検索画面
細胞材料開発室サイト

戻る 戻る
RCB0098 : A549  update : 2018/07/06
細胞特性(Comment:英)Lung carcinoma, refer to ATCC CCL185
細胞特性(日)ヒト肺癌細胞の一つで、1972年に樹立された。制ガン剤のスクリーニングに利用される。
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)Basically, there is no restriction regarding academic use.
使用条件(日)学術研究における利用につきましては原則として使用制限はありません。
備考(英)
備考(日)
提供申込書類 依頼書C-0001.pdf   同意書(非営利)C-0003.pdf   同意書(営利)C-0003p.pdf  
提供同意書は、使用機関及び使用内容に応じて二種類あります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は別途ご相談(cellbank.brc@riken.jp)を承ります。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 Abe, Shin-ichiro
樹立者 Giard, D. J.
寄託日 1986
動物種 human < Mammals
属名 Homo
種名 sapiens
性別 Male
採取組織 lung
病歴 adenocarcinoma
細胞分類 cancer
細胞寿命 infinite
細胞形態 epithelial-like
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 DMEM (low glucose) + 10% FBS
抗生物質 Free
継代方法 0.25% trypsin
継代密度 1 : 8 split
継代・培地交換頻度 Subculture : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ (-)
個体識別検査 OK
アイソザイム検査 LD, NP, G6PD
染色体検査 59-64(50) : 59(3),60(2),61(8),62(21),63(14),64(2)
画像情報
寄託時情報
ロット情報
文献情報 Reference(英) 2件
Reference(日) 1件
利用者成果(英) 88件
利用者成果(日) 0件

トップへページトップへ
Reference(英)
2114  Honma M, Hayashi M, Ohno T, Mizusawa H, Saijo K, Sofuni T.  Heterogeneity of the Y chromosome following long-term culture of the human lung cancer cell line A549.  In Vitro Cell Dev Biol Anim  1996  32(5):262-4  PubMed ID: 8792154
4609  Lieber M, Smith B, Szakal A, Nelson-Rees W, Todaro G.  A continuous tumor-cell line from a human lung carcinoma with properties of type II alveolar epithelial cells.  Int J Cancer  1976  17(1):62-70  PubMed ID: 175022

トップへページトップへ
Reference(日)
1708  清水信義  ヒト腺癌 : A549  生体の科学  1992  43:395 

トップへページトップへ
利用者成果(英)
11371  Aki T, Unuma K, Noritake K, Hirayama N, Funakoshi T, Uemura K.  Formation of high molecular weight p62 by CORM-3.  PLoS ONE  2019    PubMed ID: 30620762
4061  Kobayashi A, Autsavapromporn N, Ahmad TAFT, Oikawa M, Homma-Takeda S, Furusawa Y, Wang J, Konishi T.   BYSTANDER WI-38 CELLS MODULATE DNA DOUBLE-STRAND BREAK REPAIR IN MICROBEAM-TARGETED A549 CELLS THROUGH GAP JUNCTION INTERCELLULAR COMMUNICATION.  Radiat Prot Dosimetry   2019    PubMed ID: 30535060
4759  Halil I. Ciftci, Mohamed O. Radwan, Safiye E. Ozturk, N. Gokce Ulusoy, Ece Sozer, Doha E. Ellakwa, Zeynep Ocak, Mustafa Can, Taha F.S. Ali, Howaida I. Abd-Alla, Nurettin Yayli, Hiroshi Tateishi, Masami Otsuka and Mikako Fujita  Design, Synthesis and Biological Evaluation of Pentacyclic Triterpene Derivatives: Optimization of Anti-ABL Kinase Activity  Molecules  2019  24:3535 
5357  Takahashi D, Moriyama J, Nakamura T, Miki E, Takahashi E, Sato A, Akaike T, Itto-Nakama K, Arimoto H.  AUTACs: Cargo-Specific Degraders Using Selective Autophagy.  Mol Cell  2019  76(5):797-810  PubMed ID: 31606272
11675  Dr. Ze Yuan, Prof. Toshihiro Nakamura, Dr. Shanmugavel Chinnathambi, Prof. Yanbai Pu, Prof. Naoto Shirahata, Prof. Kiyoto Matsuishi  Facile Formation of Stable Water‐Dispersed Luminescent Silicon Nanocrystals by Laser Processing in Liquid: Toward Fluorescent Labeling for Bio‐Imaging  CHEMNANOMAT  2019   
