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RCB0224 : ST2  update : 2018/07/06
CommentBone marrow stroma cell-derived
Comment from the depositor
Terms and conditionsBasically, there is no restriction regarding academic use.
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC( regarding any kind of for-profit use.
Basic information Depositor Nishikawa, Shin-ichi
Originator Nishikawa, Shin-ichi
Year of deposit 1987
Animal mouse < Mammals
Strain name BALB/c
Tissue bone marrow
Classification other
History Nishikawa(Kumamoto Univ.)
Lifespan infinite
Morphology fibroblast-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 1-2 times/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
SSLP (mouse) OK
Isozyme LD, NP
Chromosome mode 70-80(50) : /74(5),75(5),76(6),77(11),78(12)/
deposit info
lot info
Reference information Reference 6
User's Publication 200

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3292  Hayashi S, Kunisada T, Ogawa M, Sudo T, Kodama H, Suda T, Nishikawa S, Nishikawa S  Stepwise progression of B lineage differentiation supported by interleukin 7 and other stromal cell molecules.  J Exp Med  1990  171:1683-95  PubMed ID: 2332734
8597  P A Welch, P D Burrows, A Namen, S Gillis, M D Cooper  Bone Marrow Stromal Cells and interleukin-7 Induce Coordinate Expression of the BP-1/6C3 Antigen and pre-B Cell Growth  Int Immunol  1990  2 (8), 697-705   PubMed ID: 2083232
1987  Tominaga A, Mita S, Kikuchi Y, Hitoshi Y, Takatsu K, Nishikawa S, Ogawa M  Establishment of IL-5-dependent early B cell lines by long-term bone marrow cultures.  Growth Factors  1989  1:135-46  PubMed ID: 2624778
2570  Sudo T, Ito M, Ogawa Y, Iizuka M, Kodama H, Kunisada T, Hayashi S, Ogawa M, Sakai K, Nishikawa S  Interleukin 7 production and function in stromal cell-dependent B cell development.  J Exp Med  1989  170:333-8  PubMed ID: 2787384
965  Ogawa M, Nishikawa S, Ikuta K, Yamamura F, Naito M, Takahashi K, Nishikawa S  B cell ontogeny in murine embryo studied by a culture system with the monolayer of a stromal cell clone, ST2: B cell progenitor develops first in the embryonal body rather than in the yolk sac.  EMBO J  1988  7:1337-43  PubMed ID: 3261687
2571  Nishikawa S, Ogawa M, Nishikawa S, Kunisada T, Kodama H  B lymphopoiesis on stromal cell clone: stromal cell clones acting on different stages of B cell differentiation.  Eur J Immunol  1988  18:1767-71  PubMed ID: 3264531

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User's Publication
6952  Minamizaki T, Nakao Y, Irie Y, Ahmed F, Itoh S, Sarmin N, Yoshioka H, Nobukiyo A, Fujimoto C, Niida S, Sotomaru Y, Tanimoto K, Kozai K, Sugiyama T, Bonnelye E, Takei Y, Yoshiko Y.  The matrix vesicle cargo miR-125b accumulates in the bone matrix, inhibiting bone resorption in mice.  Commun Biol  2020  ;3(1):30  PubMed ID: 31949279
11318  Hagiwara H, Nakata K, Miyazaki H, Maehashi S, Komiyama Y, Aida R, Yoshida S, Kokubu D, Hagiwara K, Yoshida K.  4-Hydroxyderricin inhibits osteoclast formation and accelerates osteoblast differentiation.  Cytotechnology  2019    PubMed ID: 30474804
11323  Yu J, Kim HM, Kim KP, Son Y, Kim MS, Park KS.  Ceramide kinase regulates the migration of bone marrow-derived mesenchymal stem cells.  Biochem. Biophys. Res. Commun.  2019    PubMed ID: 30502084
