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1371 Bertram, J S, Janik P Establishment of a cloned line of Lewis Lung Carcinoma cells adapted to cell culture. Cancer Lett 1980 11:63-73 PubMed ID: 7226139 DOI: 10.1016/0304-3835(80)90130-5

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22791 Yamane K, Yamaguchi K, Teruya Y, Miyake N, Nakayama Y, Nonaka T, Chikumi H, Yamasaki A. ULBP2 Promotes Tumor Progression by Suppressing NKG2D-Mediated Anti-Tumor Immunity. Int J Mol Sci 2025 26(7) PubMed ID: 40243581 DOI: 10.3390/ijms26072950

21589 Sun L, Morikawa K, Sogo Y, Sugiura Y. MHY1485 potentiates immunogenic cell death induction and anti-cancer immunity following irradiation. J Radiat Res 2024 PubMed ID: 38330507 DOI: 10.1093/jrr/rrad107

21687 Hayashi Y, Hashimoto M, Takaoka K, Takemoto T, Takakura N, Kidoya H. Tumor endothelial cell-derived Sfrp1 supports the maintenance of cancer stem cells via Wnt signaling. In Vitro Cell Dev Biol Anim 2024 PubMed ID: 38625488 DOI: 10.1007/s11626-024-00899-y

22717 Jia Z, Maishi N, Takekawa H, Matsuda AY, Nakade T, Nakamura T, Harashima H, Hida Y, Hida K. Targeting Tumor Endothelial Cells by EGCG Using Specific Liposome Delivery System Inhibits Vascular Inflammation and Thrombosis Cancer Med 2024 13(23):e70462 PubMed ID: 39629553 DOI: 10.1002/cam4.70462

22807 Kashimoto R, Ohgitani E, Makimura Y, Miyazaki T, Kimura C, Shin-Ya M, Nishimura H, Pezzotti G, Watanabe T, Mazda O. Lignin Isolated by Microwave-Assisted Acid-Catalyzed Solvolysis Induced Cell Death in Mammalian Tumor Cells by Modulating Apoptotic Pathways Molecules 2024 29(23):5490 PubMed ID: 39683650 DOI: 10.3390/molecules29235490

19757 Deguchi A, Watanabe-Takahashi M, Mishima T, Omori T, Ohto U, Arashiki N, Nakamura F, Nishikawa K, Maru Y. Novel multivalent S100A8 inhibitory peptides attenuate tumor progression and metastasis by inhibiting the TLR4-dependent pathway Cancer Gene Ther 2023 30(7):973-984 PubMed ID: 36932197 DOI: 10.1038/s41417-023-00604-3

19778 Yuan X, Wang X. An In Situ Chemotherapy Drug Combined with Immune Checkpoint Inhibitor for Chemoimmunotherapy Nanomaterials (Basel) 2023 13(24):3144 PubMed ID: 38133040 DOI: 10.3390/nano13243144

19791 Ota Y, Nagai Y, Hirose Y, Hori S, Koga-Yamakawa E, Eguchi K, Sumida K, Murata M, Umehara H, Yamamoto S. DSP-0509, a systemically available TLR7 agonist, exhibits combination effect with immune checkpoint blockade by activating anti-tumor immune effects Front Immunol 2023 14:1055671 PubMed ID: 36793737 DOI: 10.3389/fimmu.2023.1055671

21076 Sato M, Maishi N, Hida Y, Yanagawa-Matsuda A, Alam MT, Sakakibara-Konishi J, Nam JM, Onodera Y, Konno S, Hida K. Angiogenic inhibitor pre-administration improves the therapeutic effects of immunotherapy. Cancer Med 2023 PubMed ID: 36808261 DOI: 10.1002/cam4.5696

21087 Shimizu T, Matsuzaki T, Fukuda S, Yoshioka C, Shimazaki Y, Takese S, Yamanaka K, Nakae T, Ishibashi M, Hamamoto H, Ando H, Ishima Y, Ishida T. Ionic Liquid-Based Transcutaneous Peptide Antitumor Vaccine: Therapeutic Effect in a Mouse Tumor Model. AAPS J 2023 25(2):27 PubMed ID: 36805860 DOI: 10.1208/s12248-023-00790-w

