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HPS0002 : 253G1  update : 2019/09/06
CommentHuman iPS cell line. HPS0063 and HPS0076 were derived from the same patient. Order Form (C-0042, C-0034). Please see CiRA , Kyoto University if you are a researcher at a for-profit organization.
Comment from the depositor
Terms and conditions1) The RECIPIENT belongs to a not-for-profit academic organization (i.e., a university or another institution of higher education or any nonprofit scientific or educational organization, including government agencies). 2) Attach TERMS and CONDITIONS to MTA (C-0034) .
Remarks
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor http://www.cira.kyoto-u.ac.jp/
Originator Yamanaka, Shinya
Year of deposit 2008
Animal human < Mammals
Genus Homo
Species sapiens
Race Caucasian
Gender Female
Age at sampling 36 years
Tissue skin
Classification iPS
Recombinant recombinant
Exogene pMXs, Oct3/4, Sox2, Klf4, pLenti6/UbC/V5-DEST, mouse Slc7a1
Lifespan infinite
Morphology ES-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives Primate ES Cell Medium + 4ng/ml human basic FGF
Antibiotics Free
Passage method 0.25% trypsin + 0.1% collagenase type IV + 20% KSR + 1mM CaCl2 + PBS(-)
Coating dish 0.1% gelatin coated dish
Culture information Passage ratio 1 : 3-6 split
SC frequency Subculture : once/4-5 days, Medium Renewal : every day
Temperature 37 ℃
CO2 concentration 5 %
Feeder cells SNL 76/7
Feeder treatment X-rays 5000R (or MMC)
Feeder seed cells 1.5-2.5 x 10^(6) cells/100 mm dish
Freeze medium DAP213 : Medium + 2M DMSO + 1M Acetamide + 3M Propyleneglycol
Freezing method Vitrification
Mycoplasma (-)
STR (human) OK
Chromosome mode 46XX(20)
Images
deposit info
lot info
Relational File deposit infolot info
SDS_DAP(MEM)_Japanese.pdf
Reference information Reference 1
User's Publication 83


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Reference
3673  Nakagawa M, Koyanagi M, Tanabe K, Takahashi K, Ichisaka T, Aoi T, Okita K, Mochiduki Y, Takizawa N, Yamanaka S.  Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts.  Nat Biotechnol  2008  26(1):101-6  PubMed ID: 18059259

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User's Publication
7038  Liu L, Kamei KI, Yoshioka M, Nakajima M, Li J, Fujimoto N, Terada S, Tokunaga Y, Koyama Y, Sato H, Hasegawa K, Nakatsuji N, Chen Y.  Nano-on-micro fibrous extracellular matrices for scalable expansion of human ES/iPS cells.  Biomaterials  2017  124:47-54  PubMed ID: 28187394
7047  Numaga-Tomita T, Kitajima N, Kuroda T, Nishimura A, Miyano K, Yasuda S, Kuwahara K, Sato Y, Ide T, Birnbaumer L, Sumimoto H, Mori Y, Nishida M.  TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis.  Sci Rep  2016  6:39383  PubMed ID: 27991560
7080  Hayashi R, Ishikawa Y, Sasamoto Y, Katori R, Nomura N, Ichikawa T, Araki S, Soma T, Kawasaki S, Sekiguchi K, Quantock AJ, Tsujikawa M, Nishida K.  Co-ordinated ocular development from human iPS cells and recovery of corneal function.  Nature  2016  531:376-80  PubMed ID: 26958835
7083  Matsuura K, Seta H, Haraguchi Y, Alsayegh K, Sekine H, Shimizu T, Hagiwara N, Yamazaki K, Okano T.  TRPV-1-mediated elimination of residual iPS cells in bioengineered cardiac cell sheet tissues.  Sci Rep  2016  6:21747  PubMed ID: 26888607
7271  Fujiwara N, Shimizu J, Takai K, Arimitsu N, Ueda Y, Wakisaka S, Suzuki T, Suzuki N.  Cellular and molecular mechanisms of the restoration of human APP transgenic mouse cognitive dysfunction after transplant of human iPS cell-derived neural cells.  Exp. Neurol.  2015  271:423-31  PubMed ID: 26196079
