrocyte cell death through multiple pathways.  Toxicol. Lett.  2015  234:13-9  PubMed ID: 25659934
Le BQ, Fernandes H, Bouten CV, Karperien M, van Blitterswijk C, de Boer J.  High-Throughput Screening Assay for the Identification of Compounds Enhancing Collagenous Extracellular Matrix Production by ATDC5 Cells.  Tissue Eng Part C Methods  2015  21:726-36  PubMed ID: 25604243
Morimoto R, Obinata A.  Overexpression of hematopoietically expressed homeoprotein induces nonapoptotic cell death in mouse prechondrogenic ATDC5 cells.  Biol. Pharm. Bull.  2011  34:1589-95  PubMed ID: 21963500
Endo T, Kobayashi T.  Thyroid-specific gene expression in chondrocytes.  Biochem. Biophys. Res. Commun.  2011  416:227-31  PubMed ID: 21945616
Mirza R, Qiao S, Tateyama K, Miyamoto T, Xiuli L, Seo H.  3β-Hydroxysterol-Delta24 reductase plays an important role in long bone growth by protecting chondrocytes from reactive oxygen species.  J. Bone Miner. Metab.  2011  30:144-53  PubMed ID: 21845517
Chen L, Qanie D, Jafari A, Taipaleenmaki H, Jensen CH, Saamanen AM, Sanz ML, Laborda J, Abdallah BM, Kassem M.  Delta-like 1/fetal antigen-1 (Dlk1/FA1) is a novel regulator of chondrogenic cell differentiation via inhibition of the Akt kinase-dependent pathway.  J. Biol. Chem.  2011  286:32140-9  PubMed ID: 21724852
Yan C, Wang Y, Shen XY, Yang G, Jian J, Wang HS, Chen GQ, Wu Q.  MicroRNA regulation associated chondrogenesis of mouse MSCs grown on polyhydroxyalkanoates.  Biomaterials  2011  32:6435-44  PubMed ID: 21665270
Chen W, Zhang X, Siu RK, Chen F, Shen J, Zara JN, Culiat CT, Tetradis S, Ting K, Soo C.  Nfatc2 is a primary response gene of Nell-1 regulating chondrogenesis in ATDC5 cells.  J. Bone Miner. Res.  2011  26:1230-41  PubMed ID: 21611965
Morimoto R, Yamamoto A, Akimoto Y, Obinata A.  Homeoprotein Hex is expressed in mouse developing chondrocytes.  J. Biochem.  2011  150:61-71  PubMed ID: 21454303
Yang CL, Chen HW, Wang TC, Wang YJ.  A novel fibrin gel derived from hyaluronic acid-grafted fibrinogen.  Biomed Mater  2011  6:025009  PubMed ID: 21393811
Yoshimura K, Miyamoto Y, Yasuhara R, Maruyama T, Akiyama T, Yamada A, Takami M, Suzawa T, Tsunawaki S, Tachikawa T, Baba K, Kamijo R.  Monocarboxylate transporter-1 is required for cell death in mouse chondrocytic ATDC5 cells exposed to interleukin-1beta via late phase activation of nuclear factor kappaB and expression of phagocyte-type NADPH oxidase.  J. Biol. Chem.  2011  286:14744-52  PubMed ID: 21372137
Shimada H, Sakakima H, Tsuchimochi K, Matsuda F, Komiya S, Goldring MB, Ijiri K.  Senescence of chondrocytes in aging articular cartilage: GADD45β mediates p21 expression in association with C/EBPβ in senescence-accelerated mice.  Pathol. Res. Pract.  2011  207:225-31  PubMed ID: 21353395
Amano K, Hata K, Muramatsu S, Wakabayashi M, Takigawa Y, Ono K, Nakanishi M, Takashima R, Kogo M, Matsuda A, Nishimura R, Yoneda T.  Arid5a cooperates with Sox9 to stimulate chondrocyte-specific transcription.  Mol. Biol. Cell  2011  22:1300-11  PubMed ID: 21346191
Takeshita N, Yoshimi E, Hatori C, Kumakura F, Seki N, Shimizu Y.  Alleviating effects of AS1892802, a Rho kinase inhibitor, on osteoarthritic disorders in rodents.  J. Pharmacol. Sci.  2011  115:481-9  PubMed ID: 21325780
Yoon HE, Kim KS, Kim IY.  14-3-3 η inhibits chondrogenic differentiation of ATDC5 cell.  Biochem. Biophys. Res. Commun.  2011  406:59-63  PubMed ID: 21291861
