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RCB0224 : ST2  update : 2018/07/06
CommentBone marrow stroma cell-derived
Comment from the depositor
Restriction (Category)a
Terms and conditionsBasically, there is no restriction regarding academic use.
Remarks
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor Nishikawa, Shin-ichi
Originator Nishikawa, Shin-ichi
Year of deposit 1987
Animal mouse < Mammals
Strain name BALB/c
Tissue bone marrow
Classification other
History Nishikawa(Kumamoto Univ.)
Lifespan infinite
Morphology fibroblast-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 1-2 times/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
SSLP (mouse) OK
Isozyme LD, NP
Chromosome mode 70-80(50) : /74(5),75(5),76(6),77(11),78(12)/
Images
deposit info
lot info
Reference information Reference 4
User's Publication 113


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Reference
Hayashi S, Kunisada T, Ogawa M, Sudo T, Kodama H, Suda T, Nishikawa S, Nishikawa S  Stepwise progression of B lineage differentiation supported by interleukin 7 and other stromal cell molecules.  J Exp Med  1990  171:1683-95 
Sudo T, Ito M, Ogawa Y, Iizuka M, Kodama H, Kunisada T, Hayashi S, Ogawa M, Sakai K, Nishikawa S  Interleukin 7 production and function in stromal cell-dependent B cell development.  J Exp Med  1989  170:333-8 
Ogawa M, Nishikawa S, Ikuta K, Yamamura F, Naito M, Takahashi K, Nishikawa S  B cell ontogeny in murine embryo studied by a culture system with the monolayer of a stromal cell clone, ST2: B cell progenitor develops first in the embryonal body rather than in the yolk sac.  EMBO J  1988  7:1337-43 
Nishikawa S, Ogawa M, Nishikawa S, Kunisada T, Kodama H  B lymphopoiesis on stromal cell clone: stromal cell clones acting on different stages of B cell differentiation.  Eur J Immunol  1988  18:1767-71 

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User's Publication
Sakai H, Nakamura F, Kuno M  Synergetic activation of outwardly rectifying Cl- currents by hypotonic stress and external Ca2+ in murine osteoclasts  J Physiol  1999  515:157-168 
Sakiyama H, Nonaka T, Masuda R, Inoue N, Kuboki Y, Iijima M, Hirabayasi Y, Takahagi M, Yoshida K, Kuriiwa K, Yoshida M, Imajoh-Ohmi S  Characterization of mineral deposits formed in cultures of a hamster tartrate-resistant acid phosphatase (TRAP) and alkaline phosphatase (ALP) double-positive cell line (CCP).  Cell Tissue Res  2002  309:269-79  PubMed ID: 12172786
Notoya M, Otsuka E, Yamaguchi A, Hagiwara H  Runx-2 is not essential for the vitamin D-regulated expression of RANKL and osteoprotegerin in osteoblastic cells.  Biochem Biophys Res Commun  2004  324:655-60  PubMed ID: 15474477
Nishida S, Tsubaki M, Hoshino M, Namimatsu A, Uji H, Yoshioka S, Tanimori Y, Yanae M, Iwaki M, Irimajiri K  Nitrogen-containing bisphosphonate, YM529/ONO-5920 (a novel minodronic acid), inhibits RANKL expression in a cultured bone marrow stromal cell line ST2.  Biochem Biophys Res Commun  2005  328:91-7  PubMed ID: 15670755
Shibata T, Sakai H, Nakamura F, Shioi A, Kuno M  Differential effect of high extracellular Ca2+ on K+ and Cl- conductances in murine osteoclasts.  J Membr Biol  1997  158:59-67 
Shuto T, Jimi E, Kukita T, Hirata M, Koga T  Granulocyte-macrophage colony stimulating factor suppresses lipopolysaccharide-induced osteoclast-like cell formation in mouse bone marrow cultures.  Endocrinology  1994  134:831-7 
