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RCB0041 : HL60  update : 2018/07/06
CommentDifferentiate to granulocytes and monocytes
Comment from the depositor
Terms and conditionsBasically, there is no restriction regarding academic use.
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC( regarding any kind of for-profit use.
Basic information Depositor Ohno, Tadao
Year of deposit 1986
Animal human < Mammals
Genus Homo
Species sapiens
Gender Female
Tissue blood
Case history promyelocytic leukemia
Classification cancer
History Tokyo Uni.
Lifespan infinite
Morphology lymphocyte-like
deposit info
lot info
Medium Medium List
Culture type Suspension cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method dilution
Culture information Passage ratio 1 : 10 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR (human) OK
Virus (HIV) (-)
Virus (HTLV-1) (-)
Isozyme LD, NP
Chromosome mode 44-175(50) : 44(8),45(15),46(4),87(1),88(6)/
deposit info
lot info
Reference information Reference 7
User's Publication 89

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973  Collins, S J, Gallo, R C, Gallagher, R E  Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture.  Nature  1977  270:347-9  PubMed ID: 271272
1468  Shimizu N, Ohta M, Fujiwara C, Sagara J, Mochizuki N, Oda T, Utiyama H  A Gene Coding for a Zinc Finger Protein Is Induced during 12-O-Tetradecanoylphorbol-13-Acetate-Stimulated HL-60 Cell Differentiation  J Biochem  1992  111:272-277  PubMed ID: 1569051
1467  Oguro K, Sakamoto K, Kitajima K, Oda T, Hirano T, Shimizu N, Utiyama H  Determination of Transcriptional Activities of Typical Gene Promoters in HL-60  J Biochem  1992  111:103-108  PubMed ID: 1607356
1466  Shimizu N, Ohta M, Fujiwara C, Sagara J, Mochizuki N, Oda T, Utiyama H  Expression of a novel immediate early gene during 12-O-tetradecanoylphorbol-13-acetate-induced macrophagic differentiation of HL-60 cells.  J Biol Chem  1991  266:12157-61  PubMed ID: 2061303
2033  Drexler, H G, Otsuka K, Gaedicke G, Minowada J  Changes in isoenzyme profiles during induction of differentiation in human myelomonocytic leukemia cell lines.  Cancer Res  1986  46:6078-82  PubMed ID: 2946400
697  Hozumi M  Established leukemia cell lines: their role in the understanding and control of leukemia proliferation.  Crit Rev Oncol Hematol  1985  3:235-77  PubMed ID: 3899390
5042  Haruta Y, Seon BK.  Distinct human leukemia-associated cell surface glycoprotein GP160 defined by monoclonal antibody SN6.  Proc Natl Acad Sci U S A  1986  ;83(20):7898-902  PubMed ID: 3464004

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User's Publication
3413  Yamashita, Satoko, Katayama, Hideki, Saitoh, Hiroyuki, Akao, Tetsuyuki, Park, Yu Shin, Mizuki, Eiichi, Ohba, Michio, Ito, Akio  Typical Three-Domain Cry Proteins of Bacillus thuringiensis Strain A1462 Exhibit Cytocidal Activity on Limited Human Cancer Cells.  J Biochem  2005  138:663-72  PubMed ID: 16428294
2980  Horiguchi-Yamada J et al  An intermediate dose of X-ray irradiation induces apoptosis following G2 arrest in human leukemia HL60 cells  Jikeikai Med.  2001  48:27-38 
2892  Katayama H, Yokota H, Akao T, Nakamura O, Ohba M, Mekada E, Mizuki E  Parasporin-1, a novel cytotoxic protein to human cells from non-insecticidal parasporal inclusions of Bacillus thuringiensis  J Biochem (Tokyo)  2005  137:17-25  PubMed ID: 15713879