9502  Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, Ito S, Kurosawa K, Yamaguchi K, Sugiura Y, Takizaki H, Yamashita Y, Katakura R, Sato I, Kawai M, Okada Y, Watanabe H, Kondoh G, Matsumoto S, Kishimoto A, Obata M, Matsumoto M, Fukuhara T, Motohashi H, Suematsu M, Komatsu M, Nakayama KI, Watanabe T, Soga T, Shima H, Maemondo M, Tanuma N.  PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth.  Cancer Cell  2018  33:355-367.e7  PubMed ID: 29533781
10702  Horibe S, Tanahashi T, Kawauchi S, Murakami Y, Rikitake Y.  Mechanism of recipient cell-dependent differences in exosome uptake.  BMC Cancer  2018  18:47  PubMed ID: 29306323
10803  Sugimoto M, Kitagawa Y, Yamada M, Yajima Y, Utoh R, Seki M.  Micropassage-embedding composite hydrogel fibers enable quantitative evaluation of cancer cell invasion under 3D coculture conditions.  Lab Chip  2018  18:1378-1387  PubMed ID: 29658964
10805  Tahara K, Kobayashi M, Yoshida S, Onodera R, Inoue N, Takeuchi H.  Effects of cationic liposomes with stearylamine against virus infection.  Int J Pharm  2018  543:311-317  PubMed ID: 29625169
11049  Sasaki M, Anindita PD, Ito N, Sugiyama M, Carr M, Fukuhara H, Ose T, Maenaka K, Takada A, Hall WW, Orba Y, Sawa H  The Role of Heparan Sulfate Proteoglycans as an Attachment Factor for Rabies Virus Entry and Infection.  J Infect Dis  2018  217(11):1740-1749  PubMed ID: 29529215
11076  Toyama K, Nomura W, Kobayakawa T, Tamamura H.  Delivery of a Proapoptotic Peptide to EGFR-Positive Cancer Cells by a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR.  Bioconjug. Chem.  2018  29(6):2050-2057  PubMed ID: 29763296
11177  Kobayashi A, Konishi T.  Radiation quality effects alteration in COX-2 pathway to trigger radiation-induced bystander response in A549 lung carcinoma cells.  J. Radiat. Res.  2018  59(6):754-759  PubMed ID: 30124879
11164  Mogi K, Hayashida K, Yamamoto T.  Damage-less Handling of Exosomes Using an Ion-depletion Zone in a Microchannel.  Anal Sci  2018  34(8):875-880  PubMed ID: 30101880
4072    MiR-301a/b function as oncomiRs in non-small-cell lung cancer  Integr Mol Med  2018  5: 1-6 
4097  Sasaki M, Anindita PD, Phongphaew W, Carr M, Kobayashi S, Orba Y, Sawa H.  Development of a rapid and quantitative method for the analysis of viral entry and release using a NanoLuc luciferase complementation assay.  Virus Res  2018  243:69-74  PubMed ID: 29074234
4132  Abd El-Hafeez AA, Fujimura T, Kamei R, Hirakawa N, Baba K, Ono K, Kawamoto S.  Synergistic tumor suppression by a Perilla frutescens-derived methoxyflavanone and anti-cancer tyrosine kinase inhibitors in A549 human lung adenocarcinoma.  Cytotechnology  2018    PubMed ID: 28756527
4133  Kanemaru R, Takahashi F, Kato M, Mitsuishi Y, Tajima K, Ihara H, Hidayat M, Wirawan A, Koinuma Y, Hayakawa D, Yagishita S, Ko R, Sato T, Harada N, Kodama Y, Nurwidya F, Sasaki S, Niwa SI, Takahashi K.  Dasatinib Suppresses TGFβ-Mediated Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells and Inhibits Pulmonary Fibrosis.  Lung  2018    PubMed ID: 29926178
