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RCB0041 : HL60  update : 2018/07/06
CommentDifferentiate to granulocytes and monocytes
Comment from the depositor
Use conditiona
Use condition descriptionBasically, there is no restriction regarding academic use.
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor Ohno, Tadao
Year of deposit 1986
Animal human < Mammals
Genus Homo
Species sapiens
Gender Female
Tissue blood
Case history promyelocytic leukemia
Classification cancer
History Tokyo Uni.
Lifespan infinite
Morphology lymphocyte-like
deposit info
lot info
Medium Medium List
Culture type Suspension cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method dilution
Culture information Passage ratio 1 : 10 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR (human) OK
Virus (HIV) (-)
Virus (HTLV-1) (-)
Isozyme LD, NP
Chromosome mode 44-175(50) : 44(8),45(15),46(4),87(1),88(6)/
Images
deposit info
lot info
Reference information Reference 7
User's Publication 78


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Reference
Collins, S J, Gallo, R C, Gallagher, R E  Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture.  Nature  1977  270:347-9 
Shimizu N, Ohta M, Fujiwara C, Sagara J, Mochizuki N, Oda T, Utiyama H  A Gene Coding for a Zinc Finger Protein Is Induced during 12-O-Tetradecanoylphorbol-13-Acetate-Stimulated HL-60 Cell Differentiation  J Biochem (Tokyo)  1992  111:272-277 
Oguro K, Sakamoto K, Kitajima K, Oda T, Hirano T, Shimizu N, Utiyama H  Determination of Transcriptional Activities of Typical Gene Promoters in HL-60  J Biochem (Tokyo)  1992  111:103-108 
Shimizu N, Ohta M, Fujiwara C, Sagara J, Mochizuki N, Oda T, Utiyama H  Expression of a novel immediate early gene during 12-O-tetradecanoylphorbol-13-acetate-induced macrophagic differentiation of HL-60 cells.  J Biol Chem  1991  266:12157-61 
Drexler, H G, Otsuka K, Gaedicke G, Minowada J  Changes in isoenzyme profiles during induction of differentiation in human myelomonocytic leukemia cell lines.  Cancer Res  1986  46:6078-82 
Hozumi M  Established leukemia cell lines: their role in the understanding and control of leukemia proliferation.  Crit Rev Oncol Hematol  1985  3:235-77 
Klein E, Klein G, Nadkarni, J S, Nadkarni, J J, Wigzell H, Clifford P  Surface IgM-kappa specificity on a Burkitt lymphoma cell in vivo and in derived culture lines.  Cancer Res  1968  28:1300-10 

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User's Publication
Yamashita, Satoko, Katayama, Hideki, Saitoh, Hiroyuki, Akao, Tetsuyuki, Park, Yu Shin, Mizuki, Eiichi, Ohba, Michio, Ito, Akio  Typical Three-Domain Cry Proteins of Bacillus thuringiensis Strain A1462 Exhibit Cytocidal Activity on Limited Human Cancer Cells.  J Biochem  2005  138:663-72 
Horiguchi-Yamada J et al  An intermediate dose of X-ray irradiation induces apoptosis following G2 arrest in human leukemia HL60 cells  Jikeikai Med.  2001  48:27-38 
Katayama H, Yokota H, Akao T, Nakamura O, Ohba M, Mekada E, Mizuki E  Parasporin-1, a novel cytotoxic protein to human cells from non-insecticidal parasporal inclusions of Bacillus thuringiensis  J Biochem (Tokyo)  2005  137:17-25 