2905  Jiang B, Hattori N, Liu B, Nakayama Y, Kitagawa K, Sumita K, Inagaki C  Expression and roles of Cl- channel ClC-5 in cell cycles of myeloid cells.  Biochem Biophys Res Commun  2004  317:192-7  PubMed ID: 15047167
2924  Jiang B, Hattori N, Liu B, Nakayama Y, Kitagawa K, Inagaki C  Suppression of cell proliferation with induction of p21 by Cl(-) channel blockers in human leukemic cells.  Eur J Pharmacol  2004  488:27-34  PubMed ID: 15044032
2994  Nogami M, Nogami O, Kagotani K, Okumura M, Taguchi H, Ikemura T, Okumura K  Intranuclear arrangement of human chromosome 12 correlates to large-scale replication domains.  Chromosoma  2000  108:514-22  PubMed ID: 10794573
2071  Kaya K, Sano T, Shiraishi F  Astasin, a novel cytotoxic carbohydrate-conjugated ergosterol from the colorless euglenoid, Astasia longa.  Biochim Biophys Acta  1995  1255:201-4  PubMed ID: 7696335
1844  Tanaka Y, Yoshihara K, Tsuyuki M, Kamiya T  Apoptosis induced by adenosine in human leukemia HL-60 cells.  Exp Cell Res  1994  213:242-52  PubMed ID: 8020596
2982  Horiguchi-Yamada J, Yamada H  Differing responses of G2-related genes during differentiation of HL60 cells induced by TPA or DMSO.  Mol Cell Biochem  1993  119:29-34  PubMed ID: 8455582
2960  Ogata S, Takeuchi M, Fujita H, Shibata K, Okumura K, Taguchi H  Apoptosis induced by nicotinamide-related compounds and quinolinic acid in HL-60 cells.  Biosci Biotechnol Biochem  2000  64:327-32  PubMed ID: 10737189
1459  Tanaka Y, Yoshihara K, Tsuyuki M, Itaya-Hironaka A, Inada Y, Kamiya T  Retinoic acid-specific induction of a protein kinase C isoform during differentiation of HL-60 cells  J Biochem (Tokyo)  1992  111:265-271  PubMed ID: 1569050
2073  Kaya K, Sano T, Shiraishi F  Tetrahydropyran ring-containing fatty acid-combined taurine (tetrathermoyltaurine) in the taurolipid fraction of Tetrahymena thermophila.  Biochim Biophys Acta  1992  1127:22-7  PubMed ID: 1627630
1328  Tanaka Y, Tsuyuki M, Itaya-Hironaka A, Inada Y, Yoshihara K, Kamiya T  Retinoic acid-induced differentiation-specific, C-kinase-dependent phosphorylation of cytosolic 44 and 32 kDa proteins in HL-60 cells.  Biochem Biophys Res Commun  1990  168:1253-60  PubMed ID: 2161220
2990  Nagai M, Yamada H, Nakada S, Ochi K, Nemoto T, Takahara S, Hoshina S, Horiguchi-Yamada J  A macrolide antibiotic, roxithromycin, inhibits the growth of human myeloid leukemia HL60 cells by producing multinucleate cells.  Mol Cell Biochem  1995  144:191-5  PubMed ID: 7623791
2981  Horiguchi-Yamada J, Yamada H, Nakada S, Ochi K, Nemoto T  Changes of G1 cyclins, cdk2, and cyclin A during the differentiation of HL60 cells induced by TPA.  Mol Cell Biochem  1994  132:31-7  PubMed ID: 8078506
2072  Kaya K, Sano T, Watanabe, M M, Shiraishi F, Ito H  Thioic O-acid ester in sulfolipid isolated from freshwater picoplankton cyanobacterium, Synechococcus sp.  Biochim Biophys Acta  1993  1169:39-45  PubMed ID: 8334148
1947  Tanaka Y, Yoshihara K, Tohno Y, Kojima K, Kameoka M, Kamiya T  Inhibition and down-regulation of poly(ADP-ribose) polymerase results in a marked resistance of HL-60 cells to various apoptosis-inducers  Cell Mol Biol  1995  41:771-781  PubMed ID: 8535170
1968  Kawase T, Ogata S, Orikasa M, Burns, D M  1,25-Dihydroxyvitamin D3 promotes prostaglandin E1-induced differentiation of HL-60 cells  Calcified Tissue International  1995  57:359-366  PubMed ID: 8564798
