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RCB0224 : ST2  update : 2018/07/06
CommentBone marrow stroma cell-derived
特性(日) わが国で開発されたマウス骨髄由来のストローマ細胞で、造血幹細胞の増殖を支持できるため、フィーダーとして使用される。
寄託者特性(英)
寄託者特性(日)
使用条件a
使用条件(英)Basically, there is no restriction regarding academic use.
使用条件(日)学術研究における利用につきましては原則として使用制限はありません。
提供申込書類 依頼書C-0001.pdf   同意書(非営利)C-0003.pdf   同意書(営利)C-0003p.pdf  
提供同意書は、使用機関及び使用内容に応じて二種類あります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は別途ご相談(cellbank.brc@riken.jp)を承ります。
細胞基本情報 寄託者 Nishikawa, Shin-ichi
樹立者 Nishikawa, Shin-ichi
寄託日 1987
動物種 mouse < Mammals
動物系統名 BALB/c
採取組織 bone marrow
細胞分類 other
入手歴 Nishikawa(Kumamoto Univ.)
細胞寿命 infinite
細胞形態 fibroblast-like
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 RPMI1640 + 10% FBS
抗生物質 Free
継代方法 0.25% trypsin
継代密度 1 : 8 split
継代または培地交換頻度 Subculture : 1-2 times/week, Medium Renewal : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ (-)
マウス系統検査 OK
アイソザイム検査 LD, NP
染色体検査 70-80(50) : /74(5),75(5),76(6),77(11),78(12)/
画像情報
寄託時情報
ロット情報
文献情報 Reference(英) 4件
Reference(日) 2件
利用者成果(英) 127件
利用者成果(日) 1件

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Reference(英)
Hayashi S, Kunisada T, Ogawa M, Sudo T, Kodama H, Suda T, Nishikawa S, Nishikawa S  Stepwise progression of B lineage differentiation supported by interleukin 7 and other stromal cell molecules.  J Exp Med  1990  171:1683-95 
Sudo T, Ito M, Ogawa Y, Iizuka M, Kodama H, Kunisada T, Hayashi S, Ogawa M, Sakai K, Nishikawa S  Interleukin 7 production and function in stromal cell-dependent B cell development.  J Exp Med  1989  170:333-8 
Ogawa M, Nishikawa S, Ikuta K, Yamamura F, Naito M, Takahashi K, Nishikawa S  B cell ontogeny in murine embryo studied by a culture system with the monolayer of a stromal cell clone, ST2: B cell progenitor develops first in the embryonal body rather than in the yolk sac.  EMBO J  1988  7:1337-43 
Nishikawa S, Ogawa M, Nishikawa S, Kunisada T, Kodama H  B lymphopoiesis on stromal cell clone: stromal cell clones acting on different stages of B cell differentiation.  Eur J Immunol  1988  18:1767-71 

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Reference(日)
吉田尚弘,林眞一,西川伸一  骨髄幹細胞の長期培養法とその応用-大理石病マウスを具体例として-  生体防御  1990  7:145-149 
西川里美  バイオテクノロジ-素材としての培養細胞 ハイブリドーマと免疫  蛋白質 核酸 酵素  1990  35:2281 

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利用者成果(英)
Sakai H, Nakamura F, Kuno M  Synergetic activation of outwardly rectifying Cl- currents by hypotonic stress and external Ca2+ in murine osteoclasts  J Physiol  1999  515:157-168 
Sakiyama H, Nonaka T, Masuda R, Inoue N, Kuboki Y, Iijima M, Hirabayasi Y, Takahagi M, Yoshida K, Kuriiwa K, Yoshida M, Imajoh-Ohmi S  Characterization of mineral deposits formed in cultures of a hamster tartrate-resistant acid phosphatase (TRAP) and alkaline phosphatase (ALP) double-positive cell line (CCP).  Cell Tissue Res  2002  309:269-79 
Notoya M, Otsuka E, Yamaguchi A, Hagiwara H  Runx-2 is not essential for the vitamin D-regulated expression of RANKL and osteoprotegerin in osteoblastic cells.  Biochem Biophys Res Commun  2004  324:655-60 