11366  Yang X, Wang G, Wang Y, Zhou J, Yuan H, Li X, Liu Y, Wang B.  Histone demethylase KDM7A reciprocally regulates adipogenic and osteogenic differentiation via regulation of C/EBPα and canonical Wnt signalling.  J. Cell. Mol. Med.  2019    PubMed ID: 30614617
11439  Yu Y, Newman H, Shen L, Sharma D, Hu G, Mirando AJ, Zhang H, Knudsen E, Zhang GF, Hilton MJ, Karner CM.  Glutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells.  Cell Metab.  2019    PubMed ID: 30773468
11460  Strauss FJ, Di Summa F, Stähli A, Matos L, Vaca F, Schuldt G, Gruber R.  TGF-β activity in acid bone lysate adsorbs to titanium surface.  Clin Implant Dent Relat Res  2019    PubMed ID: 30817088
11607  Kusuyama J, Seong C, Makarewicz NS, Ohnishi T, Shima K, Semba I, Bandow K, Matsuguchi T.  Low intensity pulsed ultrasound (LIPUS) maintains osteogenic potency by the increased expression and stability of Nanog through spleen tyrosine kinase (Syk) activation.  Cell. Signal.  2019    PubMed ID: 31228531
11638  Crawford M, Leclerc V, Barr K, Dagnino L.  Essential Role for Integrin-Linked Kinase in Melanoblast Colonization of the Skin.  J. Invest. Dermatol.  2019    PubMed ID: 31330146
11659  Jin‐Ran Chen, Umesh D Wankhade, Alexander W Alund, Michael L Blackburn, Kartik Shankar, Oxana P Lazarenko  3‐(3‐Hydroxyphenyl)‐Propionic Acid (PPA) Suppresses Osteoblastic Cell Senescence to Promote Bone Accretion in Mice  JBMR Plus  2019   
11813  Böhm AM, Dirckx N, Tower RJ, Peredo N, Vanuytven S, Theunis K, Nefyodova E, Cardoen R, Lindner V, Voet T, Van Hul M, Maes C.  Activation of Skeletal Stem and Progenitor Cells for Bone Regeneration Is Driven by PDGFRβ Signaling.  Dev. Cell  2019    PubMed ID: 31543445
11856  Hamaya E, Fujisawa T, Tamura M.  Osteoadherin serves roles in the regulation of apoptosis and growth in MC3T3‑E1 osteoblast cells.  Int. J. Mol. Med.  2019    PubMed ID: 31638177
11881  Shiraishi N, Masumoto H, Takahashi K, Tenkumo T, Anada T, Suzuki O, Ogawa T, Sasaki K.  Histomorphometric assessments of peri-implant bone around Ti-Nb-Sn alloy implants with low Young's modulus.  Dent Mater J  2019    PubMed ID: 31666486
11883  Conaway HH, Henning P, Lie A, Tuckermann J, Lerner UH.  Glucocorticoids employ the monomeric glucocorticoid receptor to potentiate vitamin D3 and parathyroid hormone-induced osteoclastogenesis.  FASEB J.  2019    PubMed ID: 31675485
6927  Persson E, Souza PPC, Floriano-Marcelino T, Conaway HH, Henning P, Lerner UH.Front Immunol. 2019 May 28;10:1164. doi: 10.3389/fimmu.2019.01164. eCollection 2019.  Activation of Shc1 Allows Oncostatin M to Induce RANKL and Osteoclast Formation More Effectively Than Leukemia Inhibitory Factor.  Front Immunol  2019  2019 May 28;10:1164  PubMed ID: 31191537
6935  SOO LENG LEE*, ZAINAL ARIFF ABDUL RAHMAN, HIDETSUGU TSUJIGIWA, MEI HAMADA, KIYOFUMI TAKABATAKE, KEISUKE NAKANO, HITOSHI NAGATSUKA & CHONG HUAT SIAR  An in vitro Three-Dimensional Co-Culture System for Ameloblastoma Modelling  Sains Malaysiana  2019  48(8):1697–1706 
10459  Kusuyama J, Kamisono A, ChangHwan S, Amir MS, Bandow K, Eiraku N, Ohnishi T, Matsuguchi T.  Spleen tyrosine kinase influences the early stages of multilineage differentiation of bone marrow stromal cell lines by regulating phospholipase C gamma activities.  J. Cell. Physiol.  2018  233:2549-2559  PubMed ID: 28786489
10666  Takeno A, Kanazawa I, Notsu M, Tanaka KI, Sugimoto T.  Inhibition of adenosine monophosphate-activated protein kinase suppresses bone morphogenetic protein-2-induced mineralization of osteoblasts via Smad-independent mechanisms.  Endocr. J.  2018  65:291-298  PubMed ID: 29249772
