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RCB0535 : RAW 264  update : 2018/07/31
CommentBuck-up culture of ECA8510291 . Mouse leukemic monocyte. Abelson leukemia virus induced. Application consideration
Comment from the depositor
Restriction (Category)a
Terms and conditionsBasically, there is no restriction regarding academic use.
Remarks
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor ECACC
Year of deposit 1990
Animal mouse < Mammals
Strain name BALB/c
Tissue leukemic monocyte
Classification transformed
History overseas, ECACC
Lifespan infinite
Morphology other
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives MEM + 10% FBS + 0.1mM NEAA
Antibiotics Free
Passage method 0.25% trypsin + 0.02% EDTA
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Animal PCR OK
SSLP (mouse) OK
Images
deposit info
lot info
Reference information Reference 1
User's Publication 220


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Reference
Ralph P, Nakoinz I  Antibody-dependent killing of erythrocyte and tumor targets by macrophage-related cell lines: enhancement by PPD and LPS.  J Immunol  1977  119:950-54 

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User's Publication
Kimura, T. et al  Novel PVA-DNA nanoparticles prepared by ultra high pressure technology for gene delivery  Materials Science and Engineering C  2004  24:797-801 
Ito T, Morimatsu M, Oonuma T, Shiina T, Kitamura H, Syuto B  Transcriptional regulation of the MAIL gene in LPS-stimulated RAW264 mouse macrophages.  Gene  2004  342:137-43  PubMed ID: 15527973
Shimomura-Shimizu M, Sugiyama K, Muroi M, Tanamoto K  Alachlor and carbaryl suppress lipopolysaccharide-induced iNOS expression by differentially inhibiting NF-kappaB activation.  Biochem Biophys Res Commun  2005  332:793-9  PubMed ID: 15907790
Itoh CE, Kizaki T, Hitomi Y, Hanawa T, Kamiya S, Ookawara T, Suzuki K, Izawa T, Saitoh D, Haga S, Ohno H  Down-regulation of beta2-adrenergic receptor expression by exercise training increases IL-12 production by macrophages following LPS stimulation.  Biochem Biophys Res Commun  2004  322:979-84  PubMed ID: 15336560
Tanida N, Ohno N, Adachi Y, Matsuura M, Nakano M, Kiso M, Hasegawa A, Yadomae T  Modification of Immunopharmacologicaln Activities of Synthetic Monosaccharide Lipid A Analogue, GLA60, by Lysozyme  J Biochem (Tokyo)  1992  112:616-623 
Yamashita M, Niki H, Yamada M, Mue S, Ohuchi K  Induction of nitric oxide synthase by lipopolysaccharide and its inhibition by auranofin in RAW 264.7 cells.  Eur J Pharmacol  1997  338:151-8 
Okada S, Zhang H, Hatano M, Tokuhisa T  A physiologic role of Bcl-xL induced in activated macrophages.  J Immunol  1998  160:2590-6 
Abe-Dohmae S, Suzuki S, Wada Y, Aburatani H, Vance, D E, Yokoyama S  Characterization of apolipoprotein-mediated HDL generation induced by cAMP in a murine macrophage cell line.  Biochemistry  2000  39:11092-9 