Choi HJ, Nepal M, Park YR, Lee HK, Oh SR, Soh Y.  Stimulation of chondrogenesis in ATDC5 chondroprogenitor cells and hypertrophy in mouse by Genkwadaphnin.  Eur. J. Pharmacol.  2011  655:9-15  PubMed ID: 21266170
Conde J, Gomez R, Bianco G, Scotece M, Lear P, Dieguez C, Gomez-Reino J, Lago F, Gualillo O.  Expanding the adipokine network in cartilage: identification and regulation of novel factors in human and murine chondrocytes.  Ann. Rheum. Dis.  2011  70:551-9  PubMed ID: 21216818
Nakajima M, Miyamoto Y, Ikegawa S.  Cloning and characterization of the osteoarthritis-associated gene DVWA.  J. Bone Miner. Metab.  2010  29:300-8  PubMed ID: 21057832
Choi BH, Choi YS, Kang DG, Kim BJ, Song YH, Cha HJ.  Cell behavior on extracellular matrix mimic materials based on mussel adhesive protein fused with functional peptides.  Biomaterials  2010  31:8980-8  PubMed ID: 20832110
Bertotti A, Bracco C, Girolami F, Torti D, Gastaldi S, Galimi F, Medico E, Elvin P, Comoglio PM, Trusolino L.  Inhibition of Src impairs the growth of met-addicted gastric tumors.  Clin. Cancer Res.  2010  16:3933-43  PubMed ID: 20628031
Huang BL, Brugger SM, Lyons KM.  Stage-specific control of connective tissue growth factor (CTGF/CCN2) expression in chondrocytes by Sox9 and beta-catenin.  J. Biol. Chem.  2010  285:27702-12  PubMed ID: 20571031
Temu TM, Wu KY, Gruppuso PA, Phornphutkul C.  The mechanism of ascorbic acid-induced differentiation of ATDC5 chondrogenic cells.  Am. J. Physiol. Endocrinol. Metab.  2010  299:E325-34  PubMed ID: 20530736
Hojo H, Yano F, Ohba S, Igawa K, Nakajima K, Komiyama Y, Kan A, Ikeda T, Yonezawa T, Woo JT, Takato T, Nakamura K, Kawaguchi H, Chung UI.  Identification of oxytetracycline as a chondrogenic compound using a cell-based screening system.  J. Bone Miner. Metab.  2010  28:627-33  PubMed ID: 20376510
Iacono A, Gomez R, Sperry J, Conde J, Bianco G, Meli R, Gomez-Reino JJ, Smith AB 3rd, Gualillo O.  Effect of oleocanthal and its derivatives on inflammatory response induced by lipopolysaccharide in a murine chondrocyte cell line.  Arthritis Rheum.  2010  62:1675-82  PubMed ID: 20201078
Fukai A, Kawamura N, Saito T, Oshima Y, Ikeda T, Kugimiya F, Higashikawa A, Yano F, Ogata N, Nakamura K, Chung UI, Kawaguchi H.  Akt1 in murine chondrocytes controls cartilage calcification during endochondral ossification under physiologic and pathologic conditions.  Arthritis Rheum.  2010  62:826-36  PubMed ID: 20187155
Shirakura M, Tanimoto K, Eguchi H, Miyauchi M, Nakamura H, Hiyama K, Tanimoto K, Tanaka E, Takata T, Tanne K.  Activation of the hypoxia-inducible factor-1 in overloaded temporomandibular joint, and induction of osteoclastogenesis.  Biochem. Biophys. Res. Commun.  2010  393:800-5  PubMed ID: 20171183
Kushibiki T, Tajiri T, Ninomiya Y, Awazu K.  Chondrogenic mRNA expression in prechondrogenic cells after blue laser irradiation.  J. Photochem. Photobiol. B, Biol.  2010  98:211-5  PubMed ID: 20163967
Oue T, Yoneda A, Uehara S, Yamanaka H, Fukuzawa M.  Increased expression of the hedgehog signaling pathway in pediatric solid malignancies.  J. Pediatr. Surg.  2010  45:387-92  PubMed ID: 20152358
Noguchi K, Watanabe Y, Fuse T, Takizawa M.  A new chondrogenic differentiation initiator with the ability to up-regulate SOX trio expression.  J. Pharmacol. Sci.  2010  112:89-97  PubMed ID: 20051655
