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RCB0224 : ST2  update : 2018/07/06
CommentBone marrow stroma cell-derived
Comment from the depositor
Terms and conditionsBasically, there is no restriction regarding academic use.
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC( regarding any kind of for-profit use.
Basic information Depositor Nishikawa, Shin-ichi
Originator Nishikawa, Shin-ichi
Year of deposit 1987
Animal mouse < Mammals
Strain name BALB/c
Tissue bone marrow
Classification other
History Nishikawa(Kumamoto Univ.)
Lifespan infinite
Morphology fibroblast-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 1-2 times/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
SSLP (mouse) OK
Isozyme LD, NP
Chromosome mode 70-80(50) : /74(5),75(5),76(6),77(11),78(12)/
deposit info
lot info
Reference information Reference 4
User's Publication 185

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3292  Stepwise progression of B lineage differentiation supported by interleukin 7 and other stromal cell molecules.  Hayashi S, Kunisada T, Ogawa M, Sudo T, Kodama H, Suda T, Nishikawa S, Nishikawa S  J Exp Med  1990  171:1683-95  PubMed ID: 2332734
2570  Interleukin 7 production and function in stromal cell-dependent B cell development.  Sudo T, Ito M, Ogawa Y, Iizuka M, Kodama H, Kunisada T, Hayashi S, Ogawa M, Sakai K, Nishikawa S  J Exp Med  1989  170:333-8  PubMed ID: 2787384
965  B cell ontogeny in murine embryo studied by a culture system with the monolayer of a stromal cell clone, ST2: B cell progenitor develops first in the embryonal body rather than in the yolk sac.  Ogawa M, Nishikawa S, Ikuta K, Yamamura F, Naito M, Takahashi K, Nishikawa S  EMBO J  1988  7:1337-43  PubMed ID: 3261687
2571  B lymphopoiesis on stromal cell clone: stromal cell clones acting on different stages of B cell differentiation.  Nishikawa S, Ogawa M, Nishikawa S, Kunisada T, Kodama H  Eur J Immunol  1988  18:1767-71  PubMed ID: 3264531

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User's Publication
3294  Analysis of fatty acid composition in human bone marrow aspirates.  Deshimaru, Ryota, Ishitani, Ken, Makita, Kazuya, Horiguchi, Fumi, Nozawa, Shiro  Keio J Med  2005  54:150-5  PubMed ID: 16237277
2998  Synergetic activation of outwardly rectifying Cl- currents by hypotonic stress and external Ca2+ in murine osteoclasts  Sakai H, Nakamura F, Kuno M  J Physiol  1999  515:157-168  PubMed ID: 9925886
2773  Characterization of mineral deposits formed in cultures of a hamster tartrate-resistant acid phosphatase (TRAP) and alkaline phosphatase (ALP) double-positive cell line (CCP).  Sakiyama H, Nonaka T, Masuda R, Inoue N, Kuboki Y, Iijima M, Hirabayasi Y, Takahagi M, Yoshida K, Kuriiwa K, Yoshida M, Imajoh-Ohmi S  Cell Tissue Res  2002  309:269-79  PubMed ID: 12172786
2871  Runx-2 is not essential for the vitamin D-regulated expression of RANKL and osteoprotegerin in osteoblastic cells.  Notoya M, Otsuka E, Yamaguchi A, Hagiwara H  Biochem Biophys Res Commun  2004  324:655-60  PubMed ID: 15474477
2879  Nitrogen-containing bisphosphonate, YM529/ONO-5920 (a novel minodronic acid), inhibits RANKL expression in a cultured bone marrow stromal cell line ST2.  Nishida S, Tsubaki M, Hoshino M, Namimatsu A, Uji H, Yoshioka S, Tanimori Y, Yanae M, Iwaki M, Irimajiri K  Biochem Biophys Res Commun  2005  328:91-7  PubMed ID: 15670755
2997  Differential effect of high extracellular Ca2+ on K+ and Cl- conductances in murine osteoclasts.  Shibata T, Sakai H, Nakamura F, Shioi A, Kuno M  J Membr Biol  1997  158:59-67  PubMed ID: 9211721