10731  Kumeta M, Takahashi D, Takeyasu K, Yoshimura SH.  Cell type-specific suppression of mechanosensitive genes by audible sound stimulation.  PLoS ONE  2018  13:e0188764  PubMed ID: 29385174
10764  Takeda T, Tsubaki M, Tomonari Y, Kawashima K, Itoh T, Imano M, Satou T, Nishida S.  Bavachin induces the apoptosis of multiple myeloma cell lines by inhibiting the activation of nuclear factor kappa B and signal transducer and activator of transcription 3.  Biomed. Pharmacother.  2018  100:486-494  PubMed ID: 29477912
10844  Takenaka Y, Mikami K, Seno S, Matsuda H.  Automated transition analysis of activated gene regulation during diauxic nutrient shift in Escherichia coli and adipocyte differentiation in mouse cells.  BMC Bioinformatics  2018  19:89  PubMed ID: 29745848
11198  Ikebuchi Y, Aoki S, Honma M, Hayashi M, Sugamori Y, Khan M, Kariya Y, Kato G, Tabata Y, Penninger JM, Udagawa N, Aoki K, Suzuki H.  Coupling of bone resorption and formation by RANKL reverse signalling.  Nature  2018  561(7722):195-200  PubMed ID: 30185903
11099  Asparuhova MB, Caballe-Serrano J, Buser D, Chappuis V.  Bone-conditioned medium contributes to initiation and progression of osteogenesis by exhibiting synergistic TGF-β1/BMP-2 activity.  Int J Oral Sci  2018  10(2):20  PubMed ID: 29895828
11124  Kida J, Hata K, Nakamura E, Yagi H, Takahata Y, Murakami T, Maeda Y, Nishimura R.  Interaction of LEF1 with TAZ is necessary for the osteoblastogenic activity of Wnt3a.  Sci Rep  2018  8(1):10375  PubMed ID: 29991769
11153  Kuroda M, Ueda K, Kioka N.  Vinexin family (SORBS) proteins regulate mechanotransduction in mesenchymal stem cells.  Sci Rep  2018  8(1):11581  PubMed ID: 30068914
11193  Eppell SJ, Tong W, McMasters J, Soenjaya Y, Barbu AM, Ko A, Baskin JZ.  Minor Review: An Overview of a Synthetic Nanophase Bone Substitute.  Materials (Basel)  2018  11(9)  PubMed ID: 30158464
4348  Kokubun K, Matsumura S, Yudasaka M, Iijima S, Shiba K.  Immobilization of a carbon nanomaterial-based localized drug-release system using a bispecific material-binding peptide.  Int J Nanomedicine  2018    PubMed ID: 29588591
4349  Takeno A, Kanazawa I, Notsu M, Tanaka KI, Sugimoto T.  Phloretin Promotes Adipogenesis via Mitogen-Activated Protein Kinase Pathways in Mouse Marrow Stromal ST2 Cells.  Int J Mol Sci  2018    PubMed ID: 29904032
4350  Aoto K, Ito K, Aoki S.  Complex formation between platelet-derived growth factor receptor β and transforming growth factor β receptor regulates the differentiation of mesenchymal stem cells into cancer-associated fibroblasts.  Oncotarget  2018    PubMed ID: 30344924
4351  Dubon MJ, Yu J, Choi S, Park KS.  Transforming growth factor β induces bone marrow mesenchymal stem cell migration via noncanonical signals and N-cadherin.  J. Cell. Physiol.  2018    PubMed ID: 28213973
4502  Choi SM, Park JW.  Multifunctional effects of a modification of SLA titanium implant surface with strontium-containing nanostructures on immunoinflammatory and osteogenic cell function.  J Biomed Mater Res A  2018  106(12):3009-3020  PubMed ID: 30192064
9589  Miron RJ, Fujioka-Kobayashi M, Zhang Y, Caballé-Serrano J, Shirakata Y, Bosshardt DD, Buser D, Sculean A.  Osteogain improves osteoblast adhesion, proliferation and differentiation on a bovine-derived natural bone mineral.  Clin Oral Implants Res  2017  28:327-333  PubMed ID: 26919609