7518  Kagawa Y, Matsuura K, Shimizu T, Tsuneda S.  Direct measurement of local dissolved oxygen concentration spatial profiles in a cell culture environment.  Biotechnol. Bioeng.  2015  112:1263-74  PubMed ID: 25565074
7542  M Iinuma, T Umehara, N Arimitsu, J Shimizu, H Misawa, K Takai, N Fujiwara, A Fujii, Y Ueda, S Wakisaka, T Suzuki, C Hirotsu, M Beppu, N Suzuki  Induction of neural cells with spinal motoneuron phenotype from human iPS cells and the trans-plantation to totally transected spinal cords in mice.  Inflammation and Regeneration  2015  35:154-163 
7562  Takuya Kuroda, Satoshi Yasuda, Satoko Matsuyama a, Keiko Tano, Shinji Kusakawa, Yoshiki Sawa, Shin Kawamata, Yoji Sato  Highly sensitive droplet digital PCR method for detection of residual undifferentiated cells in cardiomyocytes derived from human pluripotent stem cells.  Regenerative Therapy  2015  2:17-23 
7597  Teramura T, Takehara T, Onodera Y, Nakagawa K, Hamanishi C, Fukuda K.  Mechanical stimulation of cyclic tensile strain induces reduction of pluripotent related gene expressions via activation of Rho/ROCK and subsequent decreasing of AKT phosphorylation in human induced pluripotent stem cells.  Biochem. Biophys. Res. Commun.  2012  417:836-41  PubMed ID: 22206673
7771  Ogawa S, Tokumoto Y, Miyake J, Nagamune T.  Induction of oligodendrocyte differentiation from adult human fibroblast-derived induced pluripotent stem cells.  In Vitro Cell. Dev. Biol. Anim.  2011  47:464-9  PubMed ID: 21695581
9539  Amano Y, Nishiguchi A, Matsusaki M, Iseoka H, Miyagawa S, Sawa Y, Seo M, Yamaguchi T, Akashi M.  Development of vascularized iPSC derived 3D-cardiomyocyte tissues by filtration Layer-by-Layer technique and their application for pharmaceutical assays.  Acta Biomater  2016  33:110-21  PubMed ID: 26821339
9674  Yamada S, Asanagi M, Hirata N, Itagaki H, Sekino Y, Kanda Y.  Tributyltin induces mitochondrial fission through Mfn1 degradation in human induced pluripotent stem cells.  Toxicol In Vitro  2016  34:257-63  PubMed ID: 27133438
9686  Konagaya S, Iwata H.  Reproducible preparation of spheroids of pancreatic hormone positive cells from human iPS cells: An in vitro study.  Biochim. Biophys. Acta  2016  1860:2008-16  PubMed ID: 27180174
9814  Suga M, Tachikawa S, Tateyama D, Ohnuma K, Furue MK.  Imaging-cytometry revealed spatial heterogeneities of marker expression in undifferentiated human pluripotent stem cells.  In Vitro Cell. Dev. Biol. Anim.  2017  53:83-91  PubMed ID: 27573412
9838  Tomotsune D, Hirashima K, Fujii M, Yue F, Matsumoto K, Takizawa-Shirasawa S, Yokoyama T, Sasaki K.  Enrichment of Pluripotent Stem Cell-Derived Hepatocyte-Like Cells by Ammonia Treatment.  PLoS ONE  2016  11:e0162693  PubMed ID: 27632182
10071  Kamao H, Mandai M, Ohashi W, Hirami Y, Kurimoto Y, Kiryu J, Takahashi M.  Evaluation of the Surgical Device and Procedure for Extracellular Matrix-Scaffold-Supported Human iPSC-Derived Retinal Pigment Epithelium Cell Sheet Transplantation.  Invest. Ophthalmol. Vis. Sci.  2017  58:211-220  PubMed ID: 28114582
10089  Burden ML, Burden AC.  The American Diabetes Association screening questionnaire for diabetes. Is it worthwhile in the U.K.?  Diabetes Care  1994  17:97  PubMed ID: 8112198