Jiang B, Hattori N, Liu B, Nakayama Y, Kitagawa K, Sumita K, Inagaki C  Expression and roles of Cl- channel ClC-5 in cell cycles of myeloid cells.  Biochem Biophys Res Commun  2004  317:192-7 
Jiang B, Hattori N, Liu B, Nakayama Y, Kitagawa K, Inagaki C  Suppression of cell proliferation with induction of p21 by Cl(-) channel blockers in human leukemic cells.  Eur J Pharmacol  2004  488:27-34 
Nogami M, Nogami O, Kagotani K, Okumura M, Taguchi H, Ikemura T, Okumura K  Intranuclear arrangement of human chromosome 12 correlates to large-scale replication domains.  Chromosoma  2000  108:514-22 
Kaya K, Sano T, Shiraishi F  Astasin, a novel cytotoxic carbohydrate-conjugated ergosterol from the colorless euglenoid, Astasia longa.  Biochim Biophys Acta  1995  1255:201-4 
Tanaka Y, Yoshihara K, Tsuyuki M, Kamiya T  Apoptosis induced by adenosine in human leukemia HL-60 cells.  Exp Cell Res  1994  213:242-52 
Horiguchi-Yamada J, Yamada H  Differing responses of G2-related genes during differentiation of HL60 cells induced by TPA or DMSO.  Mol Cell Biochem  1993  119:29-34 
Ogata S, Takeuchi M, Fujita H, Shibata K, Okumura K, Taguchi H  Apoptosis induced by nicotinamide-related compounds and quinolinic acid in HL-60 cells.  Biosci Biotechnol Biochem  2000  64:327-32 
Tanaka Y, Yoshihara K, Tsuyuki M, Itaya-Hironaka A, Inada Y, Kamiya T  Retinoic acid-specific induction of a protein kinase C isoform during differentiation of HL-60 cells  J Biochem (Tokyo)  1992  111:265-271 
Kaya K, Sano T, Shiraishi F  Tetrahydropyran ring-containing fatty acid-combined taurine (tetrathermoyltaurine) in the taurolipid fraction of Tetrahymena thermophila.  Biochim Biophys Acta  1992  1127:22-7 
Tanaka Y, Tsuyuki M, Itaya-Hironaka A, Inada Y, Yoshihara K, Kamiya T  Retinoic acid-induced differentiation-specific, C-kinase-dependent phosphorylation of cytosolic 44 and 32 kDa proteins in HL-60 cells.  Biochem Biophys Res Commun  1990  168:1253-60 
Nagai M, Yamada H, Nakada S, Ochi K, Nemoto T, Takahara S, Hoshina S, Horiguchi-Yamada J  A macrolide antibiotic, roxithromycin, inhibits the growth of human myeloid leukemia HL60 cells by producing multinucleate cells.  Mol Cell Biochem  1995  144:191-5 
Horiguchi-Yamada J, Yamada H, Nakada S, Ochi K, Nemoto T  Changes of G1 cyclins, cdk2, and cyclin A during the differentiation of HL60 cells induced by TPA.  Mol Cell Biochem  1994  132:31-7 
Kaya K, Sano T, Watanabe, M M, Shiraishi F, Ito H  Thioic O-acid ester in sulfolipid isolated from freshwater picoplankton cyanobacterium, Synechococcus sp.  Biochim Biophys Acta  1993  1169:39-45 
Tanaka Y, Yoshihara K, Tohno Y, Kojima K, Kameoka M, Kamiya T  Inhibition and down-regulation of poly(ADP-ribose) polymerase results in a marked resistance of HL-60 cells to various apoptosis-inducers  Cell Mol Biol  1995  41:771-781 
Kawase T, Ogata S, Orikasa M, Burns, D M  1,25-Dihydroxyvitamin D3 promotes prostaglandin E1-induced differentiation of HL-60 cells  Calcified Tissue International  1995  57:359-366 
Numazawa S, Honma Y, Yamamoto T, Yoshida T, Kuroiwa Y  A cardiotonic steroid bufalin-like factor in human plasma induces leukemia cell differentiation.  Leuk Res  1995  19:945-53 
Suzuki S, Kobayashi H, Sekine R, Kumagai M, Mikoshiba M, Mori J, Hara M, Ichikawa K, Hashizume K  3,5,3'-Triiodo-L-thyronine potentiates all-trans-retinoic acid-induced apoptosis during differentiation of the promyeloleukemic cell HL-60.  Endocrinology  1997  138:805-9 
