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Cell No. : Cell Name
RCB0557 : B16 melanoma 4A5  update : 2024/03/21
CommentMelanin pigment producing mouse melanoma. Application consideration
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Sugimoto, Yoshinori
Year of deposit 1990
Original cell B16 melanoma
Animal _mouse < Mammals
Strain name C57BL/6
Tissue skin
Disease name melanoma
Classification cancer
Lifespan infinite
Morphology fibroblast-like
Cellosaurus(Expasy) CVCL_4612
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium DMEM (low glucose) + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 1-2 times/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
SSLP(mouse) OK
Isozyme LD, NP
Images
deposit info
lot info
Reference information Reference 3
User's Publication 95


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Reference
587  Silagi S  Control of pigment production in mouse melanoma cells in vitro. Evocation and maintenance.  J Cell Biol  1969  43:263-74  PubMed ID: 4981070   DOI: 10.1083/jcb.43.2.263
3488  HU F, LESNEY PF.  THE ISOLATION AND CYTOLOGY OF TWO PIGMENT CELL STRAINS FROM B-16 MOUSE MELANOMAS  Cancer Res  1964  24:1634-43.  PubMed ID: 14234007  
547  Riley,V.  Enzymatic determination of transmissible replicating factors associated with mouse tumors.  Ann N Y Acad Sci  1963  100:762-790  PubMed ID: 13973915  

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User's Publication
17768  Azumi J, Takeda T, Shimada Y, Zhuang T, Tokuji Y, Sakamoto N, Aso H, Nakamura T.  Organogermanium THGP Induces Differentiation into M1 Macrophages and Suppresses the Proliferation of Melanoma Cells via Phagocytosis  Int J Mol Sci  2023  24(3):1885  PubMed ID: 36768216   DOI: 10.3390/ijms24031885
15286  Yuki Ohno, Shiori Kondo, Kiho Tajima, Toshiyuki Shibata, Tomohiro Itoh  Effect of Phlorotannins Isolated From Eisenia bicyclis on Melanogenesis in Mouse B16 Melanoma Cells  Natural Product Communications  2021  16:1934578X2110192    DOI: 10.1177/1934578x211019264
10006  Tomohiro Itoh, Kanako Fukatani, Ayaka Nakashima, Kengo Suzuki  MicroRNA-141-3p and microRNA-200a-3p Regulate α-Melanocyte Stimulating Hormone-Stimulated Melanogenesis by Directly Targeting Microphthalmia-Associated Transcription Factor  Sci Rep  2020  10(1):2149  PubMed ID: 32034251   DOI: 10.1038/s41598-020-58911-w
12162  Kazuhiro Kagotani, Hiroko Nakayama, Liqing Zang, Yuki Fujimoto, Akihito Hayashi, Ryoji Sono, Norihiro Nishimura, and Yasuhito Shimada  Lecithin-Based Dermal Drug Delivery for Anti-Pigmentation Maize Ceramide  Molecules  2020    PubMed ID: 32244349   DOI: 10.3390/molecules25071595
12172  Kosuke Nishi, Mizuki Mori, Daisuke Nakayama, Junna Sato, In-Hae Kim, Minju Kim, Songmun Kim & Takuya Sugahara  Anti-melanogenic activity of methanolic extract from leaves of Sorbaria sorbifolia var. stellipila Max. on α-MSH-stimulated B16 melanoma 4A5 cells  Biomedical Dermatology  2020      DOI: 10.1186/s41702-020-0061-z
17184  Hiroyuki Akazawa, Takuro Shinozaki, Motohiko Ukiya, Toshihiro Akihisa, Manosroi Jiradej, Harukuni Tokuda, Makoto Fukatsu  Biological Activities of Flavonoids from the Wood Extract of Artocarpus heterophyllus L. (Jackfruit)  The Natural Products Journal  2020  10:216-225    DOI: 10.2174/2210315508666181018103353