2060  Numazawa S, Honma Y, Yamamoto T, Yoshida T, Kuroiwa Y  A cardiotonic steroid bufalin-like factor in human plasma induces leukemia cell differentiation.  Leuk Res  1995  19:945-53  PubMed ID: 8632664
2189  Suzuki S, Kobayashi H, Sekine R, Kumagai M, Mikoshiba M, Mori J, Hara M, Ichikawa K, Hashizume K  3,5,3'-Triiodo-L-thyronine potentiates all-trans-retinoic acid-induced apoptosis during differentiation of the promyeloleukemic cell HL-60.  Endocrinology  1997  138:805-9  PubMed ID: 9003018
2061  Sugimoto H, Nishino H  [Effect of recombinant human basic fibroblast growth factor (bFGF) on the growth of human tumor cell lines]  Hum Cell  1996  9:129-40  PubMed ID: 9183641
2961  Ogata S, Okumura K, Taguchi H  A simple and rapid method for the detection of poly(ADP-ribose) by flow cytometry.  Biosci Biotechnol Biochem  2000  64:510-5  PubMed ID: 10803947
2964  Nogami M, Kohda A, Taguchi H, Nakao M, Ikemura T, Okumura K  Relative locations of the centromere and imprinted SNRPN gene within chromosome 15 territories during the cell cycle in HL60 cells  J Cell Sci  2000  113:2157-5165  PubMed ID: 10825289
2962  Ogata S, Miyake Y, Yamamoto K, Okumura K, Taguchi H  Apoptosis induced by the flavonoid from lemon fruit (Citrus limon BURM. f.) and its metabolites in HL-60 cells.  Biosci Biotechnol Biochem  2000  64:1075-8  PubMed ID: 10879486
2963  Ogata S, Takeuchi M, Fujita H, Shibata K, Okumura K, Taguchi H  Apoptosis induced by niacin-related compounds in K562 cells but not in normal human lymphocytes.  Biosci Biotechnol Biochem  2000  64:1142-6  PubMed ID: 10923782
2965  Kohda A, Taguchi H, Okumura K  Visualization of biallelic expression of the imprinted SNRPN gene induced by inhibitors of DNA methylation and histone deacetylation.  Biosci Biotechnol Biochem  2001  65:1236-9  PubMed ID: 11440148
2966  Kohda A, Taguchi H, Okumura K  Preparation of extended metaphase chromosomes from human cultured cells using a topoisomerase II inhibitor, ICRF-193.  Biosci Biotechnol Biochem  2001  65:1248-51  PubMed ID: 11440151
2550  Tamura, H O, Taniguchi K, Hayashi E, Hiyoshi Y, Nagai F  Expression profiling of sulfotransferases in human cell lines derived from extra-hepatic tissues.  Biol Pharm Bull  2001  24:1258-62  PubMed ID: 11725959
2967  Ogata S, Inoue K, Iwata K, Okumura K, Taguchi H  Apoptosis induced by picolinic acid-related compounds in HL-60 cells.  Biosci Biotechnol Biochem  2001  65:2337-9  PubMed ID: 11758936
2549  Nagai, Fusako, Hiyoshi, Yasuko, Sugimachi, Kumiko, Tamura, Hiro-Omi  Cytochrome P450 (CYP) expression in human myeloblastic and lymphoid cell lines.  Biol Pharm Bull  2002  25:383-5  PubMed ID: 11913539
2968  Iwata, Keiko, Ogata, Shin, Okumura, Katsuzumi, Taguchi, Hiroshi  Induction of differentiation in human promyelocytic leukemia HL-60 cell line by niacin-related compounds.  Biosci Biotechnol Biochem  2003  67:1132-5  PubMed ID: 12834294
2969  Iwata, Keiko, Ogata, Shin, Okumura, Katsuzumi, Taguchi, Hiroshi  Expression of CD38 in human promyelocytic leukemia HL-60 cell line during differentiation by niacin-related compounds.  Biosci Biotechnol Biochem  2003  67:1836-9  PubMed ID: 12951526
2670  Yamaguchi, Noboru, Kubo, Chie, Masuhiro, Yoshikazu, Lally, Edward T, Koga, Toshihiko, Hanazawa, Shigemasa  Tumor necrosis factor alpha enhances Actinobacillus actinomycetemcomitans leukotoxin-induced HL-60 cell apoptosis by stimulating lymphocyte function-associated antigen 1 expression.  Infect Immun  2004  72:269-76  PubMed ID: 14688105