21315 Okamoto M, Sasai M, Kuratani A, Okuzaki D, Arai M, Wing JB, Sakaguchi S, Yamamoto M. A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity. Cell Rep 2023 42(7):112813 PubMed ID: 37440410 DOI: 10.1016/j.celrep.2023.112813

21378 Han Y, Tomita T, Kato M, Ashihara N, Higuchi Y, Matoba H, Wang W, Hayashi H, Itoh Y, Takahashi S, Kurita H, Nakayama J, Okumura N, Hiratsuka S. Citrullinated fibrinogen-SAAs complex causes vascular metastagenesis. Nat Commun 2023 14(1):4960 PubMed ID: 37620307 DOI: 10.1038/s41467-023-40371-1

21432 Inoue M, Iizuka Y, Nakamura K, Sato GE, Mizowaki T. Role of albumin Cys34 redox state in the progression of differentiated thyroid carcinoma and induction of ferroptosis. Free Radic Biol Med 2023 PubMed ID: 37806598 DOI: 10.1016/j.freeradbiomed.2023.10.015

17499 Bishoy El-Aarag, Evet El-Tahan, Magdy Zahran New Thalidomide Derivative with An Anti-Migrative and Anti-Proliferative Effects on Lewis Lung Carcinoma Cell Egyptian Journal of Chemistry 2022 DOI: 10.21608/ejchem.2022.109507.4997

18101 Sugimoto C, Murakami Y, Ishii E, Fujita H, Wakao H. Reprogramming and redifferentiation of mucosal-associated invariant T cells reveal tumor inhibitory activity Elife 2022 11:e70848 PubMed ID: 35379387 DOI: 10.7554/eLife.70848

20693 Yamazaki K, Hoshi M, Tezuka H, Morita N, Hirayama M, Sato F, Yoshida S, Saito K. D‑allose enhances the efficacy of hydroxychloroquine against Lewis lung carcinoma cell growth by inducing autophagy. Oncol Rep 2022 47(6) PubMed ID: 35543153 DOI: 10.3892/or.2022.8328

20730 Mizuno R, Hojo H, Takahashi M, Kashio S, Enya S, Nakao M, Konishi R, Yoda M, Harata A, Hamanishi J, Kawamoto H, Mandai M, Suzuki Y, Miura M, Bamba T, Izumi Y, Kawaoka S. Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase. Nat Commun 2022 13(1):3346 PubMed ID: 35705545 DOI: 10.1038/s41467-022-30926-z

20055 Watanabe R, Esaki T, Ohashi R, Kuroda M, Kawashima H, Komura H, Natsume-Kitatani Y, Mizuguchi K. Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration. J Med Chem 2021 PubMed ID: 33619967 DOI: 10.1021/acs.jmedchem.0c02011

20199 Tomita T, Kato M, Mishima T, Matsunaga Y, Sanjo H, Ito KI, Minagawa K, Matsui T, Oikawa H, Takahashi S, Takao T, Iwai N, Mino T, Takeuchi O, Maru Y, Hiratsuka S. Extracellular mRNA transported to the nucleus exerts translation-independent function. Nat Commun 2021 12(1):3655 PubMed ID: 34135341 DOI: 10.1038/s41467-021-23969-1

20222 Hu L, Hayashi Y, Kidoya H, Takakura N. Endothelial cell-derived Apelin inhibits tumor growth by altering immune cell localization. Sci Rep 2021 11(1):14047 PubMed ID: 34234274 DOI: 10.1038/s41598-021-93619-5

20235 Sun L, Morikawa K, Sogo Y, Sugiura Y. MHY1485 enhances X-irradiation-induced apoptosis and senescence in tumor cells. J Radiat Res 2021 PubMed ID: 34265852 DOI: 10.1093/jrr/rrab057

20284 Ieguchi K, Tomita T, Takao T, Omori T, Mishima T, Shimizu I, Tognolini M, Lodola A, Tsunoda T, Kobayashi S, Wada S, Maru Y. Analysis of ADAM12-Mediated Ephrin-A1 Cleavage and Its Biological Functions. Int J Mol Sci 2021 22(5) PubMed ID: 33804570 DOI: 10.3390/ijms22052480