11365  Kawasaki T, Sato A, Tominaga Y, Suzuki Y, Oyama T, Tadokoro M, Tsukiyama K, Nokihara K, Zen H.  Photo-Modification of Melanin by a Mid-infrared Free-electron Laser.  Photochem. Photobiol.  2019    PubMed ID: 30613988   DOI: 10.1111/php.13079
11374  Wang W, Nakashima S, Nakamura S, Oda Y, Matsuda H.  Anti-proliferative effect of auriculataoside A on B16 melanoma 4A5 cells by suppression of Cdc42-Rac1-RhoA signaling protein levels.  J Nat Med  2019    PubMed ID: 30627935   DOI: 10.1007/s11418-018-01278-0
11473  Wang W, Zhang Y, Nakashima S, Nakamura S, Wang T, Yoshikawa M, Matsuda H.  Inhibition of melanin production by anthracenone dimer glycosides isolated from Cassia auriculata seeds.  J Nat Med  2019    PubMed ID: 30847755   DOI: 10.1007/s11418-018-01276-2
5791  Takuya Seko, Shintaro Imamura, Kenji Ishihara, Yumiko Yamashita, Michiaki Yamashita  Selenoneine suppresses melanin synthesis by inhibiting tyrosinase in murine B16 melanoma cells and 3D-cultured human melanocytes  Fisheries Science   2019  1–9    DOI: 10.1007/s12562-019-01376-2
14699  Azumi J, Takeda T, Shimada Y, Aso H, Nakamura T.  The Organogermanium Compound THGP Suppresses Melanin Synthesis via Complex Formation with L-DOPA on Mushroom Tyrosinase and in B16 4A5 Melanoma Cells  Int J Mol Sci  2019  20(19):4785  PubMed ID: 31561511   DOI: 10.3390/ijms20194785
10603  Taira N, Katsuyama Y, Yoshioka M, Okano Y, Masaki H.  3-O-Glyceryl-2-O-hexyl ascorbate suppresses melanogenesis by interfering with intracellular melanosome transport and suppressing tyrosinase protein synthesis.  J Cosmet Dermatol  2018  17(6):1209-1215  PubMed ID: 29115012   DOI: 10.1111/jocd.12451
10830  Katsuyama Y, Taira N, Yoshioka M, Okano Y, Masaki H.  3-O-Glyceryl-2-O-hexyl Ascorbate Suppresses Melanogenesis through Activation of the Autophagy System.  Biol. Pharm. Bull.  2018  41:824-827  PubMed ID: 29709921   DOI: 10.1248/bpb.b17-01042
11067    Compositions and melanogenesis-inhibitory activities of the extracts of defatted shea (Vitellaria paradoxa) kernels from seven African countries  Journal of Food Composition and Analysis  2018  70, 89-97    DOI: 10.1016/j.jfca.2018.04.010
14922  Taira N, Katsuyama Y, Yoshioka M, Muraoka O, Morikawa T.  Structural Requirements of Alkylglyceryl-l-Ascorbic Acid Derivatives for Melanogenesis Inhibitory Activity  Int J Mol Sci   2018  19(4):1144  PubMed ID: 29642633   DOI: 10.3390/ijms19041144
10675  Manse Y, Ninomiya K, Nishi R, Hashimoto Y, Chaipech S, Muraoka O, Morikawa T.  Labdane-Type Diterpenes, Galangalditerpenes A-C, with Melanogenesis Inhibitory Activity from the Fruit of Alpinia galanga.  Molecules  2017  22:  PubMed ID: 29261124   DOI: 10.3390/molecules22122279
14436  Yoshiaki Manse, Kiyofumi Ninomiya, Akane Okazaki, Eriko Okada-Nishida, Takahiro Imagawa, Mami Imamura-Mizushima, Yuki Yamano, Kinji Kaname, Sho Nakamura, Toshio Morikawa  Melanogenesis Inhibitory Activity of Diterpenoid and Triterpenoid Constituents from the Aerial Part of Isodon trichocarpus  Natural Product Communications  2017  12:1934578X1701200    DOI: 10.1177/1934578x1701200809