Wakabayashi T, Matsumine A, Nakazora S, Hasegawa M, Iino T, Ota H, Sonoda H, Sudo A, Uchida A.  Fibulin-3 negatively regulates chondrocyte differentiation.  Biochem. Biophys. Res. Commun.  2009  391:1116-21  PubMed ID: 20005202
Tsuritani K, Takeda J, Sakagami J, Ishii A, Eriksson T, Hara T, Ishibashi H, Koshihara Y, Yamada K, Yoneda Y.  Cytokine receptor-like factor 1 is highly expressed in damaged human knee osteoarthritic cartilage and involved in osteoarthritis downstream of TGF-beta.  Calcif. Tissue Int.  2009  86:47-57  PubMed ID: 19921088
Owen HC, Ahmed SF, Farquharson C.  Chondrocyte p21(WAF1/CIP1) expression is increased by dexamethasone but does not contribute to dexamethasone-induced growth retardation in vivo.  Calcif. Tissue Int.  2009  85:326-34  PubMed ID: 19727539
Ti?li RS, Gumu?derelio?lu M.  Chondrogenesis on BMP-6 loaded chitosan scaffolds in stationary and dynamic cultures.  Biotechnol. Bioeng.  2009  104:601-10  PubMed ID: 19575410
Nakajima S, Naruto T, Miyamae T, Imagawa T, Mori M, Nishimaki S, Yokota S.  Interleukin-6 inhibits early differentiation of ATDC5 chondrogenic progenitor cells.  Cytokine  2009  47:91-7  PubMed ID: 19535264
Kishimoto KN, Oxford CL, Reddi AH.  Stimulation of the side population fraction of ATDC5 chondroprogenitors by hypoxia.  Cell Biol. Int.  2009  33:1222-9  PubMed ID: 19524690
Gomez R, Lago F, Gomez-Reino JJ, Dieguez C, Gualillo O.  Expression and modulation of ghrelin O-acyltransferase in cultured chondrocytes.  Arthritis Rheum.  2009  60:1704-9  PubMed ID: 19479831
Gevers EF, Hannah MJ, Waters MJ, Robinson IC.  Regulation of rapid signal transducer and activator of transcription-5 phosphorylation in the resting cells of the growth plate and in the liver by growth hormone and feeding.  Endocrinology  2009  150:3627-36  PubMed ID: 19359380
Nakamura Y, Takarada T, Kodama A, Hinoi E, Yoneda Y.  Predominant promotion by tacrolimus of chondrogenic differentiation to proliferating chondrocytes.  J. Pharmacol. Sci.  2009  109:413-23  PubMed ID: 19270431
Hayashida M, Okazaki K, Fukushi J, Sakamoto A, Iwamoto Y.  CCAAT/enhancer binding protein beta mediates expression of matrix metalloproteinase 13 in human articular chondrocytes in inflammatory arthritis.  Arthritis Rheum.  2009  60:708-16  PubMed ID: 19248099
Kotzsch A, Nickel J, Seher A, Sebald W, Muller TD.  Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity.  EMBO J.  2009  28:937-47  PubMed ID: 19229295
Kumagishi K, Nishida K, Yamaai T, Momota R, Miyaki S, Hirohata S, Naito I, Asahara H, Ninomiya Y, Ohtsuka A.  A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9) expression by chondrocytes during endochondral ossification.  Arch. Histol. Cytol.  2009  72:175-85  PubMed ID: 20513980
Yasuda K, Kitamura N, Gong JP, Arakaki K, Kwon HJ, Onodera S, Chen YM, Kurokawa T, Kanaya F, Ohmiya Y, Osada Y.  A novel double-network hydrogel induces spontaneous articular cartilage regeneration in vivo in a large osteochondral defect.  Macromol Biosci  2008  9:307-16  PubMed ID: 19031389
Ti?li RS, Gumu?derelio?lu M.  Evaluation of alginate-chitosan semi IPNs as cartilage scaffolds.  J Mater Sci Mater Med  2008  20:699-709  PubMed ID: 18987950
Saremba S, Nickel J, Seher A, Kotzsch A, Sebald W, Mueller TD.  Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand.  FEBS J.  2007  275:172-83  PubMed ID: 18070108
Tamayama T, Maemura K, Kanbara K, Hayasaki H, Yabumoto Y, Yuasa M, Watanabe M.  Expression of GABA(A) and GABA(B) receptors in rat growth plate chondrocytes: activation of the GABA receptors promotes proliferation of mouse chondrogenic ATDC5 cells.  Mol. Cell. Biochem.  2005  273:117-26  PubMed ID: 16013446