4134  Sato Y, Yoshino H, Kazama Y, Kashiwakura I.  Involvement of caspase‑8 in apoptosis enhancement by cotreatment with retinoic acid‑inducible gene‑I‑like receptor agonist and ionizing radiation in human non‑small cell lung cancer.  Mol Med Rep  2018    PubMed ID: 30320341
4135  Horibe S, Kawauchi S, Tanahashi T, Sasaki N, Mizuno S, Rikitake Y.  CD44v-dependent upregulation of xCT is involved in the acquisition of cisplatin-resistance in human lung cancer A549 cells.  Biochem. Biophys. Res. Commun.  2018    PubMed ID: 30448176
4136  Sakaizawa T, Matsumura T, Fujii C, Hida S, Toishi M, Shiina T, Yoshida K, Hamanaka K, Ito KI, Taniguchi S.  Potential Role of ASC, a Proapoptotic Protein, for Determining the Cisplatin Susceptibility of Lung Cancer Cells.  Tohoku J. Exp. Med.  2018    PubMed ID: 29459573
4137  Hayashi Y, Higashi T, Motoyama K, Jono H, Ando Y, Arima H.  In vitro and in vivo siRNA delivery to hepatocyte utilizing ternary complexation of lactosylated dendrimer/cyclodextrin conjugates, siRNA and low-molecular-weight sacran.  Int. J. Biol. Macromol.  2018    PubMed ID: 28964842
4138  Morimoto Y, Kishida T, Kotani SI, Takayama K, Mazda O.  Interferon-β signal may up-regulate PD-L1 expression through IRF9-dependent and independent pathways in lung cancer cells.  Biochem. Biophys. Res. Commun.  2018    PubMed ID: 30446226
4139  Sakashita M, Sakashita S, Murata Y, Shiba-Ishii A, Kim Y, Matsuoka R, Nakano N, Sato Y, Noguchi M.  High expression of ovarian cancer immunoreactive antigen domain containing 2 (OCIAD2) is associated with poor prognosis in lung adenocarcinoma.  Pathol. Int.  2018    PubMed ID: 30320419
4141  Suzuki S, Okada M, Takeda H, Kuramoto K, Sanomachi T, Togashi K, Seino S, Yamamoto M, Yoshioka T, Kitanaka C.  Involvement of GLUT1-mediated glucose transport and metabolism in gefitinib resistance of non-small-cell lung cancer cells.  Oncotarget  2018    PubMed ID: 30220973
4468  Sasaki K, Miyashita Y, Asai D, Funamoto D, Sato K, Yamaguchi Y, Mishima Y, Iino T, Takaishi S, Nagano J, Kishimura A, Mori T, Katayama Y.  A peptide inhibitor of antibody-dependent cell-mediated cytotoxicity against EGFR/folate receptor-α double positive cells.  Medchemcomm  2018  9(5):783-788  PubMed ID: 30108967
10274  Akihisa T, Yokokawa S, Ogihara E, Matsumoto M, Zhang J, Kikuchi T, Koike K, Abe M.  Melanogenesis-Inhibitory and Cytotoxic Activities of Limonoids, Alkaloids, and Phenolic Compounds from Phellodendron amurense Bark.  Chem. Biodivers.  2017  14:  PubMed ID: 28425165
10280  Seike M, Kim CH, Zou F, Noro R, Chiba M, Ishikawa A, Κunugi S, Kubota K, Gemma A.  AXL and GAS6 co-expression in lung adenocarcinoma as a prognostic classifier.  Oncol. Rep.  2017  37:3261-3269  PubMed ID: 28440492
10381  Kobayashi A, Tengku Ahmad TAF, Autsavapromporn N, Oikawa M, Homma-Takeda S, Furusawa Y, Wang J, Konishi T.  Enhanced DNA double-strand break repair of microbeam targeted A549 lung carcinoma cells by adjacent WI38 normal lung fibroblast cells via bi-directional signaling.  Mutat. Res.  2017  803-805:1-8  PubMed ID: 28689138
10924    Biocompatible CdSe/ZnS quantum dot micelles for long-term cell imaging without alteration to the native structure of the blood plasma protein human serum albumin  RSC Adv  2017  7, 2392-2402 
