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RCB0009 : PC-12  update : 2018/07/06
CommentPheochromocytoma, differentiate by NGF stimulation
Comment from the depositor
Restriction (Category)a
Terms and conditionsBasically, there is no restriction regarding academic use.
Remarks
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor Noda, Makoto
Originator L. Green & A. Tischler
Year of deposit 1986
Animal rat < Mammals
Genus Rattus
Species norvegicus
Tissue pheochromocytoma
Classification cancer
History Mitubishi-Seimeiken-T.Amano
Lifespan infinite
Morphology other
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives DMEM (low glucose) + 10% FBS + 10% HS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 4-8 split
SC frequency Subculture : 1-2 times/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Animal PCR OK
Images
deposit info
lot info
Reference information Reference 4
User's Publication 128


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Reference
1318  Greene, L A, Tischler, A S  Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.  Proc Natl Acad Sci U S A  1976  73:2424-8 
1078  Levi A, Eldridge, J D, Paterson, B M  Molecular cloning of a gene sequence regulated by nerve growth factor.  Science  1985  229:393-5 
1079  Biocca S, Cattaneo A, Calissano P  A macromolecular structure favouring microtubule assembly in NGF-differentiated pheochromocytoma cells (PC12).  EMBO J  1983  2:643-8 
1726  Satoh M, Takeuchi M  Establishment of HPRT-Deficient Cell Lines from Mouse Neuroblastoma Neuro-2A and RAT Pheochromocytoma PC-12  Res Commun Inst Ferment  1993  16:43268 

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User's Publication
2717  Ishido M, Masuo Y  Transcriptome of pituitary adenylate cyclase-activating polypeptide-differentiated PC12 cells  Regul Pept  2004  15:15-21  PubMed ID: 15518888
2647  Rajebhosale M, Greenwood S, Vidugiriene J, Jeromin A, Hilfiker S  Phosphatidylinositol 4-OH kinase is a downstream target of neuronal calcium sensor-1 in enhancing exocytosis in neuroendocrine cells  J Biol Chem  2002  278:6075-6084  PubMed ID: 12471042
2716  Makino N, Sasaki K, Hashida K, Sakakura Y  A metabolic model describing the H2O2 elimination by mammalian cells including H2O2 permeation through cytoplasmic and peroxisomal membranes: comparison with experimental data.  Biochim Biophys Acta  2004  1673:149-59  PubMed ID: 15279886
3015  Tagaya M, Furuno A, Mizushima S  SNAP prevents Mg(2+)-ATP-induced release of N-ethylmaleimide-sensitive factor from the Golgi apparatus in digitonin-permeabilized PC12 cells.  J Biol Chem  1996  271:466-70 
2056  Shimokawa N, Miura M  Detection of living cells that express AP1 using a fluorolabeled DNA probe.  FEBS Lett  1996  388:16-20 
2198  Suzuki A  Amyloid beta-protein induces necrotic cell death mediated by ICE cascade in PC12 cells.  Exp Cell Res  1997  234:507-11 
1646  Ito M, Maruhashi M, Sakai N, Mizoue K, Hanada K  NG-011 and NG-012, novel potentiators of nerve growth factor. I. Taxonomy, isolation, and physico-chemical and biological properties  J Antibiot (Tokyo)  1992  45:1559-1565 
1972  Ishizuka T, Ino H, Sawa K, Suzuki N, Tatibana M  Promoter region of the mouse cyclin-dependent kinase 5-encoding gene.  Gene  1995  166:267-71 
2055  Ishizuka T, Sawa K, Kita K, Ino H, Sonoda T, Suzuki N, Tatibana M  Promoter region of the rat phosphoribosylpyrophosphate synthetase-associated protein 39.  Biochim Biophys Acta  1996  1306:34-7 
2191  Kamata H, Tanaka C, Yagisawa H, Hirata H  Nerve growth factor and forskolin prevent H2O2-induced apoptosis in PC12 cells by glutathione independent mechanism.  Neurosci Lett  1996  212:179-82 
2190  Kamata H, Tanaka C, Yagisawa H, Matsuda S, Gotoh Y, Nishida E, Hirata H  Suppression of nerve growth factor-induced neuronal differentiation of PC12 cells. N-acetylcysteine uncouples the signal transduction from ras to the mitogen-activated protein kinase cascade.  J Biol Chem  1996  271:33018-25 