Flanagan, A M, Horton, M A, Dorey, E L, Collins, D A, Evely, R S, Moseley, J M, Firkin, F C, Chambers, T J, Helfrich, M H, Martin, T J  An assessment of the ability of human bone marrow cultures to generate osteoclasts.  Int J Exp Pathol  1992  73:387-401 
Athanasou, N A, Quinn, J M  Human tumour-associated macrophages are capable of bone resorption.  Br J Cancer  1992  65:523-6 
Kerby, J A, Hattersley G, Collins, D A, Chambers, T J  Derivation of osteoclasts from hematopoietic colony-forming cells in culture.  J Bone Miner Res  1992  7:353-62 
Shioi A, Teitelbaum, S L, Ross, F P, Welgus, H G, Suzuki H, Ohara J, Lacey, D L  Interleukin 4 Inhibits Murine Osteoclast Formation In Vitro  J Cell Biol  1991  47:272-277 
Hong, M H, Jin, C H, Sato T, Ishimi Y, Abe E, Suda T  Transcriptional regulation of the production of the third component of complement (C3) by 1 alpha,25-dihydroxyvitamin D3 in mouse marrow-derived stromal cells (ST2) and primary osteoblastic cells.  Endocrinology  1991  129:2774-9 
Sato T, Hong, M H, Jin, C H, Ishimi Y, Udagawa N, Shinki T, Abe E, Suda T  The specific production of the third component of complement by osteoblastic cells treated with 1 alpha,25-dihydroxyvitamin D3.  FEBS Lett  1991  285:21-4 
Udagawa N, Takahashi N, Akatsu T, Tanaka H, Sasaki T, Nishihara T, Koga T, Martin, T J, Suda T  Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells.  Proc Natl Acad Sci U S A  1990  87:7260-4 
Udagawa N, Takahashi N, Akatsu T, Sasaki T, Yamaguchi A, Kodama H, Martin, T J, Suda T  The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells.  Endocrinology  1989  125:1805-13 
Jimi E, Shuto T, Koga T  Macrophage colony-stimulating factor and interleukin-1 alpha maintain the survival of osteoclast-like cells.  Endocrinology  1995  136:808-11 
Jimi E, Shuto T, Ikebe T, Jingushi S, Hirata M, Koga T  Basic fibroblast growth factor inhibits osteoclast-like cell formation.  J Cell Physiol  1996  168:395-402 
Nishikawa M, Yamamoto M, Murakami T, Akatsu T, Kugai N, Nagata N  A third-generation bisphosphonate, YM175, inhibits osteoclast formation in murine cocultures by inhibiting proliferation of precursor cells via supporting cell-dependent mechanisms.  J Bone Miner Res  1998  13:986-95 
Kitazawa R, Kitazawa S, Maeda S  Promoter structure of mouse RANKL/TRANCE/OPGL/ODF gene.  Biochim Biophys Acta  1999  1445:134-41 
Otsuka E, Yamaguchi A, Hirose S, Hagiwara H  Characterization of osteoblastic differentiation of stromal cell line ST2 that is induced by ascorbic acid  Am J Physiol  1999  277(1 Pt 1):132-138 
Yuhara S, Kasagi S, Inoue A, Otsuka E, Hirose S, Hagiwara H  Effects of nicotine on cultured cells suggest that it can influence the formation and resorption of bone.  Eur J Pharmacol  1999  383:387-93 
Otsuka E, Kato Y, Hirose S, Hagiwara H  Role of ascorbic acid in the osteoclast formation: induction of osteoclast differentiation factor with formation of the extracellular collagen matrix.  Endocrinology  2000  141:3006-11 
Sakiyama H, Masuda R, Inoue N, Yamamoto K, Kuriiwa K, Nakagawa K, Yoshida K  Establishment and characterization of macrophage-like cell lines expressing osteoclast-specific markers.  J Bone Miner Metab  2001  19:220-7 
Masuda R, Sakiyama H, Nonaka T, Kwan A, Nakagawa K, Moriya H, Imajoh-Ohmi S, Honjo M, Yoshida K  Establishment and characterization of tartrate-resistant acid phosphatase and alkaline phosphatase double positive cell lines.  Cell Tissue Res  2001  304:351-9 