Yano F, Kugimiya F, Ohba S, Ikeda T, Chikuda H, Ogasawara T, Ogata N, Takato T, Nakamura K, Kawaguchi H, Chung UI.  The canonical Wnt signaling pathway promotes chondrocyte differentiation in a Sox9-dependent manner.  Biochem. Biophys. Res. Commun.  2005  333:1300-8  PubMed ID: 15979579
Hinoi E, Wang L, Takemori A, Yoneda Y.  Functional expression of particular isoforms of excitatory amino acid transporters by rodent cartilage.  Biochem. Pharmacol.  2005  70:70-81  PubMed ID: 15894296
French DM, Kaul RJ, D'Souza AL, Crowley CW, Bao M, Frantz GD, Filvaroff EH, Desnoyers L.  WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair.  Am. J. Pathol.  2004  165:855-67  PubMed ID: 15331410
Nakajima M, Negishi Y, Tanaka H, Kawashima K.  p21(Cip-1/SDI-1/WAF-1) expression via the mitogen-activated protein kinase signaling pathway in insulin-induced chondrogenic differentiation of ATDC5 cells.  Biochem. Biophys. Res. Commun.  2004  320:1069-75  PubMed ID: 15249198
Fujita T, Azuma Y, Fukuyama R, Hattori Y, Yoshida C, Koida M, Ogita K, Komori T.  Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling.  J. Cell Biol.  2004  166:85-95  PubMed ID: 15226309
Keller S, Nickel J, Zhang JL, Sebald W, Mueller TD.  Molecular recognition of BMP-2 and BMP receptor IA.  Nat. Struct. Mol. Biol.  2004  11:481-8  PubMed ID: 15064755
Nishimura H, Nishimura M, Oda R, Yamanaka K, Matsubara T, Ozaki Y, Sekiya K, Hamada T, Kato Y.  Lectins induce resistance to proteases and/or mechanical stimulus in all examined cells--including bone marrow mesenchymal stem cells--on various scaffolds.  Exp. Cell Res.  2004  295:119-27  PubMed ID: 15051495
Meng F, Zhang Z, Chen W, Huang G, He A, Hou C, Long Y, Yang Z, Zhang Z, Liao W.  MicroRNA-320 regulates matrix metalloproteinase-13 expression in chondrogenesis and interleukin-1β-induced chondrocyte responses.  Osteoarthr. Cartil.  2016  24:932-41  PubMed ID: 26774733
Niu Q, Li F, Zhang L, Xu X, Liu Y, Gao J, Feng X.  Role of the Wnt/β-catenin signaling pathway in the response of chondrocytes to mechanical loading.  Int. J. Mol. Med.  2016  37:755-62  PubMed ID: 26821383
Abella V, Scotece M, Conde J, López V, Pirozzi C, Pino J, Gómez R, Lago F, González-Gay MÁ, Gualillo O.  The novel adipokine progranulin counteracts IL-1 and TLR4-driven inflammatory response in human and murine chondrocytes via TNFR1.  Sci Rep  2016  6:20356  PubMed ID: 26853108
Saito M, Mulati M, Talib SZ, Kaldis P, Takeda S, Okawa A, Inose H.  The Indispensable Role of Cyclin-Dependent Kinase 1 in Skeletal Development.  Sci Rep  2016  6:20622  PubMed ID: 26860366
Caron MM, Emans PJ, Sanen K, Surtel DA, Cremers A, Ophelders D, van Rhijn LW, Welting TJ.  The Role of Prostaglandins and COX-Enzymes in Chondrogenic Differentiation of ATDC5 Progenitor Cells.  PLoS ONE  2016  11:e0153162  PubMed ID: 27050768
Pathak JL, Verschueren P, Lems WF, Bravenboer N, Klein-Nulend J, Bakker AD, Luyten FP.  Serum of patients with active rheumatoid arthritis inhibits differentiation of osteochondrogenic precursor cells.  Connect. Tissue Res.  2016  57:226-35  PubMed ID: 27050327
Conde J, Otero M, Scotece M, Abella V, López V, Pino J, Gómez R, Lago F, Goldring MB, Gualillo O.  E74-like factor 3 and nuclear factor-κB regulate lipocalin-2 expression in chondrocytes.  J. Physiol. (Lond.)  2016  594:6133-6146  PubMed ID: 27222093