3079  Granulocyte-macrophage colony stimulating factor suppresses lipopolysaccharide-induced osteoclast-like cell formation in mouse bone marrow cultures.  Shuto T, Jimi E, Kukita T, Hirata M, Koga T  Endocrinology  1994  134:831-7  PubMed ID: 8299579
1513  An assessment of the ability of human bone marrow cultures to generate osteoclasts.  Flanagan, A M, Horton, M A, Dorey, E L, Collins, D A, Evely, R S, Moseley, J M, Firkin, F C, Chambers, T J, Helfrich, M H, Martin, T J  Int J Exp Pathol  1992  73:387-401  PubMed ID: 1320395
1512  Human tumour-associated macrophages are capable of bone resorption.  Athanasou, N A, Quinn, J M  Br J Cancer  1992  65:523-6  PubMed ID: 1562461
1515  Derivation of osteoclasts from hematopoietic colony-forming cells in culture.  Kerby, J A, Hattersley G, Collins, D A, Chambers, T J  J Bone Miner Res  1992  7:353-62  PubMed ID: 1585838
1514  Interleukin 4 Inhibits Murine Osteoclast Formation In Vitro  Shioi A, Teitelbaum, S L, Ross, F P, Welgus, H G, Suzuki H, Ohara J, Lacey, D L  J Cell Biol  1991  47:272-277  PubMed ID: 1665152
1431  Transcriptional regulation of the production of the third component of complement (C3) by 1 alpha,25-dihydroxyvitamin D3 in mouse marrow-derived stromal cells (ST2) and primary osteoblastic cells.  Hong, M H, Jin, C H, Sato T, Ishimi Y, Abe E, Suda T  Endocrinology  1991  129:2774-9  PubMed ID: 1935807
1382  The specific production of the third component of complement by osteoblastic cells treated with 1 alpha,25-dihydroxyvitamin D3.  Sato T, Hong, M H, Jin, C H, Ishimi Y, Udagawa N, Shinki T, Abe E, Suda T  FEBS Lett  1991  285:21-4  PubMed ID: 2065778
1330  Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells.  Udagawa N, Takahashi N, Akatsu T, Tanaka H, Sasaki T, Nishihara T, Koga T, Martin, T J, Suda T  Proc Natl Acad Sci U S A  1990  87:7260-4  PubMed ID: 2169622
1327  The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells.  Udagawa N, Takahashi N, Akatsu T, Sasaki T, Yamaguchi A, Kodama H, Martin, T J, Suda T  Endocrinology  1989  125:1805-13  PubMed ID: 2676473
2064  Macrophage colony-stimulating factor and interleukin-1 alpha maintain the survival of osteoclast-like cells.  Jimi E, Shuto T, Koga T  Endocrinology  1995  136:808-11  PubMed ID: 7835314
2065  Basic fibroblast growth factor inhibits osteoclast-like cell formation.  Jimi E, Shuto T, Ikebe T, Jingushi S, Hirata M, Koga T  J Cell Physiol  1996  168:395-402  PubMed ID: 8707875
2274  A third-generation bisphosphonate, YM175, inhibits osteoclast formation in murine cocultures by inhibiting proliferation of precursor cells via supporting cell-dependent mechanisms.  Nishikawa M, Yamamoto M, Murakami T, Akatsu T, Kugai N, Nagata N  J Bone Miner Res  1998  13:986-95  PubMed ID: 9626630
2545  Promoter structure of mouse RANKL/TRANCE/OPGL/ODF gene.  Kitazawa R, Kitazawa S, Maeda S  Biochim Biophys Acta  1999  1445:134-41  PubMed ID: 10209265
2370  Characterization of osteoblastic differentiation of stromal cell line ST2 that is induced by ascorbic acid  Otsuka E, Yamaguchi A, Hirose S, Hagiwara H  Am J Physiol  1999  277(1 Pt 1):132-138  PubMed ID: 10409116
2420  Effects of nicotine on cultured cells suggest that it can influence the formation and resorption of bone.  Yuhara S, Kasagi S, Inoue A, Otsuka E, Hirose S, Hagiwara H  Eur J Pharmacol  1999  383:387-93  PubMed ID: 10594333
2430  Role of ascorbic acid in the osteoclast formation: induction of osteoclast differentiation factor with formation of the extracellular collagen matrix.  Otsuka E, Kato Y, Hirose S, Hagiwara H  Endocrinology  2000  141:3006-11  PubMed ID: 10919289
2771  Establishment and characterization of macrophage-like cell lines expressing osteoclast-specific markers.  Sakiyama H, Masuda R, Inoue N, Yamamoto K, Kuriiwa K, Nakagawa K, Yoshida K  J Bone Miner Metab  2001  19:220-7  PubMed ID: 11448014
