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RCB0222 : NB1RGB  update : 2019/02/05
細胞特性(Comment:英)Normal human skin fibroblast, RCB original
細胞特性(日)当室で新たに培養化されたヒト新生児皮膚由来の正常二倍体線維芽細胞で有限寿命を有する。17、29、36、47、53、61のPDLのロットをそろえてある。提供申し込み時にはPDLも指定のこと。
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)Basically, there is no restriction regarding academic use.
使用条件(日)学術研究における利用につきましては原則として使用制限はありません。
備考(英)
備考(日)
提供申込書類 依頼書C-0001.pdf   同意書(非営利)C-0003.pdf   同意書(営利)C-0003p.pdf  
提供同意書は、使用機関及び使用内容に応じて二種類あります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は別途ご相談(cellbank.brc@riken.jp)を承ります。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 Ohno,T. & Kojima
樹立者 Ohno, T. & Kurita, K.
寄託日 1987
動物種 human < Mammals
属名 Homo
種名 sapiens
人種 Japanese
性別 Male
3 days
採取組織 skin
細胞分類 normal
初代培養日 1987
細胞寿命 finite
細胞形態 fibroblast-like
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 MEM ALPHA + 10% FBS
抗生物質 Free
継代方法 0.25% trypsin
継代密度 1 : 4 split
継代・培地交換頻度 Subculture : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ (-)
個体識別検査 OK
ウィルス(HIV) (-)
アイソザイム検査 LD, NP
染色体検査 46(50)
画像情報
寄託時情報
ロット情報
文献情報 Reference(英) 0件
Reference(日) 0件
利用者成果(英) 203件
利用者成果(日) 31件

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Reference(英)

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Reference(日)

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利用者成果(英)
11435  Iwasawa C, Tamura R, Sugiura Y, Suzuki S, Kuzumaki N, Narita M, Suematsu M, Nakamura M, Yoshida K, Toda M, Okano H, Miyoshi H.  Increased Cytotoxicity of Herpes Simplex Virus Thymidine Kinase Expression in Human Induced Pluripotent Stem Cells.  Int J Mol Sci  2019    PubMed ID: 30769780
11637  Kobayashi Y, Cordonier CEJ, Noda Y, Nagase F, Enomoto J, Kageyama T, Honma H, Maruo S, Fukuda J.  Tailored cell sheet engineering using microstereolithography and electrochemical cell transfer.  Sci Rep  2019    PubMed ID: 31320678
11737  Iwahashi H, Kawashima Y, Masaki H.  Interleukin-1 alpha derived from ultraviolet B-exposed keratinocytes is associated with a decrease of endocytic collagen receptor Endo180.  Photodermatol Photoimmunol Photomed  2019    PubMed ID: 31376337
11875  Shimada M, Tsukada K, Kagawa N, Matsumoto Y.  Reprogramming and differentiation-dependent transcriptional alteration of DNA damage response and apoptosis genes in human induced pluripotent stem cells.  J. Radiat. Res.  2019    PubMed ID: 31665364
11880  Machihara K, Namba T.  BAP31 Inhibits Cell Adaptation to ER Stress Conditions, Negatively Regulating Autophagy Induction by Interaction with STX17.  Cells  2019    PubMed ID: 31671609
11882  Inaniwa T, Suzuki M, Sato S, Muramatsu M, Noda A, Iwata Y, Kanematsu N, Shirai T, Noda K.  Effect of external magnetic fields on biological effectiveness of proton beams.  Int. J. Radiat. Oncol. Biol. Phys.  2019    PubMed ID: 31678633
10673  Someya T, Sano K, Hara K, Sagane Y, Watanabe T, Wijesekara RGS.  Fibroblast and keratinocyte gene expression following exposure to extracts of neem plant (Azadirachta indica).  Data Brief  2018  16:982-992  PubMed ID: 29322079
10677  Yaekashiwa N, Otsuki S, Hayashi S, Kawase K.  Investigation of the non-thermal effects of exposing cells to 70-300 GHz irradiation using a widely tunable source.  J. Radiat. Res.  2018  59:116-121  PubMed ID: 29281029
10761  Uto T, Tung NH, Ohta T, Juengsanguanpornsuk W, Hung LQ, Hai NT, Long DD, Thuong PT, Okubo S, Hirata S, Shoyama Y.  Antiproliferative activity and apoptosis induction by trijuganone C isolated from the root of Salvia miltiorrhiza Bunge (Danshen).  Phytother Res  2018  32:657-666  PubMed ID: 29464799
10819  Mizuno M, Yaekashiwa N, Watanabe S.  Analysis of dermal composite conditions using collagen absorption characteristics in the THz range.  Biomed Opt Express  2018  9:2277-2283  PubMed ID: 29760986
11263  Sano K, Kawanobe H, Someya T.  Effect of cupuassu butter on human skin cells.  Data Brief  2018    PubMed ID: 30370321
11266  Tezuka T, Ota A, Karnan S, Matsuura K, Yokoo K, Hosokawa Y, Vigetti D, Passi A, Hatano S, Umezawa K, Watanabe H.  The plant alkaloid conophylline inhibits matrix formation of fibroblasts.  J. Biol. Chem.  2018    PubMed ID: 30377255
11339  Yonezawa T, Momota R, Iwano H, Zhao S, Hakozaki T, Soh C, Sawaki S, Toyama K, Oohashi T.  Unripe peach (Prunus persica) extract ameliorates damage from UV irradiation and improved collagen XVIII expression in 3D skin model.  J Cosmet Dermatol  2018    PubMed ID: 30548159
4430  Shigeo Takashima, Kayoko Toyoshi, Nobuyuki Shimozawa  Analyses of the fatty acid separation principle using liquid chromatography-mass spectrometry  Medical Mass Spectrometry  2018  2 
4431    Verification of the non-thermal effects of THz-wave on human cells  IEEE Xplore  2018   
4306  Someya T, Sano K, Hara K, Sagane Y, Watanabe T, Wijesekara RGS.  Fibroblast and keratinocyte gene expression following exposure to the extracts of holy basil plant (Ocimum tenuiflorum), malabar nut plant (Justicia adhatoda), and emblic myrobalan plant (Phyllanthus emblica).  Data Brief  2018    PubMed ID: 29876372
4307  Sano K, Someya T, Hara K, Sagane Y, Watanabe T, Wijesekara RGS.  Effect of traditional plants in Sri Lanka on skin fibroblast cell number.  Data Brief  2018    PubMed ID: 29900360
5667  Masao SUZUKI and Noriko USAMI   Cell-killing effect by the targeted cytoplasmic irradiation in normal human fibroblasts with monochromatic X-ray microbeams (2)  Photon Factory Activity Report   2018  36 
5683  Horie M et al  TBX4 is involved in the super-enhancer-driven transcriptional programs underlying features specific to lung fibroblasts.  Am J Physiol Lung Cell Mol Physiol  2018  314(1):L177-L191  PubMed ID: 28971975
5687  Neil F. Johnson  Pulmonary Toxicity of Benzalkonium Chloride  Journal of Aerosol Medicine and Pulmonary Drug Delivery  2018  31 
5688  Sano K, Gotoh M1, Dodo K, Tajima N, Shimizu Y, Murakami-Murofushi K.  Age-related changes in cyclic phosphatidic acid-induced hyaluronic acid synthesis in human fibroblasts.  Hum Cell  2018  31(1):72-77  PubMed ID: 29063508
5689  Warashina T, Miyase T.  New 8,12;8,20-diepoxy-8,14-secopregnane hexa- and hepta-glycosides from the roots of Asclepias tuberosa.  J Nat Med  2018  72(1):347-356  PubMed ID: 29177792
5690  Iñiguez-Moreno M, Avila-Novoa MG, Gutiérrez-Lomelí M.  Resistance of pathogenic and spoilage microorganisms to disinfectants in the presence of organic matter and their residual effect on stainless steel and polypropylene.  J Glob Antimicrob Resist  2018  197-201  PubMed ID: 29698753
5691  Kocot J, Kiełczykowska M, Luchowska-Kocot D, Kurzepa J, Musik I.  Antioxidant Potential of Propolis, Bee Pollen, and Royal Jelly: Possible Medical Application.  Oxid MedCell Longev  2018  2018:7074209  PubMed ID: 29854089