Suzuki S, Abe-Dohmae S, Fukutomi T, Ito S, Itoh M, Yokoyama S  Enhancement of the cAMP-induced apolipoprotein-mediated cellular lipid release by calmodulin inhibitors W7 and W5 from RAW 264 mouse macrophage cell line cells.  J Cardiovasc Pharmacol  2000  36:609-16 
Haruta I, Kato Y, Hashimoto E, Minjares C, Kennedy S, Uto H, Yamauchi K, Kobayashi M, Yusa S, Muller U, Hayashi N, Miyazaki T  Association of AIM, a novel apoptosis inhibitory factor, with hepatitis via supporting macrophage survival and enhancing phagocytotic function of macrophages.  J Biol Chem  2001  276:22910-4 
Shiina T, Morimatsu M, Kitamura H, Ito T, Kidou S, Matsubara K, Matsuda Y, Saito M, Syuto B  Genomic organization, chromosomal localization, and promoter analysis of the mouse Mail gene.  Immunogenetics  2001  53:649-55 
Kizaki, Takako, Suzuki, Kenji, Hitomi, Yoshiaki, Taniguchi, Naoyuki, Saitoh, Daizoh, Watanabe, Kenji, Onoe, Kazunori, Day, Noorbibi K, Good, Robert A, Ohno, Hideki  Uncoupling protein 2 plays an important role in nitric oxide production of lipopolysaccharide-stimulated macrophages.  Proc Natl Acad Sci U S A  2002  99:9392-7  PubMed ID: 12089332
Muroi, Masashi, Tanamoto, Ken-Ichi  The polysaccharide portion plays an indispensable role in Salmonella lipopolysaccharide-induced activation of NF-kappaB through human toll-like receptor 4.  Infect Immun  2002  70:6043-7  PubMed ID: 12379680
Suzuki, Shogo, Nishimaki-Mogami, Tomoko, Tamehiro, Norimasa, Inoue, Kazuhide, Arakawa, Reijiro, Abe-Dohmae, Sumiko, Tanaka, Arowu R, Ueda, Kazumitsu, Yokoyama, Shinji  Verapamil increases the apolipoprotein-mediated release of cellular cholesterol by induction of ABCA1 expression via Liver X receptor-independent mechanism.  Arterioscler Thromb Vasc Biol  2004  24:519-25  PubMed ID: 14726413
Okuhira, Kei-ichiro, Tsujita, Maki, Yamauchi, Yoshio, Abe-Dohmae, Sumiko, Kato, Koichi, Handa, Tetsurou, Yokoyama, Shinji  Potential involvement of dissociated apoA-I in the ABCA1-dependent cellular lipid release by HDL.  J Lipid Res  2004  45:645-52  PubMed ID: 14729855
Ban, Hyun Seung, Suzuki, Katsuya, Lim, Soon Sung, Jung, Sang Hoon, Lee, Sanghyun, Ji, Jun, Lee, Hye Seung, Lee, Yeon Sil, Shin, Kuk Hyun, Ohuchi, Kazuo  Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase and tumor necrosis factor-alpha by 2'-hydroxychalcone derivatives in RAW 264.7 cells.  Biochem Pharmacol  2004  67:1549-57  PubMed ID: 15041472
Kato, Sawako, Yuzawa, Yukio, Tsuboi, Naotake, Maruyama, Shoichi, Morita, Yoshiki, Matsuguchi, Tetsuya, Matsuo, Seiichi  Endotoxin-induced chemokine expression in murine peritoneal mesothelial cells: the role of toll-like receptor 4.  J Am Soc Nephrol  2004  15:1289-99 
Takahashi, Tetsuyuki, Takasuka, Nobuo, Iigo, Masaaki, Baba, Masaki, Nishino, Hoyoku, Tsuda, Hiroyuki, Okuyama, Toru  Isoliquiritigenin, a flavonoid from licorice, reduces prostaglandin E2 and nitric oxide, causes apoptosis, and suppresses aberrant crypt foci development.  Cancer Sci  2004  95:448-53  PubMed ID: 15132774
Adachi, Yoshiyuki, Ishii, Takashi, Ikeda, Yoshihiko, Hoshino, Akiyoshi, Tamura, Hiroshi, Aketagawa, Jun, Tanaka, Shigenori, Ohno, Naohito  Characterization of beta-glucan recognition site on C-type lectin, dectin 1.  Infect Immun  2004  72:4159-71  PubMed ID: 15213161