2772  Establishment and characterization of tartrate-resistant acid phosphatase and alkaline phosphatase double positive cell lines.  Masuda R, Sakiyama H, Nonaka T, Kwan A, Nakagawa K, Moriya H, Imajoh-Ohmi S, Honjo M, Yoshida K  Cell Tissue Res  2001  304:351-9  PubMed ID: 11456411
2546  Vitamin D(3) augments osteoclastogenesis via vitamin D-responsive element of mouse RANKL gene promoter.  Kitazawa, Riko, Kitazawa, Sohei  Biochem Biophys Res Commun  2002  290:650-5  PubMed ID: 11785948
3000  Na+ dependence of extracellular Ca2+-sensing mechanisms leading to activation of an outwardly rectifying Cl- channel in murine osteoclasts.  Sakuta K, Sakai H, Mori H, Morihata H, Kuno M  Bone  2002  31:374-80  PubMed ID: 12231409
2999  Cell swelling as an intermediate signal leading to activation of a Cl- channel in extracellular calcium-sensing of murine osteoclasts.  Sakuta, Koichi, Morihata, Hirokazu, Mori, Hiroyuki, Sakai, Hiromu, Kuno, Miyuki  Osaka City Med J  2002  48:29-38  PubMed ID: 12375695
3059  Involvement of p38MAP kinase in bone morphogenetic protein-4-induced osteoprotegerin in mouse bone-marrow-derived stromal cells.  Tazoe, Michiko, Mogi, Makio, Goto, Shigemi, Togari, Akifumi  Arch Oral Biol  2003  48:615-9  PubMed ID: 12828991
2910  Nitric oxide regulates receptor activator of nuclear factor-kappaB ligand and osteoprotegerin expression in bone marrow stromal cells.  Fan, Xian, Roy, Eileen, Zhu, Liping, Murphy, Tamara C, Ackert-Bicknell, Cheryl, Hart, C Michael, Rosen, Clifford, Nanes, Mark S, Rubin, Janet  Endocrinology  2004  145:751-9  PubMed ID: 14563699
2926  WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair.  French, Dorothy M, Kaul, Raji J, D'Souza, Aloma L, Crowley, Craig W, Bao, Min, Frantz, Gretchen D, Filvaroff, Ellen H, Desnoyers, Luc  Am J Pathol  2004  165:855-67  PubMed ID: 15331410
3366  Native, not nitrated, cytochrome c and mitochondria-derived hydrogen peroxide drive osteoclast apoptosis.  Oursler, Merry Jo, Bradley, Elizabeth W, Elfering, Sarah L, Giulivi, Cecilia  Am J Physiol Cell Physiol  2005  288:C156-68  PubMed ID: 15342339
3183  A CCAAT/enhancer binding protein beta isoform, liver-enriched inhibitory protein, regulates commitment of osteoblasts and adipocytes.  Hata, Kenji, Nishimura, Riko, Ueda, Mio, Ikeda, Fumiyo, Matsubara, Takuma, Ichida, Fumitaka, Hisada, Kunihiro, Nokubi, Takashi, Yamaguchi, Akira, Yoneda, Toshiyuki  Mol Cell Biol  2005  25:1971-9  PubMed ID: 15713650
2843  Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma.  Takeuchi, Tamotsu, Adachi, Yoshihiro, Ohtsuki, Yuji  Am J Pathol  2005  166:1817-26  PubMed ID: 15920166
3377  Prostate cancer cells promote osteoblastic bone metastases through Wnts.  Hall, Christopher L, Bafico, Anna, Dai, Jinlu, Aaronson, Stuart A, Keller, Evan T  Cancer Res  2005  65:7554-60  PubMed ID: 16140917
7111  Enhancement of osteoblastic differentiation in alginate gel beads with bioactive octacalcium phosphate particles.  Endo K, Anada T, Yamada M, Seki M, Sasaki K, Suzuki O.  Biomed Mater  2015  10:065019  PubMed ID: 26657659
7186  New bone formation induced by surface strontium-modified ceramic bone graft substitute.  Park JW, Kang DG, Hanawa T.  Oral Dis  2015  22:53-61  PubMed ID: 26458092
7265  Orthotopic Osteogenecity Enhanced by a Porous Gelatin Sponge in a Critical-Sized Rat Calvaria Defect.  Kanda N, Anada T, Handa T, Kobayashi K, Ezoe Y, Takahashi T, Suzuki O.  Macromol Biosci  2015  15:1647-55  PubMed ID: 26200698
7434  Substance P enhances the proliferation and migration potential of murine bone marrow-derived mesenchymal stem cell-like cell lines.  Dubon MJ, Park KS.  Exp Ther Med  2015  9:1185-1191  PubMed ID: 25780407