10021  Kanemaru A, Yamamoto K, Kawaguchi M, Fukushima T, Lin CY, Johnson MD, Camerer E, Kataoka H.  Deregulated matriptase activity in oral squamous cell carcinoma promotes the infiltration of cancer-associated fibroblasts by paracrine activation of protease-activated receptor 2.  Int. J. Cancer  2017  140:130-141  PubMed ID: 27615543
10059  Takashima S, Toyoshi K, Itoh T, Kajiwara N, Honda A, Ohba A, Takemoto S, Yoshida S, Shimozawa N.  Detection of unusual very-long-chain fatty acid and ether lipid derivatives in the fibroblasts and plasma of patients with peroxisomal diseases using liquid chromatography-mass spectrometry.  Mol. Genet. Metab.  2017  120:255-268  PubMed ID: 28089346
10431  Tamura I, Shirafuta Y, Jozaki K, Kajimura T, Shinagawa M, Maekawa R, Taketani T, Asada H, Sato S, Tamura H, Sugino N.  Novel Function of a Transcription Factor WT1 in Regulating Decidualization in Human Endometrial Stromal Cells and Its Molecular Mechanism.  Endocrinology  2017  158:3696-3707  PubMed ID: 28977591
10435  Tung NH, Uto T, Hai NT, Li G, Shoyama Y.  Quassinoids from the Root of Eurycoma longifolia and Their Antiproliferative Activity on Human Cancer Cell Lines.  Pharmacogn Mag  2017  13:459-462  PubMed ID: 28839372
10516  Bashar MK, Hashimoto K, Gotoh M, Kori H.  Analyzing orientation patterns of human skin fibroblasts using image gradient information.  Conf Proc IEEE Eng Med Biol Soc  2017  2017:600-603  PubMed ID: 29059944
10582  Nobeyama Y, Watanabe Y, Nakagawa H.  Silencing of G0/G1 switch gene 2 in cutaneous squamous cell carcinoma.  PLoS ONE  2017  12:e0187047  PubMed ID: 29073263
10995    Distinction of dermal conditions related to collagen state using THz spectroscopy  IEEE Xplore:  2017   
5679  Autsavapromporn N, Liu C, Konishi T.  Impact of Co-Culturing with Fractionated Carbon-Ion-Irradiated Cancer Cells on Bystander Normal Cells and Their Progeny.  Radiat Res  2017  188(3):335-341  PubMed ID: 2868654
5680  Ginting TE, Suryatenggara J, Christian S, Mathew G.  Proinflammatory response induced by Newcastle disease virus in tumor and normal cells.  Oncolytic Virother  2017  6:21-30  PubMed ID: 28293547
5682  Yamauchi K, Mitsunaga T, Afroze SH, Uddin MN.  Structure-Activity Relationships of Methylquercetin on Anti-migration and Anti-proliferation Activity in B16 Melanoma Cells.  Anticancer Res  2017  37(4):1575-1579  PubMed ID: 28373417
5684  Futami 1, Sato K, Miyazaki K, Suzuki K, Nakamura T, Tojo A.  Efficacy and Safety of Doubly-Regulated Vaccinia Virus in a Mouse Xenograft Model of Multiple Myeloma.  Mol Ther Oncolytics  2017  6:57-68  PubMed ID: 28808676
5686  Michaelidesová A, Vachelová J, Puchalska M, Brabcová KP, Vondráček V, Sihver L, Davídková M  Relative biological effectiveness in a proton spread-out Bragg peak formed by pencil beam scanning mode.  Australas Phys Eng Sci Med  2017  40(2):359-368  PubMed ID: 28321635
9771  Li JR, Suzuki T, Nishimura H, Kishima M, Maeda S, Suzuki H.  Asymmetric Regulation of Peripheral Genes by Two Transcriptional Regulatory Networks.  PLoS ONE  2016  11:e0160459  PubMed ID: 27483142
9830  Yoshino A, Polouliakh N, Meguro A, Takeuchi M, Kawagoe T, Mizuki N.  Chum salmon egg extracts induce upregulation of collagen type I and exert antioxidative effects on human dermal fibroblast cultures.  Clin Interv Aging  2016  11:1159-68  PubMed ID: 27621603
9844  Horie M, Yamaguchi Y, Saito A, Nagase T, Lizio M, Itoh M, Kawaji H, Lassmann T, Carninci P, Forrest AR, Hayashizaki Y, Suzutani T, Kappert K, Micke P, Ohshima M.  Transcriptome analysis of periodontitis-associated fibroblasts by CAGE sequencing identified DLX5 and RUNX2 long variant as novel regulators involved in periodontitis.  Sci Rep  2016  6:33666  PubMed ID: 27645561
10855  Junk  Engineering thick cell sheets by electrochemical desorption of oligopeptides on membrane substrates  Regenerative Therapy  2016  3 : 24-31 
5665  Verkhovtsev A, Surdutovich E, Solov'yov AV.  Multiscale approach predictions for biological outcomes in ion-beam cancer therapy.  Sci Rep  2016  6:27654  PubMed ID: 27297618
5666  Katsuhisa Yamada ; Masahiro Suzuki ; Michiyasu Nomura ; Yuji Shibata ; Chiaki Imada  Cell viability of human fibroblasts cultured with various ratios of calcium and magnesium and effects of deep seawater supplementation  IEEE  2016  6-8 
5668  Ohba T, Ishisaka M, Tsujii S, Tsuruma K, Shimazawa M, Kubo K, Umigai N, Iwawaki T, Hara H.  Crocetin protects ultraviolet A-induced oxidative stress and cell death in skin in vitro and in vivo.  Eur J Pharmacol  2016  789:244-253  PubMed ID: 27452919
5669  Kwofie KD et al  Antitrypanosomal Activities and Mechanisms of Action of Novel Tetracyclic Iridoids from Morinda lucida Benth.  Antimicrob Agents Chemother  2016  60(6):3283-90  PubMed ID: 26953191
5670  H Oesten S Loeck S Helmbrecht F Tillner P Wohlfahrt J Schuemann A Luehr  SU‐F‐T‐682: In‐Vivo Simulation of the Relative Biological Effectiveness in Proton Therapy Using a Monte Carlo Method  Medical Physics  2016  43:3621-3621 
5671  Kwofie K. D et al  In-vitro Anti-trypanosomal Activities and Mechanisms of Action of Novel Tetracyclic Iridoids from Morinda lucida Benth   AAC Accepted Manuscript Posted Online  2016  7 
5672  Nobeyama Y, Nakagawa H.  Aberrant demethylation and expression of MAGEB2 in a subset of malignant peripheral nerve sheath tumors from neurofibromatosis type 1.  J Dermatol Sci.  2016  81(2):118-23  PubMed ID: 26642794
5673  Yamaba H, Haba M, Kunita M, Sakaida T, Tanaka H, Yashiro Y, Nakata S.  Morphological change of skin fibroblasts induced by UV Irradiation is involved in photoaging.  Exp Dermatol  2016  Suppl 3:45-51  PubMed ID: 27539902
5678  Koyama S, Narita E, Shinohara N, Miyakoshi J.  Effect of low-dose X-ray irradiation on micronucleus formation in human embryo, newborn and child cells.  Int J Radiat Biol  2016  92(12):790-795  PubMed ID: 27579525
7135  Saito Y, Tsuruma K, Ichihara K, Shimazawa M, Hara H.  Brazilian green propolis water extract up-regulates the early expression level of HO-1 and accelerates Nrf2 after UVA irradiation.  BMC Complement Altern Med  2015  15:421  PubMed ID: 26611539
7296  Uto T, Tung NH, Appiah-Opong R, Aning A, Morinaga O, Edoh D, Nyarko AK, Shoyama Y.  Antiproliferative and Pro-Apoptotic Activity of Diarylheptanoids Isolated from the Bark of Alnus japonica in Human Leukemia Cell Lines.  Am. J. Chin. Med.  2015  43:757-67  PubMed ID: 26119959
7303  Kobayashi H, Nobeyama Y, Nakagawa H.  Tumor-suppressive effects of natural-type interferon-β through CXCL10 in melanoma.  Biochem. Biophys. Res. Commun.  2015  464:416-21  PubMed ID: 26102027