Hatao, Fumihiko, Muroi, Masashi, Hiki, Naoki, Ogawa, Toshihisa, Mimura, Yoshikazu, Kaminishi, Michio, Tanamoto, Ken-ichi  Prolonged Toll-like receptor stimulation leads to down-regulation of IRAK-4 protein.  J Leukoc Biol  2004  76:904-8  PubMed ID: 15258191
Matsumoto, Masahito, Kogawa, Masakazu, Wada, Seiki, Takayanagi, Hiroshi, Tsujimoto, Masafumi, Katayama, Shigehiro, Hisatake, Koji, Nogi, Yasuhisa  Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1.  J Biol Chem  2004  279:45969-79  PubMed ID: 15304486
Ikeda, Fumiyo, Nishimura, Riko, Matsubara, Takuma, Tanaka, Sakae, Inoue, Jun-ichiro, Reddy, Sakamuri V, Hata, Kenji, Yamashita, Kenji, Hiraga, Toru, Watanabe, Toshiyuki, Kukita, Toshio, Yoshioka, Katsuji, Rao, Anjana, Yoneda, Toshiyuki  Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation.  J Clin Invest  2004  114:475-84 
Musikacharoen, Tipayaratn, Oguma, Asako, Yoshikai, Yasunobu, Chiba, Norika, Masuda, Akio, Matsuguchi, Tetsuya  Interleukin-15 induces IL-12 receptor beta1 gene expression through PU.1 and IRF 3 by targeting chromatin remodeling.  Blood  2005  105:711-20  PubMed ID: 15345588
Ito, Mikiko, Matsuka, Naoko, Izuka, Michiyo, Haito, Sakiko, Sakai, Yuko, Nakamura, Rie, Segawa, Hiroko, Kuwahata, Masashi, Yamamoto, Hironori, Pike, Wesley J, Miyamoto, Ken-ichi  Characterization of inorganic phosphate transport in osteoclast-like cells.  Am J Physiol Cell Physiol  2005  288:C921-31  PubMed ID: 15601753
Aki, Daisuke, Mashima, Ryuichi, Saeki, Kazuko, Minoda, Yasumasa, Yamauchi, Moriyasu, Yoshimura, Akihiko  Modulation of TLR signalling by the C-terminal Src kinase (Csk) in macrophages.  Genes Cells  2005  10:357-68 
Arakawa, Reijiro, Tamehiro, Norimasa, Nishimaki-Mogami, Tomoko, Ueda, Kazumitsu, Yokoyama, Shinji  Fenofibric acid, an active form of fenofibrate, increases apolipoprotein A-I-mediated high-density lipoprotein biogenesis by enhancing transcription of ATP-binding cassette transporter A1 gene in a liver X receptor-dependent manner.  Arterioscler Thromb Vasc Biol  2005  25:1193-7  PubMed ID: 15790930
Hou, De-Xing, Yanagita, Takashi, Uto, Takuhiro, Masuzaki, Satoko, Fujii, Makoto  Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked macrophages: structure-activity relationship and molecular mechanisms involved.  Biochem Pharmacol  2005  70:417-25  PubMed ID: 15963474
Hassan, Ferdaus, Islam, Shamima, Mu, Mya Mya, Ito, Hiroyasu, Koide, Naoki, Mori, Isamu, Yoshida, Tomoaki, Yokochi, Takashi  Lipopolysaccharide prevents doxorubicin-induced apoptosis in RAW 264.7 macrophage cells by inhibiting p53 activation.  Mol Cancer Res  2005  3:373-9  PubMed ID: 16046548
Suganami, Takayoshi, Nishida, Junko, Ogawa, Yoshihiro  A Paracrine Loop Between Adipocytes and Macrophages Aggravates Inflammatory Changes. Role of Free Fatty Acids and Tumor Necrosis Factor {alpha}  Arterioscler Thromb Vasc Biol  2005  25:2062-2068 