7440  Biomechanical evaluation of Ti-Nb-Sn alloy implants with a low Young's modulus.  Takahashi K, Shiraishi N, Ishiko-Uzuka R, Anada T, Suzuki O, Masumoto H, Sasaki K.  Int J Mol Sci  2015  16:5779-88  PubMed ID: 25775158
7509  Hyaluronan inhibits BMP-induced osteoblast differentiation.  Kaneko K, Higuchi C, Kunugiza Y, Yoshida K, Sakai T, Yoshikawa H, Nakata K.  FEBS Lett.  2015  589:447-54  PubMed ID: 25592835
7511  Erythropoietin promotes bone formation through EphrinB2/EphB4 signaling.  Li C, Shi C, Kim J, Chen Y, Ni S, Jiang L, Zheng C, Li D, Hou J, Taichman RS, Sun H.  J. Dent. Res.  2015  94:455-63  PubMed ID: 25586589
7570  Characterization of partially hydrolyzed OCP crystals deposited in a gelatin matrix as a scaffold for bone tissue engineering.  Y Ezoe, T Anada, H Yamazaki, T Handa, K Kobayashi, T Takahashi, O. Suzuki  J Nanoparticle Res.  2015  17:127 
7600  The effect of an octacalcium phosphate co-precipitated gelatin composite on the repair of critical-sized rat calvarial defects.  Handa T, Anada T, Honda Y, Yamazaki H, Kobayashi K, Kanda N, Kamakura S, Echigo S, Suzuki O.  Acta Biomater  2011  8:1190-200  PubMed ID: 22198138
7673  Sonic hedgehog signaling promotes growth of oral squamous cell carcinoma cells associated with bone destruction.  Honami T, Shimo T, Okui T, Kurio N, Hassan NM, Iwamoto M, Sasaki A.  Oral Oncol.  2011  48:49-55  PubMed ID: 21945071
7674  Dose-specific effects of tumor necrosis factor alpha on osteogenic differentiation of mesenchymal stem cells.  Huang H, Zhao N, Xu X, Xu Y, Li S, Zhang J, Yang P.  Cell Prolif.  2011  44:420-7  PubMed ID: 21951285
7774  Erlotinib inhibits osteolytic bone invasion of human non-small-cell lung cancer cell line NCI-H292.  Furugaki K, Moriya Y, Iwai T, Yorozu K, Yanagisawa M, Kondoh K, Fujimoto-Ohuchi K, Mori K.  Clin. Exp. Metastasis  2011  28:649-59  PubMed ID: 21688034
7829  Mangiferin induces apoptosis by suppressing Bcl-xL and XIAP expressions and nuclear entry of NF-κB in HL-60 cells.  Shoji K, Tsubaki M, Yamazoe Y, Satou T, Itoh T, Kidera Y, Tanimori Y, Yanae M, Matsuda H, Taga A, Nakamura H, Nishida S.  Arch. Pharm. Res.  2011  34:469-75  PubMed ID: 21547680
7921  Anti-tumor effect in human breast cancer by TAE226, a dual inhibitor for FAK and IGF-IR in vitro and in vivo.  Kurio N, Shimo T, Fukazawa T, Takaoka M, Okui T, Hassan NM, Honami T, Hatakeyama S, Ikeda M, Naomoto Y, Sasaki A.  Exp. Cell Res.  2011  317:1134-46  PubMed ID: 21338601
7943  A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation.  Hu R, Liu W, Li H, Yang L, Chen C, Xia ZY, Guo LJ, Xie H, Zhou HD, Wu XP, Luo XH.  J. Biol. Chem.  2011  286:12328-39  PubMed ID: 21324897
7955  Regulation of CXCL12 expression by canonical Wnt signaling in bone marrow stromal cells.  Tamura M, Sato MM, Nashimoto M.  Int. J. Biochem. Cell Biol.  2011  43:760-7  PubMed ID: 21296678
8004  Wnt signalling mediates the cross-talk between bone marrow derived pre-adipocytic and pre-osteoblastic cell populations.  Taipaleenmaki H, Abdallah BM, AlDahmash A, Saamanen AM, Kassem M.  Exp. Cell Res.  2011  317:745-56  PubMed ID: 21211534
8025  Octaarginine-modified liposomes enhance the anti-oxidant effect of Lecithinized superoxide dismutase by increasing its cellular uptake.  Furukawa R, Yamada Y, Takenaga M, Igarashi R, Harashima H.  Biochem. Biophys. Res. Commun.  2010  404:796-801  PubMed ID: 21168389
8069  Methods for investigation of osteoclastogenesis using mouse embryonic stem cells.  Tsuneto M, Yamane T, Hayashi S.  Methods Mol. Biol.  2010  690:239-53  PubMed ID: 21042997