9860  Fujioka-Kobayashi M, Schaller B, Saulacic N, Zhang Y, Miron RJ.  Growth factor delivery of BMP9 using a novel natural bovine bone graft with integrated atelo-collagen type I: Biosynthesis, characterization, and cell behavior.  J Biomed Mater Res A  2017  105:408-418  PubMed ID: 27699987
9874  Fujioka-Kobayashi M, Mottini M, Kobayashi E, Zhang Y, Schaller B, Miron RJ.  An in vitro study of fibrin sealant as a carrier system for recombinant human bone morphogenetic protein (rhBMP)-9 for bone tissue engineering.  J Craniomaxillofac Surg  2017  45:27-32  PubMed ID: 27840120
9878  Fujioka-Kobayashi M, Schaller B, Zhang Y, Kandalam U, Hernandez M, Miron RJ.  Recombinant human bone morphogenetic protein (rhBMP)9 induces osteoblast differentiation when combined with demineralized freeze-dried bone allografts (DFDBAs) or biphasic calcium phosphate (BCP).  Clin Oral Investig  2017  21:1883-1893  PubMed ID: 27771827
9967  Miron RJ, Fujioka-Kobayashi M, Zhang Y, Sculean A, Pippenger B, Shirakata Y, Kandalam U, Hernandez M.  Osteogain® loaded onto an absorbable collagen sponge induces attachment and osteoblast differentiation of ST2 cells in vitro.  Clin Oral Investig  2017  21:2265-2272  PubMed ID: 27909893
9975  Sato M, Suzuki T, Kawano M, Tamura M.  Circulating osteocyte-derived exosomes contain miRNAs which are enriched in exosomes from MLO-Y4 cells.  Biomed Rep  2017  6:223-231  PubMed ID: 28357077
10067  Zhang M, Osisami M, Dai J, Keller JM, Escara-Wilke J, Mizokami A, Keller ET.  Bone Microenvironment Changes in Latexin Expression Promote Chemoresistance.  Mol. Cancer Res.  2017  15:457-466  PubMed ID: 28087740
10074  Takano A, Fukuda T, Shinjo T, Iwashita M, Matsuzaki E, Yamamichi K, Takeshita M, Sanui T, Nishimura F.  Angiopoietin-like protein 2 is a positive regulator of osteoblast differentiation.  Metab. Clin. Exp.  2017  69:157-170  PubMed ID: 28285646
10090  Kuroda M, Wada H, Kimura Y, Ueda K, Kioka N.  Vinculin promotes nuclear localization of TAZ to inhibit ECM stiffness-dependent differentiation into adipocytes.  J. Cell. Sci.  2017  130:989-1002  PubMed ID: 28115535
10104  Chaweewannakorn W, Ariyoshi W, Okinaga T, Morikawa K, Saeki K, Maki K, Nishihara T.  Ameloblastin and enamelin prevent osteoclast formation by suppressing RANKL expression via MAPK signaling pathway.  Biochem. Biophys. Res. Commun.  2017  485:621-626  PubMed ID: 28161637
10125  Fujioka-Kobayashi M, Schaller B, Saulacic N, Pippenger BE, Zhang Y, Miron RJ.  Absorbable collagen sponges loaded with recombinant bone morphogenetic protein 9 induces greater osteoblast differentiation when compared to bone morphogenetic protein 2.  Clin Exp Dent Res  2017  3:32-40  PubMed ID: 29744176
10316  Aikawa T, Matsubara H, Ugaji S, Shirakawa J, Nagai R, Munesue S, Harashima A, Yamamoto Y, Tsuchiya H.  Contribution of methylglyoxal to delayed healing of bone injury in diabetes.  Mol Med Rep  2017  16:403-409  PubMed ID: 28534951
10395  Takada H, Ibaragi S, Eguchi T, Okui T, Obata K, Masui M, Morisawa A, Takabatake K, Kawai H, Yoshioka N, Hassan NMM, Shimo T, Hu GF, Nagatsuka H, Sasaki A.  Semaphorin 4D promotes bone invasion in head and neck squamous cell carcinoma.  Int. J. Oncol.  2017  51:625-632  PubMed ID: 28656278