Uto, Takuhiro, Fujii, Makoto, Hou, De-Xing  6-(Methylsulfinyl)hexyl isothiocyanate suppresses inducible nitric oxide synthase expression through the inhibition of Janus kinase 2-mediated JNK pathway in lipopolysaccharide-activated murine macrophages.  Biochem Pharmacol  2005  70:1211-21  PubMed ID: 16139249
Komiya C, Tanaka M, Tsuchiya K, Shimazu N, Mori K, Furuke S, Miyachi Y, Shiba K, Yamaguchi S, Ikeda K, Ochi K, Nakabayashi K, Hata KI, Itoh M, Suganami T, Ogawa Y.  Antifibrotic effect of pirfenidone in a mouse model of human nonalcoholic steatohepatitis.  Sci Rep  2017  7:44754  PubMed ID: 28303974
Watanabe Y, Nagai Y, Honda H, Okamoto N, Yamamoto S, Hamashima T, Ishii Y, Tanaka M, Suganami T, Sasahara M, Miyake K, Takatsu K.  Isoliquiritigenin Attenuates Adipose Tissue Inflammation in vitro and Adipose Tissue Fibrosis through Inhibition of Innate Immune Responses in Mice.  Sci Rep  2016  6:23097  PubMed ID: 26975571
Ryohei Hamaguchi, Yukihiro Kuroda  A Novel Biomarker for Cellular Toxicity and Phospholipid Accumulation by Cationic Amphiphilic Drugs.  Chromatography  2016  37:35-38 
Taniguchi M, Ochiai A, Matsushima K, Tajima K, Kato T, Saitoh E, Tanaka T.  Endotoxin-neutralizing activity and mechanism of action of a cationic α-helical antimicrobial octadecapeptide derived from α-amylase of rice.  Peptides  2015  75:101-8  PubMed ID: 26643956
Iwawaki T, Akai R, Oikawa D, Toyoshima T, Yoshino M, Suzuki M, Takeda N, Ishikawa TO, Kataoka Y, Yamamura K.  Transgenic mouse model for imaging of interleukin-1β-related inflammation in vivo.  Sci Rep  2015  5:17205  PubMed ID: 26598133
Ohta T, Kusano K, Ido A, Miura C, Miura T.  Silkrose: A novel acidic polysaccharide from the silkmoth that can stimulate the innate immune response.  Carbohydr Polym  2015  136:995-1001  PubMed ID: 26572439
Higuchi H, Shoji T, Murase Y, Iijima S, Nishijima K.  Siglec-9 modulated IL-4 responses in the macrophage cell line RAW264.  Biosci. Biotechnol. Biochem.  2015  80:501-9  PubMed ID: 26540411
Sawada Y, Sakamoto Y, Toh M, Ohara N, Hatanaka Y, Naka A, Kishimoto Y, Kondo K, Iida K.  Milk-derived peptide Val-Pro-Pro (VPP) inhibits obesity-induced adipose inflammation via an angiotensin-converting enzyme (ACE) dependent cascade.  Mol Nutr Food Res  2015  59:2502-10  PubMed ID: 26346532
Takayama S, Hashimoto K, Kokubu E, Taniguchi M, Tajima K, Ochiai A, Saitoh E, Saito A, Ishihara K, Kato T.  Inhibitory effects of a novel cationic dodecapeptide [CL(14-25)] derived from cyanate lyase of rice on endotoxic activities of LPSs from Escherichia coli and periodontopathic Aggregatibacter actinomycetemcomitans.  Microb. Pathog.  2015  94:2-11  PubMed ID: 26318142
Tohmonda T, Yoda M, Iwawaki T, Matsumoto M, Nakamura M, Mikoshiba K, Toyama Y, Horiuchi K.  IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis.  J. Clin. Invest.  2015  125:3269-79  PubMed ID: 26193638
Tang L, Okamoto S, Shiuchi T, Toda C, Takagi K, Sato T, Saito K, Yokota S, Minokoshi Y.  Sympathetic Nerve Activity Maintains an Anti-Inflammatory State in Adipose Tissue in Male Mice by Inhibiting TNF-α Gene Expression in Macrophages.  Endocrinology  2015  156:3680-94  PubMed ID: 26132918
