検索画面
細胞材料開発室サイト

戻る 戻る
細胞番号 : 細胞名
RCB0283 : C-1300  update : 2024/01/17
細胞特性(Comment:英)Highly metastatic neuroblastoma
細胞特性(日)In vivoで高い転移性を示すニューロブラストーマ。マウスで継代移植されていたものを当室で培養系に移した。
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
使用条件(日)基礎的研究につきましては、使用制限はありません。商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。
備考(英)
備考(日)
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 Iwakawa, M. & Ando, K.
寄託日 1989
動物種 _mouse < Mammals
動物系統名 A/J
採取組織 neuroblastoma
転移 Yes
細胞分類 cancer
入手歴 Maintained in vivo in A/J mous
細胞寿命 infinite
細胞形態 other
Cellosaurus(Expasy) CVCL_4343
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Suspension cells
培地 RPMI1640 + 5% FBS
培養方法 浮遊細胞の培養に関する一般的な注意
抗生物質 Free
継代方法 dilution
継代密度 1 : 10 split
継代・培地交換頻度 Subculture : 1-2 times/week, Medium Renewal : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ (-)
マウス系統検査 OK
アイソザイム検査 LD, NP
文献情報 Reference(英) 15件
Reference(日) 1件
利用者成果(英) 19件
利用者成果(日) 1件

トップへページトップへ
Reference(英)
5233  Goshima Y1, Ohsako S, Yamauchi T.  Overexpression of Ca2+/calmodulin-dependent protein kinase II in Neuro2a and NG108-15 neuroblastoma cell lines promotes neurite outgrowth and growth cone motility.  J Neurosci  1993  13(2):559-67  PubMed ID: 8381167   DOI: 10.1523/JNEUROSCI.13-02-00559.1993
186  Chelmicka-Schorr E, Checinski ME, Jones KH, Yu RC, Arnason BG.  Sympathetic nervous system trophism for neuroblastoma and its age dependence in rats  Cancer Res  1986  46(11):5504-6  PubMed ID: 3756898  
185  Chelmicka-Schorr E, Jones KH, Checinski ME, Yu RC, Arnason BG.  nfluence of the sympathetic nervous system on the growth of neuroblastoma in vivo and in vitro  Cancer Res  1985  45(12 Pt 1):6213-5.  PubMed ID: 4063972  
1659  Etoh T, Ohnuma N, Takahashi H, Taniguchi M  [Analysis of cellular immunity of mouse neuroblastoma (C-1300) and human neuroblastoma]  Nippon Gan Chiryo Gakkai Shi  1982  17:1247-54  PubMed ID: 7153616  
184  Pons G, O'Dea RF, Mirkin BL.  Biological characterization of the C-1300 murine neuroblastoma: an in vivo neural crest tumor model  Cancer Res  1982  42(9):3719-23  PubMed ID: 7105037  
5234  Zimmerman JM, Piffaretti JC.  Interaction of tetanus toxin and toxoid with cultured neuroblastoma cells. Analysis by immunofluorescence.  Naunyn Schmiedebergs Arch Pharmacol  1977  296(3):271-7  PubMed ID: 320489   DOI: 10.1007/bf00498693
4688  Matsuzawa H, Nirenberg M.  Receptor-mediated shifts in cGMP and cAMP levels in neuroblastoma cells.  Proc Natl Acad Sci U S A  1975  72(9):3472-6  PubMed ID: 171662   DOI: 10.1073/pnas.72.9.3472
644  Amano T, Hamprecht B, Kemper W  High activity of choline acetyltransferase induced in neuroblastoma x glia hybrid cells.  Exp Cell Res  1974  85:399-408  PubMed ID: 4857160   DOI: 10.1016/0014-4827(74)90142-6
5235  Narotzky R, Bondareff W.  Biogenic amines in cultured neuroblastoma and astrocytoma cells.  J Cell Biol  1974  63(1):64-70  PubMed ID: 4370924   DOI: 10.1083/jcb.63.1.64
646  Richelson E  Regulation of tyrosine hydroxylase activity in mouse neuroblastoma clone N1E-115.  J Neurochem  1973  21:1139-45  PubMed ID: 4148612   DOI: 10.1111/j.1471-4159.1973.tb07568.x
4687  Amano T, Richelson E, Nirenberg M.  Neurotransmitter synthesis by neuroblastoma clones (neuroblast differentiation-cell culture-choline acetyltransferase-acetylcholinesterase-tyrosine hydroxylase-axons-dendrites).  Proc Natl Acad Sci U S A  1972  69(1):258-63  PubMed ID: 4400294   DOI: 10.1073/pnas.69.1.258
183  Siman-Tov R, Sachs L.  Enzyme regulation in neuroblastoma cells. Selection of clones with low acetylcholinesterase activity and the independent control of acetylcholinesterase and choline-O-acetyltransferase  Eur J Biochem  1972  30(1):123-9  PubMed ID: 4343804   DOI: 10.1111/j.1432-1033.1972.tb02078.x
4685  Blume A, Gilbert F, Wilson S, Farber J, Rosenberg R, Nirenberg M.  Regulation of acetylcholinesterase in neuroblastoma cells.  Proc Natl Acad Sci U S A  1970  67(2):786-92  PubMed ID: 5289021   DOI: 10.1073/pnas.67.2.786
643  Klebe,R.J. and Ruddle,F.H.  165. Neuloblastoma:cell culture analysis of a differentiating stem cell system.  J Cell Biol  1969  43:69   
4686  Augusti-Tocco G, Sato G.  Establishment of functional clonal lines of neurons from mouse neuroblastoma.  Proc Natl Acad Sci U S A.  1969  64(1):311-5  PubMed ID: 5263016   DOI: 10.1073/pnas.64.1.311