7536  K Shikano, K Chiba, S Miyata  Response of Human Skin Fibroblasts to Mechanical Stretch in Wound Healing Process Analyzed Using a Three-Dimensional Culture Model.  Advanced Biomedical Engineering  2015  4:170?178 
7574  Yuji SHIBATA, Katsuhisa YAMADA, Chiaki IMADA, Takeshi KOBAYASHI, Takeshi TERAHARA  Phenotypic Characterization of a Microbe Producing Substances for Oxidative Stress Resistance Isolated from the Deep Seawater in Izu-Akazawa, Japan.  Deep Ocean Water Research  2015  15:117-124 
5645  Tomita M, Maeda M.  Mechanisms and biological importance of photon-induced bystander responses: do they have an impact on low-dose radiation responses.  J Radiat Res  2015  56(2):205-19  PubMed ID: 25361549
5651  Suzuki M et al  New anti-trypanosomal active tetracyclic iridoid isolated from Morinda lucida Benth.  Bioorg Med Chem Lett  2015  25(15):3030-3  PubMed ID: 26048790
5652  Tokuyama E, Nagai Y, Takahashi K, Kimata Y, Naruse K.  Mechanical Stretch on Human Skin Equivalents Increases the Epidermal Thickness and Develops the Basement Membrane.  PLoS One  2015  10(11):e0141989  PubMed ID: 26528823
5653  Tabata A, Ohkubo Y, Anyoji N, Hojo K, Tomoyasu T, Tatematsu Y, Ohkura K, Nagamune H.  Development of a Sortase A-mediated Peptide-labeled Liposome Applicable to Drug-delivery Systems.  Anticancer Res  2015  35(8):4411-7  PubMed ID: 26168480
5654  Sadahira Y, Sugihara T, Fujiwara H, Nishimura H, Suetsugu Y, Takeshita M, Okamura S, Goto M.  WRN protein as a novel erythroblast immunohistochemical marker with applications for the diagnosis of Werner syndrome.  Virchows Arch  2015  466(3):343-50  PubMed ID: 25503078
5656  Autsavapromporn N, Plante I, Liu C, Konishi T, Usami N, Funayama T, Azzam EI, Murakami T, Suzuki M.  Genetic changes in progeny of bystander human fibroblasts after microbeam irradiation with X-rays, protons or carbon ions: the relevance to cancer risk.  Int J Radiat Biol  2015  91(1):62-70  PubMed ID: 25084840
5655  Khayrul Bashar et al  Pattern quantification from human skin fibroblast images: Image quantification for fibroblast chracterization  IEEE  2015  28-30 
5658  Shirai A1, Onitsuka M, Maseda H, Omasa T.  Effect of polyphenols on reactive oxygen species production and cell growth of human dermal fibroblasts after irradiation with ultraviolet-A light.  Biocontrol Sci  2015  20(1):27-33  PubMed ID: 25817810
5660  Morita R, Suzuki M, Kasahara H, Shimizu N, Shichita T, Sekiya T, Kimura A, Sasaki K, Yasukawa H, Yoshimura A.  ETS transcription factor ETV2 directly converts human fibroblasts into functional endothelial cells.  Proc Natl Acad Sci U S A.   2015  112(1):160-5  PubMed ID: 25540418
5661  Jain I, Kumar V, Satyanarayana T.  Xylooligosaccharides: an economical prebiotic from agroresidues and their health benefits.  Indian J Exp Biol  2015  53(3):131-42  PubMed ID: 25872243
5663  Quartuccio SM, Schindler K.  Functions of Aurora kinase C in meiosis and cancer.  Front Cell Dev Biol  2015  3:50  PubMed ID: 26347867
5529  Maeda-Sano K, Gotoh M, Morohoshi T, Someya T, Murofushi H, Murakami-Murofushi K.   Cyclic phosphatidic acid and lysophosphatidic acid induce hyaluronic acid synthesis via CREB transcription factor regulation in human skin fibroblasts.  Biochim Biophys Acta  2014  1841(9):1256-63  PubMed ID: 24845645
5641  Tomaru Y, Hasegawa R, Suzuki T, Sato T4 Kubosaki A1, Suzuki M, Kawaji H, Forrest AR, Hayashizaki Y; FANTOM Consortium, Shin JW, Suzuki H.  A transient disruption of fibroblastic transcriptional regulatory network facilitates trans-differentiation.  Nucleic Acids Res  2014  2(14):8905-13  PubMed ID: 25013174
5642  Narongchai Autsavapromporn, Masao Suzuki, Cuihua Liu, Takeshi Murakami  Short- and long-term effects from the communication between carbon-irradiated cancer cells and non-irradiated human cells: implication for radiotherapy and space radiation  Journal of Radiation Research  2014  55, i52–i53 
5643  Ishikawa K, Ishikawa A, Shoji Y, Imai T.  A genotoxic stress-responsive miRNA, miR-574-3p, delays cell growth by suppressing the enhancer of rudimentary homolog gene in vitro.  Int J Mol Sci  2014  15(2):2971-90  PubMed ID: 24566139
5644  Kuse Y, Ogawa K, Tsuruma K, Shimazawa M, Hara H.  Damage of photoreceptor-derived cells in culture induced by light emitting diode-derived blue light.  Sci Rep  2014  4:5223  PubMed ID: 24909301
5633  Tung NH, Suzuki M, Uto T, Morinaga O, Kwofie KD, Ammah N, Koram KA, Aboagye F, Edoh D, Yamashita T, Yamaguchi Y, Setsu T, Yamaoka S, Ohta N, Shoyama Y.  Anti-trypanosomal activity of diarylheptanoids isolated from the bark of Alnus japonica.  Am J Chin Med  2014  42(5):1245-60  PubMed ID: 25178281
5646  Samuel Tetteh, David. K. Dodoo, Regina AppiahOpong, Isaac Tuffou  Cytotoxicity, antioxidant and glutathione S-transferase inhibitory activity of palladium(II) chloride complexes bearing nucleobase ligands  Transition Met Chem  2014  39:667–674 
5647  Hara M, Fujii T, Hashizume R, Nomura Y.  Effect of strain on human dermal fibroblasts in a three-dimensional collagen sponge.  Cytotechnology  2014  66(5):723-8  PubMed ID: 24096838
5648  Adachi H, Murakami Y, Tanaka H, Nakata S.  Increase of stratifin triggered by ultraviolet irradiation is possibly related to premature aging of human skin.  Exp Dermatol  2014  Suppl 1:32-6  PubMed ID: 25234834
5649  Hara M, Nakashima M, Fujii T, Uehara K, Yokono C, Hashizume R, Nomura Y.  Construction of collagen gel scaffolds for mechanical stress analysis.  Biosci Biotechnol Biochem  2014  78(3):458-61  PubMed ID: 25036833
5650  Słonina D, Biesaga B, Swakoń J, Kabat D, Grzanka L, Ptaszkiewicz M, Sowa U.  Relative biological effectiveness of the 60-MeV therapeutic proton beam at the Institute of Nuclear Physics (IFJ PAN) in Kraków, Poland.  Radiat Environ Biophys  2014  53(4):745-54  PubMed ID: 25037857
5623  Friedrich T, Scholz U, Elsässer T, Durante M, Scholz M.  Systematic analysis of RBE and related quantities using a database of cell survival experiments with ion beam irradiation.  J Radiat Res  2013  54(3):494-514  PubMed ID: 23266948
5628  Autsavapromporn N, Suzuki M, Plante I, Liu C, Uchihori Y, Hei TK, Azzam EI, Murakami T.  Participation of gap junction communication in potentially lethal damage repair and DNA damage in human fibroblasts exposed to low- or high-LET radiation.  Mutat Res  2013  756(1-2):78-85  PubMed ID: 23867854
5629  Tabata A, Ohkubo Y, Tamura M, Tomoyasu T, Ohkura K, Nagamune H.  Construction of an improved drug delivery system tool with enhanced versatility in cell-targeting.  Anticancer Res  2013  33(7):2905-10  PubMed ID: 23780978
5630  Wada M, Suzuki M, Liu C, Kaneko Y, Fukuda S, Ando K, Matsufuji N.  Modeling the biological response of normal human cells, including repair processes, to fractionated carbon beam irradiation.  J Radiat Res  2013  54(5):798-807  PubMed ID: 23449640