Nishida S, Tsubaki M, Hoshino M, Namimatsu A, Uji H, Yoshioka S, Tanimori Y, Yanae M, Iwaki M, Irimajiri K  Nitrogen-containing bisphosphonate, YM529/ONO-5920 (a novel minodronic acid), inhibits RANKL expression in a cultured bone marrow stromal cell line ST2.  Biochem Biophys Res Commun  2005  328:91-7 
Shibata T, Sakai H, Nakamura F, Shioi A, Kuno M  Differential effect of high extracellular Ca2+ on K+ and Cl- conductances in murine osteoclasts.  J Membr Biol  1997  158:59-67 
Shuto T, Jimi E, Kukita T, Hirata M, Koga T  Granulocyte-macrophage colony stimulating factor suppresses lipopolysaccharide-induced osteoclast-like cell formation in mouse bone marrow cultures.  Endocrinology  1994  134:831-7 
Flanagan, A M, Horton, M A, Dorey, E L, Collins, D A, Evely, R S, Moseley, J M, Firkin, F C, Chambers, T J, Helfrich, M H, Martin, T J  An assessment of the ability of human bone marrow cultures to generate osteoclasts.  Int J Exp Pathol  1992  73:387-401 
Athanasou, N A, Quinn, J M  Human tumour-associated macrophages are capable of bone resorption.  Br J Cancer  1992  65:523-6 
Kerby, J A, Hattersley G, Collins, D A, Chambers, T J  Derivation of osteoclasts from hematopoietic colony-forming cells in culture.  J Bone Miner Res  1992  7:353-62 
Shioi A, Teitelbaum, S L, Ross, F P, Welgus, H G, Suzuki H, Ohara J, Lacey, D L  Interleukin 4 Inhibits Murine Osteoclast Formation In Vitro  J Cell Biol  1991  47:272-277 
Hong, M H, Jin, C H, Sato T, Ishimi Y, Abe E, Suda T  Transcriptional regulation of the production of the third component of complement (C3) by 1 alpha,25-dihydroxyvitamin D3 in mouse marrow-derived stromal cells (ST2) and primary osteoblastic cells.  Endocrinology  1991  129:2774-9 
Sato T, Hong, M H, Jin, C H, Ishimi Y, Udagawa N, Shinki T, Abe E, Suda T  The specific production of the third component of complement by osteoblastic cells treated with 1 alpha,25-dihydroxyvitamin D3.  FEBS Lett  1991  285:21-4 
Udagawa N, Takahashi N, Akatsu T, Tanaka H, Sasaki T, Nishihara T, Koga T, Martin, T J, Suda T  Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells.  Proc Natl Acad Sci U S A  1990  87:7260-4 
Udagawa N, Takahashi N, Akatsu T, Sasaki T, Yamaguchi A, Kodama H, Martin, T J, Suda T  The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells.  Endocrinology  1989  125:1805-13 
Jimi E, Shuto T, Koga T  Macrophage colony-stimulating factor and interleukin-1 alpha maintain the survival of osteoclast-like cells.  Endocrinology  1995  136:808-11 
Jimi E, Shuto T, Ikebe T, Jingushi S, Hirata M, Koga T  Basic fibroblast growth factor inhibits osteoclast-like cell formation.  J Cell Physiol  1996  168:395-402 
Nishikawa M, Yamamoto M, Murakami T, Akatsu T, Kugai N, Nagata N  A third-generation bisphosphonate, YM175, inhibits osteoclast formation in murine cocultures by inhibiting proliferation of precursor cells via supporting cell-dependent mechanisms.  J Bone Miner Res  1998  13:986-95 
Kitazawa R, Kitazawa S, Maeda S  Promoter structure of mouse RANKL/TRANCE/OPGL/ODF gene.  Biochim Biophys Acta  1999  1445:134-41 