Hashimoto M, Sasaki JI, Yamaguchi S, Kawai K, Kawakami H, Iwasaki Y, Imazato S.  Gold Nanoparticles Inhibit Matrix Metalloproteases without Cytotoxicity.  J. Dent. Res.  2015  94:1085-91  PubMed ID: 26040283
Suzuki N, Takimoto K, Kawashima N.  Cathepsin K Inhibitor Regulates Inflammation and Bone Destruction in Experimentally Induced Rat Periapical Lesions.  J Endod  2015  41:1474-9  PubMed ID: 25990199
Miyazaki T, Miyauchi S, Anada T, Tawada A, Suzuki O.  Chondroitin Sulfate-E Binds to Both Osteoactivin and Integrin αVβ3 and Inhibits Osteoclast Differentiation.  J. Cell. Biochem.  2015  116:2247-57  PubMed ID: 25820496
Takeuchi T, Shimakawa G, Tamura M, Yokosawa H, Arata Y.  ISG15 regulates RANKL-induced osteoclastogenic differentiation of RAW264 cells.  Biol. Pharm. Bull.  2015  38:482-6  PubMed ID: 25757932
Hashimoto M, Imazato S.  Cytotoxic and genotoxic characterization of aluminum and silicon oxide nanoparticles in macrophages.  Dent Mater  2015  31:556-64  PubMed ID: 25749564
Kawabata K, Kato Y, Sakano T, Baba N, Hagiwara K, Tamura A, Baba S, Natsume M, Ohigashi H.  Effects of phytochemicals on in vitro anti-inflammatory activity of Bifidobacterium adolescentis.  Biosci. Biotechnol. Biochem.  2015  79:799-807  PubMed ID: 25721815
Hashimoto M, Sasaki J, Imazato S.  Investigation of the cytotoxicity of aluminum oxide nanoparticles and nanowires and their localization in L929 fibroblasts and RAW264 macrophages.  J. Biomed. Mater. Res. Part B Appl. Biomater.  2015  104:241-52  PubMed ID: 25715832
Higashijima Y, Tanaka T, Yamaguchi J, Tanaka S, Nangaku M.  Anti-inflammatory role of DPP-4 inhibitors in a nondiabetic model of glomerular injury.  Am. J. Physiol. Renal Physiol.  2015  308:F878-87  PubMed ID: 25656369
Kim YI, Mohri S, Hirai S, Lin S, Goto T, Ohyane C, Sakamoto T, Takahashi H, Shibata D, Takahashi N, Kawada T.  Tomato extract suppresses the production of proinflammatory mediators induced by interaction between adipocytes and macrophages.  Biosci. Biotechnol. Biochem.  2015  79:82-7  PubMed ID: 25603813
Taniguchi M, Ochiai A, Takahashi K, Nakamichi S, Nomoto T, Saitoh E, Kato T, Tanaka T.  Antimicrobial activity and mechanism of action of a novel cationic α-helical octadecapeptide derived from α-amylase of rice.  Biopolymers  2015  104:73-83  PubMed ID: 25581614
F Shima, T Akagi, M Shudo, E Mochizuki, T Tsuda, S Kuwabata M Akashi  Interaction between living cells and polymeric particles: potential application of ionic liquid for evaluating the cellular uptake of biodegradable polymeric particles composed of poly(amino acid).  Polymer Journal  2015  47:631-638 
Hiroi M, Sakaeda Y, Yamaguchi H, Ohmori Y.  Anti-inflammatory cytokine interleukin-4 inhibits inducible nitric oxide synthase gene expression in the mouse macrophage cell line RAW264.7 through the repression of octamer-dependent transcription.  Mediators Inflamm.  2014  2013:369693  PubMed ID: 24459328