Ogata S, Okumura K, Taguchi H  A simple and rapid method for the detection of poly(ADP-ribose) by flow cytometry.  Biosci Biotechnol Biochem  2000  64:510-5 
Nogami M, Kohda A, Taguchi H, Nakao M, Ikemura T, Okumura K  Relative locations of the centromere and imprinted SNRPN gene within chromosome 15 territories during the cell cycle in HL60 cells  J Cell Sci  2000  113:2157-5165 
Ogata S, Miyake Y, Yamamoto K, Okumura K, Taguchi H  Apoptosis induced by the flavonoid from lemon fruit (Citrus limon BURM. f.) and its metabolites in HL-60 cells.  Biosci Biotechnol Biochem  2000  64:1075-8 
Ogata S, Takeuchi M, Fujita H, Shibata K, Okumura K, Taguchi H  Apoptosis induced by niacin-related compounds in K562 cells but not in normal human lymphocytes.  Biosci Biotechnol Biochem  2000  64:1142-6 
Kohda A, Taguchi H, Okumura K  Visualization of biallelic expression of the imprinted SNRPN gene induced by inhibitors of DNA methylation and histone deacetylation.  Biosci Biotechnol Biochem  2001  65:1236-9 
Kohda A, Taguchi H, Okumura K  Preparation of extended metaphase chromosomes from human cultured cells using a topoisomerase II inhibitor, ICRF-193.  Biosci Biotechnol Biochem  2001  65:1248-51 
Tamura, H O, Taniguchi K, Hayashi E, Hiyoshi Y, Nagai F  Expression profiling of sulfotransferases in human cell lines derived from extra-hepatic tissues.  Biol Pharm Bull  2001  24:1258-62 
Ogata S, Inoue K, Iwata K, Okumura K, Taguchi H  Apoptosis induced by picolinic acid-related compounds in HL-60 cells.  Biosci Biotechnol Biochem  2001  65:2337-9 
Nagai, Fusako, Hiyoshi, Yasuko, Sugimachi, Kumiko, Tamura, Hiro-Omi  Cytochrome P450 (CYP) expression in human myeloblastic and lymphoid cell lines.  Biol Pharm Bull  2002  25:383-5 
Iwata, Keiko, Ogata, Shin, Okumura, Katsuzumi, Taguchi, Hiroshi  Induction of differentiation in human promyelocytic leukemia HL-60 cell line by niacin-related compounds.  Biosci Biotechnol Biochem  2003  67:1132-5 
Iwata, Keiko, Ogata, Shin, Okumura, Katsuzumi, Taguchi, Hiroshi  Expression of CD38 in human promyelocytic leukemia HL-60 cell line during differentiation by niacin-related compounds.  Biosci Biotechnol Biochem  2003  67:1836-9 
Yamaguchi, Noboru, Kubo, Chie, Masuhiro, Yoshikazu, Lally, Edward T, Koga, Toshihiko, Hanazawa, Shigemasa  Tumor necrosis factor alpha enhances Actinobacillus actinomycetemcomitans leukotoxin-induced HL-60 cell apoptosis by stimulating lymphocyte function-associated antigen 1 expression.  Infect Immun  2004  72:269-76 
Nonaka, Mihoko, Ikeda, Hisazumi, Inokuchi, Tsugio  Inhibitory effect of heat shock protein 70 on apoptosis induced by photodynamic therapy in vitro.  Photochem Photobiol  2004  79:94-8 
Ito, Akio, Sasaguri, Yasuyuki, Kitada, Sakae, Kusaka, Yoshitomo, Kuwano, Kyoko, Masutomi, Kenjiro, Mizuki, Eiichi, Akao, Tetsuyuki, Ohba, Michio  A Bacillus thuringiensis crystal protein with selective cytocidal action to human cells.  J Biol Chem  2004  279:21282-6 
Matsumoto, Yoko, Iwamoto, Yasunori, Matsushita, Taku, Ueoka, Ryuichi  Novel mechanism of hybrid liposomes-induced apoptosis in human tumor cells.  Int J Cancer  2005  115:377-82 