Otsuka E, Yamaguchi A, Hirose S, Hagiwara H  Characterization of osteoblastic differentiation of stromal cell line ST2 that is induced by ascorbic acid  Am J Physiol  1999  277(1 Pt 1):132-138 
Yuhara S, Kasagi S, Inoue A, Otsuka E, Hirose S, Hagiwara H  Effects of nicotine on cultured cells suggest that it can influence the formation and resorption of bone.  Eur J Pharmacol  1999  383:387-93 
Otsuka E, Kato Y, Hirose S, Hagiwara H  Role of ascorbic acid in the osteoclast formation: induction of osteoclast differentiation factor with formation of the extracellular collagen matrix.  Endocrinology  2000  141:3006-11 
Sakiyama H, Masuda R, Inoue N, Yamamoto K, Kuriiwa K, Nakagawa K, Yoshida K  Establishment and characterization of macrophage-like cell lines expressing osteoclast-specific markers.  J Bone Miner Metab  2001  19:220-7 
Masuda R, Sakiyama H, Nonaka T, Kwan A, Nakagawa K, Moriya H, Imajoh-Ohmi S, Honjo M, Yoshida K  Establishment and characterization of tartrate-resistant acid phosphatase and alkaline phosphatase double positive cell lines.  Cell Tissue Res  2001  304:351-9 
Kitazawa, Riko, Kitazawa, Sohei  Vitamin D(3) augments osteoclastogenesis via vitamin D-responsive element of mouse RANKL gene promoter.  Biochem Biophys Res Commun  2002  290:650-5 
Sakuta K, Sakai H, Mori H, Morihata H, Kuno M  Na+ dependence of extracellular Ca2+-sensing mechanisms leading to activation of an outwardly rectifying Cl- channel in murine osteoclasts.  Bone  2002  31:374-80 
Sakuta, Koichi, Morihata, Hirokazu, Mori, Hiroyuki, Sakai, Hiromu, Kuno, Miyuki  Cell swelling as an intermediate signal leading to activation of a Cl- channel in extracellular calcium-sensing of murine osteoclasts.  Osaka City Med J  2002  48:29-38 
Tazoe, Michiko, Mogi, Makio, Goto, Shigemi, Togari, Akifumi  Involvement of p38MAP kinase in bone morphogenetic protein-4-induced osteoprotegerin in mouse bone-marrow-derived stromal cells.  Arch Oral Biol  2003  48:615-9 
Fan, Xian, Roy, Eileen, Zhu, Liping, Murphy, Tamara C, Ackert-Bicknell, Cheryl, Hart, C Michael, Rosen, Clifford, Nanes, Mark S, Rubin, Janet  Nitric oxide regulates receptor activator of nuclear factor-kappaB ligand and osteoprotegerin expression in bone marrow stromal cells.  Endocrinology  2004  145:751-9 
French, Dorothy M, Kaul, Raji J, D'Souza, Aloma L, Crowley, Craig W, Bao, Min, Frantz, Gretchen D, Filvaroff, Ellen H, Desnoyers, Luc  WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair.  Am J Pathol  2004  165:855-67 
Oursler, Merry Jo, Bradley, Elizabeth W, Elfering, Sarah L, Giulivi, Cecilia  Native, not nitrated, cytochrome c and mitochondria-derived hydrogen peroxide drive osteoclast apoptosis.  Am J Physiol Cell Physiol  2005  288:C156-68 
Hata, Kenji, Nishimura, Riko, Ueda, Mio, Ikeda, Fumiyo, Matsubara, Takuma, Ichida, Fumitaka, Hisada, Kunihiro, Nokubi, Takashi, Yamaguchi, Akira, Yoneda, Toshiyuki  A CCAAT/enhancer binding protein beta isoform, liver-enriched inhibitory protein, regulates commitment of osteoblasts and adipocytes.  Mol Cell Biol  2005  25:1971-9 