T. Atsumi, A. Iwashita, I. Ohtsuka, N. Kakiuchi, Y. Sasaki, M. Mikage, K. Toriizuka  Effects of Atractylodis Lanceae Rhizoma on in?ammatory mediator production from the RAW264 macrophage cell line.  J Traditional Medicines  2013  30:124-131 
Funakoshi T, Yamashita K, Ichikawa N, Fukai M, Suzuki T, Goto R, Oura T, Kobayashi N, Katsurada T, Ichihara S, Ozaki M, Umezawa K, Todo S.  A novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates inflammatory colonic injury in mice.  J Crohns Colitis  2012  6:215-25  PubMed ID: 22325176
Takano K, Sato K, Negishi Y, Aramaki Y.  Involvement of actin cytoskeleton in macrophage apoptosis induced by cationic liposomes.  Arch. Biochem. Biophys.  2011  518:89-94  PubMed ID: 22203089
Takahashi K, Sugiyama T, Tokoro S, Neri P, Mori H.  Inhibition of interferon-γ-induced nitric oxide production by 10-hydroxy-trans-2-decenoic acid through inhibition of interferon regulatory factor-8 induction.  Cell. Immunol.  2011  273:73-8  PubMed ID: 22177846
Uto T, Morinaga O, Tanaka H, Shoyama Y.  Analysis of the synergistic effect of glycyrrhizin and other constituents in licorice extract on lipopolysaccharide-induced nitric oxide production using knock-out extract.  Biochem. Biophys. Res. Commun.  2011  417:473-8  PubMed ID: 22178686
Nakagawa S, Arai Y, Kishida T, Hiraoka N, Tsuchida S, Inoue H, Sakai R, Mazda O, Kubo T.  Lansoprazole inhibits nitric oxide and prostaglandin E(2) production in murine macrophage RAW 264.7 cells.  Inflammation  2011  35:1062-8  PubMed ID: 22134422
Yamamoto H, Abe Y, Miyazato A, Tanno D, Tanaka M, Miyasaka T, Ishii K, Kawakami K.  Cryptococcus neoformans suppresses the activation of bone marrow-derived dendritic cells stimulated with its own DNA, but not with DNA from other fungi.  FEMS Immunol. Med. Microbiol.  2011  63:363-72  PubMed ID: 22092563
Uto T, Qin GW, Morinaga O, Shoyama Y.  17-Hydroxy-jolkinolide B, a diterpenoid from Euphorbia fischeriana, inhibits inflammatory mediators but activates heme oxygenase-1 expression in lipopolysaccharide-stimulated murine macrophages.  Int. Immunopharmacol.  2011  12:101-9  PubMed ID: 22080918
Uchida M, Oyanagi E, Kremenik MJ, Sasaki J, Yano H.  Interferon-beta, but not tumor necrosis factor-alpha, production in response to poly I:C is maintained despite exhaustive exercise in mice.  J Physiol Sci  2011  62:59-62  PubMed ID: 21968540
Sugiyama T, Takahashi K, Tokoro S, Gotou T, Neri P, Mori H.  Inhibitory effect of 10-hydroxy-trans-2-decenoic acid on LPS-induced IL-6 production via reducing IκB-ζ expression.  Innate Immun  2011  18:429-37  PubMed ID: 21948282
Chen J, Qin S, Xiao J, Tanigawa S, Uto T, Hashimoto F, Fujii M, Hou DX.  A genome-wide microarray highlights the antiinflammatory genes targeted by oolong tea theasinensin A in macrophages.  Nutr Cancer  2011  63:1064-73  PubMed ID: 21864060
Sakamoto T, Yamaguchi Y, Goto T, Takahashi N, Kawada T.  An in vitro analysis system using a fluorescence protein reporter for evaluating anti-inflammatory effects in macrophages.  Biosci. Biotechnol. Biochem.  2011  75:1582-7  PubMed ID: 21821941