4526  Yusuke Hiraku, Yoshihiro Nishikawa, Ning Ma, Tahmina Afroza, Kosuke Mizobuchi, Ryo Ishiyama, Yuta Matsunaga, Takamichi Ichinose, Shosuke Kawanishi, Mariko Murata  Nitrative DNA damage induced by carbon-black nanoparticles in macrophages and lung epithelial cells  Mutation Research/Genetic Toxicology and Environmental Mutagenesis  2017  818, 7-16  PubMed ID: 28477879
7050  Kajiura K, Masuda K, Naruto T, Kohmoto T, Watabnabe M, Tsuboi M, Takizawa H, Kondo K, Tangoku A, Imoto I.  Frequent silencing of the candidate tumor suppressor TRIM58 by promoter methylation in early-stage lung adenocarcinoma.  Oncotarget  2016  8:2890-2905  PubMed ID: 27926516
7063  Morita S, Noguchi H, Horii T, Nakabayashi K, Kimura M, Okamura K, Sakai A, Nakashima H, Hata K, Nakashima K, Hatada I.  Targeted DNA demethylation in vivo using dCas9-peptide repeat and scFv-TET1 catalytic domain fusions.  Nat. Biotechnol.  2016  34:1060-1065  PubMed ID: 27571369
9581  Shimobaba S, Taga S, Akizuki R, Hichino A, Endo S, Matsunaga T, Watanabe R, Yamaguchi M, Yamazaki Y, Sugatani J, Ikari A.  Claudin-18 inhibits cell proliferation and motility mediated by inhibition of phosphorylation of PDK1 and Akt in human lung adenocarcinoma A549 cells.  Biochim. Biophys. Acta  2016  1863:1170-8  PubMed ID: 26919807
9774  Nagashima S, Kobayashi T, Tanaka T, Tanggis , Jirintai S, Takahashi M, Nishizawa T, Okamoto H.  Analysis of adaptive mutations selected during the consecutive passages of hepatitis E virus produced from an infectious cDNA clone.  Virus Res.  2016  223:170-80  PubMed ID: 27485920
5653  Tabata A, Ohkubo Y, Anyoji N, Hojo K, Tomoyasu T, Tatematsu Y, Ohkura K, Nagamune H.  Development of a Sortase A-mediated Peptide-labeled Liposome Applicable to Drug-delivery Systems.  Anticancer Res  2015  35(8):4411-7  PubMed ID: 26168480
6014  Nagashima S, Jirintai S, Takahashi M, Kobayashi T, Tanggis, Nishizawa T, Kouki T, Yashiro T, Okamoto H.  Hepatitis E virus egress depends on the exosomal pathway, with secretory exosomes derived from multivesicular bodies.  J Gen Virol  2014  95(Pt 10):2166-75  PubMed ID: 24970738
3914  Kazuhiro Hiyama, Hirofumi Matsui, Masato Tamura, Osamu Shimokawa, Mariko Hiyama, Tsuyoshi Kaneko, Yumiko Nagano, Ichinosuke Hyodo, Junko Tanaka, Yoshihiro Miwa, Tetsuo Ogawa, Takeo Nakanishi and Ikumi Tamai  Cancer cells uptake porphyrins via heme carrier protein 1  Journal of Porphyrins and Phthalocyanines  2013  17:36-43 
5376  Murata M, Nakano K, Tahara K, Tozuka Y, Takeuchi H.  Pulmonary delivery of elcatonin using surface-modified liposomes to improve systemic absorption: polyvinyl alcohol with a hydrophobic anchor and chitosan oligosaccharide as effective surface modifiers.  Eur J Pharm Biopharm  2012  80(2):340-6  PubMed ID: 22036988
5620  Tabata A, Ohkubo Y, Sakakura E, Tomoyasu T, Ohkura K, Nagamune H.  Investigation of a bacterial pore-forming chimera toxin for application as a novel drug-delivery system tool.  Anticancer Res  2012  32(6):2323-9  PubMed ID: 22641669