5631  Uto T, Sakamoto A, Tung NH, Fujiki T, Kishihara K, Oiso S, Kariyazono H, Morinaga O, Shoyama Y.  Anti-Proliferative Activities and Apoptosis Induction by Triterpenes Derived from Eriobotrya japonica in Human Leukemia Cell Lines.  Int J Mol Sci  2013  14(2):4106-20  PubMed ID: 23429195
5632  Murase H, Shimazawa M1, Kakino M2, Ichihara K3, Tsuruma K1, Hara H1.  The Effects of Brazilian Green Propolis against Excessive Light-Induced Cell Damage in Retina and Fibroblast Cells.  Evid Based Complement Alternat Med.  2013  2013:238279  PubMed ID: 24416064
5634  Autsavapromporn N, Suzuki M, Funayama T, Usami N, Plante I, Yokota Y, Mutou Y, Ikeda H, Kobayashi K, Kobayashi Y, Uchihori Y, Hei TK, Azzam EI, Murakami T.  Gap junction communication and the propagation of bystander effects induced by microbeam irradiation in human fibroblast cultures: the impact of radiation quality.  Radiat Res  2013  180(4):367-75  PubMed ID: 23987132
5635  Tung NH, Uto T, Sakamoto A, Hayashida Y, Hidaka Y, Morinaga O, Lhieochaiphant S, Shoyama Y.  Antiproliferative and apoptotic effects of compounds from the flower of Mammea siamensis (Miq.) T. Anders. on human cancer cell lines.  Bioorg Med Chem Lett  2013  23(1):158-62  PubMed ID: 23206866
5636  Yamaguchi K, He S, Li Z, Murata K, Hitomi N, Mozumi M, Ariga R, Enomoto T.  Quantification of major royal jelly protein 1 in fresh royal jelly by indirect enzyme-linked immunosorbent assay.  Biosci Biotechnol Biochem  2013  77(6):1310-2  PubMed ID: 23748766
5637  Shirai A, Endo T, Maseda H, Omasa T.  Synthesis of thiazole derivatives and evaluation of their antiamoebic activity and cytotoxicity.  Biocontrol Sci  2013  18(4):183-91  PubMed ID: 24366623
5638  Shirai A, Fumoto Y, Shouno T, Maseda H, Omasa T.  Synthesis and biological activity of thiazolyl-acetic acid derivatives as possible antimicrobial agents.  Biocontrol Sci  2013  18(2):59-73  PubMed ID: 23796637
5640  Mairani A, Böhlen TT, Dokic I, Cabal G, Brons S, Haberer T.  Modelling of cell killing due to sparsely ionizing radiation in normoxic and hypoxic conditions and an extension to high LET radiation.  Int J Radiat Biol  2013  89(10):782-93  PubMed ID: 23627742
5522  Takahashi M, Asikin Y, Takara K, Wada K.  Screening of medicinal and edible plants in Okinawa, Japan, for enhanced proliferative and collagen synthesis activities in NB1RGB human skin fibroblast cells.  Biosci Biotechnol Biochem  2012  76(12):2317-20  PubMed ID: 23221723
5619  Makoto Takahashi, Tomotake Morita, Tokuma Fukuoka, Tomohiro Imura, Dai Kitamoto  Glycolipid Biosurfactants, Mannosylerythritol Lipids, Show Antioxidant and Protective Effects against H2O2-Induced Oxidative Stress in Cultured Human Skin Fibroblasts  Journal of Oleo Science  2012  61:457-464 
5620  Tabata A, Ohkubo Y, Sakakura E, Tomoyasu T, Ohkura K, Nagamune H.  Investigation of a bacterial pore-forming chimera toxin for application as a novel drug-delivery system tool.  Anticancer Res  2012  32(6):2323-9  PubMed ID: 22641669
5621  Sato T, Watanabe R, Sihver L, Niita K.  Applications of the microdosimetric function implemented in the macroscopic particle transport simulation code PHITS.  Int J Radiat Biol  2012  88(1-2):143-50  PubMed ID: 21823823
5622  Takasao N, Tsuji-Naito K, Ishikura S, Tamura A, Akagawa M.  Cinnamon extract promotes type I collagen biosynthesis via activation of IGF-I signaling in human dermal fibroblasts.  J Agric Food Chem  2012  60(5):1193-200  PubMed ID: 22233457
5624  Maeda R, Ida T, Ihara H, Sakamoto T.  Induction of apoptosis in MCF-7 cells by β-1,3-xylooligosaccharides prepared from Caulerpa lentillifera.  Biosci Biotechnol Biochem  2012  76(5):1032-4  PubMed ID: 22738982
5625  Nishiyama Y, Shimada Y, Yokoi T, Kobayashi H, Higuchi T, Eto Y, Ida H, Ohashi T.  Akt inactivation induces endoplasmic reticulum stress-independent autophagy in fibroblasts from patients with Pompe disease.  Mol Genet Metab  2012  107(3):490-5  PubMed ID: 23041259
5626  Suzuki T, Nakano-Ikegaya M, Yabukami-Okuda H, de Hoon M, Severin J, Saga-Hatano S, Shin JW, Kubosaki A, Simon C, Hasegawa Y, Hayashizaki Y, Suzuki H.  Reconstruction of monocyte transcriptional regulatory network accompanies monocytic functions in human fibroblasts.  PLoS One  2012  7(3):e33474  PubMed ID: 22428058
5457  Warashina T, Umehara K, Miyase T.  Constituents from the roots of Taraxacum platycarpum and their effect on proliferation of human skin fibroblasts.  Chem Pharm Bull (Tokyo)  2012  60(2):205-12  PubMed ID: 22293479
5627  Nakamura S, Moriura T, Park S, Fujimoto K, Matsumoto T, Ohta T, Matsuda H, Yoshikawa M.  Melanogenesis inhibitory and fibroblast proliferation accelerating effects of noroleanane- and oleanane-type triterpene oligoglycosides from the flower buds of Camellia japonica.  J Nat Prod  2012  75(8):1425-30  PubMed ID: 22834923
7780  Sprung CN, Cholewa M, Usami N, Kobayashi K, Crosbie JC.  DNA damage and repair kinetics after microbeam?radiation therapy emulation in living?cells using monoenergetic synchrotron X-ray microbeams.  J Synchrotron Radiat  2011  18:630-6  PubMed ID: 21685681
5615  Chizuru Tsuruoka  Difference in Biological Effectiveness Due to The Endpoints and Radiation Quality  Biological Sciences in Space  2011  25:13-17 
5616  Warashina T, Umehara K, Miyase T, Noro T.  8,12;8,20-diepoxy-8,14-secopregnane glycosides from roots of Asclepias tuberosa and their effect on proliferation of human skin fibroblasts.  Phytochemistry  2011  72(14-15):1865-75  PubMed ID: 21703653
5617  Ando Y, Tomaru Y, Morinaga A, Burroughs AM, Kawaji H, Kubosaki A, Kimura R, Tagata M, Ino Y, Hirano H, Chiba J, Suzuki H, Carninci P, Hayashizaki Y.  Nuclear pore complex protein mediated nuclear localization of dicer protein in human cells.  PLoS One  2011  6(8):e23385  PubMed ID: 21858095
8158  Michikawa Y, Suga T, Ishikawa A, Hayashi H, Oka A, Inoko H, Iwakawa M, Imai T.  Genome wide screen identifies microsatellite markers associated with acute adverse effects following radiotherapy in cancer patients.  BMC Med. Genet.  2010  11:123  PubMed ID: 20701746
8280  Tsuruoka C, Furusawa Y, Anzai K, Okayasu R, Suzuki M.  Rejoining kinetics of G1-PCC breaks induced by different heavy-ion beams with a similar LET value.  Mutat. Res.  2010  701:47-51  PubMed ID: 20420934
8354  Takebayashi J, Ishii R, Chen J, Matsumoto T, Ishimi Y, Tai A.  Reassessment of antioxidant activity of arbutin: multifaceted evaluation using five antioxidant assay systems.  Free Radic. Res.  2010  44:473-8  PubMed ID: 20166881