8102  Palmatine attenuates osteoclast differentiation and function through inhibition of receptor activator of nuclear factor-κb ligand expression in osteoblast cells.  Lee JW, Mase N, Yonezawa T, Seo HJ, Jeon WB, Cha BY, Nagai K, Woo JT.  Biol. Pharm. Bull.  2010  33:1733-9  PubMed ID: 20930384
8113  Antitumor effect of temsirolimus against oral squamous cell carcinoma associated with bone destruction.  Okui T, Shimo T, Fukazawa T, Kurio N, Hassan NM, Honami T, Takaoka M, Naomoto Y, Sasaki A.  Mol. Cancer Ther.  2010  9:2960-9  PubMed ID: 20858724
8139  Arming a replicating adenovirus with osteoprotegerin reduces the tumor burden in a murine model of osteolytic bone metastases of breast cancer.  Cody JJ, Rivera AA, Lyons GR, Yang SW, Wang M, Sarver DB, Wang D, Selander KS, Kuo HC, Meleth S, Feng X, Siegal GP, Douglas JT.  Cancer Gene Ther.  2010  17:893-905  PubMed ID: 20798695
8182  Epinephrine accelerates osteoblastic differentiation by enhancing bone morphogenetic protein signaling through a cAMP/protein kinase A signaling pathway.  Uemura T, Ohta Y, Nakao Y, Manaka T, Nakamura H, Takaoka K.  Bone  2010  47:756-65  PubMed ID: 20637325
8220  Cytodifferentiation activity of synthetic human enamel sheath protein peptides.  Kakegawa A, Oida S, Gomi K, Nagano T, Yamakoshi Y, Fukui T, Kanazashi M, Arai T, Fukae M.  J. Periodont. Res.  2010  45:643-9  PubMed ID: 20572923
8359  Inhibitory effect of luteolin on osteoclast differentiation and function.  Lee JW, Ahn JY, Hasegawa S, Cha BY, Yonezawa T, Nagai K, Seo HJ, Jeon WB, Woo JT.  Cytotechnology  2010  61:125-34  PubMed ID: 20162352
8493  Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance.  Kurtova AV, Balakrishnan K, Chen R, Ding W, Schnabl S, Quiroga MP, Sivina M, Wierda WG, Estrov Z, Keating MJ, Shehata M, Jager U, Gandhi V, Kay NE, Plunkett W, Burger JA.  Blood  2009  114:4441-50  PubMed ID: 19762485
8530  Stimulation of ectopic bone formation in response to BMP-2 by Rho kinase inhibitor: a pilot study.  Yoshikawa H, Yoshioka K, Nakase T, Itoh K.  Clin. Orthop. Relat. Res.  2009  467:3087-95  PubMed ID: 19609629
8570  Octacalcium phosphate-precipitated alginate scaffold for bone regeneration.  Fuji T, Anada T, Honda Y, Shiwaku Y, Koike H, Kamakura S, Sasaki K, Suzuki O.  Tissue Eng Part A  2009  15:3525-35  PubMed ID: 19456237
8584  Indirect antitumor effects of bisphosphonates on prostatic LNCaP cells co-cultured with bone cells.  Tanaka T, Kawashima H, Ohnishi K, Matsumura K, Yoshimura R, Matsuyama M, Kuratsukuri K, Nakatani T.  Anticancer Res.  2009  29:1089-94  PubMed ID: 19414350
8594  Down-regulation of mTOR leads to up-regulation of osteoprotegerin in bone marrow cells.  Mogi M, Kondo A.  Biochem. Biophys. Res. Commun.  2009  384:82-6  PubMed ID: 19393224
8652  Osteoinductive capacity and heat stability of recombinant human bone morphogenetic protein-2 produced by Escherichia coli and dimerized by biochemical processing.  Yano K, Hoshino M, Ohta Y, Manaka T, Naka Y, Imai Y, Sebald W, Takaoka K.  J. Bone Miner. Metab.  2009  27:355-63  PubMed ID: 19229473
8669  The effect of microstructure of octacalcium phosphate on the bone regenerative property.  Honda Y, Anada T, Kamakura S, Morimoto S, Kuriyagawa T, Suzuki O.  Tissue Eng Part A  2009  15:1965-73  PubMed ID: 19132890
8766  Immobilized recombinant human bone morphogenetic protein-2 enhances the phosphorylation of receptor-activated Smads.  Yamachika E, Tsujigiwa H, Shirasu N, Ueno T, Sakata Y, Fukunaga J, Mizukawa N, Yamada M, Sugahara T.  J Biomed Mater Res A  2008  88:599-607  PubMed ID: 18314893
8891  Immobilized rhBMP-2/succinylated type I atelocollagen gene expression of intracellular signaling molecules on ST2 cells.  Tsujigiwa H, Nagatsuka H, Lee YJ, Han PP, Gunduz M, Legeros RZ, Inoue M, Yamada M, Nagai N.  J Biomed Mater Res A  2006  77:507-11  PubMed ID: 16482552