10308  Iseoka H, Miyagawa S, Fukushima S, Saito A, Masuda S, Yajima S, Ito E, Sougawa N, Takeda M, Harada A, Lee JK, Sawa Y.  Pivotal Role of Non-cardiomyocytes in Electromechanical and Therapeutic Potential of Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissue.  Tissue Eng Part A  2018  24:287-300  PubMed ID: 28498040
10426  Tateno H, Saito S.  Engineering of a Potent Recombinant Lectin-Toxin Fusion Protein to Eliminate Human Pluripotent Stem Cells.  Molecules  2017  22:  PubMed ID: 28698527
10503  Suzuki T, Shimizu Y, Furuhata E, Maeda S, Kishima M, Nishimura H, Enomoto S, Hayashizaki Y, Suzuki H.  RUNX1 regulates site specificity of DNA demethylation by recruitment of DNA demethylation machineries in hematopoietic cells.  Blood Adv  2017  1:1699-1711  PubMed ID: 29296817
10737  Kato Y, Kim MH, Kino-Oka M.  Comparison of growth kinetics between static and dynamic cultures of human induced pluripotent stem cells.  J. Biosci. Bioeng.  2018    PubMed ID: 29398548
10891    Human iPS cell derived neural cell sheets exhibit mature neural and extendable scaffold functions and promote recovery in injured mouse spinal cords  J Stem Cell Res Med  2016  1: 41-47 
10933    Impairment of the transition from proliferative stage to prehypertrophic stage in chondrogenic differentiation of human induced pluripotent stem cells harboring the causative mutation of achondroplasia in fibroblast growth factor receptor 3  Regenerative Therapy  2017  6, 15-20  PubMed ID: 30271835
11171  Yamada S, Kubo Y, Yamazaki D, Sekino Y, Nomura Y, Yoshida S, Kanda Y.  Tributyltin Inhibits Neural Induction of Human Induced Pluripotent Stem Cells.  Sci Rep  2018    PubMed ID: 30108368
11235  Yoda K, Ohnuki Y, Kurosawa H.  Optimization of the treatment conditions with glycogen synthase kinase-3 inhibitor towards enhancing the proliferation of human induced pluripotent stem cells while maintaining an undifferentiated state under feeder-free conditions.  J. Biosci. Bioeng.  2018    PubMed ID: 30292671
11234  Yasuda S, Kusakawa S, Kuroda T, Miura T, Tano K, Takada N, Matsuyama S, Matsuyama A, Nasu M, Umezawa A, Hayakawa T, Tsutsumi H, Sato Y.  Tumorigenicity-associated characteristics of human iPS cell lines.  PLoS ONE  2018    PubMed ID: 30286143
11325  Yamada S, Yamazaki D, Kanda Y.  5-Fluorouracil inhibits neural differentiation via Mfn1/2 reduction in human induced pluripotent stem cells.  J Toxicol Sci  2018    PubMed ID: 30518710
11400  Konagaya S, Iwata H.  Chemically defined conditions for long-term maintenance of pancreatic progenitors derived from human induced pluripotent stem cells.  Sci Rep  2019    PubMed ID: 30679498
11424  Dion J, Minoshima F, Saito S, Kiyoi K, Hasehira K, Tateno H.  Photoactivable elimination of tumorigenic human induced pluripotent stem cells using a lectin-doxorubicin prodrug conjugate.  Chembiochem  2019    PubMed ID: 30737871
11482  Matsumoto E, Koide N, Hanzawa H, Kiyama M, Ohta M, Kuwabara J, Takeda S, Takahashi M.  Fabricating retinal pigment epithelial cell sheets derived from human induced pluripotent stem cells in an automated closed culture system for regenerative medicine.  PLoS ONE  2019    PubMed ID: 30865653
4069  Tadashi Kosawada, Email author Keita, Ohnishi, Hiroaki Satoh, Zhong-gang Feng, Kaoru Goto  Novel methods to apply micro dynamic stimulations on cultured adhesive cells and its application in constructing gel-embedded three-dimensional neuronal structures differentiated from human iPS cells  Microsystem Technologies  2018  24:625–638 