10401  Ouji Y, Sakagami M, Omori H, Higashiyama S, Kawai N, Kitahara T, Wanaka A, Yoshikawa M.  Efficient induction of inner ear hair cell-like cells from mouse ES cells using combination of Math1 transfection and conditioned medium from ST2 stromal cells.  Stem Cell Res  2017  23:50-56  PubMed ID: 28689068
10647  Ono-Ohmachi A, Ishida Y, Morita Y, Kato K, Y Nara T.  Milk Basic Protein Facilitates Increased Bone Mass in Growing Mice.  J. Nutr. Sci. Vitaminol.  2017  63:315-322  PubMed ID: 29225316
9531  Tsubaki M, Takeda T, Yoshizumi M, Ueda E, Itoh T, Imano M, Satou T, Nishida S.  RANK-RANKL interactions are involved in cell adhesion-mediated drug resistance in multiple myeloma cell lines.  Tumour Biol.  2016  37:9099-110  PubMed ID: 26762414
9558  Pal SK, Nguyen CT, Morita KI, Miki Y, Kayamori K, Yamaguchi A, Sakamoto K.  THBS1 is induced by TGFB1 in the cancer stroma and promotes invasion of oral squamous cell carcinoma.  J. Oral Pathol. Med.  2016  45:730-739  PubMed ID: 26850833
9575  Dubon MJ, Park KS.  The mechanisms of substance P-mediated migration of bone marrow-derived mesenchymal stem cell-like ST2 cells.  Int. J. Mol. Med.  2016  37:1105-11  PubMed ID: 26936322
9639  Yoshikawa M, Ouji Y.  Induction of Inner Ear Hair Cells from Mouse Embryonic Stem Cells In Vitro.  Methods Mol. Biol.  2016  1516:257-267  PubMed ID: 27032944
9752  Ye X, Huang H, Zhao N, Zhang J, Yang P.  Inhibition of Runx2 signaling by TNF-α in ST2 murine bone marrow stromal cells undergoing osteogenic differentiation.  In Vitro Cell. Dev. Biol. Anim.  2016  52:1026-1033  PubMed ID: 27401008
9785  Kusuyama J, Komorizono A, Bandow K, Ohnishi T, Matsuguchi T.  CXCL3 positively regulates adipogenic differentiation.  J. Lipid Res.  2016  57:1806-1820  PubMed ID: 27512010
9882  Moriwaki S, Into T, Suzuki K, Miyauchi M, Takata T, Shibayama K, Niida S.  γ-Glutamyltranspeptidase is an endogenous activator of Toll-like receptor 4-mediated osteoclastogenesis.  Sci Rep  2016  6:35930  PubMed ID: 27775020
9961  Onishi T, Tazawa H, Hashimoto Y, Takeuchi M, Otani T, Nakamura S, Sakurai F, Mizuguchi H, Kishimoto H, Umeda Y, Shirakawa Y, Urata Y, Kagawa S, Fujiwara T.  Tumor-specific delivery of biologics by a novel T-cell line HOZOT.  Sci Rep  2016  6:38060  PubMed ID: 27901098
9966  Fujioka-Kobayashi M, Schaller B, Kobayashi E, Hernandez M, Zhang Y, Miron RJ.  Hyaluronic Acid Gel-Based Scaffolds as Potential Carrier for Growth Factors: An In Vitro Bioassay on Its Osteogenic Potential.  J Clin Med  2016  5:  PubMed ID: 27916889
10871  Du M, Pan W, Duan X, Yang P, Ge S.  Lower dosage of aspirin promotes cell growth and osteogenic differentiation in murine bone marrow stromal cells  J Dent Sci  2016  11:315-322  PubMed ID: 30894990
10887  Sarocha Suthon, Koichi Matsuo and Suchinda Malaivijitnond  Pueraria mirifica phytoestrogens interrupt RANKL/OPG/RANK signaling in osteoblast precursor ST2 cells, but not in osteoblast–osteoclast coculture  The 11th Conference on Science and Technology for Youth  2016  73-85 
10893    Designing Porous Bone Tissue Engineering Scaffolds with Enhanced Mechanical Properties from Composite Hydrogels Composed of Modified Alginate, Gelatin and Bioactive Glass  ACS Biomater. Sci. Eng.  2016  2, 2240–2254 
10902    Effects of gallotannin on osteoclastogenesis and the p38 MAP kinase pathway  Orthodontic Waves  2016  75, 105-113 
7111  Endo K, Anada T, Yamada M, Seki M, Sasaki K, Suzuki O.  Enhancement of osteoblastic differentiation in alginate gel beads with bioactive octacalcium phosphate particles.  Biomed Mater  2015  10:065019  PubMed ID: 26657659