8913  Effects of Immobilized rhBMP-2/atelocollagen in vivo and in vitro  Hidetsugu Tsujigiwa, Andrea P. Rodriguez, Tohru Takagi, Hu Hai Long, Kan Rui, Zhenfu Lu, Xie Wei Li, Gao Wen-Xin, Jin Tan and Jing Xiao  J Hard Tissue Biology  2006  15:27-33 
8993  Effects of immobilized recombinant human bone morphogenetic protein-2/succinylated type I atelocollagen on cellular activity of ST2 cells.  Tsujigiwa H, Nagatsuka H, Gunduz M, Rodriguez A, Rivera RS, Legeros RZ, Inoue M, Nagai N.  J Biomed Mater Res A  2005  75:210-5  PubMed ID: 16059889
9055  Platelets can neutralize hydrogen peroxide in an acute toxicity model with cells involved in granulation tissue formation.  Kandler B, Maitz P, Fischer MB, Watzek G, Gruber R.  Bone  2005  36:671-7  PubMed ID: 15784190
9531  RANK-RANKL interactions are involved in cell adhesion-mediated drug resistance in multiple myeloma cell lines.  Tsubaki M, Takeda T, Yoshizumi M, Ueda E, Itoh T, Imano M, Satou T, Nishida S.  Tumour Biol.  2016  37:9099-110  PubMed ID: 26762414
9558  THBS1 is induced by TGFB1 in the cancer stroma and promotes invasion of oral squamous cell carcinoma.  Pal SK, Nguyen CT, Morita KI, Miki Y, Kayamori K, Yamaguchi A, Sakamoto K.  J. Oral Pathol. Med.  2016  45:730-739  PubMed ID: 26850833
9575  The mechanisms of substance P-mediated migration of bone marrow-derived mesenchymal stem cell-like ST2 cells.  Dubon MJ, Park KS.  Int. J. Mol. Med.  2016  37:1105-11  PubMed ID: 26936322
9589  Osteogain improves osteoblast adhesion, proliferation and differentiation on a bovine-derived natural bone mineral.  Miron RJ, Fujioka-Kobayashi M, Zhang Y, Caballé-Serrano J, Shirakata Y, Bosshardt DD, Buser D, Sculean A.  Clin Oral Implants Res  2017  28:327-333  PubMed ID: 26919609
9639  Induction of Inner Ear Hair Cells from Mouse Embryonic Stem Cells In Vitro.  Yoshikawa M, Ouji Y.  Methods Mol. Biol.  2016  1516:257-267  PubMed ID: 27032944
9752  Inhibition of Runx2 signaling by TNF-α in ST2 murine bone marrow stromal cells undergoing osteogenic differentiation.  Ye X, Huang H, Zhao N, Zhang J, Yang P.  In Vitro Cell. Dev. Biol. Anim.  2016  52:1026-1033  PubMed ID: 27401008
9785  CXCL3 positively regulates adipogenic differentiation.  Kusuyama J, Komorizono A, Bandow K, Ohnishi T, Matsuguchi T.  J. Lipid Res.  2016  57:1806-1820  PubMed ID: 27512010
9860  Growth factor delivery of BMP9 using a novel natural bovine bone graft with integrated atelo-collagen type I: Biosynthesis, characterization, and cell behavior.  Fujioka-Kobayashi M, Schaller B, Saulacic N, Zhang Y, Miron RJ.  J Biomed Mater Res A  2017  105:408-418  PubMed ID: 27699987
9874  An in vitro study of fibrin sealant as a carrier system for recombinant human bone morphogenetic protein (rhBMP)-9 for bone tissue engineering.  Fujioka-Kobayashi M, Mottini M, Kobayashi E, Zhang Y, Schaller B, Miron RJ.  J Craniomaxillofac Surg  2017  45:27-32  PubMed ID: 27840120
9878  Recombinant human bone morphogenetic protein (rhBMP)9 induces osteoblast differentiation when combined with demineralized freeze-dried bone allografts (DFDBAs) or biphasic calcium phosphate (BCP).  Fujioka-Kobayashi M, Schaller B, Zhang Y, Kandalam U, Hernandez M, Miron RJ.  Clin Oral Investig  2017  21:1883-1893  PubMed ID: 27771827
9882  γ-Glutamyltranspeptidase is an endogenous activator of Toll-like receptor 4-mediated osteoclastogenesis.  Moriwaki S, Into T, Suzuki K, Miyauchi M, Takata T, Shibayama K, Niida S.  Sci Rep  2016  6:35930  PubMed ID: 27775020
9961  Tumor-specific delivery of biologics by a novel T-cell line HOZOT.  Onishi T, Tazawa H, Hashimoto Y, Takeuchi M, Otani T, Nakamura S, Sakurai F, Mizuguchi H, Kishimoto H, Umeda Y, Shirakawa Y, Urata Y, Kagawa S, Fujiwara T.  Sci Rep  2016  6:38060  PubMed ID: 27901098