Takeuchi, Tamotsu, Adachi, Yoshihiro, Ohtsuki, Yuji  Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma.  Am J Pathol  2005  166:1817-26 
Hall, Christopher L, Bafico, Anna, Dai, Jinlu, Aaronson, Stuart A, Keller, Evan T  Prostate cancer cells promote osteoblastic bone metastases through Wnts.  Cancer Res  2005  65:7554-60 
Endo K, Anada T, Yamada M, Seki M, Sasaki K, Suzuki O.  Enhancement of osteoblastic differentiation in alginate gel beads with bioactive octacalcium phosphate particles.  Biomed Mater  2015  10:065019  PubMed ID: 26657659
Park JW, Kang DG, Hanawa T.  New bone formation induced by surface strontium-modified ceramic bone graft substitute.  Oral Dis  2015  22:53-61  PubMed ID: 26458092
Kanda N, Anada T, Handa T, Kobayashi K, Ezoe Y, Takahashi T, Suzuki O.  Orthotopic Osteogenecity Enhanced by a Porous Gelatin Sponge in a Critical-Sized Rat Calvaria Defect.  Macromol Biosci  2015  15:1647-55  PubMed ID: 26200698
Dubon MJ, Park KS.  Substance P enhances the proliferation and migration potential of murine bone marrow-derived mesenchymal stem cell-like cell lines.  Exp Ther Med  2015  9:1185-1191  PubMed ID: 25780407
Takahashi K, Shiraishi N, Ishiko-Uzuka R, Anada T, Suzuki O, Masumoto H, Sasaki K.  Biomechanical evaluation of Ti-Nb-Sn alloy implants with a low Young's modulus.  Int J Mol Sci  2015  16:5779-88  PubMed ID: 25775158
Kaneko K, Higuchi C, Kunugiza Y, Yoshida K, Sakai T, Yoshikawa H, Nakata K.  Hyaluronan inhibits BMP-induced osteoblast differentiation.  FEBS Lett.  2015  589:447-54  PubMed ID: 25592835
Li C, Shi C, Kim J, Chen Y, Ni S, Jiang L, Zheng C, Li D, Hou J, Taichman RS, Sun H.  Erythropoietin promotes bone formation through EphrinB2/EphB4 signaling.  J. Dent. Res.  2015  94:455-63  PubMed ID: 25586589
Y Ezoe, T Anada, H Yamazaki, T Handa, K Kobayashi, T Takahashi, O. Suzuki  Characterization of partially hydrolyzed OCP crystals deposited in a gelatin matrix as a scaffold for bone tissue engineering.  J Nanoparticle Res.  2015  17:127 
Handa T, Anada T, Honda Y, Yamazaki H, Kobayashi K, Kanda N, Kamakura S, Echigo S, Suzuki O.  The effect of an octacalcium phosphate co-precipitated gelatin composite on the repair of critical-sized rat calvarial defects.  Acta Biomater  2011  8:1190-200  PubMed ID: 22198138
Honami T, Shimo T, Okui T, Kurio N, Hassan NM, Iwamoto M, Sasaki A.  Sonic hedgehog signaling promotes growth of oral squamous cell carcinoma cells associated with bone destruction.  Oral Oncol.  2011  48:49-55  PubMed ID: 21945071
Huang H, Zhao N, Xu X, Xu Y, Li S, Zhang J, Yang P.  Dose-specific effects of tumor necrosis factor alpha on osteogenic differentiation of mesenchymal stem cells.  Cell Prolif.  2011  44:420-7  PubMed ID: 21951285
Furugaki K, Moriya Y, Iwai T, Yorozu K, Yanagisawa M, Kondoh K, Fujimoto-Ohuchi K, Mori K.  Erlotinib inhibits osteolytic bone invasion of human non-small-cell lung cancer cell line NCI-H292.  Clin. Exp. Metastasis  2011  28:649-59  PubMed ID: 21688034