Kitazawa, Riko, Kitazawa, Sohei  Vitamin D(3) augments osteoclastogenesis via vitamin D-responsive element of mouse RANKL gene promoter.  Biochem Biophys Res Commun  2002  290:650-5  PubMed ID: 11785948
Sakuta K, Sakai H, Mori H, Morihata H, Kuno M  Na+ dependence of extracellular Ca2+-sensing mechanisms leading to activation of an outwardly rectifying Cl- channel in murine osteoclasts.  Bone  2002  31:374-80  PubMed ID: 12231409
Sakuta, Koichi, Morihata, Hirokazu, Mori, Hiroyuki, Sakai, Hiromu, Kuno, Miyuki  Cell swelling as an intermediate signal leading to activation of a Cl- channel in extracellular calcium-sensing of murine osteoclasts.  Osaka City Med J  2002  48:29-38  PubMed ID: 12375695
Tazoe, Michiko, Mogi, Makio, Goto, Shigemi, Togari, Akifumi  Involvement of p38MAP kinase in bone morphogenetic protein-4-induced osteoprotegerin in mouse bone-marrow-derived stromal cells.  Arch Oral Biol  2003  48:615-9  PubMed ID: 12828991
Fan, Xian, Roy, Eileen, Zhu, Liping, Murphy, Tamara C, Ackert-Bicknell, Cheryl, Hart, C Michael, Rosen, Clifford, Nanes, Mark S, Rubin, Janet  Nitric oxide regulates receptor activator of nuclear factor-kappaB ligand and osteoprotegerin expression in bone marrow stromal cells.  Endocrinology  2004  145:751-9  PubMed ID: 14563699
French, Dorothy M, Kaul, Raji J, D'Souza, Aloma L, Crowley, Craig W, Bao, Min, Frantz, Gretchen D, Filvaroff, Ellen H, Desnoyers, Luc  WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair.  Am J Pathol  2004  165:855-67  PubMed ID: 15331410
Oursler, Merry Jo, Bradley, Elizabeth W, Elfering, Sarah L, Giulivi, Cecilia  Native, not nitrated, cytochrome c and mitochondria-derived hydrogen peroxide drive osteoclast apoptosis.  Am J Physiol Cell Physiol  2005  288:C156-68  PubMed ID: 15342339
Hata, Kenji, Nishimura, Riko, Ueda, Mio, Ikeda, Fumiyo, Matsubara, Takuma, Ichida, Fumitaka, Hisada, Kunihiro, Nokubi, Takashi, Yamaguchi, Akira, Yoneda, Toshiyuki  A CCAAT/enhancer binding protein beta isoform, liver-enriched inhibitory protein, regulates commitment of osteoblasts and adipocytes.  Mol Cell Biol  2005  25:1971-9  PubMed ID: 15713650
Takeuchi, Tamotsu, Adachi, Yoshihiro, Ohtsuki, Yuji  Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma.  Am J Pathol  2005  166:1817-26  PubMed ID: 15920166
Hall, Christopher L, Bafico, Anna, Dai, Jinlu, Aaronson, Stuart A, Keller, Evan T  Prostate cancer cells promote osteoblastic bone metastases through Wnts.  Cancer Res  2005  65:7554-60  PubMed ID: 16140917
Endo K, Anada T, Yamada M, Seki M, Sasaki K, Suzuki O.  Enhancement of osteoblastic differentiation in alginate gel beads with bioactive octacalcium phosphate particles.  Biomed Mater  2015  10:065019  PubMed ID: 26657659
Park JW, Kang DG, Hanawa T.  New bone formation induced by surface strontium-modified ceramic bone graft substitute.  Oral Dis  2015  22:53-61  PubMed ID: 26458092
Kanda N, Anada T, Handa T, Kobayashi K, Ezoe Y, Takahashi T, Suzuki O.  Orthotopic Osteogenecity Enhanced by a Porous Gelatin Sponge in a Critical-Sized Rat Calvaria Defect.  Macromol Biosci  2015  15:1647-55  PubMed ID: 26200698
Dubon MJ, Park KS.  Substance P enhances the proliferation and migration potential of murine bone marrow-derived mesenchymal stem cell-like cell lines.  Exp Ther Med  2015  9:1185-1191  PubMed ID: 25780407