9966  Hyaluronic Acid Gel-Based Scaffolds as Potential Carrier for Growth Factors: An In Vitro Bioassay on Its Osteogenic Potential.  Fujioka-Kobayashi M, Schaller B, Kobayashi E, Hernandez M, Zhang Y, Miron RJ.  J Clin Med  2016  5:  PubMed ID: 27916889
9967  Osteogain® loaded onto an absorbable collagen sponge induces attachment and osteoblast differentiation of ST2 cells in vitro.  Miron RJ, Fujioka-Kobayashi M, Zhang Y, Sculean A, Pippenger B, Shirakata Y, Kandalam U, Hernandez M.  Clin Oral Investig  2017  21:2265-2272  PubMed ID: 27909893
9975  Circulating osteocyte-derived exosomes contain miRNAs which are enriched in exosomes from MLO-Y4 cells.  Sato M, Suzuki T, Kawano M, Tamura M.  Biomed Rep  2017  6:223-231  PubMed ID: 28357077
10067  Bone Microenvironment Changes in Latexin Expression Promote Chemoresistance.  Zhang M, Osisami M, Dai J, Keller JM, Escara-Wilke J, Mizokami A, Keller ET.  Mol. Cancer Res.  2017  15:457-466  PubMed ID: 28087740
10074  Angiopoietin-like protein 2 is a positive regulator of osteoblast differentiation.  Takano A, Fukuda T, Shinjo T, Iwashita M, Matsuzaki E, Yamamichi K, Takeshita M, Sanui T, Nishimura F.  Metab. Clin. Exp.  2017  69:157-170  PubMed ID: 28285646
10090  Vinculin promotes nuclear localization of TAZ to inhibit ECM stiffness-dependent differentiation into adipocytes.  Kuroda M, Wada H, Kimura Y, Ueda K, Kioka N.  J. Cell. Sci.  2017  130:989-1002  PubMed ID: 28115535
10104  Ameloblastin and enamelin prevent osteoclast formation by suppressing RANKL expression via MAPK signaling pathway.  Chaweewannakorn W, Ariyoshi W, Okinaga T, Morikawa K, Saeki K, Maki K, Nishihara T.  Biochem. Biophys. Res. Commun.  2017  485:621-626  PubMed ID: 28161637
10123  Dorsal tunica albuginea plication for hypospadias curvature.  Baskin LS, Duckett JW.  J. Urol.  1994  151:1668-71  PubMed ID: 8189595
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5203  Retinaldehyde dehydrogenase 1 deficiency inhibits PPARγ-mediated bone loss and marrow adiposity.  Nallamshetty S, Le PT, Wang H, Issacsohn MJ, Reeder DJ, Rhee EJ, Kiefer FW, Brown JD, Rosen CJ, Plutzky J  Bone  2014  281-91  PubMed ID: 25064526
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6530  Dose-dependent osteogenic effect of octacalcium phosphate on mouse bone marrow stromal cells.  Anada T, Kumagai T, Honda Y, Masuda T, Kamijo R, Kamakura S, Yoshihara N, Kuriyagawa T, Shimauchi H, Suzuki O.  Tissue Eng Part A  2008  14(6):965-78  PubMed ID: 19230123
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11607  Low intensity pulsed ultrasound (LIPUS) maintains osteogenic potency by the increased expression and stability of Nanog through spleen tyrosine kinase (Syk) activation.  Kusuyama J, Seong C, Makarewicz NS, Ohnishi T, Shima K, Semba I, Bandow K, Matsuguchi T.  Cell. Signal.  2019    PubMed ID: 31228531
11638  Essential Role for Integrin-Linked Kinase in Melanoblast Colonization of the Skin.  Crawford M, Leclerc V, Barr K, Dagnino L.  J. Invest. Dermatol.  2019    PubMed ID: 31330146
11659  3‐(3‐Hydroxyphenyl)‐Propionic Acid (PPA) Suppresses Osteoblastic Cell Senescence to Promote Bone Accretion in Mice  Jin‐Ran Chen, Umesh D Wankhade, Alexander W Alund, Michael L Blackburn, Kartik Shankar, Oxana P Lazarenko  JBMR Plus  2019   
11813  Activation of Skeletal Stem and Progenitor Cells for Bone Regeneration Is Driven by PDGFRβ Signaling.  Böhm AM, Dirckx N, Tower RJ, Peredo N, Vanuytven S, Theunis K, Nefyodova E, Cardoen R, Lindner V, Voet T, Van Hul M, Maes C.  Dev. Cell  2019    PubMed ID: 31543445