Shoji K, Tsubaki M, Yamazoe Y, Satou T, Itoh T, Kidera Y, Tanimori Y, Yanae M, Matsuda H, Taga A, Nakamura H, Nishida S.  Mangiferin induces apoptosis by suppressing Bcl-xL and XIAP expressions and nuclear entry of NF-κB in HL-60 cells.  Arch. Pharm. Res.  2011  34:469-75  PubMed ID: 21547680
Kurio N, Shimo T, Fukazawa T, Takaoka M, Okui T, Hassan NM, Honami T, Hatakeyama S, Ikeda M, Naomoto Y, Sasaki A.  Anti-tumor effect in human breast cancer by TAE226, a dual inhibitor for FAK and IGF-IR in vitro and in vivo.  Exp. Cell Res.  2011  317:1134-46  PubMed ID: 21338601
Hu R, Liu W, Li H, Yang L, Chen C, Xia ZY, Guo LJ, Xie H, Zhou HD, Wu XP, Luo XH.  A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation.  J. Biol. Chem.  2011  286:12328-39  PubMed ID: 21324897
Tamura M, Sato MM, Nashimoto M.  Regulation of CXCL12 expression by canonical Wnt signaling in bone marrow stromal cells.  Int. J. Biochem. Cell Biol.  2011  43:760-7  PubMed ID: 21296678
Taipaleenmaki H, Abdallah BM, AlDahmash A, Saamanen AM, Kassem M.  Wnt signalling mediates the cross-talk between bone marrow derived pre-adipocytic and pre-osteoblastic cell populations.  Exp. Cell Res.  2011  317:745-56  PubMed ID: 21211534
Furukawa R, Yamada Y, Takenaga M, Igarashi R, Harashima H.  Octaarginine-modified liposomes enhance the anti-oxidant effect of Lecithinized superoxide dismutase by increasing its cellular uptake.  Biochem. Biophys. Res. Commun.  2010  404:796-801  PubMed ID: 21168389
Tsuneto M, Yamane T, Hayashi S.  Methods for investigation of osteoclastogenesis using mouse embryonic stem cells.  Methods Mol. Biol.  2010  690:239-53  PubMed ID: 21042997
Lee JW, Mase N, Yonezawa T, Seo HJ, Jeon WB, Cha BY, Nagai K, Woo JT.  Palmatine attenuates osteoclast differentiation and function through inhibition of receptor activator of nuclear factor-κb ligand expression in osteoblast cells.  Biol. Pharm. Bull.  2010  33:1733-9  PubMed ID: 20930384
Okui T, Shimo T, Fukazawa T, Kurio N, Hassan NM, Honami T, Takaoka M, Naomoto Y, Sasaki A.  Antitumor effect of temsirolimus against oral squamous cell carcinoma associated with bone destruction.  Mol. Cancer Ther.  2010  9:2960-9  PubMed ID: 20858724
Cody JJ, Rivera AA, Lyons GR, Yang SW, Wang M, Sarver DB, Wang D, Selander KS, Kuo HC, Meleth S, Feng X, Siegal GP, Douglas JT.  Arming a replicating adenovirus with osteoprotegerin reduces the tumor burden in a murine model of osteolytic bone metastases of breast cancer.  Cancer Gene Ther.  2010  17:893-905  PubMed ID: 20798695
Uemura T, Ohta Y, Nakao Y, Manaka T, Nakamura H, Takaoka K.  Epinephrine accelerates osteoblastic differentiation by enhancing bone morphogenetic protein signaling through a cAMP/protein kinase A signaling pathway.  Bone  2010  47:756-65  PubMed ID: 20637325
Kakegawa A, Oida S, Gomi K, Nagano T, Yamakoshi Y, Fukui T, Kanazashi M, Arai T, Fukae M.  Cytodifferentiation activity of synthetic human enamel sheath protein peptides.  J. Periodont. Res.  2010  45:643-9  PubMed ID: 20572923
Lee JW, Ahn JY, Hasegawa S, Cha BY, Yonezawa T, Nagai K, Seo HJ, Jeon WB, Woo JT.  Inhibitory effect of luteolin on osteoclast differentiation and function.  Cytotechnology  2010  61:125-34  PubMed ID: 20162352