7186  Park JW, Kang DG, Hanawa T.  New bone formation induced by surface strontium-modified ceramic bone graft substitute.  Oral Dis  2015  22:53-61  PubMed ID: 26458092
7265  Kanda N, Anada T, Handa T, Kobayashi K, Ezoe Y, Takahashi T, Suzuki O.  Orthotopic Osteogenecity Enhanced by a Porous Gelatin Sponge in a Critical-Sized Rat Calvaria Defect.  Macromol Biosci  2015  15:1647-55  PubMed ID: 26200698
7434  Dubon MJ, Park KS.  Substance P enhances the proliferation and migration potential of murine bone marrow-derived mesenchymal stem cell-like cell lines.  Exp Ther Med  2015  9:1185-1191  PubMed ID: 25780407
7440  Takahashi K, Shiraishi N, Ishiko-Uzuka R, Anada T, Suzuki O, Masumoto H, Sasaki K.  Biomechanical evaluation of Ti-Nb-Sn alloy implants with a low Young's modulus.  Int J Mol Sci  2015  16:5779-88  PubMed ID: 25775158
7509  Kaneko K, Higuchi C, Kunugiza Y, Yoshida K, Sakai T, Yoshikawa H, Nakata K.  Hyaluronan inhibits BMP-induced osteoblast differentiation.  FEBS Lett.  2015  589:447-54  PubMed ID: 25592835
7511  Li C, Shi C, Kim J, Chen Y, Ni S, Jiang L, Zheng C, Li D, Hou J, Taichman RS, Sun H.  Erythropoietin promotes bone formation through EphrinB2/EphB4 signaling.  J. Dent. Res.  2015  94:455-63  PubMed ID: 25586589
7570  Y Ezoe, T Anada, H Yamazaki, T Handa, K Kobayashi, T Takahashi, O. Suzuki  Characterization of partially hydrolyzed OCP crystals deposited in a gelatin matrix as a scaffold for bone tissue engineering.  J Nanoparticle Res.  2015  17:127 
8888  Abe-Ohya R, Ishikawa T, Shiozawa H, Suda K, Nara F.  Identification of metals from osteoblastic ST-2 cell supernatants as novel OGR1 agonists.  J Recept Signal Transduct Res  2015  35(5):485-92  PubMed ID: 26053506
6619  Peng J, Nemec M, Brolese E, Bosshardt DD, Schaller B, Buser D, Gruber R  Bone-Conditioned Medium Inhibits Osteogenic and Adipogenic Differentiation of Mesenchymal Cells In Vitro.  Clin Implant Dent Relat Res  2015  17(5):938-49  PubMed ID: 24461197
5203  Nallamshetty S, Le PT, Wang H, Issacsohn MJ, Reeder DJ, Rhee EJ, Kiefer FW, Brown JD, Rosen CJ, Plutzky J  Retinaldehyde dehydrogenase 1 deficiency inhibits PPARγ-mediated bone loss and marrow adiposity.  Bone  2014  281-91  PubMed ID: 25064526
6610  Nishikawa R, Anada T, Ishiko-Uzuka R, Suzuki O.  Osteoblastic differentiation of stromal ST-2 cells from octacalcium phosphate exposure via p38 signaling pathway.  Dent Mater J  2014  33(2):242-51  PubMed ID: 24598239
6097  Oue E, Lee JW, Sakamoto K, Iimura T, Aoki K, Kayamori K, Michi Y, Yamashiro M, Harada K, Amagasa T, Yamaguchi A.  CXCL2 synthesized by oral squamous cell carcinoma is involved in cancer-associated bone destruction.  Biochem Biophys Res Commun  2012  424(3):456-61  PubMed ID: 22771802
6102  Tsubaki M, Satou T, Itoh T, Imano M, Yanae M, Kato C, Takagoshi R, Komai M, Nishida S.  Bisphosphonate- and statin-induced enhancement of OPG expression and inhibition of CD9, M-CSF, and RANKL expressions via inhibition of the Ras/MEK/ERK pathway and activation of p38MAPK in mouse bone marrow stromal cell line ST2.  Mol Cell Endocrinol  2012  361(1-2):219-31  PubMed ID: 22579611
7600  Handa T, Anada T, Honda Y, Yamazaki H, Kobayashi K, Kanda N, Kamakura S, Echigo S, Suzuki O.  The effect of an octacalcium phosphate co-precipitated gelatin composite on the repair of critical-sized rat calvarial defects.  Acta Biomater  2011  8:1190-200  PubMed ID: 22198138