6432  Jirintai S, Jinshan, Tanggis, Manglai D, Mulyanto, Takahashi M, Nagashima S, Kobayashi T, Nishizawa T, Okamoto H.  Molecular analysis of hepatitis E virus from farm rabbits in Inner Mongolia, China and its successful propagation in A549 and PLC/PRF/5 cells.  Virus Res  2012  170(1-2):126-37  PubMed ID: 23041252
7717  Miura T, Kakehashi H, Shinkai Y, Egara Y, Hirose R, Cho AK, Kumagai Y.  GSH-mediated S-transarylation of a quinone glyceraldehyde-3-phosphate dehydrogenase conjugate.  Chem. Res. Toxicol.  2011  24:1836-44  PubMed ID: 21827172
7806  Hoshino A, Ishii G, Ito T, Aoyagi K, Ohtaki Y, Nagai K, Sasaki H, Ochiai A.  Podoplanin-positive fibroblasts enhance lung adenocarcinoma tumor formation: podoplanin in fibroblast functions for tumor progression.  Cancer Res.  2011  71:4769-79  PubMed ID: 21610106
7900  Tahara K, Sakai T, Yamamoto H, Takeuchi H, Hirashima N, Kawashima Y.  Improvements in transfection efficiency with chitosan modified poly(DL-lactide-co-glycolide) nanospheres prepared by the emulsion solvent diffusion method, for gene delivery.  Chem. Pharm. Bull.  2011  59:298-301  PubMed ID: 21372409
7951  Okamoto H.  Hepatitis E virus cell culture models.  Virus Res.  2011  161:65-77  PubMed ID: 21316402
5322  Akihisa T, Kikuchi T, Nagai H, Ishii K, Tabata K, Suzuki T.  4-Hydroxyderricin from Angelica keiskei roots induces caspase-dependent apoptotic cell death in HL60 human leukemia cells.  J Oleo Sci  2011  60(2):71-7  PubMed ID: 21263202
5863  Yoshii Y, Waki A, Yoshida K, Kakezuka A, Kobayashi M, Namiki H, Kuroda Y, Kiyono Y, Yoshii H, Furukawa T, Asai T, Okazawa H, Gelovani JG, Fujibayashi Y.  The use of nanoimprinted scaffolds as 3D culture models to facilitate spontaneous tumor cell migration and well-regulated spheroid formation.  Biomaterials  2011  32(26):6052-8  PubMed ID: 21640378
6008  Horie M, Kato H, Endoh S, Fujita K, Nishio K, Komaba LK, Fukui H, Nakamura A, Miyauchi A, Nakazato T, Kinugasa S, Yoshida Y, Hagihara Y, Morimoto Y, Iwahashi H.  Evaluation of cellular influences of platinum nanoparticles by stable medium dispersion.  Metallomics  2011  3(11):1244-52  PubMed ID: 21804981
8043  Tada E, Toyomura K, Nakamura H, Sasaki H, Saito T, Kaneko M, Okuma Y, Murayama T.  Activation of ceramidase and ceramide kinase by vanadate via a tyrosine kinase-mediated pathway.  J. Pharmacol. Sci.  2010  114:420-32  PubMed ID: 21127389
8125  Ishigaki Y, Nakamura Y, Takehara T, Nemoto N, Kurihara T, Koga H, Nakagawa H, Takegami T, Tomosugi N, Miyazawa S, Kuwabata S.  Ionic liquid enables simple and rapid sample preparation of human culturing cells for scanning electron microscope analysis.  Microsc. Res. Tech.  2010  74:415-20  PubMed ID: 20830703
8176  Haruki T, Shomori K, Hamamoto Y, Taniguchi Y, Nakamura H, Ito H.  Geminin expression in small lung adenocarcinomas: implication of prognostic significance.  Lung Cancer  2010  71:356-62  PubMed ID: 20650542
8186  Tsuji S, Tsuura Y, Morohoshi T, Shinohara T, Oshita F, Yamada K, Kameda Y, Ohtsu T, Nakamura Y, Miyagi Y.  Secretion of intelectin-1 from malignant pleural mesothelioma into pleural effusion.  Br. J. Cancer  2010  103:517-23  PubMed ID: 20628387