2369  Takekoshi K, Nomura F, Isobe K, Motooka M, Nammoku T, Nakai T  Identification and initial characterization of stathmin by the differential display method in nerve growth factor-treated PC12 cells.  Eur J Endocrinol  1998  138:707-12 
2367  Kitani T, Ishida A, Okuno S, Takeuchi M, Kameshita I, Fujisawa H  Molecular cloning of Ca2+/calmodulin-dependent protein kinase phosphatase  J Biochem (Tokyo)  1999  125:1022-1028 
3070  Sassa T, Gomi H, Sun W, Ikeda T, Thompson, R F, Itohara S  Identification of variants and dual promoters of murine serine/threonine kinase KKIAMRE.  J Neurochem  2000  74:1809-19  PubMed ID: 10800923
3010  Mashima J, Nagahama M, Hatsuzawa K, Tani K, Horigome T, Yamamoto A, Tagaya M  N-ethylmaleimide-sensitive factor is associated with the nuclear envelope.  Biochem Biophys Res Commun  2000  274:559-64 
3068  Hayashi H, Ishisaki A, Suzuki M, Imamura T  BMP-2 augments FGF-induced differentiation of PC12 cells through upregulation of FGF receptor-1 expression.  J Cell Sci  2001  114:1387-95 
2642  Saito, T K, Takahashi M, Muguruma H, Niki E, Mabuchi K  Phototoxic process after rapid photosensitive membrane damage of 5,5&quot;-bis(aminomethyl)-2,2':5',2&quot;-terthiophene dihydrochloride.  J Photochem Photobiol B  2001  61:114-21 
2715  Hashida, Kanae, Sakakura, Yuki, Makino, Nobuo  Kinetic studies on the hydrogen peroxide elimination by cultured PC12 cells: rate limitation by glucose-6-phosphate dehydrogenase.  Biochim Biophys Acta  2002  1572:85-90  PubMed ID: 12204336
3163  Takezawa, Takezawa, Takenouchi, Takato, Imai, Kei, Takahashi, Toru, Hashizume, Kazuyoshi  Cell culture on thin tissue sections commonly prepared for histopathology.  FASEB J  2002  16:1847-9  PubMed ID: 12223453
3007  Nagahama, Masami, Usui, Shihomi, Shinohara, Takashi, Yamaguchi, Tomohiro, Tani, Katsuko, Tagaya, Mitsuo  Inactivation of Galpha(z) causes disassembly of the Golgi apparatus.  J Cell Sci  2002  115:4483-93  PubMed ID: 12414994
3067  Hayashi, Hisaki, Ishisaki, Akira, Imamura, Toru  Smad mediates BMP-2-induced upregulation of FGF-evoked PC12 cell differentiation.  FEBS Lett  2003  536:30-4  PubMed ID: 12586333
3184  Shimokawa, Noriaki, Qiu, Chun-Hong, Seki, Takayuki, Dikic, Ivan, Koibuchi, Noriyuki  Phosphorylation of JNK is involved in regulation of H(+)-induced c-Jun expression.  Cell Signal  2004  16:723-9  PubMed ID: 15093613
3186  Masuda, Seiko, Murakami, Makoto, Takanezawa, Yasukazu, Aoki, Junken, Arai, Hiroyuki, Ishikawa, Yukio, Ishii, Toshiharu, Arioka, Manabu, Kudo, Ichiro  Neuronal expression and neuritogenic action of group X secreted phospholipase A2.  J Biol Chem  2005  280:23203-14  PubMed ID: 15781456
7102  Yoshida S, Teshima T, Kuribayashi-Shigetomi K, Takeuchi S.  Mobile Microplates for Morphological Control and Assembly of Individual Neural Cells.  Adv Healthc Mater  2015  5:415-20  PubMed ID: 26712104
7123  Sawaguchi Y, Ueno S, Nishiyma Y, Yamazaki R, Matsuzaki T.  Establishment of a Novel In Vitro Model for Predicting Incidence and Severity of Microtubule-targeting Agent-induced Peripheral Neuropathy.  Anticancer Res.  2015  35:6431-7  PubMed ID: 26637853
7131  Saito Y, Ishii KA, Aita Y, Ikeda T, Kawakami Y, Shimano H, Hara H, Takekoshi K.  Loss of SDHB Elevates Catecholamine Synthesis and Secretion Depending on ROS Production and HIF Stabilization.  Neurochem. Res.  2015  41:696-706  PubMed ID: 26620190
7160  Jin Y, Tsuchiya A, Kanno T, Nishizaki T.  Amyloid-β peptide increases cell surface localization of α7 ACh receptor to protect neurons from amyloid β-induced damage.  Biochem. Biophys. Res. Commun.  2015  468:157-60  PubMed ID: 26522221
7224  Kanno T, Tsuchiya A, Tanaka A, Nishizaki T.  Combination of PKCε Activation and PTP1B Inhibition Effectively Suppresses Aβ-Induced GSK-3β Activation and Tau Phosphorylation.  Mol. Neurobiol.  2015  53:4787-97  PubMed ID: 26328540