3341  Nonaka, Mihoko, Ikeda, Hisazumi, Inokuchi, Tsugio  Inhibitory effect of heat shock protein 70 on apoptosis induced by photodynamic therapy in vitro.  Photochem Photobiol  2004  79:94-8  PubMed ID: 14982037
2894  Ito, Akio, Sasaguri, Yasuyuki, Kitada, Sakae, Kusaka, Yoshitomo, Kuwano, Kyoko, Masutomi, Kenjiro, Mizuki, Eiichi, Akao, Tetsuyuki, Ohba, Michio  A Bacillus thuringiensis crystal protein with selective cytocidal action to human cells.  J Biol Chem  2004  279:21282-6  PubMed ID: 15026424
3391  Matsumoto, Yoko, Iwamoto, Yasunori, Matsushita, Taku, Ueoka, Ryuichi  Novel mechanism of hybrid liposomes-induced apoptosis in human tumor cells.  Int J Cancer  2005  115:377-82  PubMed ID: 15700314
3071  Suzuki, Takuji, Koyama, Yu, Ichikawa, Hiroyasu, Tsushima, Koji, Abe, Kouichi, Hayakawa, Sumio, Kuruto-Niwa, Ryoko, Nozawa, Ryushi, Isemura, Mamoru  1,25-Dihydroxyvitamin D3 suppresses gene expression of eukaryotic translation initiation factor 2 in human promyelocytic leukemia HL-60 cells  Cell Struct Funct  2005  30:1-6  PubMed ID: 15951637
7093  Monzen S, Chiba M, Hosokawa Y.  Genetic network profiles associated with established resistance to ionizing radiation in acute promyelocytic leukemia cells and their extracellular vesicles.  Oncol. Rep.  2016  35:749-56  PubMed ID: 26718911
7138  Nagashima H.  Rubratoxin-B-induced secretion of chemokine ligands of cysteine-cysteine motif chemokine receptor 5 (CCR5) and its dependence on heat shock protein 90 in HL60 cells.  Environ. Toxicol. Pharmacol.  2015  40:997-1000  PubMed ID: 26595743
7166  Uesugi S, Fujisawa N, Yoshida J, Watanabe M, Dan S, Yamori T, Shiono Y, Kimura K.  Pyrrocidine A, a metabolite of endophytic fungi, has a potent apoptosis-inducing activity against HL60 cells through caspase activation via the Michael addition.  J. Antibiot.  2015  69:133-40  PubMed ID: 26506860
7568  Tung NH, Uto T, Morinaga O, Shoyama Y  Chemical Constituents from the Aerial Parts of Bupleurum falcatum L. and Biological Evidences.  Natural Product Sciences  2015  21:71-75 
7690  Abe N, Abe H, Nagai C, Harada M, Hatakeyama H, Harashima H, Ohshiro T, Nishihara M, Furukawa K, Maeda M, Tsuneda S, Ito Y.  Synthesis, structure, and biological activity of dumbbell-shaped nanocircular RNAs for RNA interference.  Bioconjug. Chem.  2011  22:2082-92  PubMed ID: 21899349
7741  Nagashima H, Kushiro M, Nakagawa H.  Nuclear factor-κB inhibitors alleviate nivalenol-induced cytotoxicity in HL60 cells.  Environ. Toxicol. Pharmacol.  2011  31:258-61  PubMed ID: 21787693
7829  Shoji K, Tsubaki M, Yamazoe Y, Satou T, Itoh T, Kidera Y, Tanimori Y, Yanae M, Matsuda H, Taga A, Nakamura H, Nishida S.  Mangiferin induces apoptosis by suppressing Bcl-xL and XIAP expressions and nuclear entry of NF-κB in HL-60 cells.  Arch. Pharm. Res.  2011  34:469-75  PubMed ID: 21547680
8307  Okada M, Nadanaka S, Shoji N, Tamura J, Kitagawa H.  Biosynthesis of heparan sulfate in EXT1-deficient cells.  Biochem. J.  2010  428:463-71  PubMed ID: 20377530
8340  Aburai N, Yoshida M, Ohnishi M, Kimura K.  Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in vitro and induces apoptosis via phosphorylation of p38 in HL60 cells.  Biosci. Biotechnol. Biochem.  2010  74:548-52  PubMed ID: 20208361
8362  Aburai N, Yoshida M, Ohnishi M, Kimura K.  Pisiferdiol and pisiferic acid isolated from Chamaecyparis pisifera activate protein phosphatase 2C in vitro and induce caspase-3/7-dependent apoptosis via dephosphorylation of Bad in HL60 cells.  Phytomedicine  2010  17:782-8  PubMed ID: 20153620