Kurtova AV, Balakrishnan K, Chen R, Ding W, Schnabl S, Quiroga MP, Sivina M, Wierda WG, Estrov Z, Keating MJ, Shehata M, Jager U, Gandhi V, Kay NE, Plunkett W, Burger JA.  Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance.  Blood  2009  114:4441-50  PubMed ID: 19762485
Yoshikawa H, Yoshioka K, Nakase T, Itoh K.  Stimulation of ectopic bone formation in response to BMP-2 by Rho kinase inhibitor: a pilot study.  Clin. Orthop. Relat. Res.  2009  467:3087-95  PubMed ID: 19609629
Fuji T, Anada T, Honda Y, Shiwaku Y, Koike H, Kamakura S, Sasaki K, Suzuki O.  Octacalcium phosphate-precipitated alginate scaffold for bone regeneration.  Tissue Eng Part A  2009  15:3525-35  PubMed ID: 19456237
Tanaka T, Kawashima H, Ohnishi K, Matsumura K, Yoshimura R, Matsuyama M, Kuratsukuri K, Nakatani T.  Indirect antitumor effects of bisphosphonates on prostatic LNCaP cells co-cultured with bone cells.  Anticancer Res.  2009  29:1089-94  PubMed ID: 19414350
Mogi M, Kondo A.  Down-regulation of mTOR leads to up-regulation of osteoprotegerin in bone marrow cells.  Biochem. Biophys. Res. Commun.  2009  384:82-6  PubMed ID: 19393224
Yano K, Hoshino M, Ohta Y, Manaka T, Naka Y, Imai Y, Sebald W, Takaoka K.  Osteoinductive capacity and heat stability of recombinant human bone morphogenetic protein-2 produced by Escherichia coli and dimerized by biochemical processing.  J. Bone Miner. Metab.  2009  27:355-63  PubMed ID: 19229473
Honda Y, Anada T, Kamakura S, Morimoto S, Kuriyagawa T, Suzuki O.  The effect of microstructure of octacalcium phosphate on the bone regenerative property.  Tissue Eng Part A  2009  15:1965-73  PubMed ID: 19132890
Yamachika E, Tsujigiwa H, Shirasu N, Ueno T, Sakata Y, Fukunaga J, Mizukawa N, Yamada M, Sugahara T.  Immobilized recombinant human bone morphogenetic protein-2 enhances the phosphorylation of receptor-activated Smads.  J Biomed Mater Res A  2008  88:599-607  PubMed ID: 18314893
Tsujigiwa H, Nagatsuka H, Lee YJ, Han PP, Gunduz M, Legeros RZ, Inoue M, Yamada M, Nagai N.  Immobilized rhBMP-2/succinylated type I atelocollagen gene expression of intracellular signaling molecules on ST2 cells.  J Biomed Mater Res A  2006  77:507-11  PubMed ID: 16482552
Hidetsugu Tsujigiwa, Andrea P. Rodriguez, Tohru Takagi, Hu Hai Long, Kan Rui, Zhenfu Lu, Xie Wei Li, Gao Wen-Xin, Jin Tan and Jing Xiao  Effects of Immobilized rhBMP-2/atelocollagen in vivo and in vitro  J Hard Tissue Biology  2006  15:27-33 
Deshimaru R, Ishitani K, Makita K, Horiguchi F, Nozawa S.  Analysis of fatty acid composition in human bone marrow aspirates.  Keio J Med  2005  54:150-5  PubMed ID: 16237277
Hall CL, Bafico A, Dai J, Aaronson SA, Keller ET.  Prostate cancer cells promote osteoblastic bone metastases through Wnts.  Cancer Res.  2005  65:7554-60  PubMed ID: 16140917
Tsujigiwa H, Nagatsuka H, Gunduz M, Rodriguez A, Rivera RS, Legeros RZ, Inoue M, Nagai N.  Effects of immobilized recombinant human bone morphogenetic protein-2/succinylated type I atelocollagen on cellular activity of ST2 cells.  J Biomed Mater Res A  2005  75:210-5  PubMed ID: 16059889