Itoh T, Hamada N, Terazawa R, Ito M, Ohno K, Ichihara M, Nozawa Y, Ito M.  Molecular hydrogen inhibits lipopolysaccharide/interferon γ-induced nitric oxide production through modulation of signal transduction in macrophages.  Biochem. Biophys. Res. Commun.  2011  411:143-9  PubMed ID: 21723254
Fujimoto A, Akifusa S, Hirofuji T, Yamashita Y.  Involvement of suppressor of cytokine signaling-1 in globular adiponectin-induced granulocyte colony-stimulating factor in RAW 264 cell.  Mol. Immunol.  2011  48:2052-8  PubMed ID: 21764457
Abiko Y, Miura T, Phuc BH, Shinkai Y, Kumagai Y.  Participation of covalent modification of Keap1 in the activation of Nrf2 by tert-butylbenzoquinone, an electrophilic metabolite of butylated hydroxyanisole.  Toxicol. Appl. Pharmacol.  2011  255:32-9  PubMed ID: 21651925
Haque A, Noman AS, Koide N, Odkhuu E, Naiki Y, Hashimoto S, Komatsu T, Yoshida T, Yokochi T.  An ADP ribosylation factor-GTPase activating protein negatively regulates the production of proinflammatory mediators in response to lipopolysaccharide.  Cancer Immunol. Immunother.  2011  60:1439-46  PubMed ID: 21644032
Egusa H, Doi M, Saeki M, Fukuyasu S, Akashi Y, Yokota Y, Yatani H, Kamisaki Y.  The small molecule harmine regulates NFATc1 and Id2 expression in osteoclast progenitor cells.  Bone  2011  49:264-74  PubMed ID: 21504804
Akagi T, Shima F, Akashi M.  Intracellular degradation and distribution of protein-encapsulated amphiphilic poly(amino acid) nanoparticles.  Biomaterials  2011  32:4959-67  PubMed ID: 21482432
Yamazaki Y, Kawano Y.  Inhibitory effects of herbal alkaloids on the tumor necrosis factor-α and nitric oxide production in lipopolysaccharide-stimulated RAW264 macrophages.  Chem. Pharm. Bull.  2011  59:388-91  PubMed ID: 21372424
Kurio N, Shimo T, Fukazawa T, Takaoka M, Okui T, Hassan NM, Honami T, Hatakeyama S, Ikeda M, Naomoto Y, Sasaki A.  Anti-tumor effect in human breast cancer by TAE226, a dual inhibitor for FAK and IGF-IR in vitro and in vivo.  Exp. Cell Res.  2011  317:1134-46  PubMed ID: 21338601
Arisaka M, Takano K, Negishi Y, Arima H, Aramaki Y.  Involvement of lipid rafts in macrophage apoptosis induced by cationic liposomes.  Arch. Biochem. Biophys.  2011  508:72-7  PubMed ID: 21315683
Ichioka M, Suganami T, Tsuda N, Shirakawa I, Hirata Y, Satoh-Asahara N, Shimoda Y, Tanaka M, Kim-Saijo M, Miyamoto Y, Kamei Y, Sata M, Ogawa Y.  Increased expression of macrophage-inducible C-type lectin in adipose tissue of obese mice and humans.  Diabetes  2011  60:819-26  PubMed ID: 21282371
Haque A, Koide N, Iftakhar-E-Khuda I, Noman AS, Odkhuu E, Badamtseren B, Naiki Y, Komatsu T, Yoshida T, Yokochi T.  Flavopiridol inhibits lipopolysaccharide-induced TNF-α production through inactivation of nuclear factor-κB and mitogen-activated protein kinases in the MyD88-dependent pathway.  Microbiol. Immunol.  2011  55:160-7  PubMed ID: 21204955