8394  Bando M, Hiroshima Y, Kataoka M, Herzberg MC, Ross KF, Shinohara Y, Yamamoto T, Nagata T, Kido J.  Modulation of calprotectin in human keratinocytes by keratinocyte growth factor and interleukin-1alpha.  Immunol. Cell Biol.  2010  88:328-33  PubMed ID: 20065999
5611  Wakabayashi H, Narita T, Suga A, Sakagami H.  Hormetic response of cultured normal and tumor cells to 2-aminotropone derivatives.  In Vivo  2010  24(1):39-44  PubMed ID: 20133973
5613  Matsuura T, Egashira Y, Nishio T, Matsumoto Y, Wada M, Koike S, Furusawa Y, Kohno R, Nishioka S, Kameoka S, Tsuchihara K, Kawashima M, Ogino T.  Apparent absence of a proton beam dose rate effect and possible differences in RBE between Bragg peak and plateau.  Med Phys  2010  37(10):5376-81  PubMed ID: 21089773
8515  Suzuki M, Tsuruoka C, Uchihori Y, Kitamura H, Liu CH.  Radiation-quality dependent cellular response in mutation induction in normal human cells.  J. Radiat. Res.  2009  50:395-9  PubMed ID: 19680011
8516  Tanaka H, Murakami Y, Ishii I, Nakata S.  Involvement of a forkhead transcription factor, FOXO1A, in UV-induced changes of collagen metabolism.  J. Investig. Dermatol. Symp. Proc.  2009  14:60-2  PubMed ID: 19675556
8673  Chizuru Tsuruoka, Masao Suzuki, Yoshiya Furusawa, Kazunori Anzai and Ryuichi Okayasu  The Influence of Mutation Induction in Normal Human Fibroblasts Irradiated with X Rays and Iron Ions  Biological Sciences in Space  2009  23:55-60 
5603  Takahashi M, Kitamoto D, Asikin Y, Takara K, Wada K.  Liposomes encapsulating Aloe vera leaf gel extract significantly enhance proliferation and collagen synthesis in human skin cell lines.  J Oleo Sci  2009  58(12):643-50  PubMed ID: 19915322
5604  Akiyama M, Okano K, Fukada Y, Okano T.  Macrophage inhibitory cytokine MIC-1 is upregulated by short-wavelength light in cultured normal human dermal fibroblasts.  FEBS Lett  2009  583(5):933-7  PubMed ID: 19302795
5606  Satoshi Onoue, Risa Nonaka, Fumiaki Sato, Chiharu Koide, Akinobu Hayashi, Hiroshi Wachi  Involvement of reactive oxygen species in abnormal tropoelastin deposition induced by UVA-photosensitizers  Journal of Health Science  2009  55:946-951 
5607  Korcyl M, Waligórski MP.  Track structure effects in a study of cell killing in normal human skin fibroblasts.  Int J Radiat Biol  2009  85(12):1101-13  PubMed ID: 19995236
5610  Nobuyuki Hamada  The Bystander Response to Heavy-Ion Radiation: Intercellular Signaling Between Irradiated and Non-Irradiated Cells  Biological Sciences in Space  2009  23:195-201 
5597  Shibayama H, Hisama M, Matsuda S, Ohtsuki M, Iwaki M.  Effect of a novel ascorbic derivative, disodium isostearyl 2-O-L-ascorbyl phosphate on human dermal fibroblasts: increased collagen synthesis and inhibition of MMP-1.  Biol Pharm Bull  2008  31(4):563-8  PubMed ID: 18379041
5598  Tsuruoka C, Suzuki M, Hande MP, Furusawa Y, Anzai K, Okayasu R.  The difference in LET and ion species dependence for induction of initially measured and non-rejoined chromatin breaks in normal human fibroblasts.  Radiat Res  2008  170(2):163-71  PubMed ID: 18666815
5599  Murayama A, Ohmori K, Fujimura A, Minami H, Yasuzawa-Tanaka K, Kuroda T, Oie S, Daitoku H, Okuwaki M, Nagata K, Fukamizu A, Kimura K, Shimizu T, Yanagisawa J.  Epigenetic control of rDNA loci in response to intracellular energy status.  Cell  2008  133(4):627-39  PubMed ID: 18485871
5600  Fujii T, Wakaizumi M, Ikami T, Saito M.  Amla (Emblica officinalis Gaertn.) extract promotes procollagen production and inhibits matrix metalloproteinase-1 in human skin fibroblasts.  J Ethnopharmacol  2008  119(1):53-7  PubMed ID: 18588964
5602  Tanaka H, Yamaba H, Kosugi N, Mizutani H, Nakata S.  Fermentable metabolite of Zymomonas mobilis controls collagen reduction in photoaging skin by improving TGF-beta/Smad signaling suppression.  Arch Dermatol Res  2008  300 Suppl 1:S57-64  PubMed ID: 18060420
9428  Chirila T, Barnard Z, Zainuddin, Harkin DG, Schwab IR, Hirst L.  Bombyx mori silk fibroin membranes as potential substrata for epithelial constructs used in the management of ocular surface disorders.  Tissue Eng Part A  2008  14(7):1203-11  PubMed ID: 18380593
3579  Sudo K, Kanno M, Miharada K, Ogawa S, Hiroyama T, Saijo K, Nakamura Y.  Mesenchymal progenitors able to differentiate into osteogenic, chondrogenic, and/or adipogenic cells in vitro are present in most primary fibroblast-like cell populations.  Stem Cells  2007  25(7):1610-7  PubMed ID: 17395773
5591  Tsuboi K, Moritake T, Tsuchida Y, Tokuuye K, Matsumura A, Ando K.  Cell cycle checkpoint and apoptosis induction in glioblastoma cells and fibroblasts irradiated with carbon beam.  J Radiat Res  2007  48(4):317-25  PubMed ID: 17548940
5594  Yasuda G, Nishi R, Watanabe E, Mori T, Iwai S, Orioli D, Stefanini M, Hanaoka F, Sugasawa K.  In vivo destabilization and functional defects of the xeroderma pigmentosum C protein caused by a pathogenic missense mutation.  Mol Cell Biol  2007  7(19):6606-14  PubMed ID: 17682058
5595  Nakanishi A, Han X, Saito H, Taguchi K, Ohta Y, Imajoh-Ohmi S, Miki Y.  Interference with BRCA2, which localizes to the centrosome during S and early M phase, leads to abnormal nuclear division.  Biochem Biophys Res Commun  2007  355(1):34-40  PubMed ID: 17286961
5596  Ohkura K.  Exploring unique structures: flexibility is a significant factor in biological activity.  Biol Pharm Bull  2007  30(6):1025-36  PubMed ID: 17541149
3431  Sugihara, Eiji, Kanai, Masayuki, Saito, Soichiro, Nitta, Takayuki, Toyoshima, Hideo, Nakayama, Keiko, Nakayama, Keiichi I, Fukasawa, Kenji, Schwab, Manfred, Saya, Hideyuki, Miwa, Masanao  Suppression of centrosome amplification after DNA damage depends on p27 accumulation.  Cancer Res  2006  66:4020-9  PubMed ID: 16618721
5585  H. Hromčíková   Damage Induction and Repair Processes in Chinese Hamster Cells and Normal Human Skin Fibroblasts Irradiated by Light Ions of Different Energies  WDS'06 Proceedings of Contributed Papers, Part III  2006  101–106 
5586  Usami N, Maeda M, Eguchi-Kasai K, Maezawa H, Kobayashi K.  Radiation-induced gamma-H2AX in mammalian cells irradiated with a synchrotron X-ray microbeam.  Radiat Prot Dosimetry  2006  122(1-4):307-9  PubMed ID: 17182605
5587  Y Kawashima et al  Molecular alterations of decorin in photoaging process  Journal of Dermatological Science Supplement  2006  2,:S51—S56 
5588  T Yoshitomi et al  The structure of artificial lipids possessing oligo(ethylene glycol) and their behavior in water  Colloids and Surfaces A: Physicochemical and Engineering Aspects  2006  284–285:276-283 
2826  Takahagi Y, Fujimura T, Miyagawa S, Nagashima H, Shigehisa T, Shirakura R, Murakami H  Production of alpha 1,3-galactosyltransferase gene knockout pigs expressing both human decay-accelerating factor and N-acetylglucosaminyltransferase III.  Mol Reprod Dev  2005  71:331-8  PubMed ID: 15806557