Kim H, Park H, Lee JW, Lee KY.  Magnetic field-responsive release of transforming growth factor beta 1 from heparin-modified alginate ferrogels.  Carbohydr Polym  2016  151:467-473  PubMed ID: 27474590
Choi HJ, Kwon S, Kim DW.  A post-translational modification cascade employing HDAC9-PIASy-RNF4 axis regulates chondrocyte hypertrophy by modulating Nkx3.2 protein stability.  Cell. Signal.  2016  28:1336-48  PubMed ID: 27312341
Nakajima M, Kou I, Ohashi H, , Ikegawa S.  Identification and Functional Characterization of RSPO2 as a Susceptibility Gene for Ossification of the Posterior Longitudinal Ligament of the Spine.  Am. J. Hum. Genet.  2016  99:202-7  PubMed ID: 27374772
Higa K, Kitamura N, Kurokawa T, Goto K, Wada S, Nonoyama T, Kanaya F, Sugahara K, Gong JP, Yasuda K.  Fundamental biomaterial properties of tough glycosaminoglycan-containing double network hydrogels newly developed using the molecular stent method.  Acta Biomater  2016  43:38-49  PubMed ID: 27427226
Kikuchi M, Shimada M, Matsuzaka T, Ishii K, Nakagawa Y, Takayanagi M, Yamada N, Shimano H.  Crucial Role of Elovl6 in Chondrocyte Growth and Differentiation during Growth Plate Development in Mice.  PLoS ONE  2016  11:e0159375  PubMed ID: 27467521
Lin Y, Ohkawara B, Ito M, Misawa N, Miyamoto K, Takegami Y, Masuda A, Toyokuni S, Ohno K.  Molecular hydrogen suppresses activated Wnt/β-catenin signaling.  Sci Rep  2016  6:31986  PubMed ID: 27558955
Jiang M, Fu X, Yang H, Long F, Chen J.  mTORC1 Signaling Promotes Limb Bud Cell Growth and Chondrogenesis.  J. Cell. Biochem.  2017  118:748-753  PubMed ID: 27606668
Chen W, Chen L, Zhang Z, Meng F, Huang G, Sheng P, Zhang Z, Liao W.  MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylation.  Biochim. Biophys. Acta  2016  1863:2881-2891  PubMed ID: 27638301
Imamura M, Higashi K, Yamaguchi K, Asakura K, Furihata T, Terui Y, Satake T, Maegawa J, Yasumura K, Ibuki A, Akase T, Nishimura K, Kashiwagi K, Linhardt RJ, Igarashi K, Toida T.  Polyamines release the let-7b-mediated suppression of initiation codon recognition during the protein synthesis of EXT2.  Sci Rep  2016  6:33549  PubMed ID: 27650265
Taniguchi Y, Kawata M, Ho Chang S, Mori D, Okada K, Kobayashi H, Sugita S, Hosaka Y, Inui H, Taketomi S, Yano F, Ikeda T, Akiyama H, Mills AA, Chung UI, Tanaka S, Kawaguchi H, Saito T.  Regulation of Chondrocyte Survival in Mouse Articular Cartilage by p63.    2017  69:598-609  PubMed ID: 27792866
Kobayashi H, Chang SH, Mori D, Itoh S, Hirata M, Hosaka Y, Taniguchi Y, Okada K, Mori Y, Yano F, Chung UI, Akiyama H, Kawaguchi H, Tanaka S, Saito T.  Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes.  Nat Commun  2016  7:13336  PubMed ID: 27830706
Chen Z, Jin T, Lu Y.  AntimiR-30b Inhibits TNF-α Mediated Apoptosis and Attenuated Cartilage Degradation through Enhancing Autophagy.  Cell. Physiol. Biochem.  2016  40:883-894  PubMed ID: 27941314
Hagerty RC.  Central suspension technique of the midface.  Plast. Reconstr. Surg.  1995  96:728-30  PubMed ID: 7638301
Funato S, Yasuhara R, Yoshimura K, Miyamoto Y, Kaneko K, Suzawa T, Chikazu D, Mishima K, Baba K, Kamijo R.  Extracellular matrix loss in chondrocytes after exposure to interleukin-1β in NADPH oxidase-dependent manner.  Cell Tissue Res.  2017  368:135-144  PubMed ID: 28070636