14684  Fujihara K, Takahashi K, Koyama K, Kinoshita K.  Triterpenoid saponins from Polaskia chichipe Backbg. and their inhibitory or promotional effects on the melanogenesis of B16 melanoma cells  J Nat Med  2017  71(4):606-616  PubMed ID: 28497306   DOI: 10.1007/s11418-017-1082-9
7101  Ninomiya K, Matsumoto T, Chaipech S, Miyake S, Katsuyama Y, Tsuboyama A, Pongpiriyadacha Y, Hayakawa T, Muraoka O, Morikawa T.  Simultaneous quantitative analysis of 12 methoxyflavones with melanogenesis inhibitory activity from the rhizomes of Kaempferia parviflora.  J Nat Med  2016  70:179-89  PubMed ID: 26711832   DOI: 10.1007/s11418-015-0955-z
12210  Amal Sallam, Amira Mira, Ahmed Ashour, Kuniyoshi Shimizu  Acetylcholine esterase inhibitors and melanin synthesis inhibitors from Salvia officinalis  Phytomedicine  2016  23(10):1005-11  PubMed ID: 27444345   DOI: 10.1016/j.phymed.2016.06.014
13684  Horiba H, Nakagawa T, Zhu Q, Ashour A, Watanabe A, Shimizu K.  Biological Activities of Extracts from Different Parts of Cryptomeria japonica  Nat Prod Commun  2016  11(9):1337-1342  PubMed ID: 30807038  
14166  Morikawa T, Ninomiya K, Kuramoto H, Kamei I, Yoshikawa M, Muraoka O.  Phenylethanoid and phenylpropanoid glycosides with melanogenesis inhibitory activity from the flowers of Narcissus tazetta var. chinensis  J Nat Med  2016  70(1):89-101  PubMed ID: 26475459   DOI: 10.1007/s11418-015-0941-5
14174  Manse Y, Ninomiya K, Nishi R, Kamei I, Katsuyama Y, Imagawa T, Chaipech S, Muraoka O, Morikawa T.  Melanogenesis inhibitory activity of a 7-O-9'-linked neolignan from Alpinia galanga fruit  Bioorg Med Chem  2016  24(23):6215-6224  PubMed ID: 27756508   DOI: 10.1016/j.bmc.2016.10.001
14177  Morikawa T, Kitagawa N, Tanabe G, Ninomiya K, Okugawa S, Motai C, Kamei I, Yoshikawa M, Lee IJ, Muraoka O.  Quantitative Determination of Alkaloids in Lotus Flower (Flower Buds of Nelumbo nucifera) and Their Melanogenesis Inhibitory Activity  Molecules  2016  21(7):930  PubMed ID: 27447599   DOI: 10.3390/molecules21070930
7182  Inada M, Takita M, Yokoyama S, Watanabe K, Tominari T, Matsumoto C, Hirata M, Maru Y, Maruyama T, Sugimoto Y, Narumiya S, Uematsu S, Akira S, Murphy G, Nagase H, Miyaura C.  Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling That Drives Tumor Growth, Angiogenesis, and Metastasis.  J. Biol. Chem.  2015  290:29781-93  PubMed ID: 26475855   DOI: 10.1074/jbc.M115.669481
7574  Yuji SHIBATA, Katsuhisa YAMADA, Chiaki IMADA, Takeshi KOBAYASHI, Takeshi TERAHARA  Phenotypic Characterization of a Microbe Producing Substances for Oxidative Stress Resistance Isolated from the Deep Seawater in Izu-Akazawa, Japan.  Deep Ocean Water Research  2015  15:117-124   
14531  Hisahiro Kai, Koji Matsuno  Assessment of the Effect of Arbutin Isomers and Kojic Acid on Melanin Production, Tyrosinase Activity, and Tyrosinase Expression in B16-4A5 and HMV-II Melanoma Cells  Planta Medica Letters  2015  2:e39-e41    DOI: 10.1055/s-0035-1557833
14960  T. Kikuchi, A. Ikedaya, A. Toda, K. Ikushima, T. Yamakawa, R. Okada, T. Yamada, R. Tanaka  Pyrazole alkaloids from watermelon (Citrullus lanatus) seeds  Phytochem Lett  2015  12:94-97    DOI: 10.1016/j.phytol.2015.02.017