Takeuchi T, Adachi Y, Ohtsuki Y.  Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma.  Am. J. Pathol.  2005  166:1817-26  PubMed ID: 15920166
Kandler B, Maitz P, Fischer MB, Watzek G, Gruber R.  Platelets can neutralize hydrogen peroxide in an acute toxicity model with cells involved in granulation tissue formation.  Bone  2005  36:671-7  PubMed ID: 15784190
Hata K, Nishimura R, Ueda M, Ikeda F, Matsubara T, Ichida F, Hisada K, Nokubi T, Yamaguchi A, Yoneda T.  A CCAAT/enhancer binding protein beta isoform, liver-enriched inhibitory protein, regulates commitment of osteoblasts and adipocytes.  Mol. Cell. Biol.  2005  25:1971-9  PubMed ID: 15713650
Nishida S, Tsubaki M, Hoshino M, Namimatsu A, Uji H, Yoshioka S, Tanimori Y, Yanae M, Iwaki M, Irimajiri K.  Nitrogen-containing bisphosphonate, YM529/ONO-5920 (a novel minodronic acid), inhibits RANKL expression in a cultured bone marrow stromal cell line ST2.  Biochem. Biophys. Res. Commun.  2005  328:91-7  PubMed ID: 15670755
Notoya M, Otsuka E, Yamaguchi A, Hagiwara H.  Runx-2 is not essential for the vitamin D-regulated expression of RANKL and osteoprotegerin in osteoblastic cells.  Biochem. Biophys. Res. Commun.  2004  324:655-60  PubMed ID: 15474477
Oursler MJ, Bradley EW, Elfering SL, Giulivi C.  Native, not nitrated, cytochrome c and mitochondria-derived hydrogen peroxide drive osteoclast apoptosis.  Am. J. Physiol., Cell Physiol.  2004  288:C156-68  PubMed ID: 15342339
French DM, Kaul RJ, D'Souza AL, Crowley CW, Bao M, Frantz GD, Filvaroff EH, Desnoyers L.  WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair.  Am. J. Pathol.  2004  165:855-67  PubMed ID: 15331410
Fan X, Roy E, Zhu L, Murphy TC, Ackert-Bicknell C, Hart CM, Rosen C, Nanes MS, Rubin J.  Nitric oxide regulates receptor activator of nuclear factor-kappaB ligand and osteoprotegerin expression in bone marrow stromal cells.  Endocrinology  2003  145:751-9  PubMed ID: 14563699
Tazoe M, Mogi M, Goto S, Togari A.  Involvement of p38MAP kinase in bone morphogenetic protein-4-induced osteoprotegerin in mouse bone-marrow-derived stromal cells.  Arch. Oral Biol.  2003  48:615-9  PubMed ID: 12828991
Sakuta K, Morihata H, Mori H, Sakai H, Kuno M.  Cell swelling as an intermediate signal leading to activation of a Cl- channel in extracellular calcium-sensing of murine osteoclasts.  Osaka City Med J  2002  48:29-38  PubMed ID: 12375695
Sakuta K, Sakai H, Mori H, Morihata H, Kuno M.  Na+ dependence of extracellular Ca2+-sensing mechanisms leading to activation of an outwardly rectifying Cl- channel in murine osteoclasts.  Bone  2002  31:374-80  PubMed ID: 12231409
Sakiyama H, Nonaka T, Masuda R, Inoue N, Kuboki Y, Iijima M, Hirabayasi Y, Takahagi M, Yoshida K, Kuriiwa K, Yoshida M, Imajoh-Ohmi S.  Characterization of mineral deposits formed in cultures of a hamster tartrate-resistant acid phosphatase (TRAP) and alkaline phosphatase (ALP) double-positive cell line (CCP).  Cell Tissue Res.  2002  309:269-79  PubMed ID: 12172786