15493 Yoshizawa K, Kurono R, Sato H, Ishijima E, Nasu H, Ferdaos N, Suzuki H, Negishi K. Effect of Sucrose on Cisplatin-induced Fatigue-like Behavior in Mice: Comparison With Fructose and Glucose Cancer Diagn Progn 2021 1:95-102 PubMed ID: 35403134 DOI: 10.21873/cdp.10014

13056 Yoshizawa K, Tabuchi M, Ukai S, Suzuki H, Kawano Y, Takasawa R. The Putative Glyoxalase 1 Inhibitor Piceatannol Exhibits Both Anxiolytic-like and Antitumor Effects in Mice. Anticancer Res 2020 PubMed ID: 32487622 DOI: 10.21873/anticanres.14309

17778 Toyohisa Fujita Antioxidant Effect of Hydrogen Nanobubble Contributes to Suppression of Tumor Cell Growth Biomedical Journal of Scientific & Technical Research 2019 19 DOI: 10.26717/bjstr.2019.19.003361

4047 Naito H, Iba T, Wakabayashi T, Tai-Nagara I, Suehiro JI, Jia W, Eino D, Sakimoto S, Muramatsu F, Kidoya H, Sakurai H, Satoh T, Akira S, Kubota Y, Takakura N. TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity Dev Cell 2019 48(2):151-166 PubMed ID: 30639056 DOI: 10.1016/j.devcel.2018.12.002

11311 Umakoshi M, Takahashi S, Itoh G, Kuriyama S, Sasaki Y, Yanagihara K, Yashiro M, Maeda D, Goto A, Tanaka M. Macrophage-mediated transfer of cancer-derived components to stromal cells contributes to establishment of a pro-tumor microenvironment. Oncogene 2019 PubMed ID: 30459356 DOI: 10.1038/s41388-018-0564-x

11310 Wang Y, Zenkoh J, Gerelchuluun A, Sun L, Cai S, Li X, Tsuboi K. Administration of Dendritic Cells and Anti-PD-1 Antibody Converts X-ray Irradiated Tumors Into Effective In situ Vaccines. Int. J. Radiat. Oncol. Biol. Phys. 2019 PubMed ID: 30458232 DOI: 10.1016/j.ijrobp.2018.11.019

12503 Yamasuge W, Yamamoto Y, Fujigaki H, Hoshi M, Nakamoto K, Kunisawa K, Mouri A, Nabeshima T, Saito K. Indoleamine 2,3-dioxygenase 2 depletion suppresses tumor growth in a mouse model of Lewis lung carcinoma Cancer Sci 2019 110(10):3061-3067 PubMed ID: 31444833 DOI: 10.1111/cas.14179

10609 Omori K, Morikawa T, Kunita A, Nakamura T, Aritake K, Urade Y, Fukayama M, Murata T. Lipocalin-type prostaglandin D synthase-derived PGD2 attenuates malignant properties of tumor endothelial cells. J. Pathol. 2018 244:84-96 PubMed ID: 29124765 DOI: 10.1002/path.4993

10811 Yamakawa D, Jia W, Kidoya H, Hosojima S, Torigata M, Zhang L, Takakura N. Visualization of Proliferative Vascular Endothelial Cells in Tumors in Vivo by Imaging Their Partner of Sld5-1 Promoter Activity. Am. J. Pathol. 2018 188:1300-1314 PubMed ID: 29650228 DOI: 10.1016/j.ajpath.2018.01.015

14825 Eino D, Tsukada Y, Naito H, Kanemura Y, Iba T, Wakabayashi T, Muramatsu F, Kidoya H, Arita H, Kagawa N, Fujimoto Y, Takara K, Kishima H, Takakura N. LPA4-Mediated Vascular Network Formation Increases the Efficacy of Anti-PD-1 Therapy against Brain Tumors Cancer Res 2018 78(23):6607-6620 PubMed ID: 30301839 DOI: 10.1158/0008-5472.CAN-18-0498