14978  Nakashima S, Oda Y, Nakamura S, Liu J, Onishi K, Kawabata M, Miki H, Himuro Y, Yoshikawa M, Matsuda H.  Inhibitors of melanogenesis in B16 melanoma 4A5 cells from flower buds of Lawsonia inermis (Henna)  Bioorg Med Chem Lett  2015  25(13):2702-6  PubMed ID: 25987378   DOI: 10.1016/j.bmcl.2015.04.052
15138  Hideko MOTOJIMA, Myra O. VILLAREAL, Sayuri KUME, Konomi MURAKAMI, Hanen NAJJA, Mohamed NEFFATI, Hiroko ISODA  Anti-allergy and Melanogenesis Regulatory Effects of Semi-arid and Arid Land Plants  Journal of Arid Land Studies  2015  25:65-68    DOI: 10.14976/jals.25.3_65
15146  Tanabe G, Sugano Y, Shirato M, Sonoda N, Tsutsui N, Morikawa T, Ninomiya K, Yoshikawa M, Muraoka O.  Total Synthesis of 4,5-Didehydroguadiscine: A Potent Melanogenesis Inhibitor from the Brazilian Medicinal Herb, Hornschuchia obliqua  J Nat Prod  2015  78(7):1536-42  PubMed ID: 26135746   DOI: 10.1021/np500995z
15241  Molina-Guijarro JM, García C, Macías Á, García-Fernández LF, Moreno C, Reyes F, Martínez-Leal JF, Fernández R, Martínez V, Valenzuela C, Lillo MP, Galmarini CM.  Elisidepsin Interacts Directly with Glycosylceramides in the Plasma Membrane of Tumor Cells to Induce Necrotic Cell Death  PLoS One  2015  10(10):e0140782  PubMed ID: 26474061   DOI: 10.1371/journal.pone.0140782
4813  Arung ET, Kuspradini H, Kusuma IW, Bang TH, Yamashita S, Katakura Y, Shimizu K  Effects of isolated compound from Sonneratia caseolaris leaf: a validation of traditional utilization by melanin biosynthesis and antioxidant assays  J Applied Pharmaceutical Science  2015  5:39-43    DOI: 10.7324/JAPS.2015.501007
5601  Usui K, Ikeda T, Horibe Y, Nakao M, Hoshino T, Mizushima T.  Identification of HSP70-inducing activity in Arnica montana extract and purification and characterization of HSP70-inducers  J Dermatol Sci  2015  78(1):67-75  PubMed ID: 25724362   DOI: 10.1016/j.jdermsci.2015.01.014
14696  Michiyo Kubota, Takahiro Hosoya, Syuichi Fukumoto, Tsuyoshi Miyagi, Shigenori Kumazawa  Anti-melanogenic compounds in Rubus croceacanthus  Journal of Berry Research  2014  4:127-135    DOI: 10.3233/jbr-140075
16548  Kitdamrongtham W, Ishii K, Ebina K, Zhang J, Ukiya M, Koike K, Akazawa H, Manosroi A, Manosroi J, Akihisa T.  Limonoids and flavonoids from the flowers of Azadirachta indica var. siamensis, and their melanogenesis-inhibitory and cytotoxic activities  Chem Biodivers  2014  11(1):73-84  PubMed ID: 24443427   DOI: 10.1002/cbdv.201300266
17155  Shuuichi Akazaki, Toshie Takahashi, Yujiro Nakano, Tomoki Nishida, Hirotarou Mori, Akio Takaoka, Hitomi Aoki, Huayua Chen, Takahiro Kunisada, Kenzo Koike  Three-Dimensional Analysis of Melanosomes Isolated from B16 Melanoma Cells by Using Ultra High Voltage Electron Microscopy  Microscopy Research  2014  02:1-8    DOI: 10.4236/mr.2014.21001
18807  Zhang J, Koike R, Yamamoto A, Ukiya M, Fukatsu M, Banno N, Miura M, Motohashi S, Tokuda H, Akihisa T.  Glycosidic inhibitors of melanogenesis from leaves of Passiflora edulis  Chem Biodivers  2013  10(10):1851-65  PubMed ID: 24130028   DOI: 10.1002/cbdv.201300181
18810  Chao HC, Najjaa H, Villareal MO, Ksouri R, Han J, Neffati M, Isoda H.  Arthrophytum scoparium inhibits melanogenesis through the down-regulation of tyrosinase and melanogenic gene expressions in B16 melanoma cells  Exp Dermatol  2013  22(2):131-6  PubMed ID: 23362872   DOI: 10.1111/exd.12089