2901  Takami Y, Motoki T, Yamamoto I, Gohda E  Synergistic induction of hepatocyte growth factor in human skin fibroblasts by the inflammatory cytokines interleukin-1 and interferon-gamma.  Biochem Biophys Res Commun  2005  327:212-7  PubMed ID: 15629451
2937  Tsuruoka, Chizuru, Suzuki, Masao, Kanai, Tatsuaki, Fujitaka, Kazunobu  LET and ion species dependence for cell killing in normal human skin fibroblasts.  Radiat Res  2005  163:494-500  PubMed ID: 15850410
8935  Horiba N, Itoh A, Yamaguchi M, Matsumoto T, Senda A, Nakamura H.  Effects of intracanal carbon dioxide laser irradiation on cultured human fibroblasts.  Oral Surg Oral Med Oral Pathol Oral Radiol Endod  2005  100:767-71  PubMed ID: 16301161
8957  Suzuki M, Tsuruoka C, Uchihori Y, Ebisawa S, Yasuda H, Fujitaka K.  Reduction in life span of normal human fibroblasts exposed to very low-dose-rate charged particles.  Radiat. Res.  2005  164:505-8  PubMed ID: 16187757
9133  Masao Suzuki, Chizuru Tsuruoka, Nakahiro Yasuda, Kenichi Matsumoto and Kazunobu Fujitaka  Bystander cellular effects in normal human fibroblasts irradiated with low-density carbon ions  International Congress Series  2005  1276:256-257 
5584  Matsumoto Y, Machida H, Kubota N.  Preferential sensitization of tumor cells to radiation by heat shock protein 90 inhibitor geldanamycin.  J Radiat Res  2005  46(2):215-21  PubMed ID: 15988140
5575  Ohkura K, Sukeno A, Nagamune H, Kourai H.  Bridge-linked bis-quaternary ammonium anti-microbial agents: relationship between cytotoxicity and anti-bacterial activity of 5,5'-[2,2'-(tetramethylenedicarbonyldioxy)-diethyl]bis(3-alkyl-4-methylthiazonium iodide)s.  Bioorg Med Chem  2005  13(7):2579-87  PubMed ID: 15755659
5576  Ban S1, Michikawa Y, Ishikawa K, Sagara M, Watanabe K, Shimada Y, Inazawa J, Imai T.  Radiation sensitivities of 31 human oesophageal squamous cell carcinoma cell lines.  Int J Exp Pathol  2005  86(4):231-40  PubMed ID: 16045545
5577  Naru E, Suzuki T, Moriyama M, Inomata K, Hayashi A, Arakane K, Kaji K.  Functional changes induced by chronic UVA irradiation to cultured human dermal fibroblasts.  Br J Dermatol  2005  153 Suppl 2:6-12.  PubMed ID: 16280016
5578  Kiyomi EGUCHI-KASAI, Eina TSUJITA, Norie KOUDA  Detection of DNA lesion induced by heavy ion irradiation using anti gamma-H2AX antibody  The 48th Annual Meeting of The Japan Radiation Research Society  2005   
5579  Tsuchiya N, Yamanaka R, Yajima N, Homma J, Sano M, Komata T, Ikeda T, Fujimoto I, Takahashi H, Tanaka R, Ikenaka K.  Isolation and characterization of an N-linked oligosaccharide that is increased in glioblastoma tissue and cell lines.  Int J Oncol  2005  27(5):1231-9  PubMed ID: 16211217
5580  Yuko Okamoto  Recent Trends of Alternative Methods to Phototoxicity Testing in Japan  Alternatives to Animal Testing and Experimentation  2005  11:39-48 
5567  Saito Y, Shiga A, Yoshida Y, Furuhashi T, Fujita Y, Niki E.  Effects of a novel gaseous antioxidative system containing a rosemary extract on the oxidation induced by nitrogen dioxide and ultraviolet radiation.  Biosci Biotechnol Biochem  2004  68(4):781-6  PubMed ID: 15118303
5568  Yamada H, Murata M, Suzuki K, Koizumi S.  Ultraviolet irradiation increases the sensitivity of cultured human skin cells to cadmium probably through the inhibition of metallothionein gene expression.  Toxicol Appl Pharmacol  2004  200(3):251-7  PubMed ID: 15504461
5569  Kiyomi Eguchi-kasai, Eina Tsujita, Norie Kouda, Tsuneko Ikeda, Isamu Hayata  Detection of DNA lesion induced by heavy ion irradiation using anti gamma-H2AX antibody in cultured human fibroblasts  The 47th Annual Meeting of The Japan Radiation Research Society  2004   
5570  Takahashi-Yanaga F, Shiraishi F, Hirata M, Miwa Y, Morimoto S, Sasaguri T.  Glycogen synthase kinase-3beta is tyrosine-phosphorylated by MEK1 in human skin fibroblasts.  Biochem Biophys Res Commun  2004  316(2):411-5  PubMed ID: 15020233
5572  oriko Usami, Kiyomi Eguchi-kasai, Hiroshi Maezawa, Katsumi Kobayashi  Visualization of localized DNA damage produced by synchrotron X-ray microbeam in cell nuclei  The 47th Annual Meeting of The Japan Radiation Research Society  2004   
5573  Nakazono-Kusaba A, Takahashi-Yanaga F, Miwa Y, Morimoto S, Furue M, Sasaguri T.  PKC412 induces apoptosis through a caspase-dependent mechanism in human keloid-derived fibroblasts.  Eur J Pharmacol  2004  497(2):155-60  PubMed ID: 15306200
2709  Yagi, Yasuyuki, Sotani, Tomohiro, Nagao, Toshinori, Horio, Tomoyo, Yamamoto, Itaru, Gohda, Eiichi  Induction by staurosporine of hepatocyte growth factor production in human skin fibroblasts independent of protein kinase inhibition.  Biochem Pharmacol  2003  66:1797-808  PubMed ID: 14563490
5557  Hara M, Takanashi Y, Tuzuki N, Kawakami H, Toma K, Higuchi A.  Production of interferon-beta by NB1-RGB cells cultured on peptide-lipid membranes.  Cytotechnology  2003  42(1):13-20  PubMed ID: 19002924
5558  Yamada K, Takezawa J, Ezaki O.  Translesion replication in cisplatin-treated xeroderma pigmentosum variant cells is also caffeine-sensitive: features of the error-prone DNA polymerase(s) involved in UV-mutagenesis.  DNA Repair (Amst)  2003  2(8):909-24  PubMed ID: 12893087
5559  Yamada H, Koizumi S.  Effect of ultraviolet irradiation on the protein synthesis of human skin cells: a study with a monochromatic ultraviolet irradiation apparatus.  Ind Health  2003  41(2):88-93  PubMed ID: 12725468
5560  Ohkura K, Sukeno A, Yamamoto K, Nagamune H, Maeda T, Kourai H.  Analysis of structural features of bis-quaternary ammonium antimicrobial agents 4,4'-(alpha,omega-polymethylenedithio)bis (1-alkylpyridinium iodide)s using computational simulation.  Bioorg Med Chem  2003  11(23):5035-43  PubMed ID: 14604666
5561  iyomi EGUCHI-KASAI, Hiromi OHUCHI, Norie KOUDA, Eina TSUJITA, Isamu HAYATA  Effect of Heavy Ion Exposures on Cell Cycle Progression and related proteins  The 46th Annual Meeting of The Japan Radiation Research Society  2003   
5562  Higuchi A, Takanashi Y, Tsuzuki N, Asakura T, Cho CS, Akaike T, Hara M.  Production of interferon-beta by fibroblast cells on membranes prepared with RGD-containing peptides.  J Biomed Mater Res A  2003  65(3):369-78  PubMed ID: 12746884
5563  Atsushi ITO, Shin HIYAMA, Kenya FUNAYAMA  Bystander Effect in p53 Expression Using X-ray Capillary Microbeam  The 46th Annual Meeting of The Japan Radiation Research Society  2003   
5564  Shinoda K, Shibuya M, Hibino S, Ono Y, Matsuda K, Takemura A, Zou D, Kokubo Y, Takechi A, Kudoh S.  A novel matrix metalloproteinase inhibitor, FYK-1388 suppresses tumor growth, metastasis and angiogenesis by human fibrosarcoma cell line.  Int J Oncol  2003  22(2):281-8  PubMed ID: 12527923