Takahashi K, Shiraishi N, Ishiko-Uzuka R, Anada T, Suzuki O, Masumoto H, Sasaki K.  Biomechanical evaluation of Ti-Nb-Sn alloy implants with a low Young's modulus.  Int J Mol Sci  2015  16:5779-88  PubMed ID: 25775158
Kaneko K, Higuchi C, Kunugiza Y, Yoshida K, Sakai T, Yoshikawa H, Nakata K.  Hyaluronan inhibits BMP-induced osteoblast differentiation.  FEBS Lett.  2015  589:447-54  PubMed ID: 25592835
Li C, Shi C, Kim J, Chen Y, Ni S, Jiang L, Zheng C, Li D, Hou J, Taichman RS, Sun H.  Erythropoietin promotes bone formation through EphrinB2/EphB4 signaling.  J. Dent. Res.  2015  94:455-63  PubMed ID: 25586589
Y Ezoe, T Anada, H Yamazaki, T Handa, K Kobayashi, T Takahashi, O. Suzuki  Characterization of partially hydrolyzed OCP crystals deposited in a gelatin matrix as a scaffold for bone tissue engineering.  J Nanoparticle Res.  2015  17:127 
Handa T, Anada T, Honda Y, Yamazaki H, Kobayashi K, Kanda N, Kamakura S, Echigo S, Suzuki O.  The effect of an octacalcium phosphate co-precipitated gelatin composite on the repair of critical-sized rat calvarial defects.  Acta Biomater  2011  8:1190-200  PubMed ID: 22198138
Honami T, Shimo T, Okui T, Kurio N, Hassan NM, Iwamoto M, Sasaki A.  Sonic hedgehog signaling promotes growth of oral squamous cell carcinoma cells associated with bone destruction.  Oral Oncol.  2011  48:49-55  PubMed ID: 21945071
Huang H, Zhao N, Xu X, Xu Y, Li S, Zhang J, Yang P.  Dose-specific effects of tumor necrosis factor alpha on osteogenic differentiation of mesenchymal stem cells.  Cell Prolif.  2011  44:420-7  PubMed ID: 21951285
Furugaki K, Moriya Y, Iwai T, Yorozu K, Yanagisawa M, Kondoh K, Fujimoto-Ohuchi K, Mori K.  Erlotinib inhibits osteolytic bone invasion of human non-small-cell lung cancer cell line NCI-H292.  Clin. Exp. Metastasis  2011  28:649-59  PubMed ID: 21688034
Shoji K, Tsubaki M, Yamazoe Y, Satou T, Itoh T, Kidera Y, Tanimori Y, Yanae M, Matsuda H, Taga A, Nakamura H, Nishida S.  Mangiferin induces apoptosis by suppressing Bcl-xL and XIAP expressions and nuclear entry of NF-κB in HL-60 cells.  Arch. Pharm. Res.  2011  34:469-75  PubMed ID: 21547680
Kurio N, Shimo T, Fukazawa T, Takaoka M, Okui T, Hassan NM, Honami T, Hatakeyama S, Ikeda M, Naomoto Y, Sasaki A.  Anti-tumor effect in human breast cancer by TAE226, a dual inhibitor for FAK and IGF-IR in vitro and in vivo.  Exp. Cell Res.  2011  317:1134-46  PubMed ID: 21338601
Hu R, Liu W, Li H, Yang L, Chen C, Xia ZY, Guo LJ, Xie H, Zhou HD, Wu XP, Luo XH.  A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation.  J. Biol. Chem.  2011  286:12328-39  PubMed ID: 21324897
Tamura M, Sato MM, Nashimoto M.  Regulation of CXCL12 expression by canonical Wnt signaling in bone marrow stromal cells.  Int. J. Biochem. Cell Biol.  2011  43:760-7  PubMed ID: 21296678
Taipaleenmaki H, Abdallah BM, AlDahmash A, Saamanen AM, Kassem M.  Wnt signalling mediates the cross-talk between bone marrow derived pre-adipocytic and pre-osteoblastic cell populations.  Exp. Cell Res.  2011  317:745-56  PubMed ID: 21211534
Furukawa R, Yamada Y, Takenaga M, Igarashi R, Harashima H.  Octaarginine-modified liposomes enhance the anti-oxidant effect of Lecithinized superoxide dismutase by increasing its cellular uptake.  Biochem. Biophys. Res. Commun.  2010  404:796-801  PubMed ID: 21168389
Tsuneto M, Yamane T, Hayashi S.  Methods for investigation of osteoclastogenesis using mouse embryonic stem cells.  Methods Mol. Biol.  2010  690:239-53  PubMed ID: 21042997