8238  Horie M, Nishio K, Fujita K, Kato H, Endoh S, Suzuki M, Nakamura A, Miyauchi A, Kinugasa S, Yamamoto K, Iwahashi H, Murayama H, Niki E, Yoshida Y.  Cellular responses by stable and uniform ultrafine titanium dioxide particles in culture-medium dispersions when secondary particle size was 100 nm or less.  Toxicol In Vitro  2010  24:1629-38  PubMed ID: 20541599
8436  Li F, Awale S, Tezuka Y, Kadota S.  Cytotoxic constituents of propolis from Myanmar and their structure-activity relationship.  Biol. Pharm. Bull.  2009  32:2075-8  PubMed ID: 19952433
8489  Matsuzawa Y, Kiuchi Y, Toyomura K, Matsumoto I, Nakamura H, Fujino H, Murayama T, Kawashima T.  Activation of cytosolic phospholipase A2alpha by epidermal growth factor (EGF) and phorbol ester in HeLa cells: different effects of inhibitors for EGF receptor, protein kinase C, Src, and C-Raf.  J. Pharmacol. Sci.  2009  111:182-92  PubMed ID: 19783865
8509  Awale S, Miyamoto T, Linn TZ, Li F, Win NN, Tezuka Y, Esumi H, Kadota S.  Cytotoxic constituents of Soymida febrifuga from Myanmar.  J. Nat. Prod.  2009  72:1631-6  PubMed ID: 19689125
8523  Tahara K, Sakai T, Yamamoto H, Takeuchi H, Hirashima N, Kawashima Y.  Improved cellular uptake of chitosan-modified PLGA nanospheres by A549 cells.  Int J Pharm  2009  382:198-204  PubMed ID: 19646519
8596  Fukasawa C, Ishiwada N, Ogita J, Hishiki H, Kohno Y.  The effects of disodium cromoglycate on enhanced adherence of Haemophilus influenzae to A549 cells infected with respiratory syncytial virus.  Pediatr. Res.  2009  66:168-73  PubMed ID: 19390482
8626  Iwakiri S, Mino N, Takahashi T, Sonobe M, Nagai S, Okubo K, Wada H, Date H, Miyahara R.  Higher expression of chemokine receptor CXCR7 is linked to early and metastatic recurrence in pathological stage I nonsmall cell lung cancer.  Cancer  2009  115:2580-93  PubMed ID: 19309748
8659  Kawanami Y, Morimoto Y, Kim H, Nakamura T, Machida K, Kido T, Asonuma E, Yatera K, Yoshii C, Kido M.  Calcitonin gene-related peptide stimulates proliferation of alveolar epithelial cells.  Respir. Res.  2009  10:8  PubMed ID: 19192276
8688  Yumi Motoyama,a Kanae Bekki,a Sang Woon Chung,a Ning Tang,b Takayuki Kameda,b. Akira Toriba,b Keiko Taguchi, Kazuichi Hayakawa  Oxidative Stress More Strongly Induced by ortho- Than para-quinoid Polycyclic Aromatic Hydrocarbons in A549 Cells  RCB0098  2009  55:845-850 
5877  Yamamoto H, Okumura K, Toshima S, Mukaisho K, Sugihara H, Hattori T, Kato M, Asano S.  FXYD3 protein involved in tumor cell proliferation is overproduced in human breast cancer tissues.  Biol Pharm Bull  2009  32(7):1148-54  PubMed ID: 19571376
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309
8698  Ozawa T, Miyata M, Nishimura M, Ando T, Ouyang Y, Ohba T, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Nakao A.  Transforming growth factor-beta activity in commercially available pasteurized cow milk provides protection against inflammation in mice.  J. Nutr.  2008  139:69-75  PubMed ID: 19056655
3581  Chang 1, Li W, Jia Z, Satou T, Fushiya S, Koike K.  Biologically active triterpenoid saponins from Ardisia japonica.  J Nat Prod  2007  70(2):179-87  PubMed ID: 17243725