5330  Nakamura S, Nakashima S, Oda Y, Yokota N, Fujimoto K, Matsumoto T, Ohta T, Ogawa K, Maeda S, Nishida S, Matsuda H, Yoshikawa M.  Alkaloids from Sri Lankan curry-leaf (Murraya koenigii) display melanogenesis inhibitory activity: structures of karapinchamines A and B.  Bioorg Med Chem  2013  21(5):1043-9  PubMed ID: 23376010   DOI: 10.1016/j.bmc.2013.01.012
6320  Shono M, Yoshioka R, Chatani Y, Hirai Y.  Ectopic expression of syntaxin3 affects behaviors of B16 melanoma by controlling actin dynamics.  Cell Struct Funct  2013  38(1):97-107  PubMed ID: 23546178   DOI: 10.1247/csf.12032
15955  Zhang J, Nishimoto Y, Tokuda H, Suzuki N, Yasukawa K, Kitdamrongtham W, Akazawa H, Manosroi A, Manosroi J, Akihisa T.  Cancer chemopreventive effect of bergenin from Peltophorum pterocarpum wood  Chem Biodivers  2013  10(10):1866-75  PubMed ID: 24130029   DOI: 10.1002/cbdv.201300182
16299  Nakamura S, Fujimoto K, Matsumoto T, Nakashima S, Ohta T, Ogawa K, Matsuda H, Yoshikawa M.  Acylated sucroses and acylated quinic acids analogs from the flower buds of Prunus mume and their inhibitory effect on melanogenesis  Phytochemistry  2013  92:128-36  PubMed ID: 23693120   DOI: 10.1016/j.phytochem.2013.04.012
18587  Akihisa T, Takeda A, Akazawa H, Kikuchi T, Yokokawa S, Ukiya M, Fukatsu M, Watanabe K.  Melanogenesis-inhibitory and cytotoxic activities of diarylheptanoids from Acer nikoense bark and their derivatives  Chem Biodivers  2012  9(8):1475-89  PubMed ID: 22899608   DOI: 10.1002/cbdv.201200024
18796  Kikuchi T, Watanabe K, Tochigi Y, Yamamoto A, Fukatsu M, Ezaki Y, Tanaka R, Akihisa T.  Melanogenesis inhibitory activity of sesquiterpenes from Canarium ovatum resin in mouse B16 melanoma cells  Chem Biodivers  2012  9(8):1500-7  PubMed ID: 22899610   DOI: 10.1002/cbdv.201200111
18809  Kikuchi T, Zhang J, Huang Y, Watanabe K, Ishii K, Yamamoto A, Fukatsu M, Tanaka R, Akihisa T.  Glycosidic inhibitors of melanogenesis from leaves of Momordica charantia  Chem Biodivers  2012  9(7):1221-30  PubMed ID: 22782871   DOI: 10.1002/cbdv.201100350
18816  Akihisa T, Watanabe K, Yamamoto A, Zhang J, Matsumoto M, Fukatsu M.  Melanogenesis inhibitory activity of monoterpene glycosides from Gardeniae Fructus  Chem Biodivers  2012  9(8):1490-9  PubMed ID: 22899609   DOI: 10.1002/cbdv.201200030
18819  Fujimoto K, Nakamura S, Nakashima S, Matsumoto T, Uno K, Ohta T, Miura T, Matsuda H, Yoshikawa M.  Medicinal flowers. XXXV. Nor-oleanane-type and acylated oleanane-type triterpene saponins from the flower buds of Chinese Camellia japonica and their inhibitory effects on melanogenesis  Chem Pharm Bull (Tokyo)  2012  60(9):1188-94.  PubMed ID: 22976329   DOI: 10.1248/cpb.c12-00473
5627  Nakamura S, Moriura T, Park S, Fujimoto K, Matsumoto T, Ohta T, Matsuda H, Yoshikawa M.  Melanogenesis inhibitory and fibroblast proliferation accelerating effects of noroleanane- and oleanane-type triterpene oligoglycosides from the flower buds of Camellia japonica.  J Nat Prod  2012  75(8):1425-30  PubMed ID: 22834923   DOI: 10.1021/np3001078