トップへページトップへ
Reference(日)
642  Amano,Takeo  神経芽腫細胞株-mouse C1300 neublastoma clones and their hybrids with rat C6 glioma.  組織培養  1982  8:177-183   

トップへページトップへ
利用者成果(英)
13038  Islam MR, Okada T, Merzlyak PG, Toychiev AH, Ando-Akatsuka Y, Sabirov RZ, Okada Y.  Annexin A2-S100A10 Represents the Regulatory Component of Maxi-Cl Channel Dependent on Protein Tyrosine Dephosphorylation and Intracellular Ca²⁺.  Cell Physiol Biochem  2020    PubMed ID: 32442363   DOI: 10.33594/000000238
10743  Hiramatsu T, Yoshizawa J, Miyaguni K, Sugihara T, Harada A, Kaji S, Uchida G, Kanamori D, Baba Y, Ashizuka S, Ohki T.  Thalidomide potentiates etoposide-induced apoptosis in murine neuroblastoma through suppression of NF-κB activation.  Pediatr. Surg. Int.  2018  34:443-450  PubMed ID: 29423589   DOI: 10.1007/s00383-018-4234-4
14536  Kawakubo N, Tanaka S, Kinoshita Y, Tajiri T, Yonemitsu Y, Taguchi T.  Sequential actions of immune effector cells induced by viral activation of dendritic cells to eliminate murine neuroblastoma  J Pediatr Surg  2018  53(8):1615-1620  PubMed ID: 28941928   DOI: 10.1016/j.jpedsurg.2017.08.019
8552  Yasuda C, Sakata S, Kakinoki S, Takeyama Y, Ohyanagi H, Shiozaki H.  In vivo evaluation of microspheres containing the angiogenesis inhibitor, TNP-470, and the metastasis suppression with liver metastatic model implanted neuroblastoma.  Pathophysiology  2010  17:149-55  PubMed ID: 19540735   DOI: 10.1016/j.pathophys.2009.04.003
8499  Komaru A, Ueda Y, Furuya A, Tanaka S, Yoshida K, Kato T, Kinoh H, Harada Y, Suzuki H, Inoue M, Hasegawa M, Ichikawa T, Yonemitsu Y.  Sustained and NK/CD4+ T cell-dependent efficient prevention of lung metastasis induced by dendritic cells harboring recombinant Sendai virus.  J. Immunol.  2009  183:4211-9  PubMed ID: 19734206   DOI: 10.4049/jimmunol.0803845
9524  Hidehiko Sugino, Tomoko Toyama, Yusuke Taguchi, Shigeyuki Esumi, Mitsuhiro Miyazaki, Takeshi Yagi  Negative and Positive Effects of an IAP-LTR on Nearby Pcdaalpha Gene Expression in the Central Nervous System and Neuroblastoma Cell Lines  Gene   2004  337:91-103  PubMed ID: 15276205   DOI: 10.1016/j.gene.2004.04.011
9583  Takeshi Fukami, Hitoshi Satoh, Yuko N Williams, Mari Masuda, Hiroshi Fukuhara, Tomoko Maruyama, Mika Yageta, Masami Kuramochi, Shinichi Takamoto, Yoshinori Murakami  Isolation of the Mouse Tsll1 and Tsll2 Genes, Orthologues of the Human TSLC1-like Genes 1 and 2 (TSLL1 and TSLL2)  Gene  2003  323:11-8  PubMed ID: 14659875   DOI: 10.1016/j.gene.2003.09.018
3162  Yokoyama M, Watanabe H, Nakamura M  Genomic structure and functional characterization of NBPhox (PMX2B), a homeodomain protein specific to catecholaminergic cells that is involved in second messenger-mediated transcriptional activation.  Genomics  1999  59:40-50  PubMed ID: 10395798   DOI: 10.1006/geno.1999.5845