6150  Ichwan SJ, Yamada S, Sumrejkanchanakij P, Ibrahim-Auerkari E, Eto K, Ikeda MA.  Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells.  Oncogene  2006  25(8):1216-24  PubMed ID: 16247456
6458  Misumi T, Tanaka T, Mikawa K, Nishina K, Morikawa O, Obara H.  Effects of sivelestat, a new elastase inhibitor, on IL-8 and MCP-1 production from stimulated human alveolar epithelial type II cells.  J Anesth  2006  20(3):159-65  PubMed ID: 16897233
3413  Yamashita, Satoko, Katayama, Hideki, Saitoh, Hiroyuki, Akao, Tetsuyuki, Park, Yu Shin, Mizuki, Eiichi, Ohba, Michio, Ito, Akio  Typical Three-Domain Cry Proteins of Bacillus thuringiensis Strain A1462 Exhibit Cytocidal Activity on Limited Human Cancer Cells.  J Biochem  2005  138:663-72  PubMed ID: 16428294
3412  Okajima, Shuhei, Yamaguchi, Takeo, Sakai, Yasuyuki, Nakao, Shin-ichi  Regulation of cell adhesion using a signal-responsive membrane substrate.  Biotechnol Bioeng  2005  91:237-43  PubMed ID: 15892056
3409  Sato, Masamitsu, Takahashi, Kenji, Nagayama, Kazuhiro, Arai, Yasuhito, Ito, Nobue, Okada, Mitsumasa, Minna, John D, Yokota, Jun, Kohno, Takashi  Identification of chromosome arm 9p as the most frequent target of homozygous deletions in lung cancer.  Genes Chromosomes Cancer  2005  44:405-14  PubMed ID: 16114034
3021  Fukumoto K, Yano Y, Virgona N, Hagiwara H, Sato H, Senba H, Suzuki K, Asano R, Yamada K, Yano T.  Peroxisome proliferator-activated receptor delta as a molecular target to regulate lung cancer cell growth.  FEBS Lett  2005  579(17):3829-36  PubMed ID: 15978581
3022  Yano Y, Satoh H, Fukumoto K, Kumadaki I, Ichikawa T, Yamada K, Hagiwara K, Yano T.  Induction of cytotoxicity in human lung adenocarcinoma cells by 6-O-carboxypropyl-alpha-tocotrienol, a redox-silent derivative of alpha-tocotrienol.  Int J Cancer  2005  115(5):839-46  PubMed ID: 15723336
2708  Nanda K, Miyoshi N, Nakamura Y, Shimoji Y, Tamura Y, Nishikawa Y, Uenakai K, Kohno H, Tanaka T.  Extract of vinegar "Kurosu" from unpolished rice inhibits the proliferation of human cancer cells.  J. Exp. Clin. Cancer Res.  2004  23:69-75  PubMed ID: 15149153
5416  Araki K, Hashimoto K, Ardyanto TD, Osaki M, Shomori K, Nakamura H, Ito H.  Co-expression of Cox-2 and EGFR in stage I human bronchial adenocarcinomas.  Lung Cancer  2004  45(2):161-9  PubMed ID: 15246187
2931  Okudela K, Hayashi H, Ito T, Yazawa T, Suzuki T, Nakane Y, Sato H, Ishi H, KeQin X, Masuda A, Takahashi T, Kitamura H.  K-ras gene mutation enhances motility of immortalized airway cells and lung adenocarcinoma cells via Akt activation: possible contribution to non-invasive expansion of lung adenocarcinoma.  Am J Pathol  2004  164(1):91-100  PubMed ID: 14695323
3191  Akasaki K1, Nakamura N, Tsukui N, Yokota S, Murata S, Katoh R, Michihara A, Tsuji H, Marques ET Jr, August JT.  Human dendritic cell lysosome-associated membrane protein expressed in lung type II pneumocytes.  Arch Biochem Biophys  2004  425(2):147-57  PubMed ID: 15111122