Lee JW, Mase N, Yonezawa T, Seo HJ, Jeon WB, Cha BY, Nagai K, Woo JT.  Palmatine attenuates osteoclast differentiation and function through inhibition of receptor activator of nuclear factor-κb ligand expression in osteoblast cells.  Biol. Pharm. Bull.  2010  33:1733-9  PubMed ID: 20930384
Okui T, Shimo T, Fukazawa T, Kurio N, Hassan NM, Honami T, Takaoka M, Naomoto Y, Sasaki A.  Antitumor effect of temsirolimus against oral squamous cell carcinoma associated with bone destruction.  Mol. Cancer Ther.  2010  9:2960-9  PubMed ID: 20858724
Cody JJ, Rivera AA, Lyons GR, Yang SW, Wang M, Sarver DB, Wang D, Selander KS, Kuo HC, Meleth S, Feng X, Siegal GP, Douglas JT.  Arming a replicating adenovirus with osteoprotegerin reduces the tumor burden in a murine model of osteolytic bone metastases of breast cancer.  Cancer Gene Ther.  2010  17:893-905  PubMed ID: 20798695
Uemura T, Ohta Y, Nakao Y, Manaka T, Nakamura H, Takaoka K.  Epinephrine accelerates osteoblastic differentiation by enhancing bone morphogenetic protein signaling through a cAMP/protein kinase A signaling pathway.  Bone  2010  47:756-65  PubMed ID: 20637325
Kakegawa A, Oida S, Gomi K, Nagano T, Yamakoshi Y, Fukui T, Kanazashi M, Arai T, Fukae M.  Cytodifferentiation activity of synthetic human enamel sheath protein peptides.  J. Periodont. Res.  2010  45:643-9  PubMed ID: 20572923
Lee JW, Ahn JY, Hasegawa S, Cha BY, Yonezawa T, Nagai K, Seo HJ, Jeon WB, Woo JT.  Inhibitory effect of luteolin on osteoclast differentiation and function.  Cytotechnology  2010  61:125-34  PubMed ID: 20162352
Kurtova AV, Balakrishnan K, Chen R, Ding W, Schnabl S, Quiroga MP, Sivina M, Wierda WG, Estrov Z, Keating MJ, Shehata M, Jager U, Gandhi V, Kay NE, Plunkett W, Burger JA.  Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance.  Blood  2009  114:4441-50  PubMed ID: 19762485
Yoshikawa H, Yoshioka K, Nakase T, Itoh K.  Stimulation of ectopic bone formation in response to BMP-2 by Rho kinase inhibitor: a pilot study.  Clin. Orthop. Relat. Res.  2009  467:3087-95  PubMed ID: 19609629
Fuji T, Anada T, Honda Y, Shiwaku Y, Koike H, Kamakura S, Sasaki K, Suzuki O.  Octacalcium phosphate-precipitated alginate scaffold for bone regeneration.  Tissue Eng Part A  2009  15:3525-35  PubMed ID: 19456237
Tanaka T, Kawashima H, Ohnishi K, Matsumura K, Yoshimura R, Matsuyama M, Kuratsukuri K, Nakatani T.  Indirect antitumor effects of bisphosphonates on prostatic LNCaP cells co-cultured with bone cells.  Anticancer Res.  2009  29:1089-94  PubMed ID: 19414350
Mogi M, Kondo A.  Down-regulation of mTOR leads to up-regulation of osteoprotegerin in bone marrow cells.  Biochem. Biophys. Res. Commun.  2009  384:82-6  PubMed ID: 19393224
Yano K, Hoshino M, Ohta Y, Manaka T, Naka Y, Imai Y, Sebald W, Takaoka K.  Osteoinductive capacity and heat stability of recombinant human bone morphogenetic protein-2 produced by Escherichia coli and dimerized by biochemical processing.  J. Bone Miner. Metab.  2009  27:355-63  PubMed ID: 19229473
Honda Y, Anada T, Kamakura S, Morimoto S, Kuriyagawa T, Suzuki O.  The effect of microstructure of octacalcium phosphate on the bone regenerative property.  Tissue Eng Part A  2009  15:1965-73  PubMed ID: 19132890