Suzuki, Takuji, Koyama, Yu, Ichikawa, Hiroyasu, Tsushima, Koji, Abe, Kouichi, Hayakawa, Sumio, Kuruto-Niwa, Ryoko, Nozawa, Ryushi, Isemura, Mamoru  1,25-Dihydroxyvitamin D3 suppresses gene expression of eukaryotic translation initiation factor 2 in human promyelocytic leukemia HL-60 cells  Cell Struct Funct  2005  30:1-6 
Monzen S, Chiba M, Hosokawa Y.  Genetic network profiles associated with established resistance to ionizing radiation in acute promyelocytic leukemia cells and their extracellular vesicles.  Oncol. Rep.  2016  35:749-56  PubMed ID: 26718911
Nagashima H.  Rubratoxin-B-induced secretion of chemokine ligands of cysteine-cysteine motif chemokine receptor 5 (CCR5) and its dependence on heat shock protein 90 in HL60 cells.  Environ. Toxicol. Pharmacol.  2015  40:997-1000  PubMed ID: 26595743
Uesugi S, Fujisawa N, Yoshida J, Watanabe M, Dan S, Yamori T, Shiono Y, Kimura K.  Pyrrocidine A, a metabolite of endophytic fungi, has a potent apoptosis-inducing activity against HL60 cells through caspase activation via the Michael addition.  J. Antibiot.  2015  69:133-40  PubMed ID: 26506860
Abe N, Abe H, Nagai C, Harada M, Hatakeyama H, Harashima H, Ohshiro T, Nishihara M, Furukawa K, Maeda M, Tsuneda S, Ito Y.  Synthesis, structure, and biological activity of dumbbell-shaped nanocircular RNAs for RNA interference.  Bioconjug. Chem.  2011  22:2082-92  PubMed ID: 21899349
Nagashima H, Kushiro M, Nakagawa H.  Nuclear factor-κB inhibitors alleviate nivalenol-induced cytotoxicity in HL60 cells.  Environ. Toxicol. Pharmacol.  2011  31:258-61  PubMed ID: 21787693
Shoji K, Tsubaki M, Yamazoe Y, Satou T, Itoh T, Kidera Y, Tanimori Y, Yanae M, Matsuda H, Taga A, Nakamura H, Nishida S.  Mangiferin induces apoptosis by suppressing Bcl-xL and XIAP expressions and nuclear entry of NF-κB in HL-60 cells.  Arch. Pharm. Res.  2011  34:469-75  PubMed ID: 21547680
Konno Y, Aoki M, Takagishi M, Sakai N, Koike M, Wakamatsu K, Hosoi S.  Enhancement of antibody production by the addition of Coenzyme-Q(10).  Cytotechnology  2011  63:163-70  PubMed ID: 21197574
Okada M, Nadanaka S, Shoji N, Tamura J, Kitagawa H.  Biosynthesis of heparan sulfate in EXT1-deficient cells.  Biochem. J.  2010  428:463-71  PubMed ID: 20377530
Aburai N, Yoshida M, Ohnishi M, Kimura K.  Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in vitro and induces apoptosis via phosphorylation of p38 in HL60 cells.  Biosci. Biotechnol. Biochem.  2010  74:548-52  PubMed ID: 20208361
Aburai N, Yoshida M, Ohnishi M, Kimura K.  Pisiferdiol and pisiferic acid isolated from Chamaecyparis pisifera activate protein phosphatase 2C in vitro and induce caspase-3/7-dependent apoptosis via dephosphorylation of Bad in HL60 cells.  Phytomedicine  2010  17:782-8  PubMed ID: 20153620
Tokiwano T, Satoh H, Obara T, Hirota H, Yoshizawa Y, Yamamoto Y.  A lichen substance as an antiproliferative compound against HL-60 human leukemia cells: 16-O-acetyl-leucotylic acid isolated from Myelochroa aurulenta.  Biosci. Biotechnol. Biochem.  2009  73:2525-7  PubMed ID: 19897905
Zhang G, Wu H, Zhu B, Shimoishi Y, Nakamura Y, Murata Y.  Induction of apoptosis by beta-carotene and dimethyl tetrasulfide assisted by UVA irradiation in HL-60 cells.  Biosci. Biotechnol. Biochem.  2009  73:1014-20  PubMed ID: 19420723