5565  Lee SJ, Sakurai H, Oshima K, Kim SH, Saiki I.  Anti-metastatic and anti-angiogenic activities of a new matrix metalloproteinase inhibitor, TN-6b.  Eur J Cancer  2003  39(11):1632-41  PubMed ID: 12855272
5554  Higuchi A, Takanashi Y, Ohno T, Asakura T, Cho CS, Akaike T, Hara M.  Production of interferon-beta by fibroblast cells on membranes prepared by extracellular matrix proteins.  Cytotechnology.  2002  39(3):131-7  PubMed ID: 19003305
5555    Cellular response in normal human cells exposed to chronically low-dose radiation in heavy-ion radiation field  International Congress Series  2002  1236:323-326 
5556  Fujisawa T, Igeta K, Odake S, Morita Y, Yasuda J, Morikawa T.  Highly water-soluble matrix metalloproteinases inhibitors and their effects in a rat adjuvant-induced arthritis model.  Bioorg Med Chem  2002  10(8):2569-81  PubMed ID: 12057646
5552  Ando K, Furusawa Y, Suzuki M, Nojima K, Majima H, Koike S, Aoki M, Shimizu W, Futami Y, Ogino T, Murayama S, Ikeda H.  Relative biological effectiveness of the 235 MeV proton beams at the National Cancer Center Hospital East.  J Radiat Res  2001  42(1):79-89  PubMed ID: 11393892
5553  Kobayashi H, Higashiyama M, Minamigawa K, Tanisaka K, Takano T, Yokouchi H, Kodama K, Hata T.  Examination of in vitro chemosensitivity test using collagen gel droplet culture method with colorimetric endpoint quantification.  Jpn J Cancer Res  2001  92(2):203-10  PubMed ID: 11223550
2478  Suzuki M, Kase Y, Yamaguchi H, Kanai T, Ando K  Relative biological effectiveness for cell-killing effect on various human cell lines irradiated with heavy-ion medical accelerator in Chiba (HIMAC) carbon-ion beams.  Int J Radiat Oncol Biol Phys  2000  48:241-50  PubMed ID: 10924995
2479  Suzuki M, Kase Y, Kanai T, Ando K  Change in radiosensitivity with fractionated-dose irradiation of carbon-ion beams in five different human cell lines.  Int J Radiat Oncol Biol Phys  2000  48:251-8  PubMed ID: 10924996
5545  Higuchi A, Yoshida M, Ohno T, Asakura T, Hara M.  Production of interferon-beta in a culture of fibroblast cells on some polymeric films.  Cytotechnology  2000  34(1-2):165-73  PubMed ID: 19003391
5546  Nagamune H, Maeda T, Ohkura K, Yamamoto K, Nakajima M, Kourai H.  Evaluation of the cytotoxic effects of bis-quaternary ammonium antimicrobial reagents on human cells.  Toxicol In Vitro  2000  14(2):139-47  PubMed ID: 10793292
5547  Orui H, Imaizumi S, Ogino T, Motoyama T.  Effects of bone morphogenetic protein-2 on human tumor cell growth and differentiation: a preliminary report.  J Orthop Sci  2000  5(6):600-4  PubMed ID: 11180925
5548  Kim JK, Ryll R, Ishizuka Y, Kato S.  Identification of cDNAs encoding two novel nuclear proteins, IMUP-1 and IMUP-2, upregulated in SV40-immortalized human fibroblasts.  Gene  2000  257(2):327-34  PubMed ID: 11080599
5549  Izumi M, Yanagi K, Mizuno T, Yokoi M, Kawasaki Y, Moon KY, Hurwitz J, Yatagai F, Hanaoka F.  The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase.  Nucleic Acids Res  2000  28(23):4769-77  PubMed ID: 11095689
5550  Yagi A, Sato Y, Shimomura K, Akasaki K, Tsuji H.  Distribution of verectin in Aloe vera leaves and verectin contents in clonally regenerated plants and the commercial gel powders by immunochemical screening.  Planta Med  2000  66(2):180-2  PubMed ID: 10763598
5551  Masutani C, Kusumoto R, Yamada A, Yuasa M, Araki M, Nogimori T, Yokoi M, Eki T, Iwai S, Hanaoka F.  Xeroderma pigmentosum variant: from a human genetic disorder to a novel DNA polymerase.  Cold Spring Harb Symp Quant Biol  2000  65:71-80  PubMed ID: 12760022
2358  Kimura M, Matsuda Y, Yoshioka T, Okano Y  Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3.  J Biol Chem  1999  274:7334-40  PubMed ID: 10066797
5533  Masutani C, Kusumoto R, Yamada A, Dohmae N, Yokoi M, Yuasa M, Araki M, Iwai S, Takio K, Hanaoka F.  The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta.  Nature  1999  399(6737):700-4  PubMed ID: 10385124
5542  Egawa M, Kohno Y, Kumano Y.  Oxidative effects of cigarette smoke on the human skin.  Int J Cosmet Sci  1999  21(2):83-98  PubMed ID: 18505533
3514  Katsumata K, Ikeda H, Sato M, Ishizu A, Kawarada Y, Kato H, Wakisaka A, Koike T, Yoshiki T.  Cytokine regulation of env gene expression of human endogenous retrovirus-R in human vascular endothelial cells.  Clin Immunol  1999  93(1):75-80  PubMed ID: 10497013
2357  Suzuki M, Kase Y, Kanai T, Ando K  Correlation between cell death and induction of non-rejoining PCC breaks by carbon-ion beams.  Adv Space Res  1998  22:561-8  PubMed ID: 11542786
5583  Tsuboi K1, Tsuchida Y, Nose T, Ando K.  Cytotoxic effect of accelerated carbon beams on glioblastoma cell lines with p53 mutation: clonogenic survival and cell-cycle analysis.  Int J Radiat Biol  1998  74(1):71-9  PubMed ID: 9687977
5531  H Kojima, A Sato, A Hanamura, T Katada and H Konisho  Evaluation of skin irritation in a reconstituted human dermal model (3-D model) using water insoluble fatty acids, fatty alcohols and hydrocarbons  Altern Animal Test EXperiment  1998  5:201-210 
5537  Takaoka AS, Yamada T, Gotoh M, Kanai Y, Imai K, Hirohashi S.  Cloning and characterization of the human beta4-integrin gene promoter and enhancers.  J Biol Chem  1998  273(50):33848-55  PubMed ID: 9837976
5540  Wu YL, Gohda E, Iwao M, Matsunaga T, Nagao T, Takebe T, Yamamoto I.  Stimulation of hepatocyte growth factor production by ascorbic acid and its stable 2-glucoside.  Growth Horm IGF Res  1998  8(5):421-8  PubMed ID: 10984304
5530  Yagi A, Egusa T, Arase M, Tanabe M, Tsuji H.  Isolation and characterization of the glycoprotein fraction with a proliferation-promoting activity on human and hamster cells in vitro from Aloe vera gel.  Planta Med  1997  63(1):18-21  PubMed ID: 9063091
5535  Kawaguchi Y, Tanaka H, Okada T, Konishi H, Takahashi M, Ito M, Asai J.  Effect of reactive oxygen species on the elastin mRNA expression in cultured human dermal fibroblasts.  Free Radic Biol Med  1997  23(1):162-5  PubMed ID: 9165309
5538  Sato T, Kirimura Y, Mori Y.  The co-culture of dermal fibroblasts with human epidermal keratinocytes induces increased prostaglandin E2 production and cyclooxygenase 2 activity in fibroblasts.  J Invest Dermatol  1997  109(3):334-9  PubMed ID: 9284101
5526  Yagi A, Ishizu T, Okamura N, Noguchi S, Itoh H.  Growth of cultured human bronchiogenic epithelioid CCD-14 Br cells and dermal fibroblasts, NB1 RGB treated with ginseng tetrapeptide and its isomer.  Planta Med  1996  62(2):115-8  PubMed ID: 8657740
5534  Kawaguchi Y, Tanaka H, Okada T, Konishi H, Takahashi M, Ito M, Asai J.  The effects of ultraviolet A and reactive oxygen species on the mRNA expression of 72-kDa type IV collagenase and its tissue inhibitor in cultured human dermal fibroblasts.  Arch Dermatol Res.  1996  288(1):39-44  PubMed ID: 8750933