7618  Yoshioka S, Terashita T, Yoshizumi H, Shirasaka N.  Inhibitory effects of whisky polyphenols on melanogenesis in mouse B16 melanoma cells.  Biosci. Biotechnol. Biochem.  2011  75:2278-82  PubMed ID: 22146709   DOI: 10.1271/bbb.100514
18811  Arung ET, Furuta S, Ishikawa H, Tanaka H, Shimizu K, Kondo R.  Melanin biosynthesis inhibitory and antioxidant activities of quercetin-3'-O-  Z Naturforsch C J Biosci  2011  66(5-6):209-14  PubMed ID: 21812337   DOI: 10.1515/znc-2011-5-603
15716  Hebishima T, Matsumoto Y, Watanabe G, Soma G, Kohchi C, Taya K, Hayashi Y, Hirota Y.  Oral administration of immunopotentiator from Pantoea agglomerans 1 (IP-PA1) improves the survival of B16 melanoma-inoculated model mice  Exp Anim  2011  60(2):101-9  PubMed ID: 21512265   DOI: 10.1538/expanim.60.101
8108  Fujita S, Ninomiya M, Efdi M, Ohguchi K, Nozawa Y, Koketsu M.  Isolation of chemical constituents from Enicosanthum cupulare (King) Airy-Shaw.  Nat. Prod. Res.  2010  24:1630-6  PubMed ID: 20954090   DOI: 10.1080/14786411003774338
8400  Ohguchi K, Nakajima C, Oyama M, Iinuma M, Itoh T, Akao Y, Nozawa Y, Ito M.  Inhibitory effects of flavonoid glycosides isolated from the peel of Japanese persimmon (Diospyros kaki 'Fuyu') on melanin biosynthesis.  Biol. Pharm. Bull.  2010  33:122-4  PubMed ID: 20045948   DOI: 10.1248/bpb.33.122
18805  Nakashima S, Matsuda H, Oda Y, Nakamura S, Xu F, Yoshikawa M.  Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells  Bioorg Med Chem  2010  18(6):2337-2345  PubMed ID: 20189399   DOI: 10.1016/j.bmc.2010.01.046
15647  Akihisa T, Seino K, Kaneko E, Watanabe K, Tochizawa S, Fukatsu M, Banno N, Metori K, Kimura Y.  Melanogenesis inhibitory activities of iridoid-, hemiterpene-, and fatty acid-glycosides from the fruits of Morinda citrifolia (Noni)  J Oleo Sci  2010  59(1):49-57  PubMed ID: 20032599   DOI: 10.5650/jos.59.49
8513  Matsuyama K, Villareal MO, El Omri A, Han J, Kchouk ME, Isoda H.  Effect of Tunisian Capparis spinosa L. extract on melanogenesis in B16 murine melanoma cells.  J Nat Med  2009  63:468-72  PubMed ID: 19685105   DOI: 10.1007/s11418-009-0355-3
8661  Ohguchi K, Ito M, Yokoyama K, Iinuma M, Itoh T, Nozawa Y, Akao Y.  Effects of sesquiterpene lactones on melanogenesis in mouse B16 melanoma cells.  Biol. Pharm. Bull.  2009  32:308-10  PubMed ID: 19182396   DOI: 10.1248/bpb.32.308
18803  Matsuda H, Nakashima S, Oda Y, Nakamura S, Yoshikawa M.  Melanogenesis inhibitors from the rhizomes of Alpinia officinarum in B16 melanoma cells  Bioorg Med Chem  2009  17(16):6048-53  PubMed ID: 19615910   DOI: 10.1016/j.bmc.2009.06.057
18812  Fujii T, Saito M.  Inhibitory effect of quercetin isolated from rose hip (Rosa canina L.) against melanogenesis by mouse melanoma cells  Biosci Biotechnol Biochem  2009  73(9):1989-93  PubMed ID: 19734679   DOI: 10.1271/bbb.90181
8715  Kobori M, Ohnishi-Kameyama M, Akimoto Y, Yukizaki C, Yoshida M.  Alpha-eleostearic acid and its dihydroxy derivative are major apoptosis-inducing components of bitter gourd.  J. Agric. Food Chem.  2008  56:10515-20  PubMed ID: 18959405   DOI: 10.1021/jf8020877
18680  Hanamura T, Uchida E, Aoki H.  Skin-lightening effect of a polyphenol extract from Acerola (Malpighia emarginata DC.) fruit on UV-induced pigmentation  Biosci Biotechnol Biochem  2008  72(12):3211-8  PubMed ID: 19060403   DOI: 10.1271/bbb.80421