Furukawa K, Abe H, Hibino K, Sako Y, Tsuneda S, Ito Y.  Reduction-triggered fluorescent amplification probe for the detection of endogenous RNAs in living human cells.  Bioconjug. Chem.  2009  20:1026-36  PubMed ID: 19374406
Matsuda H, Akaki J, Nakamura S, Okazaki Y, Kojima H, Tamesada M, Yoshikawa M.  Apoptosis-inducing effects of sterols from the dried powder of cultured mycelium of Cordyceps sinensis.  Chem. Pharm. Bull.  2009  57:411-4  PubMed ID: 19336939
Roy MK, Nakahara K, Na TV, Trakoontivakorn G, Takenaka M, Isobe S, Tsushida T.  Baicalein, a flavonoid extracted from a methanolic extract of Oroxylum indicum inhibits proliferation of a cancer cell line in vitro via induction of apoptosis.  Pharmazie  2007  62:149-53  PubMed ID: 17341037
Matsumoto E, Hatanaka M, Bohgaki M, Maeda S.  PKC pathway and ERK/MAPK pathway are required for induction of cyclin D1 and p21Waf1 during 12-o-tetradecanoylphorbol 13-acetate-induced differentiation of myeloleukemia cells.  Kobe J Med Sci  2007  52:181-94  PubMed ID: 17329956
Yamashita S, Katayama H, Saitoh H, Akao T, Park YS, Mizuki E, Ohba M, Ito A.  Typical three-domain cry proteins of Bacillus thuringiensis strain A1462 exhibit cytocidal activity on limited human cancer cells.  J. Biochem.  2006  138:663-72  PubMed ID: 16428294
Suzuki T, Koyama Y, Ichikawa H, Tsushima K, Abe K, Hayakawa S, Kuruto-Niwa R, Nozawa R, Isemura M.  1,25-Dihydroxyvitamin D3 suppresses gene expression of eukaryotic translation initiation factor 2 in human promyelocytic leukemia HL-60 cells.  Cell Struct. Funct.  2005  30:1-6  PubMed ID: 15951637
Katayama H, Yokota H, Akao T, Nakamura O, Ohba M, Mekada E, Mizuki E.  Parasporin-1, a novel cytotoxic protein to human cells from non-insecticidal parasporal inclusions of Bacillus thuringiensis.  J. Biochem.  2005  137:17-25  PubMed ID: 15713879
Matsumoto Y, Iwamoto Y, Matsushita T, Ueoka R.  Novel mechanism of hybrid liposomes-induced apoptosis in human tumor cells.  Int. J. Cancer  2005  115:377-82  PubMed ID: 15700314
Jiang B, Hattori N, Liu B, Nakayama Y, Kitagawa K, Sumita K, Inagaki C.  Expression and roles of Cl- channel ClC-5 in cell cycles of myeloid cells.  Biochem. Biophys. Res. Commun.  2004  317:192-7  PubMed ID: 15047167
Jiang B, Hattori N, Liu B, Nakayama Y, Kitagawa K, Inagaki C.  Suppression of cell proliferation with induction of p21 by Cl(-) channel blockers in human leukemic cells.  Eur. J. Pharmacol.  2004  488:27-34  PubMed ID: 15044032
Ito A, Sasaguri Y, Kitada S, Kusaka Y, Kuwano K, Masutomi K, Mizuki E, Akao T, Ohba M.  A Bacillus thuringiensis crystal protein with selective cytocidal action to human cells.  J. Biol. Chem.  2004  279:21282-6  PubMed ID: 15026424
Nonaka M, Ikeda H, Inokuchi T.  Inhibitory effect of heat shock protein 70 on apoptosis induced by photodynamic therapy in vitro.  Photochem. Photobiol.  2004  79:94-8  PubMed ID: 14982037
Yamaguchi N, Kubo C, Masuhiro Y, Lally ET, Koga T, Hanazawa S.  Tumor necrosis factor alpha enhances Actinobacillus actinomycetemcomitans leukotoxin-induced HL-60 cell apoptosis by stimulating lymphocyte function-associated antigen 1 expression.  Infect. Immun.  2003  72:269-76  PubMed ID: 14688105