8461  Tokiwano T, Satoh H, Obara T, Hirota H, Yoshizawa Y, Yamamoto Y.  A lichen substance as an antiproliferative compound against HL-60 human leukemia cells: 16-O-acetyl-leucotylic acid isolated from Myelochroa aurulenta.  Biosci. Biotechnol. Biochem.  2009  73:2525-7  PubMed ID: 19897905
8582  Zhang G, Wu H, Zhu B, Shimoishi Y, Nakamura Y, Murata Y.  Induction of apoptosis by beta-carotene and dimethyl tetrasulfide assisted by UVA irradiation in HL-60 cells.  Biosci. Biotechnol. Biochem.  2009  73:1014-20  PubMed ID: 19420723
8603  Furukawa K, Abe H, Hibino K, Sako Y, Tsuneda S, Ito Y.  Reduction-triggered fluorescent amplification probe for the detection of endogenous RNAs in living human cells.  Bioconjug. Chem.  2009  20:1026-36  PubMed ID: 19374406
8615  Matsuda H, Akaki J, Nakamura S, Okazaki Y, Kojima H, Tamesada M, Yoshikawa M.  Apoptosis-inducing effects of sterols from the dried powder of cultured mycelium of Cordyceps sinensis.  Chem. Pharm. Bull.  2009  57:411-4  PubMed ID: 19336939
8814  Roy MK, Nakahara K, Na TV, Trakoontivakorn G, Takenaka M, Isobe S, Tsushida T.  Baicalein, a flavonoid extracted from a methanolic extract of Oroxylum indicum inhibits proliferation of a cancer cell line in vitro via induction of apoptosis.  Pharmazie  2007  62:149-53  PubMed ID: 17341037
10047  Tchoukoua A, Tabopda TK, Uesugi S, Ohno M, Kimura KI, Kwon E, Momma H, Horo I, Çalişkan ÖA, Shiono Y, Ngadjui BT.  Triterpene saponins from the roots of Acacia albida Del. (Mimosaceae).  Phytochemistry  2017  136:31-38  PubMed ID: 28043655
10126  Yoshida J, Uesugi S, Kawamura T, Kimura KI, Hu D, Xia S, Toyooka N, Ohnishi M, Kawashima H.  (4Z,15Z)-Octadecadienoic Acid Inhibits Glycogen Synthase Kinase-3β and Glucose Production in H4IIE Cells.  Lipids  2017  52:295-301  PubMed ID: 28194557
10267  Tsunaka M, Shinki H, Koyama T.  Cell-based evaluation of changes in coagulation activity induced by antineoplastic drugs for the treatment of acute myeloid leukemia.  PLoS ONE  2017  12:e0175765  PubMed ID: 28406995
10274  Akihisa T, Yokokawa S, Ogihara E, Matsumoto M, Zhang J, Kikuchi T, Koike K, Abe M.  Melanogenesis-Inhibitory and Cytotoxic Activities of Limonoids, Alkaloids, and Phenolic Compounds from Phellodendron amurense Bark.  Chem. Biodivers.  2017  14:  PubMed ID: 28425165
10483  Mukai M, Suruga N, Saeki N, Ogawa K.  EphA receptors and ephrin-A ligands are upregulated by monocytic differentiation/maturation and promote cell adhesion and protrusion formation in HL60 monocytes.  BMC Cell Biol.  2017  18:28  PubMed ID: 28851287
10497  Tchoukoua A, Kuiate Tabopda T, Konga Simo I, Uesugi S, Ohno M, Kimura KI, Kwon E, Momma H, Shiono Y, Ngadjui BT.  Albidosides H and I, two new triterpene saponins from the barks of Acacia albida Del. (Mimosaceae).  Nat. Prod. Res.  2018  32:924-932  PubMed ID: 28868920
10592  Yamazoe H.  Multifunctional protein microparticles for medical applications.  Biomaterials  2018  155:1-12  PubMed ID: 29154040
10778  Monzen S, Chiba M, Ueno T, Morino Y, Terada K, Yamaya H, Hosokawa Y.  A radioresistant fraction of acute promyelocytic leukemia cells exhibit CD38 cell-surface antigen and mRNA expression.  Oncol Lett  2018  15:6709-6714  PubMed ID: 29616132