5541  Yamada K, Kameyama Y, Inoue S.  An improved method of alkaline sucrose density gradient sedimentation to detect less than one lesion per 1 Mb DNA.  Mutat Res  1996  364(2):125-31  PubMed ID: 8879278
2011  Matsuki H, Fujimoto N, Iwata K, Knäuper V, Okada Y, Hayakawa T.  A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 8 (neutrophil collagenase) using monoclonal antibodies.  Clin Chim Acta  1996  44(2):129-43  PubMed ID: 8714431
1973  Kojima, H., Hanamura, A., Sato, A., and Konishi, H.  Comparison of Cytotoxicity of Surfactants on a Range of Mammalian Cells Cultured under Various Conditions  Alternatives to Animal Testing and Experimentation(AATEX)  1995  3:111-120 
2012  Kojima, H., Hanamura, A., Miyamoto, S., Sato, A., Konishi, H., and Yoshimura, I.  Evaluation of Seven Alternative Assays on the Main Ingredients in Cosmetics as Predictors of Draize Eye Irritation Scores  Toxicol in Vitro  1995  9:333-340  PubMed ID: 20650095
1970  Kondo H, Yonezawa Y  Fetal-adult phenotype transition, in terms of the serum dependency and growth factor requirements, of human skin fibroblast migration.  Exp Cell Res  1995  220:501-4  PubMed ID: 7556460
1808  Matsunaga T, Gohda E, Takebe T, Wu, Y L, Iwao M, Kataoka H, Yamamoto I  Expression of hepatocyte growth factor is up-regulated through activation of a cAMP-mediated pathway.  Exp Cell Res  1994  210:326-35  PubMed ID: 7507855
2277  Gohda E, Matsunaga T, Kataoka H, Takebe T, Yamamoto I  Induction of hepatocyte growth factor in human skin fibroblasts by epidermal growth factor, platelet-derived growth factor and fibroblast growth factor.  Cytokine  1994  6:633-40  PubMed ID: 7534491
1883  Fujimoto N, Hosokawa N, Iwata K, Shinya T, Okada Y, Hayakawa T  A one-step sandwich enzyme immunoassay for inactive precursor and complexed forms of human matrix metalloproteinase 9 (92 kDa gelatinase/type IV collagenase, gelatinase B) using monoclonal antibodies.  Clin Chim Acta  1994  231:79-88  PubMed ID: 7704951
1841  Kobayashi S, Hirota Y, Sayato-Suzuki J, Takehana M, Nishimura H, Nishimura N, Tohyama C  Possible role of metallothionein in the cellular defense mechanism against UVB irradiation in neonatal human skin fibroblasts.  Photochem Photobiol  1994  59:650-6  PubMed ID: 8066125
5528  Yamada K, Itoh R.  Involvement of DNA polymerase delta and/or epsilon in joining UV-induced DNA single strand breaks in human fibroblasts (comparison of effects of butylphenyldeoxyguanosine with aphidicolin).  Biochim Biophys Acta  1994  1219(2):302-6  PubMed ID: 7918625
1811  Fujimoto N, Mouri N, Iwata K, Ohuchi E, Okada Y, Hayakawa T  A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 2 (72-kDa gelatinase/type IV collagenase) using monoclonal antibodies.  Clin Chim Acta  1993  221:91-103  PubMed ID: 8149645
1810  Fujimoto N, Zhang J, Iwata K, Shinya T, Okada Y, Hayakawa T  A one-step sandwich enzyme immunoassay for tissue inhibitor of metalloproteinases-2 using monoclonal antibodies.  Clin Chim Acta  1993  220:31-45  PubMed ID: 8287559
1782  Zhang J, Fujimoto N, Iwata K, Sakai T, Okada Y, Hayakawa T  A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 1 (interstitial collagenase) using monoclonal antibodies.  Clin Chim Acta  1993  219:1-14  PubMed ID: 8306449
1781  Obata K, Iwata K, Okada Y, Kohrin Y, Ohuchi E, Yoshida S, Shinmei M, Hayakawa T  A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 3 (stromelysin-1) using monoclonal antibodies.  Clin Chim Acta  1992  211:59-72  PubMed ID: 1281763

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5681  千葉 圭介, 鈴木 梓馬, *宮田 昌悟  UV光の照射が生体外皮膚モデルの材料特性に与える影響  日本機械学会年次大会  2017   
5685  足立 浩章, 田中 浩, 八代 洋一, 中田 悟, 平嶋 尚英  UVA照射による細胞膜コレステロールの減少は真皮線維芽細胞においてコラーゲン代謝に影響する  日本香粧品学会誌  2017  41:181-187 
5674  千葉 圭介, 宮田 昌悟  UV 光の照射が生体外真皮モデルの材料特性に与える影響  日本機械学会年次大会  2016   
5675  山羽 宏行, 田中 浩, 八代 洋一, 中田 悟  紫外線による真皮線維芽細胞における小胞体機能変化と皮膚光老化との関連性  日本香粧品学会誌  2016  40:87-92 
5676  鈴木 梓馬, 宮田 昌悟  三次元培養真皮モデルの収縮過程に及ぼす細胞成長因子の影響  日本機械学会年次大会  2016   
5677  村上 祐子, 足立 浩章, 田中 浩, 八代 洋一, 中田 悟  紫外線によるトランスポゾンの活性化に着目した皮膚老化研究  日本香粧品学会誌  2016  40:163-169 
5657  山田勝久 ・鈴木正宏1 ・野村道康1 ・柴田雄次2 ・今田千秋2  種々のカルシウム/マグネシウム比で培養したヒト線維芽細胞の活性と海洋深層水添加効果  Deep Ocean Water Research  2015  15(3): 99‒106 
5662  村上 祐子, 足立 浩章, 田中 浩, 八代 洋一, 中田 悟  眼輪筋に着目した目もとの加齢変化のメカニズム解析  日本化粧品技術者会誌  2015  49:36-41 
5609  村上 祐子, 足立 浩章, 田中 浩, 八代 洋一, 中田 悟  酸化ストレスによる真皮由来Neuregulin 1(NRG1)を介したメラニン生成促進  日本香粧品学会誌  2015  39:95-102 
5664  足立 浩章, 村上 祐子, 堀田 直和, 田中 浩, 中田 悟  Stratifinに着目した皮膚老化メカニズムに関する研究  日本化粧品技術者会誌  2015  49:211-217 
5639  村上 祐子, 足立 浩章, 坂井田 勉, 田中 浩, 八代 洋一, 中田 悟  加齢にともなうⅢ型コラーゲン/Ⅰ型コラーゲンの比率の減少メカニズム  日本化粧品技術者会誌  2013  47:278-284 
5349  大戸茂弘  物質の輸送・代謝リズムの分子時計機構の解明と操作要因の開発  コスメトロジー研究報告  2012  20:88-92 
5614  玉利 勇樹, 菓子野 元郎, 渡邉 正己  ヒト細胞のミトコンドリア制御機構におけるバイスタンダー効果の影響  日本放射線影響学会第54回大会  2011   
5618  アッサバプロンポーン ナロンチャイ , 宇佐美 徳子, 舟山 知夫, 横田 裕一郎, 武藤 泰子, 池田 裕子, 内堀 幸夫, 劉 翠華, 小林 克己, 小林 泰彦, ヘイ トム, アザム エドアー, 鈴木 雅雄  低LETおよび高LET放射線マイクロビーム照射で誘導されるバイスタンダー効果への細胞間情報伝達機構の関与  日本放射線影響学会第54回大会  2011   
5524  鶴間 佳美, 丸山 広恵, 荒木 陽子  ローヤルゼリータンパク質アピシンのヒト由来皮膚線維芽細胞株およびマウス由来骨芽細胞様細胞株に及ぼす作用  日本食品科学工学会誌  2011  58:121-126 
5612  和田 麻美, 松本 孔貴, 鶴岡 千鶴, 鈴木 雅雄, 古澤 佳也, 松藤 成弘  重粒子線少分割照射における腫瘍及び正常細胞の生存率と初期修復  日本放射線影響学会第53回大会  2010   
5608  大野 克利, 溝田 泰生, 東 幸雅, 仲野 茂, 山田 敏広  p53R2遺伝子発現に基づくヒト細胞遺伝毒性試験法(第6報)  第36回日本トキシコロジー学会学術年会  2009   
5601  江口 清美, 辻田 瑛那, 林 京子, 森 雅彦  重粒子線誘発DNA障害の解析-III  日本放射線影響学会第51回大会  2008   
5592  小田 洋, 溝口 亜紗子, 田中 信治  コラゲナーゼ産生を抑制するコエンザイムQ10配合リポソーム  膜  2007  32:54-56 
5566  江口 清美, 辻田 瑛那, 林 京子, 森 雅彦  重粒子線誘発DNA障害の解析-II  日本放射線影響学会大会講演要旨集  2007   
5589  江口 清美, 辻田 瑛那, 森 雅彦  重粒子線誘発DNA障害の解析  日本放射線影響学会第49回大会  2006   
5590  山口 力, 橋 克俊, 高村 泰輝, 藤山 浩樹, 野澤 貴浩, 伊藤 敦  X線マイクロビームによるp53発現のバイスタンダー効果の検証:Lindaneによるギャップジャンクション機能抑制の効果  日本放射線影響学会第49回大会  2006   
5593  東 美香, 廣島 佑香, 木戸 淳一, 片岡 正俊, 永田 俊彦  IL-1αとkeratinocyte growth factorによるカルプロテクチン発現の相反制御  日本歯周病学会学術大会 プログラムおよび講演抄録集  2006   
5581  岡本 裕子  局所刺激性試験代替法の開発と応用  日本薬理学雑誌  2005  125:350-357 
5582  南久美子, 西本弥生, 山崎 新, 浅賀 三之助, 森本 正則,, 駒井 功一郎   白ウコン葉に含まれる生理活性物質  近畿大学資源再生研究所報告  2005  3:49-56 
5543  宇佐美徳子, 小林 克己  低線量放射線の生物影響研究のための放射光 X 線マイクロビーム細胞照射装置  実験技術  2004  17:213-219 
5571  原 万里子  様々な高分子膜上に培養した動物細胞の生理機能  膜  2004  29:50-57 
5574  佐々木 茂乃, 小林 敏明, 熊谷 重則, 檜山 哲夫  熱ショックを与えた藍藻抽出物の線維芽細胞増殖作用およびその他の有用性  日本化粧品技術者会誌  2004  38:34-38 
5532  田中 信治, 橋爪 論, 土井 浩, 山本 昇  リゾリン脂質による皮膚のヒアルロン酸産生促進効果 (第1報)  日本油化学会誌  1997  469:969-975 
5536  田中 信治, 橋爪 論, 土井 浩, 山本 昇  リゾリン脂質による皮膚のヒアルロン酸産生促進効果 (第2報)  日本油化学会誌  1997  46:977-984 
5539  肥塚 正博, 只左 弘治, 原 聡, 小田 幸子, 谷坂 圭造, 茅原 紘  デキストラン硫酸を用いた初代ヒト癌細胞の選択的培養方法  日本農芸化学会誌  1993  67:1591-1597 



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