10663 Okuma A, Hanyu A, Watanabe S, Hara E. p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis. Nat Commun 2017 8:2050 PubMed ID: 29234059 DOI: 10.1038/s41467-017-02281-x

6349 Ponzio G, Rezzonico R, Bourget I, Allan R, Nottet N, Popa A, Magnone V, Rios G, Mari B, Barbry P. A new long noncoding RNA (lncRNA) is induced in cutaneous squamous cell carcinoma and down-regulates several anticancer and cell differentiation genes in mouse. J Biol Chem. 2017 292(30):12483-12495 PubMed ID: 28596382 DOI: 10.1074/jbc.M117.776260

14214 Tanaka M, Kuriyama S, Itoh G, Maeda D, Goto A, Tamiya Y, Yanagihara K, Yashiro M, Aiba N. Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Cancer Res 2017 77(3):684-695 PubMed ID: 27895076 DOI: 10.1158/0008-5472.CAN-16-0964

14246 Kanzaki R, Naito H, Kise K, Takara K, Eino D, Minami M, Shintani Y, Funaki S, Kawamura T, Kimura T, Okumura M, Takakura N. Gas6 derived from cancer-associated fibroblasts promotes migration of Axl-expressing lung cancer cells during chemotherapy Sci Rep 2017 7(1):10613 PubMed ID: 28878389 DOI: 10.1038/s41598-017-10873-2

14722 Kanemaru H, Yamane F, Fukushima K, Matsuki T, Kawasaki T, Ebina I, Kuniyoshi K, Tanaka H, Maruyama K, Maeda K, Satoh T, Akira S. Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages Proc Natl Acad Sci U S A 2017 114(35):E7331-E7340 PubMed ID: 28808017 DOI: 10.1073/pnas.1708598114

14736 Takara K, Eino D, Ando K, Yasuda D, Naito H, Tsukada Y, Iba T, Wakabayashi T, Muramatsu F, Kidoya H, Fukuhara S, Mochizuki N, Ishii S, Kishima H, Takakura N. Lysophosphatidic Acid Receptor 4 Activation Augments Drug Delivery in Tumors by Tightening Endothelial Cell-Cell Contact Cell Rep 2017 20(9):2072-2086 PubMed ID: 28854359 DOI: 10.1016/j.celrep.2017.07.080

7088 Mukai H, Muramatsu A, Mashud R, Kubouchi K, Tsujimoto S, Hongu T, Kanaho Y, Tsubaki M, Nishida S, Shioi G, Danno S, Mehruba M, Satoh R, Sugiura R. PKN3 is the major regulator of angiogenesis and tumor metastasis in mice. Sci Rep 2016 6:18979 PubMed ID: 26742562 DOI: 10.1038/srep18979

9613 Wang X, Li X, Yoshiyuki K, Watanabe Y, Sogo Y, Ohno T, Tsuji NM, Ito A. Comprehensive Mechanism Analysis of Mesoporous-Silica-Nanoparticle-Induced Cancer Immunotherapy. Adv Healthc Mater 2016 5:1169-76 PubMed ID: 26987867 DOI: 10.1002/adhm.201501013

9643 Naito H, Wakabayashi T, Kidoya H, Muramatsu F, Takara K, Eino D, Yamane K, Iba T, Takakura N. Endothelial Side Population Cells Contribute to Tumor Angiogenesis and Antiangiogenic Drug Resistance. Cancer Res. 2016 76:3200-10 PubMed ID: 27197162 DOI: 10.1158/0008-5472.CAN-15-2998

9822 Makiguchi T, Yamada M, Yoshioka Y, Sugiura H, Koarai A, Chiba S, Fujino N, Tojo Y, Ota C, Kubo H, Kobayashi S, Yanai M, Shimura S, Ochiya T, Ichinose M. Serum extracellular vesicular miR-21-5p is a predictor of the prognosis in idiopathic pulmonary fibrosis. Respir. Res. 2016 17:110 PubMed ID: 27596748 DOI: 10.1186/s12931-016-0427-3