7673  Honami T, Shimo T, Okui T, Kurio N, Hassan NM, Iwamoto M, Sasaki A.  Sonic hedgehog signaling promotes growth of oral squamous cell carcinoma cells associated with bone destruction.  Oral Oncol.  2011  48:49-55  PubMed ID: 21945071
7674  Huang H, Zhao N, Xu X, Xu Y, Li S, Zhang J, Yang P.  Dose-specific effects of tumor necrosis factor alpha on osteogenic differentiation of mesenchymal stem cells.  Cell Prolif.  2011  44:420-7  PubMed ID: 21951285
7774  Furugaki K, Moriya Y, Iwai T, Yorozu K, Yanagisawa M, Kondoh K, Fujimoto-Ohuchi K, Mori K.  Erlotinib inhibits osteolytic bone invasion of human non-small-cell lung cancer cell line NCI-H292.  Clin. Exp. Metastasis  2011  28:649-59  PubMed ID: 21688034
7829  Shoji K, Tsubaki M, Yamazoe Y, Satou T, Itoh T, Kidera Y, Tanimori Y, Yanae M, Matsuda H, Taga A, Nakamura H, Nishida S.  Mangiferin induces apoptosis by suppressing Bcl-xL and XIAP expressions and nuclear entry of NF-κB in HL-60 cells.  Arch. Pharm. Res.  2011  34:469-75  PubMed ID: 21547680
7921  Kurio N, Shimo T, Fukazawa T, Takaoka M, Okui T, Hassan NM, Honami T, Hatakeyama S, Ikeda M, Naomoto Y, Sasaki A.  Anti-tumor effect in human breast cancer by TAE226, a dual inhibitor for FAK and IGF-IR in vitro and in vivo.  Exp. Cell Res.  2011  317:1134-46  PubMed ID: 21338601
7943  Hu R, Liu W, Li H, Yang L, Chen C, Xia ZY, Guo LJ, Xie H, Zhou HD, Wu XP, Luo XH.  A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation.  J. Biol. Chem.  2011  286:12328-39  PubMed ID: 21324897
7955  Tamura M, Sato MM, Nashimoto M.  Regulation of CXCL12 expression by canonical Wnt signaling in bone marrow stromal cells.  Int. J. Biochem. Cell Biol.  2011  43:760-7  PubMed ID: 21296678
8004  Taipaleenmaki H, Abdallah BM, AlDahmash A, Saamanen AM, Kassem M.  Wnt signalling mediates the cross-talk between bone marrow derived pre-adipocytic and pre-osteoblastic cell populations.  Exp. Cell Res.  2011  317:745-56  PubMed ID: 21211534
8575  Yoshiaki Kariya, Masashi Honma, Akiko Hanamura, Shigeki Aoki, Tadashi Ninomiya, Yuko Nakamichi, Nobuyuki Udagawa, Hiroshi Suzuki  Rab27a and Rab27b Are Involved in Stimulation-Dependent RANKL Release From Secretory Lysosomes in Osteoblastic Cells  J Bone Miner Res  2011  26(4):689-703   PubMed ID: 20939018
8025  Furukawa R, Yamada Y, Takenaga M, Igarashi R, Harashima H.  Octaarginine-modified liposomes enhance the anti-oxidant effect of Lecithinized superoxide dismutase by increasing its cellular uptake.  Biochem. Biophys. Res. Commun.  2010  404:796-801  PubMed ID: 21168389
8069  Tsuneto M, Yamane T, Hayashi S.  Methods for investigation of osteoclastogenesis using mouse embryonic stem cells.  Methods Mol. Biol.  2010  690:239-53  PubMed ID: 21042997
8102  Lee JW, Mase N, Yonezawa T, Seo HJ, Jeon WB, Cha BY, Nagai K, Woo JT.  Palmatine attenuates osteoclast differentiation and function through inhibition of receptor activator of nuclear factor-κb ligand expression in osteoblast cells.  Biol. Pharm. Bull.  2010  33:1733-9  PubMed ID: 20930384
8113  Okui T, Shimo T, Fukazawa T, Kurio N, Hassan NM, Honami T, Takaoka M, Naomoto Y, Sasaki A.  Antitumor effect of temsirolimus against oral squamous cell carcinoma associated with bone destruction.  Mol. Cancer Ther.  2010  9:2960-9  PubMed ID: 20858724