18804  Kawano M, Matsuyama K, Miyamae Y, Shinmoto H, Kchouk ME, Morio T, Shigemori H, Isoda H.  Antimelanogenesis effect of Tunisian herb Thymelaea hirsuta extract on B16 murine melanoma cells  Exp Dermatol  2007  16(12):977-84  PubMed ID: 18031456   DOI: 10.1111/j.1600-0625.2007.00618.x
6287  Roy MK, Kobori M, Takenaka M, Nakahara K, Shinmoto H, Isobe S, Tsushida T.  Antiproliferative effect on human cancer cell lines after treatment with nimbolide extracted from an edible part of the neem tree (Azadirachta indica).  Phytother Res  2007  21(3):245-50  PubMed ID: 17163581   DOI: 10.1002/ptr.2058
15556  Kuniyoshi Shimizu, Shoko Fukunaga, Keisuke Yoshikawa, Ryuichiro Kondo  Screening of extracts of Japanese woods for melanin biosynthesis inhibition  Journal of Wood Science  2007  53:153-160    DOI: 10.1007/s10086-006-0824-1
3313  Shoji, Toshihiko, Masumoto, Saeko, Moriichi, Nina, Kobori, Masuko, Kanda, Tomomasa, Shinmoto, Hiroshi, Tsushida, Tojiro  Procyanidin trimers to pentamers fractionated from apple inhibit melanogenesis in B16 mouse melanoma cells.  J Agric Food Chem  2005  53:6105-11  PubMed ID: 16029003   DOI: 10.1021/jf050418m
17362  Enos Tangke Arung, Keisuke Yoshikawa, Kuniyoshi Shimizu, Ryuichiro Kondo  The effect of chlorophorin and its derivative on melanin biosynthesis  Holzforschung  2005  59:514-518    DOI: 10.1515/hf.2005.085
2846  Fukui M, Nakano-Hashimoto T, Okano K, Maruta Y, Suehiro Y, Hamanaka Y, Yamashita H, Imai K, Kawano MM, Hinoda Y  Therapeutic effect of dendritic cells loaded with a fusion mRNA encoding tyrosinase-related protein 2 and enhanced green fluorescence protein on B16 melanoma.  Tumour Biol  2004  25:252-7  PubMed ID: 15627888   DOI: 10.1159/000081388
3221  Ohguchi, Kenji, Banno, Yoshiko, Akao, Yukihiro, Nozawa, Yoshinori  Involvement of phospholipase D1 in melanogenesis of mouse B16 melanoma cells.  J Biol Chem  2004  279:3408-12  PubMed ID: 14615486   DOI: 10.1074/jbc.M308054200
13484  Ohara M, Kobayashi M, Fujiwara H, Kitajima S, Mitsuoka C, Watanabe H.  Blue light inhibits melanin synthesis in B16 melanoma 4A5 cells and skin pigmentation induced by ultraviolet B in guinea-pigs  Photodermatol Photoimmunol Photomed  2004  20(2):86-92  PubMed ID: 15030593   DOI: 10.1111/j.1600-0781.2004.00077.x
13675  Kuniyoshi Shimizu, Xinglian Geng, Mika Hashiguchi, Hiroto Suhara, Syoko Fukunaga, Seiji Yasutake, Ryuichiro Kondo, Mototake Tsutsui, Ikuo Sato  Indole-3-carbaldehyde: a tyrosinase inhibitor from fungus YL185  Journal of Wood Science  2003  49:349-354    DOI: 10.1007/s10086-002-0484-8
14423  Ito A, Tanaka K, Kondo K, Shinkai M, Honda H, Matsumoto K, Saida T, Kobayashi T.  Tumor regression by combined immunotherapy and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma  Cancer Sci  2003  94(3):308-13  PubMed ID: 12824927   DOI: 10.1111/j.1349-7006.2003.tb01438.x
17302  Masuko KOBORI  In Vitro-Screening for Cancer-Suppressive Effect of Food Components  Japan Agricultural Research Quarterly: JARQ  2003  37:159-165    DOI: 10.6090/jarq.37.159
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