Iwata K, Ogata S, Okumura K, Taguchi H.  Expression of CD38 in human promyelocytic leukemia HL-60 cell line during differentiation by niacin-related compounds.  Biosci. Biotechnol. Biochem.  2003  67:1836-9  PubMed ID: 12951526
Nagai F, Hiyoshi Y, Sugimachi K, Tamura HO.  Cytochrome P450 (CYP) expression in human myeloblastic and lymphoid cell lines.  Biol. Pharm. Bull.  2002  25:383-5  PubMed ID: 11913539
Tchoukoua A, Tabopda TK, Uesugi S, Ohno M, Kimura KI, Kwon E, Momma H, Horo I, Çalişkan ÖA, Shiono Y, Ngadjui BT.  Triterpene saponins from the roots of Acacia albida Del. (Mimosaceae).  Phytochemistry  2017  136:31-38  PubMed ID: 28043655
Yoshida J, Uesugi S, Kawamura T, Kimura KI, Hu D, Xia S, Toyooka N, Ohnishi M, Kawashima H.  (4Z,15Z)-Octadecadienoic Acid Inhibits Glycogen Synthase Kinase-3β and Glucose Production in H4IIE Cells.  Lipids  2017  52:295-301  PubMed ID: 28194557
Tsunaka M, Shinki H, Koyama T.  Cell-based evaluation of changes in coagulation activity induced by antineoplastic drugs for the treatment of acute myeloid leukemia.  PLoS ONE  2017  12:e0175765  PubMed ID: 28406995
Akihisa T, Yokokawa S, Ogihara E, Matsumoto M, Zhang J, Kikuchi T, Koike K, Abe M.  Melanogenesis-Inhibitory and Cytotoxic Activities of Limonoids, Alkaloids, and Phenolic Compounds from Phellodendron amurense Bark.  Chem. Biodivers.  2017  14:  PubMed ID: 28425165
Mukai M, Suruga N, Saeki N, Ogawa K.  EphA receptors and ephrin-A ligands are upregulated by monocytic differentiation/maturation and promote cell adhesion and protrusion formation in HL60 monocytes.  BMC Cell Biol.  2017  18:28  PubMed ID: 28851287
Tchoukoua A, Kuiate Tabopda T, Konga Simo I, Uesugi S, Ohno M, Kimura KI, Kwon E, Momma H, Shiono Y, Ngadjui BT.  Albidosides H and I, two new triterpene saponins from the barks of Acacia albida Del. (Mimosaceae).  Nat. Prod. Res.  2018  32:924-932  PubMed ID: 28868920
Yamazoe H.  Multifunctional protein microparticles for medical applications.  Biomaterials  2018  155:1-12  PubMed ID: 29154040
Zhang J, Zhu WF, Zhu WY, Yang PP, Xu J, Manosroi J, Kikuchi T, Abe M, Akihisa T, Feng F.  Melanogenesis-Inhibitory and Cytotoxic Activities of Chemical Constituents from the Leaves of Sauropus androgynus L. Merr. (Euphorbiaceae).  Chem. Biodivers.  2018  15:  PubMed ID: 29144597
Monzen S, Chiba M, Ueno T, Morino Y, Terada K, Yamaya H, Hosokawa Y.  A radioresistant fraction of acute promyelocytic leukemia cells exhibit CD38 cell-surface antigen and mRNA expression.  Oncol Lett  2018  15:6709-6714  PubMed ID: 29616132
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de Kerckhove M, Tanaka K, Umehara T, Okamoto M, Kanematsu S, Hayashi H, Yano H, Nishiura S, Tooyama S, Matsubayashi Y, Komatsu T, Park S, Okada Y, Takahashi R, Kawano Y, Hanawa T, Iwasaki K, Nozaki T, Torigoe H, Ikematsu K, Suzuki Y, Tanaka K, Martin P, Shimokawa I, Mori R.  Targeting <i>miR-223</i> in neutrophils enhances the?clearance of <i>Staphylococcus aureus</i> in infected?wounds.  EMBO Mol Med  2018    PubMed ID: 30171089
Kozako T, Mellini P, Ohsugi T, Aikawa A, Uchida YI, Honda SI, Suzuki T.  Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines.  BMC Cancer  2018    PubMed ID: 30081901



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