Yamachika E, Tsujigiwa H, Shirasu N, Ueno T, Sakata Y, Fukunaga J, Mizukawa N, Yamada M, Sugahara T.  Immobilized recombinant human bone morphogenetic protein-2 enhances the phosphorylation of receptor-activated Smads.  J Biomed Mater Res A  2008  88:599-607  PubMed ID: 18314893
Tsujigiwa H, Nagatsuka H, Lee YJ, Han PP, Gunduz M, Legeros RZ, Inoue M, Yamada M, Nagai N.  Immobilized rhBMP-2/succinylated type I atelocollagen gene expression of intracellular signaling molecules on ST2 cells.  J Biomed Mater Res A  2006  77:507-11  PubMed ID: 16482552
Hidetsugu Tsujigiwa, Andrea P. Rodriguez, Tohru Takagi, Hu Hai Long, Kan Rui, Zhenfu Lu, Xie Wei Li, Gao Wen-Xin, Jin Tan and Jing Xiao  Effects of Immobilized rhBMP-2/atelocollagen in vivo and in vitro  J Hard Tissue Biology  2006  15:27-33 
Tsujigiwa H, Nagatsuka H, Gunduz M, Rodriguez A, Rivera RS, Legeros RZ, Inoue M, Nagai N.  Effects of immobilized recombinant human bone morphogenetic protein-2/succinylated type I atelocollagen on cellular activity of ST2 cells.  J Biomed Mater Res A  2005  75:210-5  PubMed ID: 16059889
Kandler B, Maitz P, Fischer MB, Watzek G, Gruber R.  Platelets can neutralize hydrogen peroxide in an acute toxicity model with cells involved in granulation tissue formation.  Bone  2005  36:671-7  PubMed ID: 15784190
Tsubaki M, Takeda T, Yoshizumi M, Ueda E, Itoh T, Imano M, Satou T, Nishida S.  RANK-RANKL interactions are involved in cell adhesion-mediated drug resistance in multiple myeloma cell lines.  Tumour Biol.  2016  37:9099-110  PubMed ID: 26762414
Pal SK, Nguyen CT, Morita KI, Miki Y, Kayamori K, Yamaguchi A, Sakamoto K.  THBS1 is induced by TGFB1 in the cancer stroma and promotes invasion of oral squamous cell carcinoma.  J. Oral Pathol. Med.  2016  45:730-739  PubMed ID: 26850833
Dubon MJ, Park KS.  The mechanisms of substance P-mediated migration of bone marrow-derived mesenchymal stem cell-like ST2 cells.  Int. J. Mol. Med.  2016  37:1105-11  PubMed ID: 26936322
Miron RJ, Fujioka-Kobayashi M, Zhang Y, Caballé-Serrano J, Shirakata Y, Bosshardt DD, Buser D, Sculean A.  Osteogain improves osteoblast adhesion, proliferation and differentiation on a bovine-derived natural bone mineral.  Clin Oral Implants Res  2017  28:327-333  PubMed ID: 26919609
Yoshikawa M, Ouji Y.  Induction of Inner Ear Hair Cells from Mouse Embryonic Stem Cells In Vitro.  Methods Mol. Biol.  2016  1516:257-267  PubMed ID: 27032944
Ye X, Huang H, Zhao N, Zhang J, Yang P.  Inhibition of Runx2 signaling by TNF-α in ST2 murine bone marrow stromal cells undergoing osteogenic differentiation.  In Vitro Cell. Dev. Biol. Anim.  2016  52:1026-1033  PubMed ID: 27401008
Kusuyama J, Komorizono A, Bandow K, Ohnishi T, Matsuguchi T.  CXCL3 positively regulates adipogenic differentiation.  J. Lipid Res.  2016  57:1806-1820  PubMed ID: 27512010
Fujioka-Kobayashi M, Schaller B, Saulacic N, Zhang Y, Miron RJ.  Growth factor delivery of BMP9 using a novel natural bovine bone graft with integrated atelo-collagen type I: Biosynthesis, characterization, and cell behavior.  J Biomed Mater Res A  2017  105:408-418  PubMed ID: 27699987
Fujioka-Kobayashi M, Mottini M, Kobayashi E, Zhang Y, Schaller B, Miron RJ.  An in vitro study of fibrin sealant as a carrier system for recombinant human bone morphogenetic protein (rhBMP)-9 for bone tissue engineering.  J Craniomaxillofac Surg  2017  45:27-32  PubMed ID: 27840120