7228  Xia B, Liu H, Xie J, Wu R, Li Y.  Akt enhances nerve growth factor-induced axon growth via activating the Nrf2/ARE pathway.  Int. J. Mol. Med.  2015  36:1426-32  PubMed ID: 26324295
7423  Cueno ME, Kamio N, Seki K, Kurita-Ochiai T, Ochiai K.  High butyric acid amounts induce oxidative stress, alter calcium homeostasis, and cause neurite retraction in nerve growth factor-treated PC12 cells.  Cell Stress Chaperones  2015  20:709-13  PubMed ID: 25808460
7499  Uemura M, Ishiguro H.  Freezing behavior of adherent neuron-like cells and morphological change and viability of post-thaw cells.  Cryobiology  2015  70:122-35  PubMed ID: 25645578
7527  Florian Larramendy, Daniela Serien, Shotaro Yoshida, Laurent Jalabert, Shoji Takeuchi, Oliver Paul.  High-topography surface functionalization based on parylene-C peel-off for patterned cell growth.  2015 28th IEEE International Conference on MEMS  2015  :328-331 
7578  Ghimire Gautam S, Komatsu M, Nishigaki K.  Strong inhibition of beta-amyloid peptide aggregation realized by two-steps evolved peptides.  Chem Biol Drug Des  2014  85:356-68  PubMed ID: 25082146
7583  Takaaki Mori, Yukihiro Akiyama, Shogo Unuma, Takashi K. Saito.  High performance cell membrane perforation system for cell suspensions.  Micro-NanoMechatronics and Human Science (MHS), 2014 International Symposium on  2014  :1-3 
7590  Irie K, Murakami K, Masuda Y, Murata N, Noda Y, Hatsuta H, Murayama S, Shimizu T, Horikoshi Y, Kinoshita N, Shirasawa T.  [Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23].  Rinsho Shinkeigaku  2012  51:890-1  PubMed ID: 22277406
7619  Hoshino T, Saito I, Kometani R, Samejima K, Matsui S, Suzuki T, Mabuchi K, Kato YX.  Improvement of neuronal cell adhesiveness on parylene with oxygen plasma treatment.  J. Biosci. Bioeng.  2011  113:395-8  PubMed ID: 22138385
7641  Hoshino T, Saito I, Takano H, Samejima K, Mabuchi K, Kato YX.  Neurite outgrowth of PC12 cells on diX (parylene) family materials.  Biotechnol. Prog.  2011  28:587-90  PubMed ID: 22052685
7700  Saito Y, Tanaka Y, Aita Y, Ishii KA, Ikeda T, Isobe K, Kawakami Y, Shimano H, Hara H, Takekoshi K.  Sunitinib induces apoptosis in pheochromocytoma tumor cells by inhibiting VEGFR2/Akt/mTOR/S6K1 pathways through modulation of Bcl-2 and BAD.  Am. J. Physiol. Endocrinol. Metab.  2011  302:E615-25  PubMed ID: 21878661
7720  Toda T, Sunagawa T, Kanda T, Tagashira M, Shirasawa T, Shimizu T.  Apple Procyanidins Suppress Amyloid β-Protein Aggregation.  Biochem Res Int  2011  2011:784698  PubMed ID: 21826271
7737  Seidi A, Kaji H, Annabi N, Ostrovidov S, Ramalingam M, Khademhosseini A.  A microfluidic-based neurotoxin concentration gradient for the generation of an in vitro model of Parkinson's disease.  Biomicrofluidics  2011  5:22214  PubMed ID: 21799720
7795  Kishimoto E, Naito Y, Handa O, Okada H, Mizushima K, Hirai Y, Nakabe N, Uchiyama K, Ishikawa T, Takagi T, Yagi N, Kokura S, Yoshida N, Yoshikawa T.  Oxidative stress-induced posttranslational modification of TRPV1 expressed in esophageal epithelial cells.  Am. J. Physiol. Gastrointest. Liver Physiol.  2011  301:G230-8  PubMed ID: 21636531
7803  Sohma Y, Wang H, Taniguchi A, Hirayama Y, Kakizawa T, Yamasaki M, Mukai H, Kiso Y.  Self-assembly pathways of E22Δ-type amyloid β peptide mutants generated from non-aggregative O-acyl isopeptide precursors.  Bioorg. Med. Chem.  2011  19:3787-92  PubMed ID: 21612934
7817  Takahashi Y, Shimokawa N, Esmaeili-Mahani S, Morita A, Masuda H, Iwasaki T, Tamura J, Haglund K, Koibuchi N.  Ligand-induced downregulation of TrkA is partly regulated through ubiquitination by Cbl.  FEBS Lett.  2011  585:1741-7  PubMed ID: 21570973
7889  Hashimoto K, Ishima T.  Neurite outgrowth mediated by translation elongation factor eEF1A1: a target for antiplatelet agent cilostazol.  PLoS ONE  2011  6:e17431  PubMed ID: 21390260