3333  Kawauchi S, Sato S, Morimoto Y, Kikuchi M.  Correlation between oxygen consumption and photobleaching during in vitro photodynamic treatment with ATX-S10.Na(II) using pulsed light excitation: dependence of pulse repetition rate and irradiation time.  Photochem Photobiol  2004  80(2):216-23  PubMed ID: 15244505
2659  Ma K, Araki K, Ichwan SJ, Suganuma T, Tamamori-Adachi M, Ikeda MA.  E2FBP1/DRIL1, an AT-rich interaction domain-family transcription factor, is regulated by p53.  Mol Cancer Res  2003  1(6):438-44  PubMed ID: 12692263
6401  Tsuchiya Y, Nakajima M, Itoh S, Iwanari M, Yokoi T.  Expression of aryl hydrocarbon receptor repressor in normal human tissues and inducibility by polycyclic aromatic hydrocarbons in human tumor-derived cell lines.  Toxicol Sci  2003  72(2):253-9  PubMed ID: 12655030
3594  Igishi T, Mikami M, Murakami K, Matsumoto S, Shigeoka Y, Nakanishi H, Yasuda K, Gutkind JS, Hitsuda Y, Shimizu E.  Enhancement of cisplatin-induced cytotoxicity by ROCK inhibitor through suppression of focal adhesion kinase-independent mechanism in lung carcinoma cells.  Int J Oncol  2003  23(4):1079-85  PubMed ID: 12963988
3592  Fukuhara H, Masuda M, Yageta M, Fukami T, Kuramochi M, Maruyama T, Kitamura T, Murakami Y.  Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg.  Oncogene  2003  22(40):6160-5  PubMed ID: 13679854
3020  Yano T, Zissel G, Muller-Qernheim J, Jae Shin S, Satoh H, Ichikawa T.  Prostaglandin E2 reinforces the activation of Ras signal pathway in lung adenocarcinoma cells via EP3.  FEBS Lett  2002  518(1-3):154-8  PubMed ID: 11997037
5404  Simamura E, Hirai KI, Shimada H, Koyama J.  Apoptosis and epithelial phagocytosis in mitomycin C-treated human pulmonary adenocarcinoma A549 cells.  Tissue Cell  2001  33:161-8  PubMed ID: 11392669
5553  Kobayashi H, Higashiyama M, Minamigawa K, Tanisaka K, Takano T, Yokouchi H, Kodama K, Hata T.  Examination of in vitro chemosensitivity test using collagen gel droplet culture method with colorimetric endpoint quantification.  Jpn J Cancer Res  2001  92(2):203-10  PubMed ID: 11223550
3775  Ishibashi Y, Relman DA, Nishikawa A.  Invasion of human respiratory epithelial cells by Bordetella pertussis: possible role for a filamentous hemagglutinin Arg-Gly-Asp sequence and alpha5beta1 integrin.  Microb Pathog  2001  30(5):279-88  PubMed ID: 11373122
6400  Hatano H, Kawashima H, Ogose A, Hotta T, Endo N.  A PCR-ELISA assay for the detection of disseminated osteosarcoma cells in a mouse metastatic model.  J Orthop Sci  2001  6(3):269-75  PubMed ID: 11484122
5968  Satoh J, Kuroda Y.  Beta-catenin expression in human neural cell lines following exposure to cytokines and growth factors.  Neuropathology  2000  20(2):113-23  PubMed ID: 10935448
6454  Asano M, Yukita A, Suzuki H.  Wide spectrum of antitumor activity of a neutralizing monoclonal antibody to human vascular endothelial growth factor.  Jpn J Cancer Res  1999  90(1):93-100  PubMed ID: 10076571
3751  Kobayashi S, Kondo S, Juni K.  Permeability of peptides and proteins in human cultured alveolar A549 cell monolayer.  Pharm Res  1995  12(8):1115-9  PubMed ID: 7494821

トップへページトップへ
利用者成果(日)



戻る 戻る 理研トップページへ