Kitazawa R, Kitazawa S.  Vitamin D(3) augments osteoclastogenesis via vitamin D-responsive element of mouse RANKL gene promoter.  Biochem. Biophys. Res. Commun.  2002  290:650-5  PubMed ID: 11785948
Tsubaki M, Takeda T, Yoshizumi M, Ueda E, Itoh T, Imano M, Satou T, Nishida S.  RANK-RANKL interactions are involved in cell adhesion-mediated drug resistance in multiple myeloma cell lines.  Tumour Biol.  2016  37:9099-110  PubMed ID: 26762414
Pal SK, Nguyen CT, Morita KI, Miki Y, Kayamori K, Yamaguchi A, Sakamoto K.  THBS1 is induced by TGFB1 in the cancer stroma and promotes invasion of oral squamous cell carcinoma.  J. Oral Pathol. Med.  2016  45:730-739  PubMed ID: 26850833
Dubon MJ, Park KS.  The mechanisms of substance P-mediated migration of bone marrow-derived mesenchymal stem cell-like ST2 cells.  Int. J. Mol. Med.  2016  37:1105-11  PubMed ID: 26936322
Miron RJ, Fujioka-Kobayashi M, Zhang Y, Caballé-Serrano J, Shirakata Y, Bosshardt DD, Buser D, Sculean A.  Osteogain improves osteoblast adhesion, proliferation and differentiation on a bovine-derived natural bone mineral.  Clin Oral Implants Res  2017  28:327-333  PubMed ID: 26919609
Yoshikawa M, Ouji Y.  Induction of Inner Ear Hair Cells from Mouse Embryonic Stem Cells In Vitro.  Methods Mol. Biol.  2016  1516:257-267  PubMed ID: 27032944
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  Lower dosage of aspirin promotes cell growth and osteogenic differentiation in murine bone marrow stromal cells        PubMed ID:
  Pueraria mirifica phytoestrogens interrupt RANKL/OPG/RANK signaling in osteoblast precursor ST2 cells, but not in osteoblast–osteoclast coculture        PubMed ID:
  Designing Porous Bone Tissue Engineering Scaffolds with Enhanced Mechanical Properties from Composite Hydrogels Composed of Modified Alginate, Gelatin and Bioactive Glass        PubMed ID:
  MEIO CONDICIONADO DE OSSO DESMINERALIZADO E LIOFILIZADO ALTERA A EXPRESSÃO GÊNICA DE FIBROBLASTOS ORAIS VIA RECEPTORES TGF-ß IN VITRO        PubMed ID:
  Effects of gallotannin on osteoclastogenesis and the p38 MAP kinase pathway        PubMed ID:
  PEPTIDES HAVING OSTEOBLAST GROWTH-PROMOTING ACTIVITY AND USE THEREOF        PubMed ID:
  Pueraria mirifica phytoestrogens interrupt RANKL/OPG/RANK signaling in osteoblast precursor ST2 cells, but not in osteoblast–osteoclast coculture        PubMed ID:
  Designing Porous Bone Tissue Engineering Scaffolds with Enhanced Mechanical Properties from Composite Hydrogels Composed of Modified Alginate, Gelatin and Bioactive Glass        PubMed ID:
  MEIO CONDICIONADO DE OSSO DESMINERALIZADO E LIOFILIZADO ALTERA A EXPRESSÃO GÊNICA DE FIBROBLASTOS ORAIS VIA RECEPTORES TGF-ß IN VITRO        PubMed ID:
  Effects of gallotannin on osteoclastogenesis and the p38 MAP kinase pathway        PubMed ID:
  PEPTIDES HAVING OSTEOBLAST GROWTH-PROMOTING ACTIVITY AND USE THEREOF        PubMed ID:
  Surface Modification of Bioactive Glass Scaffolds        PubMed ID:

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左右田昌彦、 小山洋一、 丸野内棣  マクロファージ系細胞 (774.1)の分化に対するB細胞ハイブリドーマ培養上清の阻害作用  藤田学園医学会誌  1992  16:75-80 



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