7913  Hamada N, Tanaka A, Fujita Y, Itoh T, Ono Y, Kitagawa Y, Tomimori N, Kiso Y, Akao Y, Nozawa Y, Ito M.  Involvement of heme oxygenase-1 induction via Nrf2/ARE activation in protection against H2O2-induced PC12 cell death by a metabolite of sesamin contained in sesame seeds.  Bioorg. Med. Chem.  2011  19:1959-65  PubMed ID: 21345685
7923  Okano K, Yu D, Matsui A, Maezawa Y, Hosokawa Y, Kira A, Matsubara M, Liau I, Tsubokawa H, Masuhara H.  Induction of cell-cell connections by using in situ laser lithography on a perfluoroalkyl-coated cultivation platform.  Chembiochem  2011  12:795-801  PubMed ID: 21341350
7932  Yabe T, Hosoda-Yabe R, Kanamaru Y, Kiso M.  A peptide found by phage display discriminates a specific structure of a trisaccharide in heparin.  J. Biol. Chem.  2011  286:12397-406  PubMed ID: 21335559
7945  Shimizu T, Kanno T, Tanaka A, Nishizaki T.  α, β-DCP-LA selectively activates PKC-ε and stimulates neurotransmitter release with the highest potency among 4 diastereomers.  Cell. Physiol. Biochem.  2011  27:149-58  PubMed ID: 21325832
7965  Onoue S, Kuriyama K, Uchida A, Mizumoto T, Yamada S.  Inhalable sustained-release formulation of glucagon: in vitro amyloidogenic and inhalation properties, and in vivo absorption and bioactivity.  Pharm. Res.  2011  28:1157-66  PubMed ID: 21287249
8003  Itoh K, Ishima T, Kehler J, Hashimoto K.  Potentiation of NGF-induced neurite outgrowth in PC12 cells by papaverine: role played by PLC-γ, IP3 receptors.  Brain Res.  2011  1377:32-40  PubMed ID: 21211516
8020  Shen J, Maruyama IN.  Nerve growth factor receptor TrkA exists as a preformed, yet inactive, dimer in living cells.  FEBS Lett.  2010  585:295-9  PubMed ID: 21187090
8023  Bae N, Ahn T, Chung S, Oh MS, Ko H, Oh H, Park G, Yang HO.  The neuroprotective effect of modified Yeoldahanso-tang via autophagy enhancement in models of Parkinson's disease.  J Ethnopharmacol  2010  134:313-22  PubMed ID: 21172413
8030  Hashimoto K, Ishima T.  A novel target of action of minocycline in NGF-induced neurite outgrowth in PC12 cells: translation initiation [corrected] factor eIF4AI.  PLoS ONE  2010  5:e15430  PubMed ID: 21151481
8053  Murakami K, Horikoshi-Sakuraba Y, Murata N, Noda Y, Masuda Y, Kinoshita N, Hatsuta H, Murayama S, Shirasawa T, Shimizu T, Irie K.  Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23.  ACS Chem Neurosci  2010  1:747-56  PubMed ID: 22778811
8057  Murata N, Murakami K, Ozawa Y, Kinoshita N, Irie K, Shirasawa T, Shimizu T.  Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model.  Biosci. Biotechnol. Biochem.  2010  74:2299-306  PubMed ID: 21071836
8090  Maezawa Y, Okano K, Matsubara M, Masuhara H, Hosokawa Y.  Morphological evaluation of cell differentiation after the isolation of single cells by a femtosecond laser-induced impulsive force.  Biomed Microdevices  2010  13:117-22  PubMed ID: 20949320
8097  Ito Y, Kimura T, Nam K, Katoh A, Masuzawa T, Kishida A.  Effects of vibration on differentiation of cultured PC12 cells.  Biotechnol. Bioeng.  2010  108:592-9  PubMed ID: 20939009
8116  Minase T, Ishima T, Itoh K, Hashimoto K.  Potentiation of nerve growth factor-induced neurite outgrowth by the ROCK inhibitor Y-27632: a possible role of IP? receptors.  Eur. J. Pharmacol.  2010  648:67-73  PubMed ID: 20854802
8124  Yaguchi T, Nagata T, Nishizaki T.  1,2-dilinoleoyl-sn-glycero-3-phosphoethanolamine ameliorates age-related spatial memory deterioration by preventing neuronal cell death.  Behav Brain Funct  2010  6:52  PubMed ID: 20831835
8134  Takadera T, Koriyama Y, Kimura T, Kato S.  5-S-GAD attenuates Fe2+-induced lipid peroxidation and cell death in a neuronal cell model.  Neurotox Res  2010  20:26-31  PubMed ID: 20809179