9904 Hanaoka Y, Yamaguchi Y, Yamamoto H, Ishii M, Nagase T, Kurihara H, Akishita M, Ouchi Y. In Vitro and In Vivo Anticancer Activity of Human β-Defensin-3 and Its Mouse Homolog. Anticancer Res. 2016 36:5999-6004 PubMed ID: 27793926 DOI: 10.21873/anticanres.11188

5392 Tsutsumi K, Kaname T1, Shiraishi H1, Kawashiri T1, Egashira N. Polaprezinc reduces paclitaxel-induced peripheral neuropathy in rats without affecting anti-tumor activity. J Pharmacol Sci 2016 131(2):146-9 PubMed ID: 27262900 DOI: 10.1016/j.jphs.2016.04.019

14123 Tanaka M, Shimamura S, Kuriyama S, Maeda D, Goto A, Aiba N. SKAP2 Promotes Podosome Formation to Facilitate Tumor-Associated Macrophage Infiltration and Metastatic Progression Cancer Res 2016 76(2):358-69 PubMed ID: 26577701 DOI: 10.1158/0008-5472.CAN-15-1879

6338 Yu R, Zheng Y, Lucas MB, Tong YG. Elusive liver factor that causes pancreatic α cell hyperplasia: A review of literature. World J Gastrointest Pathophysiol 2015 6(4):131-9 PubMed ID: 26600971 DOI: 10.4291/wjgp.v6.i4.131

15134 Hata R, Izukuri K, Kato Y, Sasaki S, Mukaida N, Maehata Y, Miyamoto C, Akasaka T, Yang X, Nagashima Y, Takeda K, Kiyono T, Taniguchi M. Suppressed rate of carcinogenesis and decreases in tumour volume and lung metastasis in CXCL14/BRAK transgenic mice Sci Rep 2015 5:9083 PubMed ID: 25765541 DOI: 10.1038/srep09083

11037 Takemura R, Takaki H, Okada S, Shime H, Akazawa T, Oshiumi H, Matsumoto M, Teshima T, Seya T. PolyI:C-Induced, TLR3/RIP3-Dependent Necroptosis Backs Up Immune Effector-Mediated Tumor Elimination In Vivo Cancer Immunol Res 2015 3(8):902-14 PubMed ID: 25898986 DOI: 10.1158/2326-6066.CIR-14-0219

15207 Miyazaki T, Taketomi Y, Saito Y, Hosono T, Lei XF, Kim-Kaneyama JR, Arata S, Takahashi H, Murakami M, Miyazaki A. Calpastatin counteracts pathological angiogenesis by inhibiting suppressor of cytokine signaling 3 degradation in vascular endothelial cells Circ Res 2015 116(7):1170-81 PubMed ID: 25648699 DOI: 10.1161/CIRCRESAHA.116.305363

15257 Sun Y, Ito S, Nishio N, Tanaka Y, Chen N, Liu L, Isobe K. Enhancement of the acrolein-induced production of reactive oxygen species and lung injury by GADD34 Oxid Med Cell Longev 2015 2015:170309 PubMed ID: 25821552 DOI: 10.1155/2015/170309

18179 Chiba S, Ikushima H, Ueki H, Yanai H, Kimura Y, Hangai S, Nishio J, Negishi H, Tamura T, Saijo S, Iwakura Y, Taniguchi T. Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses Elife 2014 3:e04177 PubMed ID: 25149452 DOI: 10.7554/eLife.04177

13661 Hasegawa H, Yamashita K, Otubo D, Fujii S, Kamigaki T, Kuroda D, Kakeji Y. Allogeneic DCG promote lung NK cell activation and antitumor effect after invariant NKT cell activation Anticancer Res 2014 34(7):3411-7. PubMed ID: 24982348

15295 Sun Y, Ito S, Nishio N, Tanaka Y, Chen N, Isobe K. Acrolein induced both pulmonary inflammation and the death of lung epithelial cells Toxicol Lett 2014 229(2):384-92 PubMed ID: 24999835 DOI: 10.1016/j.toxlet.2014.06.021

18923 Mizumoto S, Watanabe M, Yamada S, Sugahara K. Expression of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase involved in chondroitin sulfate synthesis is responsible for pulmonary metastasis Biomed Res Int 2013 2013:656319 PubMed ID: 23555092 DOI: 10.1155/2013/656319