Le BQ, Vasilevich A, Vermeulen S, Hulshof F, Stamatialis DF, van Blitterswijk CA, de Boer J.  Micro-Topographies Promote Late Chondrogenic Differentiation Markers in the ATDC5 Cell Line.  Tissue Eng Part A  2017  23:458-469  PubMed ID: 28152670
Conde J, Lazzaro V, Scotece M, Abella V, Villar R, López V, Gonzalez-Gay MÁ, Pino J, Gómez R, Mera A, Gualillo O.  Corticoids synergize with IL-1 in the induction of LCN2.  Osteoarthr. Cartil.  2017  25:1172-1178  PubMed ID: 28185846
Wang CL, Wang H, Xiao F, Wang CD, Hu GL, Zhu JF, Shen C, Zuo B, Cui YM, Li , Yuan-Gao , Zhang XL, Chen XD.  Cyclic compressive stress-induced scinderin regulates progress of developmental dysplasia of the hip.  Biochem. Biophys. Res. Commun.  2017  485:400-408  PubMed ID: 28213129
Quang Le B, Van Blitterswijk C, De Boer J.  An Approach to In Vitro Manufacturing of Hypertrophic Cartilage Matrix for Bone Repair.  Bioengineering (Basel)  2017  4:  PubMed ID: 28952514
Im S, Kim DW.  Nkx3.2 induces oxygen concentration-independent and lysosome-dependent degradation of HIF-1α to modulate hypoxic responses in chondrocytes.  Cell. Signal.  2017  36:127-138  PubMed ID: 28479297
Cao L, Zhang F, Wang Q, Wu X.  Fabrication of chitosan/graphene oxide polymer nanofiber and its biocompatibility for cartilage tissue engineering.  Mater Sci Eng C Mater Biol Appl  2017  79:697-701  PubMed ID: 28629070
Wang P, Ying J, Luo C, Jin X, Zhang S, Xu T, Zhang L, Mi M, Chen D, Tong P, Jin H.  Osthole Promotes Bone Fracture Healing through Activation of BMP Signaling in Chondrocytes.  Int. J. Biol. Sci.  2017  13:996-1007  PubMed ID: 28924381
Yuan Y, Tan H, Dai P.  Krüppel-Like Factor 2 Regulates Degradation of Type II Collagen by Suppressing the Expression of Matrix Metalloproteinase (MMP)-13.  Cell. Physiol. Biochem.  2017  42:2159-2168  PubMed ID: 28873368
Mu W, Xu B, Ma H, Ji B, Zhang Z, Li J, Amat A, Cao L.  Halofuginone attenuates articular cartilage degeneration by inhibition of elevated TGF‑β1 signaling in articular cartilage in a rodent osteoarthritis model.  Mol Med Rep  2017  16:7679-7684  PubMed ID: 28944864
Ji B, Guo W, Ma H, Xu B, Mu W, Zhang Z, Amat A, Cao L.  Isoliquiritigenin suppresses IL-1β induced apoptosis and inflammation in chondrocyte-like ATDC5 cells by inhibiting NF-κB and exerts chondroprotective effects on a mouse model of anterior cruciate ligament transection.  Int. J. Mol. Med.  2017  40:1709-1718  PubMed ID: 29039445
Tanoue H, Morinaga J, Yoshizawa T, Yugami M, Itoh H, Nakamura T, Uehara Y, Masuda T, Odagiri H, Sugizaki T, Kadomatsu T, Miyata K, Endo M, Terada K, Ochi H, Takeda S, Yamagata K, Fukuda T, Mizuta H, Oike Y.  Angiopoietin-like protein 2 promotes chondrogenic differentiation during bone growth as a cartilage matrix factor.  Osteoarthr. Cartil.  2018  26:108-117  PubMed ID: 29074299
Xu W, Wang Y, Zhao H, Fan B, Guo K, Cai M, Zhang S.  Delta-like 2 negatively regulates chondrogenic differentiation.  J. Cell. Physiol.  2017    PubMed ID: 29057471
Kudo T, Nakatani S, Kakizaki M, Arai A, Ishida K, Wada M, Kobata K.  Supplemented Chondroitin Sulfate and Hyaluronic Acid Suppress Mineralization of the Chondrogenic Cell Line, ATDC5, via Direct Inhibition of Alkaline Phosphatase.  Biol. Pharm. Bull.  2017  40:2075-2080  PubMed ID: 29199232
Tabe S, Hikiji H, Ariyoshi W, Hashidate-Yoshida T, Shindou H, Shimizu T, Okinaga T, Seta Y, Tominaga K, Nishihara T.  Lysophosphatidylcholine acyltransferase 4 is involved in chondrogenic differentiation of ATDC5 cells.  Sci Rep  2017  7:16701  PubMed ID: 29196633