10799  Kawai C, Yamauchi A, Kuribayashi F.  Monoclonal antibody 7D5 recognizes the R147 epitope on the gp91phox , phagocyte flavocytochrome b558 large subunit.  Microbiol. Immunol.  2018  62:269-280  PubMed ID: 29573449
10882    Yeast Ca2 +-signal transduction inhibitors isolated from Dominican amber prevent the degranulation of RBL-2H3 cells through the inhibition of Ca2 +-influx  Fitoterapia  2016  113, 188-194  PubMed ID: 27491756
10907  Hosokawa Y, Saga R, Monzen S, Terashima S, Tsuruga E.  Ascorbic acid does not reduce the anticancer effect of radiotherapy  Biomed Rep  2017  6:103-107  PubMed ID: 28123717
11008    New Triterpene saponins from the stem of Acacia kamerunensis (Mimosaceae)  Phytochemistry Letters  2018  23, 21-25 
11119  Tanimura A, Miyoshi K, Horiguchi T, Hagita H, Fujisawa K, Noma T.  Mitochondrial Activity and Unfolded Protein Response are Required for Neutrophil Differentiation.  Cell. Physiol. Biochem.  2018    PubMed ID: 29972819
6831  de Kerckhove M, Tanaka K, Umehara T, Okamoto M, Kanematsu S, Hayashi H, Yano H, Nishiura S, Tooyama S, Matsubayashi Y, Komatsu T, Park S, Okada Y, Takahashi R, Kawano Y, Hanawa T, Iwasaki K, Nozaki T, Torigoe H, Ikematsu K, Suzuki Y, Tanaka K, Martin P, Shimokawa I, Mori R.  Targeting miR-223 in neutrophils enhances the?clearance of Staphylococcus aureus in infected?wounds.  EMBO Mol Med  2018    PubMed ID: 30171089
6902  Kozako T, Mellini P, Ohsugi T, Aikawa A, Uchida YI, Honda SI, Suzuki T.  Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines.  BMC Cancer  2018    PubMed ID: 30081901
4052  Kidoya H, Muramatsu F, Shimamura T, Jia W, Satoh T, Hayashi Y, Naito H, Kunisaki Y, Arai F, Seki M, Suzuki Y, Osawa T, Akira S, Takakura N.  Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis  Nat Commun  2019  10:1072  PubMed ID: 30842549
11329  Umehara T, Mori R, Mace KA, Murase T, Abe Y, Yamamoto T, Ikematsu K.  Identification of Specific miRNAs in Neutrophils of Type 2 Diabetic Mice: Overexpression of miRNA-129-2-3p Accelerates Diabetic Wound Healing.  Diabetes  2019    PubMed ID: 30523028
4095    Inhibition of FAD-dependent lysine-specific demethylases by chiral polyamine analogues  RSC Adv  2018  8, 36895-36902 
4229  Ariefta NR, Kristiana P, Aboshi T, Murayama T, Tawaraya K, Koseki T, Kurisawa N, Kimura KI, Shiono Y.  New isocoumarins, naphthoquinones, and a cleistanthane-type diterpene from Nectria pseudotrichia 120-1NP.  Fitoterapia  2018    PubMed ID: 29621598
4230  Okimura C, Sakumura Y, Shimabukuro K, Iwadate Y.  Sensing of substratum rigidity and directional migration by fast-crawling cells.  Phys Rev E  2018    PubMed ID: 29906928
4869  Kitagawa J, Hara T, Tsurumi H, Kanemura N, Kasahara S, Shimizu M, Moriwaki H.  Cell cycle-dependent priming action of granulocyte colony-stimulating factor (G-CSF) enhances in vitro apoptosis induction by cytarabine and etoposide in leukemia cell lines.  J Clin Exp Hematop  2010  50(2):99-105  PubMed ID: 21123967
4991  Tsubaki M, Ogawa N, Takeda T, Sakamoto K, Shimaoka H, Fujita A, Itoh T, Imano M, Satou T, Nishida S.  Dimethyl fumarate induces apoptosis of hematopoietic tumor cells via inhibition of NF-κB nuclear translocation and down-regulation of Bcl-xL and XIAP.  Biomed Pharmacother  2014  68(8):999-1005  PubMed ID: 25443417
4993  Tsubaki M, Itoh T, Satou T, Imano M, Komai M, Ogawa N, Mukai J, Nishida S.  Nitrogen-containing bisphosphonates induce apoptosis of hematopoietic tumor cells via inhibition of Ras signaling pathways and Bim-mediated activation of the intrinsic apoptotic pathway.  Biochem Pharmacol  2013  85(2):163-72  PubMed ID: 23085435