15795 Wang X, Li X, Onuma K, Sogo Y, Ohno T, Ito A. Zn- and Mg- containing tricalcium phosphates-based adjuvants for cancer immunotherapy Sci Rep 2013 3:2203 PubMed ID: 23857555 DOI: 10.1038/srep02203

19527 The apelin/APJ system induces maturation of the tumor vasculature and improves the efficiency of immune therapy The apelin/APJ system induces maturation of the tumor vasculature and improves the efficiency of immune therapy Oncogene 2012 31(27):3254-64 PubMed ID: 22037214 DOI: 10.1038/onc.2011.489

5377 Mizumoto S, Takahashi J, Sugahara K. Receptor for advanced glycation end products (RAGE) functions as receptor for specific sulfated glycosaminoglycans, and anti-RAGE antibody or sulfated glycosaminoglycans delivered in vivo inhibit pulmonary metastasis of tumor cells. J Biol Chem 2012 287(23):18985-94 PubMed ID: 22493510 DOI: 10.1074/jbc.M111.313437

7872 Hara K, Kasahara E, Takahashi N, Konishi M, Inoue J, Jikumaru M, Kubo S, Okamura H, Sato E, Inoue M. Mitochondria determine the efficacy of anticancer agents that interact with DNA but not the cytoskeleton. J. Pharmacol. Exp. Ther. 2011 337:838-45 PubMed ID: 21421738 DOI: 10.1124/jpet.111.179473

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3567 Yoshikawa N, Nakamura K, Yamaguchi Y, Kagota S, Shinozuka K, Kunitomo M. Reinforcement of antitumor effect of Cordyceps sinensis by 2'-deoxycoformycin, an adenosine deaminase inhibitor. In Vivo 2007 21(2):291-5 PubMed ID: 17436579

6293 Imai N, Hashimoto T, Kihara M, Yoshida S, Kawana I, Yazawa T, Kitamura H, Umemura S. Roles for host and tumor angiotensin II type 1 receptor in tumor growth and tumor-associated angiogenesis. Lab Invest 2007 87(2):189-98 PubMed ID: 17318197 DOI: 10.1038/labinvest.3700504

3290 Nakamura, Kazuki, Yoshikawa, Noriko, Yamaguchi, Yu, Kagota, Satomi, Shinozuka, Kazumasa, Kunitomo, Masaru Antitumor effect of cordycepin (3'-deoxyadenosine) on mouse melanoma and lung carcinoma cells involves adenosine A3 receptor stimulation. Anticancer Res 2006 26:43-7 PubMed ID: 16475677

18625 Cui R, Takahashi K, Takahashi F, Tanabe KK, Fukuchi Y. Endostatin gene transfer in murine lung carcinoma cells induces vascular endothelial growth factor secretion resulting in up-regulation of in vivo tumorigenecity Cancer Lett 2006 232(2):262-71 PubMed ID: 15876483 DOI: 10.1016/j.canlet.2005.02.045

13654 Kushida S, Ohmae H, Kamma H, Totsuka R, Matsumura M, Takeuchi A, Saiki I, Yanagawa T, Onizawa K, Ishii T, Ohn T. Artificial cytokine storm combined with hyperthermia induces significant anti-tumor effect in mice inoculated with lewis lung carcinoma and B16 melanoma cells Int J Hyperthermia 2006 22(8):699-712 PubMed ID: 17390999 DOI: 10.1080/02656730601088508

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17323 Kimura Y, Taniguchi M, Baba K. Antitumor and antimetastatic activities of 4-hydroxyderricin isolated from Angelica keiskei roots Planta Med 2004 70(3):211-9 PubMed ID: 15114497 DOI: 10.1055/s-2004-815537

9035 Li-Quan Wang, Byung-Sun Min, Yan Li, Norio Nakamura, Guo-Wei Qin, Can-Jun Li, Masao Hattori Annonaceous Acetogenins From the Leaves of Annona Montana Bioorg Med Chem 2002 10 (3), 561-5 PubMed ID: 11814843 DOI: 10.1016/s0968-0896(01)00303-0

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