8157  Zeng KW, Ko H, Yang HO, Wang XM.  Icariin attenuates β-amyloid-induced neurotoxicity by inhibition of tau protein hyperphosphorylation in PC12 cells.  Neuropharmacology  2010  59:542-50  PubMed ID: 20708632
8211  Okuyama T, Yamazoe H, Mochizuki N, Khademhosseini A, Suzuki H, Fukuda J.  Preparation of arrays of cell spheroids and spheroid-monolayer cocultures within a microfluidic device.  J. Biosci. Bioeng.  2010  110:572-6  PubMed ID: 20591731
8234  Okuyama T, Yamazoe H, Seto Y, Suzuki H, Fukuda J.  Cell micropatterning inside a microchannel and assays under a stable concentration gradient.  J. Biosci. Bioeng.  2010  110:230-7  PubMed ID: 20547384
8318  Goto E, Mukozawa M, Mori H, Hara M.  A rolled sheet of collagen gel with cultured Schwann cells: model of nerve conduit to enhance neurite growth.  J. Biosci. Bioeng.  2010  109:512-8  PubMed ID: 20347776
8322  Zeng KW, Wang XM, Ko H, Yang HO.  Neuroprotective effect of modified Wu-Zi-Yan-Zong granule, a traditional Chinese herbal medicine, on CoCl2-induced PC12 cells.  J Ethnopharmacol  2010  130:13-8  PubMed ID: 20347949
8333  Takadera T, Nakajima Y, Kanai Y.  Colchicine-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells.  Cell. Mol. Neurobiol.  2010  30:863-8  PubMed ID: 20300959
8392  Oyane A, Tsurushima H, Ito A.  Highly efficient gene transfer system using a laminin-DNA-apatite composite layer.  J Gene Med  2010  12:194-206  PubMed ID: 20082421
8405  Yasuyo Maezawa, Yoichiroh Hosokawa, Kazunori Okano, Mie Matsubara and Hiroshi Masuhara  In situ observation of cell-detachment process initiated by femtosecond laser-induced stress wave  Applied Physics A: Materials Science & Processing  2010  101:127-131 
8414  Aita Y, Kasahara T, Isobe K, Kawakami Y, Takekoshi K.  Effect of urotensin II on PC12 rat pheochromocytoma cells.  J. Neuroendocrinol.  2009  22:83-91  PubMed ID: 20025629
8427  Kakinoki S, Yamaoka T.  Stable modification of poly(lactic acid) surface with neurite outgrowth-promoting peptides via hydrophobic collagen-like sequence.  Acta Biomater  2009  6:1925-30  PubMed ID: 19969110
8511  Takadera T, Ohtsuka M, Aoki H.  Chelation of extracellular calcium-induced cell death was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells.  Cell. Mol. Neurobiol.  2009  30:193-8  PubMed ID: 19688259
8518  Kato YX, Saito I, Takano H, Mabuchi K, Hoshino T.  Comparison of neuronal cell adhesiveness of materials in the diX (Parylene) family.  Neurosci. Lett.  2009  464:26-8  PubMed ID: 19664682
8544  Ohnuma K, Toyota T, Ariizumi T, Sugawara T, Asashima M.  Directional migration of neuronal PC12 cells in a ratchet wheel shaped microchamber.  J. Biosci. Bioeng.  2009  108:76-83  PubMed ID: 19577197
8556  Hamada N, Fujita Y, Tanaka A, Naoi M, Nozawa Y, Ono Y, Kitagawa Y, Tomimori N, Kiso Y, Ito M.  Metabolites of sesamin, a major lignan in sesame seeds, induce neuronal differentiation in PC12 cells through activation of ERK1/2 signaling pathway.  J Neural Transm (Vienna)  2009  116:841-52  PubMed ID: 19533291
8647  Ishii T, Uto T, Mori K, Fujikawa R.  Integrin-linked kinase is involved in lactoferrin-induced anchorage-independent cell growth and survival in PC12 cells.  Life Sci.  2009  84:530-6  PubMed ID: 19230838
8723  Shinohara H, Wang F, Hossain SM.  A convenient, high-throughput method for enzyme-luminescence detection of dopamine released from PC12 cells.  Nat Protoc  2008  3:1639-44  PubMed ID: 18833200
8759  Watanabe S, Wakasugi K.  Zebrafish neuroglobin is a cell-membrane-penetrating globin.  Biochemistry  2008  47:5266-70  PubMed ID: 18416560
8838  Hiroaki SHINOHARA and Feifei WANG  Real-Time Detection of Dopamine Released from a Nerve Model Cell by an Enzyme-Catalyzed Luminescence Method and Its Application to Drug Assessment  Anal Sci  2007  23:81-84 
8867  Ohnuma K, Yomo T, Asashima M, Kaneko K.  Sorting of cells of the same size, shape, and cell cycle stage for a single cell level assay without staining.  BMC Cell Biol.  2006  7:25  PubMed ID: 16790072