15404  Obuchi M, Yamamoto J, Uddin N, Odagiri T, Iizuka H, Ohara Y.  Theiler's murine encephalomyelitis virus (TMEV) subgroup strain-specific infection in neural and non-neural cell lines  Microbiol Immunol   1999  43(9):885-9  PubMed ID: 10553681   DOI: 10.1111/j.1348-0421.1999.tb01223.x
3161  Nakamura M, Watanabe H, Kubo Y, Yokoyama M, Matsumoto T, Sasai H, Nishi Y  KQT2, a new putative potassium channel family produced by alternative splicing. Isolation, genomic structure, and alternative splicing of the putative potassium channels.  Receptors Channels  1998  5:255-71  PubMed ID: 9666519  
15408  Motohashi H, Ohta J, Engel JD, Yamamoto M.  A core region of the mafK gene IN promoter directs neurone-specific transcription in vivo  Genes Cells  1998  3(10):671-84  PubMed ID: 9893024   DOI: 10.1046/j.1365-2443.1998.00222.x
18056  Hikawa N, Takenaka T.  Mature sensory neuron-derived hybrid cell line expressing NGF-dependent neurite extension  Brain Res  1997  774(1-2):225-8  PubMed ID: 9452214   DOI: 10.1016/s0006-8993(97)81709-x
18081  Hikawa N, Takenaka T.  Method for production of neuronal hybridoma using emetine and actinomycin D  Brain Res Brain Res Protoc  1997  1(3):224-6  PubMed ID: 9385057   DOI: 10.1016/s1385-299x(96)00031-1
18086  Fukuhara S, Mukai H, Munekata E.  Activin A and all-trans-retinoic acid cooperatively enhanced the functional activity of L-type Ca2+ channels in the neuroblastoma C1300 cell line  Biochem Biophys Res Commun  1997  ;241(2):363-8  PubMed ID: 9425277   DOI: 10.1006/bbrc.1997.7639
12857  Kuwashima N.  Organ-specific adhesion of neuroblastoma cells in vitro: correlation with their hepatic metastasis potential  J Pediatr Surg  1997  32(4):546-51  PubMed ID: 9126751   DOI: 10.1016/s0022-3468(97)90704-1
2186  Fukuhara S, Mukai H, Kako K, Nakayama K, Munekata E  Further identification of neurokinin receptor types and mechanisms of calcium signaling evoked by neurokinins in the murine neuroblastoma C1300 cell line.  J Neurochem  1996  67:1282-92  PubMed ID: 8752137   DOI: 10.1046/j.1471-4159.1996.67031282.x
2066  Hikawa N, Takenaka T  Improved method for producing neuronal hybrids using emetine and actinomycin D.  Brain Res  1996  734:345-8  PubMed ID: 8896846  
2187  Fukuhara S, Mukai H, Munekata E  Pharmacological evidence for neurokinin receptors in murine neuroblastoma C1300 cells.  Peptides  1995  16:211-4  PubMed ID: 7540290   DOI: 10.1016/0196-9781(94)00166-9
17890  Saga Y, Tsukamoto T, Jing N, Kusakabe M, Sakakura T.  Murine tenascin: cDNA cloning, structure and temporal expression of isoforms  Gene  1991  104(2):177-85  PubMed ID: 1717349   DOI: 10.1016/0378-1119(91)90248-a

トップへページトップへ
利用者成果(日)
2482  田辺好英、伊藤伸一、長江逸郎  マウス神経芽腫モデルに対する liposome 封入 doxorubicin (Caelyx) の治療効果  東京医科大学雑誌  2000  58:481-493   



戻る 戻る 理研トップページへ