8139  Cody JJ, Rivera AA, Lyons GR, Yang SW, Wang M, Sarver DB, Wang D, Selander KS, Kuo HC, Meleth S, Feng X, Siegal GP, Douglas JT.  Arming a replicating adenovirus with osteoprotegerin reduces the tumor burden in a murine model of osteolytic bone metastases of breast cancer.  Cancer Gene Ther.  2010  17:893-905  PubMed ID: 20798695
8182  Uemura T, Ohta Y, Nakao Y, Manaka T, Nakamura H, Takaoka K.  Epinephrine accelerates osteoblastic differentiation by enhancing bone morphogenetic protein signaling through a cAMP/protein kinase A signaling pathway.  Bone  2010  47:756-65  PubMed ID: 20637325
8220  Kakegawa A, Oida S, Gomi K, Nagano T, Yamakoshi Y, Fukui T, Kanazashi M, Arai T, Fukae M.  Cytodifferentiation activity of synthetic human enamel sheath protein peptides.  J. Periodont. Res.  2010  45:643-9  PubMed ID: 20572923
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8183  Nose M, Yamazaki H, Hagino H, Morio Y, Hayashi S, Teshima R.  Comparison of osteoclast precursors in peripheral blood mononuclear cells from rheumatoid arthritis and osteoporosis patients.  J Bone Miner Metab  2009  27(1):57-65  PubMed ID: 19082778
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7383  Pregizer S, Barski A, Gersbach CA, García AJ, Frenkel B.  Identification of novel Runx2 targets in osteoblasts: cell type-specific BMP-dependent regulation of Tram2.  J Cell Biochem  2007  102(6):1458-71  PubMed ID: 17486635
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7392  Niikura K, Nakajima S, Takano M, Yamazaki H.  FR177995, a novel vacuolar ATPase inhibitor, exerts not only an inhibitory effect on bone destruction but also anti-immunoinflammatory effects in adjuvant-induced arthritic rats.  Bone  2007  40(4):888-94  PubMed ID: 17157574
8891  Tsujigiwa H, Nagatsuka H, Lee YJ, Han PP, Gunduz M, Legeros RZ, Inoue M, Yamada M, Nagai N.  Immobilized rhBMP-2/succinylated type I atelocollagen gene expression of intracellular signaling molecules on ST2 cells.  J Biomed Mater Res A  2006  77:507-11  PubMed ID: 16482552
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3183  Hata, Kenji, Nishimura, Riko, Ueda, Mio, Ikeda, Fumiyo, Matsubara, Takuma, Ichida, Fumitaka, Hisada, Kunihiro, Nokubi, Takashi, Yamaguchi, Akira, Yoneda, Toshiyuki  A CCAAT/enhancer binding protein beta isoform, liver-enriched inhibitory protein, regulates commitment of osteoblasts and adipocytes.  Mol Cell Biol  2005  25:1971-9  PubMed ID: 15713650
2843  Takeuchi, Tamotsu, Adachi, Yoshihiro, Ohtsuki, Yuji  Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma.  Am J Pathol  2005  166:1817-26  PubMed ID: 15920166
3377  Hall, Christopher L, Bafico, Anna, Dai, Jinlu, Aaronson, Stuart A, Keller, Evan T  Prostate cancer cells promote osteoblastic bone metastases through Wnts.  Cancer Res  2005  65:7554-60  PubMed ID: 16140917
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2871  Notoya M, Otsuka E, Yamaguchi A, Hagiwara H  Runx-2 is not essential for the vitamin D-regulated expression of RANKL and osteoprotegerin in osteoblastic cells.  Biochem Biophys Res Commun  2004  324:655-60  PubMed ID: 15474477
2910  Fan, Xian, Roy, Eileen, Zhu, Liping, Murphy, Tamara C, Ackert-Bicknell, Cheryl, Hart, C Michael, Rosen, Clifford, Nanes, Mark S, Rubin, Janet  Nitric oxide regulates receptor activator of nuclear factor-kappaB ligand and osteoprotegerin expression in bone marrow stromal cells.  Endocrinology  2004  145:751-9  PubMed ID: 14563699
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