Fujioka-Kobayashi M, Schaller B, Zhang Y, Kandalam U, Hernandez M, Miron RJ.  Recombinant human bone morphogenetic protein (rhBMP)9 induces osteoblast differentiation when combined with demineralized freeze-dried bone allografts (DFDBAs) or biphasic calcium phosphate (BCP).  Clin Oral Investig  2017  21:1883-1893  PubMed ID: 27771827
Onishi T, Tazawa H, Hashimoto Y, Takeuchi M, Otani T, Nakamura S, Sakurai F, Mizuguchi H, Kishimoto H, Umeda Y, Shirakawa Y, Urata Y, Kagawa S, Fujiwara T.  Tumor-specific delivery of biologics by a novel T-cell line HOZOT.  Sci Rep  2016  6:38060  PubMed ID: 27901098
Fujioka-Kobayashi M, Schaller B, Kobayashi E, Hernandez M, Zhang Y, Miron RJ.  Hyaluronic Acid Gel-Based Scaffolds as Potential Carrier for Growth Factors: An In Vitro Bioassay on Its Osteogenic Potential.  J Clin Med  2016  5:  PubMed ID: 27916889
Miron RJ, Fujioka-Kobayashi M, Zhang Y, Sculean A, Pippenger B, Shirakata Y, Kandalam U, Hernandez M.  Osteogain® loaded onto an absorbable collagen sponge induces attachment and osteoblast differentiation of ST2 cells in vitro.  Clin Oral Investig  2017  21:2265-2272  PubMed ID: 27909893
Sato M, Suzuki T, Kawano M, Tamura M.  Circulating osteocyte-derived exosomes contain miRNAs which are enriched in exosomes from MLO-Y4 cells.  Biomed Rep  2017  6:223-231  PubMed ID: 28357077
Moriwaki S, Into T, Suzuki K, Miyauchi M, Takata T, Shibayama K, Niida S.  γ-Glutamyltranspeptidase is an endogenous activator of Toll-like receptor 4-mediated osteoclastogenesis.  Sci Rep  2016  6:35930  PubMed ID: 27775020
Zhang M, Osisami M, Dai J, Keller JM, Escara-Wilke J, Mizokami A, Keller ET.  Bone Microenvironment Changes in Latexin Expression Promote Chemoresistance.  Mol. Cancer Res.  2017  15:457-466  PubMed ID: 28087740
Takano A, Fukuda T, Shinjo T, Iwashita M, Matsuzaki E, Yamamichi K, Takeshita M, Sanui T, Nishimura F.  Angiopoietin-like protein 2 is a positive regulator of osteoblast differentiation.  Metab. Clin. Exp.  2017  69:157-170  PubMed ID: 28285646
Kuroda M, Wada H, Kimura Y, Ueda K, Kioka N.  Vinculin promotes nuclear localization of TAZ to inhibit ECM stiffness-dependent differentiation into adipocytes.  J. Cell. Sci.  2017  130:989-1002  PubMed ID: 28115535
Chaweewannakorn W, Ariyoshi W, Okinaga T, Morikawa K, Saeki K, Maki K, Nishihara T.  Ameloblastin and enamelin prevent osteoclast formation by suppressing RANKL expression via MAPK signaling pathway.  Biochem. Biophys. Res. Commun.  2017  485:621-626  PubMed ID: 28161637
Baskin LS, Duckett JW.  Dorsal tunica albuginea plication for hypospadias curvature.  J. Urol.  1994  151:1668-71  PubMed ID: 8189595
Fujioka-Kobayashi M, Schaller B, Saulacic N, Pippenger BE, Zhang Y, Miron RJ.  Absorbable collagen sponges loaded with recombinant bone morphogenetic protein 9 induces greater osteoblast differentiation when compared to bone morphogenetic protein 2.  Clin Exp Dent Res  2017  3:32-40  PubMed ID: 29744176
Aikawa T, Matsubara H, Ugaji S, Shirakawa J, Nagai R, Munesue S, Harashima A, Yamamoto Y, Tsuchiya H.  Contribution of methylglyoxal to delayed healing of bone injury in diabetes.  Mol Med Rep  2017  16:403-409  PubMed ID: 28534951
Takada H, Ibaragi S, Eguchi T, Okui T, Obata K, Masui M, Morisawa A, Takabatake K, Kawai H, Yoshioka N, Hassan NMM, Shimo T, Hu GF, Nagatsuka H, Sasaki A.  Semaphorin 4D promotes bone invasion in head and neck squamous cell carcinoma.  Int. J. Oncol.  2017  51:625-632  PubMed ID: 28656278
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