8909  Hongo S, Watanabe T, Takahashi K, Miyazaki A.  Ndrg4 enhances NGF-induced ERK activation uncoupled with Elk-1 activation.  J. Cell. Biochem.  2006  98:185-93  PubMed ID: 16408304
8918  Takayuki Hoshino, Akinori Ozasa, Reo Kometani, Takafumi Suzuki, Shinji Matsui, and Kunihiko Mabuchi  Development of a regeneration-type neural interface: A microtube guide for axon growth of neuronal cells fabricated using focused-ion-beam chemical vapor deposition  J Vacuum Science & Technology B  2006  24:2538-2543 
8944  Waki R, Gamo S, Bessho M, Hara M.  Patterning cultured cells by visible light illumination with photosensitizers.  J. Biosci. Bioeng.  2005  100:331-4  PubMed ID: 16243285
8961  Ohnuma K, Hayashi Y, Furue M, Kaneko K, Asashima M.  Serum-free culture conditions for serial subculture of undifferentiated PC12 cells.  J. Neurosci. Methods  2005  151:250-61  PubMed ID: 16169086
9448  Saito K. T, Muguruma H, Mabuchi K.  Photodynamic assistance increases the efficiency of the process of microinjection in animal cells.  Biotechnol Lett.  2002  24:209-314 
9623  Seki K, Cueno ME, Kamio N, Saito Y, Kamimoto A, Kurita-Ochiai T, Ochiai K.  Varying butyric acid amounts induce different stress- and cell death-related signals in nerve growth factor-treated PC12 cells: implications in neuropathic pain absence during periodontal disease progression.  Apoptosis  2016  21:699-707  PubMed ID: 26994613
9769  Yoshida S, Yamamoto N, Wada N, Tomokiyo A, Hasegawa D, Hamano S, Mitarai H, Monnouchi S, Yuda A, Maeda H.  GDNF From Human Periodontal Ligament Cells Treated With Pro-Inflammatory Cytokines Promotes Neurocytic Differentiation of PC12 Cells.  J. Cell. Biochem.  2017  118:699-708  PubMed ID: 27463736
9780  Uesugi S, Muroi M, Kondoh Y, Shiono Y, Osada H, Kimura KI.  Allantopyrone A activates Keap1-Nrf2 pathway and protects PC12 cells from oxidative stress-induced cell death.  J. Antibiot.  2017  70:429-434  PubMed ID: 27507633
9834  Ogra Y, Tejima A, Hatakeyama N, Shiraiwa M, Wu S, Ishikawa T, Yawata A, Anan Y, Suzuki N.  Changes in intracellular copper concentration and copper-regulating gene expression after PC12 differentiation into neurons.  Sci Rep  2016  6:33007  PubMed ID: 27623342
9848  Mizukami-Murata S, Sakakibara F, Fujita K, Fukuda M, Kuramata M, Takagi K.  Detoxification of hydroxylated polychlorobiphenyls by Sphingomonas sp. strain N-9 isolated from forest soil.  Chemosphere  2016  165:173-182  PubMed ID: 27649311
9906  Yao W, Zhang JC, Ishima T, Ren Q, Yang C, Dong C, Ma M, Saito A, Honda T, Hashimoto K.  Antidepressant effects of TBE-31 and MCE-1, the novel Nrf2 activators, in an inflammation model of depression.  Eur. J. Pharmacol.  2016  793:21-27  PubMed ID: 27815170
10129  Hozumi Y, Fujiwara H, Kaneko K, Fujii S, Topham MK, Watanabe M, Goto K.  Diacylglycerol kinase ε localizes to subsurface cisterns of cerebellar Purkinje cells.  Cell Tissue Res.  2017  368:441-458  PubMed ID: 28191598
10182  Mir TA, Shinohara H.  Two-Dimensional Surface Plasmon Resonance Imaging System for Cellular Analysis.  Methods Mol. Biol.  2017  1571:31-46  PubMed ID: 28281248
10336  Kasai Y, Ohta T, Nakazato Y, Ito S.  Release of dopamine and ATP from PC12 cells treated with dexamethasone, reserpine and bafilomycin A1.  J. Vet. Med. Sci.  2001  63:367-72  PubMed ID: 11346169
10391  Shinsuke K, Junya K, Tomonobu U, Yoshiko K, Izumo N, Takahiko S.  Chronic irradiation with low-dose-rate 137Cs-γ rays inhibits NGF-induced neurite extension of PC12 cells via Ca2+/calmodulin-dependent kinase II activation.  J. Radiat. Res.  2017  58:809-815  PubMed ID: 29106600
10415  Mizukami-Murata S, Fujita K, Nakano T.  Effect of lower chlorinated hydroxylated-polychlorobiphenyls on development of PC12 cells.  Environ Sci Pollut Res Int  2018    PubMed ID: 28695493