5322  Akihisa T, Kikuchi T, Nagai H, Ishii K, Tabata K, Suzuki T.  4-Hydroxyderricin from Angelica keiskei roots induces caspase-dependent apoptotic cell death in HL60 human leukemia cells.  J Oleo Sci  2011  60(2):71-7  PubMed ID: 21263202
5329  Miyoshi N, Iwasaki N, Tomono S, Higashi T, Ohshima H.  Occurrence of cytotoxic 9-oxononanoyl secosterol aldehydes in human low-density lipoprotein.  Free Radic Biol Med  2013  60:73-9  PubMed ID: 23395781
5405  Takenouchi T, Munekata E.  beta-Amyloid peptide, substance P, and SEC receptor ligand activate cytoplasmic Ca2+ in neutrophil-like HL-60 cells: effect of chemotactic peptide antagonist BocMLF.  Peptides  1995  16:1019-24  PubMed ID: 8532582
5419  Saegusa S, Totsuka M, Kaminogawa S, Hosoi T.  Saccharomyces cerevisiae and Candida albicans stimulate cytokine secretion from human neutrophil-like HL-60 cells differentiated with retinoic acid or dimethylsulfoxide.  Biosci Biotechnol Biochem  2009  73(12):2600-8  PubMed ID: 19966493
2069  Okada N, Fushimi M, Nagata Y, Fukunaga T, Tsutsumi Y, Nakagawa S, Mayumi T.  Evaluation of angiogenic inhibitors with an in vivo quantitative angiogenesis method using agarose microencapsulation and mouse hemoglobin enzyme-linked immunosorbent assay.  Jpn J Cancer Res  1996  87(9):952-7  PubMed ID: 8878458
3581  Chang 1, Li W, Jia Z, Satou T, Fushiya S, Koike K.  Biologically active triterpenoid saponins from Ardisia japonica.  J Nat Prod  2007  70(2):179-87  PubMed ID: 17243725
3979  Matsumoto K, Akao Y, Kobayashi E, Ohguchi K, Ito T, Tanaka T, Iinuma M, Nozawa Y.  Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines.  J Nat Prod  2003  66(8):1124-7  PubMed ID: 12932141
5631  Uto T, Sakamoto A, Tung NH, Fujiki T, Kishihara K, Oiso S, Kariyazono H, Morinaga O, Shoyama Y.  Anti-Proliferative Activities and Apoptosis Induction by Triterpenes Derived from Eriobotrya japonica in Human Leukemia Cell Lines.  Int J Mol Sci  2013  14(2):4106-20  PubMed ID: 23429195
3930  Nemoto S, Otsuka M, Arakawa N.  Inhibitory effect of ascorbate on cell growth: relation to catalase activity.  J Nutr Sci Vitaminol (Tokyo).  1996  42(2):77-85  PubMed ID: 8780966
3964  Nagai M, Sato N.  Reciprocal gene expression of osteoclastogenesis inhibitory factor and osteoclast differentiation factor regulates osteoclast formation.  Biochem Biophys Res Commun  1999  257(3):719-23  PubMed ID: 10208850
6085  Monzen S, Takimura K, Kashiwakura I, Hosokawa Y.  Acute promyelocytic leukemia mutated to radioresistance suppressed monocyte lineage differentiation by phorbol 12-myristate 13-acetate.  Leuk Res  2013  37(9):1162-9  PubMed ID: 3773897
6132  Naito H, Kidoya H, Sato Y, Takakura N.  Induction and expression of anti-angiogenic vasohibins in the hematopoietic stem/progenitor cell population.  J Biochem  2009  145(5):653-9  PubMed ID: 19179360
6240  Tsuyuki M, Yoshihara K.  An HL-60 variant cell line defective in cholesterol synthesis.  Cell Struct Funct  1995  20(1):13-21  PubMed ID: 7796464
6241  Yoshihara K, Tsuyuki M, Itaya A, Tanaka Y, Kamiya T.  3-aminobenzamide, a potent inhibitor of poly (ADP-ribose) polymerase, causes a rapid death of HL-60 cells cultured in serum-free medium.  Mol Cell Biochem  1994  135(2):143-51  PubMed ID: 7838142

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