Hou DX, Masuzaki S, Tanigawa S, Hashimoto F, Chen J, Sogo T, Fujii M.  Oolong tea theasinensins attenuate cyclooxygenase-2 expression in lipopolysaccharide (LPS)-activated mouse macrophages: structure-activity relationship and molecular mechanisms.  J. Agric. Food Chem.  2010  58:12735-43  PubMed ID: 21082860
Miyazaki T, Miyauchi S, Anada T, Imaizumi H, Suzuki O.  Evaluation of osteoclastic resorption activity using calcium phosphate coating combined with labeled polyanion.  Anal. Biochem.  2010  410:7-12  PubMed ID: 21078287
Oshima H, Hioki K, Popivanova BK, Oguma K, Van Rooijen N, Ishikawa TO, Oshima M.  Prostaglandin E? signaling and bacterial infection recruit tumor-promoting macrophages to mouse gastric tumors.  Gastroenterology  2010  140:596-607.e7  PubMed ID: 21070778
Ueda H, Ippoushi K, Takeuchi A.  Repeated oral administration of a squeezed ginger (Zingiber officinale) extract augmented the serum corticosterone level and had anti-inflammatory properties.  Biosci. Biotechnol. Biochem.  2010  74:2248-52  PubMed ID: 21071834
Yonezawa T, Hasegawa S, Asai M, Ninomiya T, Sasaki T, Cha BY, Teruya T, Ozawa H, Yagasaki K, Nagai K, Woo JT.  Harmine, a β-carboline alkaloid, inhibits osteoclast differentiation and bone resorption in vitro and in vivo.  Eur. J. Pharmacol.  2010  650:511-8  PubMed ID: 21047508
Kamio N, Akifusa S, Yamashita Y.  Diacylglycerol kinase alpha regulates globular adiponectin-induced reactive oxygen species.  Free Radic. Res.  2010  45:336-41  PubMed ID: 21034360
Lee JW, Mase N, Yonezawa T, Seo HJ, Jeon WB, Cha BY, Nagai K, Woo JT.  Palmatine attenuates osteoclast differentiation and function through inhibition of receptor activator of nuclear factor-κb ligand expression in osteoblast cells.  Biol. Pharm. Bull.  2010  33:1733-9  PubMed ID: 20930384
Okui T, Shimo T, Fukazawa T, Kurio N, Hassan NM, Honami T, Takaoka M, Naomoto Y, Sasaki A.  Antitumor effect of temsirolimus against oral squamous cell carcinoma associated with bone destruction.  Mol. Cancer Ther.  2010  9:2960-9  PubMed ID: 20858724
Fukata N, Uchida K, Kusuda T, Koyabu M, Miyoshi H, Fukui T, Matsushita M, Nishio A, Tabata Y, Okazaki K.  The effective therapy of cyclosporine A with drug delivery system in experimental colitis.  J Drug Target  2010  19:458-67  PubMed ID: 20804404
Shikama Y, Nagai Y, Okada S, Oizumi T, Shimauchi H, Sugawara S, Endo Y.  Pro-IL-1β accumulation in macrophages by alendronate and its prevention by clodronate.  Toxicol. Lett.  2010  199:123-8  PubMed ID: 20804833
Yoshikawa K, Kokudo N, Hashimoto T, Yamamoto K, Inose T, Kimura T.  Novel phthalide compounds from Sparassis crispa (Hanabiratake), Hanabiratakelide A-C, exhibiting anti-cancer related activity.  Biol. Pharm. Bull.  2010  33:1355-9  PubMed ID: 20686231
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Yano H, Uchida M, Nakai R, Ishida K, Kato Y, Kawanishi N, Shiva D.  Exhaustive exercise reduces TNF-α and IFN-α production in response to R-848 via toll-like receptor 7 in mice.  Eur. J. Appl. Physiol.  2010  110:797-803  PubMed ID: 20602110
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