10485  Takahashi N, Onozuka W, Watanabe S, Wakasugi K.  Chimeric ZHHH neuroglobin acts as a cell membrane-penetrating inducer of neurite outgrowth.  FEBS Open Bio  2017  7:1338-1349  PubMed ID: 28904863
10511  Okutani C, Wagatsuma A, Mabuchi K, Hoshino T.  Directed cell migration in co-cultures by topographic curvature for heterogeneous tissue engineering.  Conf Proc IEEE Eng Med Biol Soc  2017  2017:1607-1610  PubMed ID: 29060190
10513  Muroi T, Matsushima Y, Kanamori R, Inoue H, Fujii W, Yogo K.  GPR62 constitutively activates cAMP signaling but is dispensable for male fertility in mice.  Reproduction  2017  154:755-764  PubMed ID: 28912303
10540  Terada K, Matsushima Y, Matsunaga K, Takata J, Karube Y, Ishige A, Chiba K.  The Kampo medicine Yokukansan (YKS) enhances nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells.  Bosn J Basic Med Sci  2018    PubMed ID: 28961087
10591  Tachizawa S, Takahashi H, Kim YJ, Odawara A, Pauty J, Ikeuchi Y, Suzuki I, Kikuchi A, Matsunaga YT.  Bundle Gel Fibers with a Tunable Microenvironment for in Vitro Neuron Cell Guiding.  ACS Appl Mater Interfaces  2017  9:43250-43257  PubMed ID: 29086563
10598  Sakagami H, Suzuki R, Shirataki Y, Iwama S, Nakagawa M, Suzuki H, Tanaka K, Tamura N, Takeshima H.  Re-evaluation of Culture Condition of PC12 and SH-SY5Y Cells Based on Growth Rate and Amino Acid Consumption.  In Vivo  2017  31:1089-1095  PubMed ID: 29102930
10615  Ishii N, Tsubouchi H, Miura A, Yanagi S, Ueno H, Shiomi K, Nakazato M.  Ghrelin alleviates paclitaxel-induced peripheral neuropathy by reducing oxidative stress and enhancing mitochondrial anti-oxidant functions in mice.  Eur. J. Pharmacol.  2018  819:35-42  PubMed ID: 29154935
10699  Murata T, Yamaguchi M, Kohno S, Takahashi C, Kakimoto M, Sugimura Y, Kamihara M, Hikita K, Kaneda N.  Regucalcin confers resistance to amyloid-β toxicity in neuronally differentiated PC12 cells.  FEBS Open Bio  2018  8:349-360  PubMed ID: 29511612
10765  Sakagami H, Tsuji M, Tomomura M, Masuda Y, Iwama S, Nakagawa M, Suzuki H, Tanaka K, Abe T, Tamura N, Tomomura A, Yokose S, Takeshima H, Natori T, Horiuchi M, Fujisawa T, Kiuchi Y, Oguchi K, Yasui T, Oizumi H, Oizumi T.  Protection of Differentiating Neuronal Cells from Amyloid β Peptide-induced Injury by Alkaline Extract of Leaves of Sasa senanensis Rehder.  In Vivo  2018  32:231-239  PubMed ID: 29475904
10856  Fujimura M, Usuki F, Cheng J, Zhao W.  Prenatal low-dose methylmercury exposure impairs neurite outgrowth and synaptic protein expression and suppresses TrkA pathway activity and eEF1A1 expression in the rat cerebellum  Toxicol Appl Pharmacol  2016  298:1-8  PubMed ID: 26965727
10925    Limonene Enhances the cAMP Response Element (CRE)-Dependent Transcriptional Activity Activated via Adenosine A2 A Receptor in a Neural-Crest Derived Cell Line, PC-12  Planta Med Int Open  2016  3: e60–e63 
10927    Sub-micrometer-scale wire-based intracellular metal microelectrode  IEEE Xplore  2017   
11111  Sakagami H, Hara Y, Shi H, Iwama S, Nakagawa M, Suzuki H, Tanaka K, Abe T, Tamura N, Takeshima H, Horie N, Kaneko T, Shiratsuchi H, Kaneko T.  Change in Anticancer Drug Sensitivity During Neuronal Differentiation of PC12 Cells.  In Vivo  2018    PubMed ID: 29936457
11143  Mohara M, Kawasaki T, Owada R, Imai T, Kanetaka H, Izumi SI, Tsukiyama K, Nakamura K.  Restoration from polyglutamine toxicity after free electron laser irradiation of neuron-like cells.  Neurosci. Lett.  2018    PubMed ID: 30044955
11215  Oguro A, Inoue T, Kudoh SN, Imaoka S.  14,15-epoxyeicosatrienoic acid produced by cytochrome P450s enhances neurite outgrowth of PC12 and rat hippocampal neuronal cells.  Pharmacol Res Perspect  2018    PubMed ID: 30237892
11214  Koh I, Furusawa K, Haga H.  Anisotropic Multi-channel Collagen Gel (MCCG) Guides the Growth Direction of the Neurite-like Processes of PC12 Cells.  Sci Rep  2018    PubMed ID: 30224813