Taipale M, Solovieva S, Leino-Arjas P, Männikkö M.  Functional polymorphisms in asporin and CILP together with joint loading predispose to hand osteoarthritis.  BMC Genet.  2017  18:108  PubMed ID: 29233086
Liang X, Wang X, Xu Q, Lu Y, Zhang Y, Xia H, Lu A, Zhang L.  Rubbery Chitosan/Carrageenan Hydrogels Constructed through an Electroneutrality System and Their Potential Application as Cartilage Scaffolds.  Biomacromolecules  2018  19:340-352  PubMed ID: 29253344
Li C, Zheng Z, Zhang X, Asatrian G, Chen E, Song R, Culiat C, Ting K, Soo C.  Nfatc1 Is a Functional Transcriptional Factor Mediating Nell-1-Induced Runx3 Upregulation in Chondrocytes.  Int J Mol Sci  2018  19:  PubMed ID: 29316655
Lin C, Shao Y, Zeng C, Zhao C, Fang H, Wang L, Pan J, Liu L, Qi W, Feng X, Qiu H, Zhang H, Chen Y, Wang H, Cai D, Xian CJ.  Blocking PI3K/AKT signaling inhibits bone sclerosis in subchondral bone and attenuates post-traumatic osteoarthritis.  J. Cell. Physiol.  2018  233:6135-6147  PubMed ID: 29323710
Korogi W, Yoshizawa T, Karim MF, Tanoue H, Yugami M, Sobuz SU, Hinoi E, Sato Y, Oike Y, Mizuta H, Yamagata K.  SIRT7 is an important regulator of cartilage homeostasis and osteoarthritis development.  Biochem. Biophys. Res. Commun.  2018    PubMed ID: 29402405
Li F, Sun J, Huang S, Su G, Pi G.  LncRNA GAS5 Overexpression Reverses LPS-Induced Inflammatory Injury and Apoptosis Through Up-Regulating KLF2 Expression in ATDC5 Chondrocytes.  Cell. Physiol. Biochem.  2018  45:1241-1251  PubMed ID: 29448248
Goto H, Nishio M, To Y, Oishi T, Miyachi Y, Maehama T, Nishina H, Akiyama H, Mak TW, Makii Y, Saito T, Yasoda A, Tsumaki N, Suzuki A.  Loss of Mob1a/b in mice results in chondrodysplasia due to YAP1/TAZ-TEAD-dependent repression of SOX9.  Development  2018  145:  PubMed ID: 29511023
Wang PE, Zhang L, Ying J, Jin X, Luo C, Xu S, Dong R, Xiao L, Tong P, Jin H.  Bushenhuoxue formula attenuates cartilage degeneration in an osteoarthritic mouse model through TGF-β/MMP13 signaling.  J Transl Med  2018  16:72  PubMed ID: 29554973
Matsumoto N, Kaneko M, Watanabe N, Itaoka M, Seki Y, Morimoto T, Torii T, Miyamoto Y, Keiichi Homma , Yamauchi J.  Treacher Collins syndrome 3 (TCS3)-associated POLR1C mutants are localized in the lysosome and inhibits chondrogenic differentiation.  Biochem. Biophys. Res. Commun.  2018  499:78-85  PubMed ID: 29567474
Liang Z, Ren C.  Emodin attenuates apoptosis and inflammation induced by LPS through up-regulating lncRNA TUG1 in murine chondrogenic ATDC5 cells.  Biomed. Pharmacother.  2018  103:897-902  PubMed ID: 29710506
Yanoshita M, Hirose N, Okamoto Y, Sumi C, Takano M, Nishiyama S, Asakawa-Tanne Y, Horie K, Onishi A, Yamauchi Y, Mitsuyoshi T, Kunimatsu R, Tanimoto K.  Cyclic Tensile Strain Upregulates Pro-Inflammatory Cytokine Expression Via FAK-MAPK Signaling in Chondrocytes.  Inflammation  2018    PubMed ID: 29737477
  High throughput screening for modulators of ACVR1 transcription potentially applicable to the treatment of Fibrodysplasia Ossificans Progressiva  Disease Models & Mechanisms  2016  9, 1067 
Yano K, Washio K, Tsumanuma Y, Yamato M, Ohta K, Okano T, Izumi Y.  The role of Tsukushi (TSK), a small leucine-rich repeat proteoglycan, in bone growth  Regen Ther  2017  7:98-107  PubMed ID: 30271858
  Semaphorin 3A inhibits inflammation in chondrocytes under excessive mechanical stress  Mediators of Inflammation  2018  2018, 9  PubMed ID: 29849491