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6693  nterleukin-11 as a stimulatory factor for bone formation prevents bone loss with advancing age in mice.  Takeuchi Y, Watanabe S, Ishii G, Takeda S, Nakayama K, Fukumoto S, Kaneta Y, Inoue D, Matsumoto T, Harigaya K, Fujita T.  J Biol Chem  2002  277(50):49011-8  PubMed ID: 12384500
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6702  Estrogen promotes early osteoblast differentiation and inhibits adipocyte differentiation in mouse bone marrow stromal cell lines that express estrogen receptor (ER) alpha or beta.  Okazaki R, Inoue D, Shibata M, Saika M, Kido S, Ooka H, Tomiyama H, Sakamoto Y, Matsumoto T.  Endocrinology  2002  143(6):2349-56  PubMed ID: 12021200
4415  Clodronate stimulates osteoblast differentiation in ST2 and MC3T3-E1 cells and rat organ cultures.  Itoh F, Aoyagi S, Furihata-Komatsu H, Aoki M, Kusama H, Kojima M, Kogo H.  Eur J Pharmacol  2003  477(1):9-16  PubMed ID: 14512092
6629  Generating murine osteoclasts from bone marrow.  Takahashi N, Udagawa N, Tanaka S, Suda T.  Methods Mol Med  2003  80:129-44  PubMed ID: 12728715
6662  The expression of matrix metalloproteinase-13 and osteocalcin in mouse osteoblasts is related to osteoblastic differentiation and is modulated by 1,25-dihydroxyvitamin D3 and thyroid hormones.  Fratzl-Zelman N, Glantschnig H, Rumpler M, Nader A, Ellinger A, Varga F.  Cell Biol Int  2003  27(6):459-68  PubMed ID: 12798773
6696  Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation.  Maeda T, Kawane T, Horiuchi N.  Endocrinology  2003  144(2):681-92  PubMed ID: 12538631
6697  Insulin-dependent adipogenesis in stromal ST2 cells derived from murine bone marrow.  Ding J, Nagai K, Woo JT.  Biosci Biotechnol Biochem  2003  67(2):314-21  PubMed ID: 12728992
6704  Effects of Eucommiae Cortex on osteoblast-like cell proliferation and osteoclast inhibition.  Ha H, Ho J, Shin S, Kim H, Koo S, Kim IH, Kim C.  Arch Pharm Res  2003  26(11):929-36  PubMed ID: 14661859
6707  Distinct anabolic response of osteoblast to low-intensity pulsed ultrasound.  Naruse K, Miyauchi A, Itoman M, Mikuni-Takagaki Y.  J Bone Miner Res  2003  18(2):360-9  PubMed ID: 12568414
6739  Roles of stromal cell RANKL, OPG, and M-CSF expression in biphasic TGF-beta regulation of osteoclast differentiation.  Karst M, Gorny G, Galvin RJ, Oursler MJ.  J Cell Physiol  2004  200(1):99-106  PubMed ID: 15137062
6866  Effects of mechanical stress and scaffold material on osteogenesis and chondrogenesis  O. Suzuki et al  IEEE Xplore:  2005   
6870  Hypoxia induces chondrocyte-specific gene expression in mesenchymal cells in association with transcriptional activation of Sox9.  Robins JC, Akeno N, Mukherjee A, Dalal RR, Aronow BJ, Koopman P, Clemens TL.  Bone  2005  37(3):313-22  PubMed ID: 16023419
6877  Sp1 and Sp3 regulate the basal transcription of receptor activator of nuclear factor kappa B ligand gene in osteoblasts and bone marrow stromal cells.  Liu J, Yang H, Liu W, Cao X, Feng X.  J Cell Biochem  2005  96(4):716-27  PubMed ID: 16052479
6927  Activation of Shc1 Allows Oncostatin M to Induce RANKL and Osteoclast Formation More Effectively Than Leukemia Inhibitory Factor.  Persson E, Souza PPC, Floriano-Marcelino T, Conaway HH, Henning P, Lerner UH.Front Immunol. 2019 May 28;10:1164. doi: 10.3389/fimmu.2019.01164. eCollection 2019.  Front Immunol  2019     PubMed ID: 31191537
6935  An in vitro Three-Dimensional Co-Culture System for Ameloblastoma Modelling  SOO LENG LEE*, ZAINAL ARIFF ABDUL RAHMAN, HIDETSUGU TSUJIGIWA, MEI HAMADA, KIYOFUMI TAKABATAKE, KEISUKE NAKANO, HITOSHI NAGATSUKA & CHONG HUAT SIAR  Sains Malaysiana  2019  48(8):1697–1706 

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