11110  Hara Y, Sakagami H, Shi H, Abe T, Tamura N, Takeshima H, Horie N, Kaneko T, Shiratsuchi H, Kaneko T.  Partial Protection of Paclitaxel-induced Neurotoxicity by Antioxidants.  In Vivo  2018    PubMed ID: 29936454
11255  Sano A, Shi H, Suzuki R, Shirataki Y, Sakagami H.  Change in Amino Acid Pools During Neuronal Differentiation of PC12 Cells.  In Vivo  2018    PubMed ID: 30348694
11262  Jamal M, Tsukamoto I, Takata M, Ito A, Tanaka N, Miki T, Takakura A, Ameno K, Kubota Y, Konishi R, Kinoshita H.  COA-Cl induces dopamine release and tyrosine hydroxylase phosphorylation: In vivo reverse microdialysis and in vitro analysis.  Brain Res.  2019    PubMed ID: 30366020
11277  Nishizaki T.  Profilin facilitates PKCε activation by accelerating ATP supply.  Biochem. Biophys. Res. Commun.  2018    PubMed ID: 30392913
11287  Nishizaki T.  Fe3+ Facilitates Endocytic Internalization of Extracellular Aβ1-42 and Enhances Aβ1-42-Induced Caspase-3/Caspase-4 Activation and Neuronal Cell Death.  Mol. Neurobiol.  2018    PubMed ID: 30402707
11344  Terada K, Migita K, Matsushima Y, Sugimoto Y, Kamei C, Matsumoto T, Mori M, Matsunaga K, Takata J, Karube Y.  Cholinesterase inhibitor rivastigmine enhances nerve growth factor-induced neurite outgrowth in PC12 cells via sigma-1 and sigma-2 receptors.  PLoS ONE  2018    PubMed ID: 30557385
11420  Yamamoto M, Shinoda K, Sasaki D, Kanai M, Sohma Y.  Design and properties of [Met35(O)]Aβ42-lactam(Asp23/Lys28) possessing a lactam tether as a salt-bridge surrogate.  Bioorg. Med. Chem.  2019    PubMed ID: 30733085
11406  Katsuyama Y, Taira N, Tsuboi T, Yoshioka M, Okano Y, Masaki H.  3-O-Laurylglyceryl ascorbate improves the development of sensitive skin through the reduction of oxidative stress.  Exp. Dermatol.  2019    PubMed ID: 30698879
11488  Matsushima Y, Terada K, Kamei C, Sugimoto Y.  Sertraline inhibits nerve growth factor-induced neurite outgrowth in PC12 cells via a mechanism involving the sigma-1 receptor.  Eur. J. Pharmacol.  2019    PubMed ID: 30902656
4436    Enhancement of PC12 axonal extension via hybrid electromagnetic and mechanical stimulation  The Japan Society of Mechanical Engineers  2018  13,18-00024-18-00024 
4439  Takanobu Haccho, Hiroshi Ichikawa, Koji Yamamoto, Yusuke Morita and Eiji Nakamachi  Development of Chemotherapy System Using Plasma Activated Medium to Enhance PC12 Axonal Extension  ASME 2018 International Mechanical Engineering Congress and Exposition  2018  3 
4315  Sun Z, Liu Y, Kong X, Wang R, Xu Y, Shang C, Huo J, Huang M, Zhao F, Bian K, Zhang S, Tu Y, Chen X.  Exendin-4 Plays a Protective Role in a Rat Model of Spinal Cord Injury Through SERCA2.  Cell. Physiol. Biochem.  2018    PubMed ID: 29794460
4316  Sakagami H, Shi H, Bandow K, Tomomura M, Tomomura A, Horiuchi M, Fujisawa T, Oizumi T.  Search of Neuroprotective Polyphenols Using the "Overlay" Isolation Method.  Molecules  2018    PubMed ID: 30042342
4317  Nishizaki T.  IL-33 suppresses GSK-3β activation through an ST2-independent MyD88/TRAF6/RIP/PI3K/Akt pathway.  Heliyon  2018    PubMed ID: 30533546
4318  Matsushima Y, Terada K, Takata J, Karube Y, Kamei C, Sugimoto Y.  Effects of fluvoxamine on nerve growth factor-induced neurite outgrowth inhibition by dexamethasone in PC12 cells.  Biosci. Biotechnol. Biochem.  2019    PubMed ID: 30543144
4381  Ohta M, Chosa N, Kyakumoto S, Yokota S, Okubo N, Nemoto A, Kamo M, Joh S, Satoh K, Ishisaki A.  IL‑1β and TNF‑α suppress TGF‑β‑promoted NGF expression in periodontal ligament‑derived fibroblasts through inactivation of TGF‑β‑induced Smad2/3‑ and p38 MAPK‑mediated signals.  Int. J. Mol. Med.  2018    PubMed ID: 29901090
4495  Masami Ishido  An Overview of Development of Quantitative Neurotoxicity Testing In vitro  Journal of Applied Life Sciences International  2018  19(2):1-9 



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