Wang Y, Kong D.  MicroRNA-136 promotes lipopolysaccharide-induced ATDC5 cell injury and inflammatory cytokine expression by targeting myeloid cell leukemia 1.  J. Cell. Biochem.  2018    PubMed ID: 30074264
Pan L, Liu D, Zhao L, Wang L, Xin M, Li X.  Long noncoding RNA MALAT1 alleviates lipopolysaccharide-induced inflammatory injury by upregulating microRNA-19b in murine chondrogenic ATDC5 cells.  J. Cell. Biochem.  2018    PubMed ID: 30145831
Dong R, Ying J, Xu T, Hu S, Zhang P, Xia C, Fang L, Jin H, Wang P.  Bushenhuoxue Formula Facilitates Articular Cartilage Repair and Attenuates Matrix Degradation by Activation of TGF-β Signaling Pathway.  Evid Based Complement Alternat Med  2018    PubMed ID: 30402118
Kudva AK, Luyten FP, Patterson J.  In Vitro Screening of Molecularly Engineered Polyethylene Glycol Hydrogels for Cartilage Tissue Engineering using Periosteum-Derived and ATDC5 Cells.  Int J Mol Sci  2018    PubMed ID: 30373138
Kim H, Choi YJ, Lee YS, Park SY, Baek JE, Kim HK, Kim BJ, Lee SH, Koh JM.  SLIT3 regulates endochondral ossification by β-catenin suppression in chondrocytes.  Biochem. Biophys. Res. Commun.  2018    PubMed ID: 30389141
Pirozzi C, Francisco V, Guida FD, Gómez R, Lago F, Pino J, Meli R, Gualillo O.  Butyrate Modulates Inflammation in Chondrocytes via GPR43 Receptor.  Cell. Physiol. Biochem.  2018    PubMed ID: 30448827
Liu G, Wang Y, Zhang M, Zhang Q.  Long non-coding RNA THRIL promotes LPS-induced inflammatory injury by down-regulating microRNA-125b in ATDC5 cells.  Int. Immunopharmacol.  2019    PubMed ID: 30521964
Shimo T, Koyama E, Okui T, Masui M, Kunisada Y, Ibaragi S, Yoshioka N, Kurio N, Yoshida S, Sasaki A, Iwamoto M.  Retinoic Receptor Signaling Regulates Hypertrophic Chondrocyte-specific Gene Expression.  In Vivo  2019    PubMed ID: 30587607
Yamaguchi Y, Kanzaki H, Miyamoto Y, Itohiya K, Fukaya S, Katsumata Y, Nakamura Y.  Nutritional supplementation with myo-inositol in growing mice specifically augments mandibular endochondral growth.  Bone  2019    PubMed ID: 30682567
Steinbusch MMF, Caron MMJ, Surtel DAM, van den Akker GGH, van Dijk PJ, Friedrich F, Zabel B, van Rhijn LW, Peffers MJ, Welting TJM.  The antiviral protein viperin regulates chondrogenic differentiation via CXCL10 protein secretion.  J. Biol. Chem.  2019    PubMed ID: 30718282
Ying H, Wang Y, Gao Z, Zhang Q.  Long non-coding RNA activated by transforming growth factor beta alleviates lipopolysaccharide-induced inflammatory injury via regulating microRNA-223 in ATDC5 cells.  Int. Immunopharmacol.  2019    PubMed ID: 30771739
Lin C, Liu L, Zeng C, Cui ZK, Chen Y, Lai P, Wang H, Shao Y, Zhang H, Zhang R, Zhao C, Fang H, Cai D, Bai X.  Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12.  Bone Res  2019    PubMed ID: 30792936
Lian C, Wang X, Qiu X, Wu Z, Gao B, Liu L, Liang G, Zhou H, Yang X, Peng Y, Liang A, Xu C, Huang D, Su P.  Collagen type II suppresses articular chondrocyte hypertrophy and osteoarthritis progression by promoting integrin β1-SMAD1 interaction.  Bone Res  2019    PubMed ID: 30854241
Chang SH, Mori D, Kobayashi H, Mori Y, Nakamoto H, Okada K, Taniguchi Y, Sugita S, Yano F, Chung UI, Kim-Kaneyama JR, Yanagita M, Economides A, Canalis E, Chen D, Tanaka S, Saito T.  Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-κB pathway.  Nat Commun  2019  10:1442  PubMed ID: 30926814



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