4113  Shoji M, Minato H, Ogaki S, Seki M, Suzuki Y, Kume S, Kuzuhara T.  Different murine-derived feeder cells alter the definitive endoderm differentiation of human induced pluripotent stem cells.  PLoS ONE  2018    PubMed ID: 30048506
4116  Uto S, Nishizawa S, Hikita A, Takato T, Hoshi K.  Application of induced pluripotent stem cells for cartilage regeneration in CLAWN miniature pig osteochondral replacement model.  Regen Ther  2018    PubMed ID: 30525076
4117  Csobonyeiova M, Polak S, Danisovic L.  Generation of Pancreatic β-cells From iPSCs and their Potential for Type 1 Diabetes Mellitus Replacement Therapy and Modelling.  Exp. Clin. Endocrinol. Diabetes  2018    PubMed ID: 30114722
4463  Masuda S, Matsuura K, Shimizu T.  Preparation of iPS cell-derived CD31<sup>+</sup> endothelial cells using three-dimensional suspension culture.  Regen Ther  2018  9:1-9  PubMed ID: 30525069
4464  Takeda M, Miyagawa S, Fukushima S, Saito A, Ito E, Harada A, Matsuura R, Iseoka H, Sougawa N, Mochizuki-Oda N, Matsusaki M, Akashi M, Sawa Y.  Development of In Vitro Drug-Induced Cardiotoxicity Assay by Using Three-Dimensional Cardiac Tissues Derived from Human Induced Pluripotent Stem Cells.  Tissue Eng Part C Methods  2018  24(1):56-67  PubMed ID: 28967302
4572  Kuroda T, Yasuda S, Tachi S, Matsuyama S, Kusakawa S, Tano K, Miura T, Matsuyama A, Sato Y.  SALL3 expression balance underlies lineage biases in human induced pluripotent stem cell differentiation.  Nat Commun  2019  10(1):2175  PubMed ID: 31092818
5449  Tateno H, Onuma Y, Ito Y, Minoshima F, Saito S, Shimizu M, Aiki Y, Asashima M, Hirabayashi J.  Elimination of tumorigenic human pluripotent stem cells by a recombinant lectin-toxin fusion protein.  Stem Cell Reports  2015  4(5):811-20  PubMed ID: 25866158
5750  Kumazaki T, Kurata S, Matsuo T, Mitsui Y, Takahashi T.  Establishment of human induced pluripotent stem cell lines from normal fibroblast TIG-1.  Hum Cell  2011  24(2):96-103  PubMed ID: 21562774
5702  Hayashi R, Ishikawa Y, Ito M, Kageyama T, Takashiba K, Fujioka T, Tsujikawa M, Miyoshi H, Yamato M, Nakamura Y, Nishida K.  Generation of corneal epithelial cells from induced pluripotent stem cells derived from human dermal fibroblast and corneal limbal epithelium.  PLoS One  2012  7(9):e45435  PubMed ID: 23029008
5706  Otsuji TG, Kurose Y, Suemori H, Tada M, Nakatsuji N.  Dynamic link between histone H3 acetylation and an increase in the functional characteristics of human ESC/iPSC-derived cardiomyocytes.  PLoS One  2012  7(9):e45010  PubMed ID: 22984602
5710  Fujiwara N, Shimizu J, Takai K, Arimitsu N, Saito A, Kono T, Umehara T, Ueda Y, Wakisaka S, Suzuki T, Suzuki N.  Restoration of spatial memory dysfunction of human APP transgenic mice by transplantation of neuronal precursors derived from human iPS cells.  Neurosci Lett  2013  557 Pt B:129-34  PubMed ID: 24466594
5714  Onuma Y, Tateno H, Hirabayashi J, Ito Y, Asashima M.  rBC2LCN, a new probe for live cell imaging of human pluripotent stem cells.  Biochem Biophys Res Commun  2013  431(3):524-9  PubMed ID: 23321312
5722  Guo CW, Kawakatsu M, Idemitsu M, Urata Y, Goto S, Ono Y, Hamano K, Li TS.  Culture under low physiological oxygen conditions improves the stemness and quality of induced pluripotent stem cells.  J Cell Physiol  2013  228(11):2159-66  PubMed ID: 23589166
5725  Imaizumi K, Nishishita N, Muramatsu M, Yamamoto T, Takenaka C, Kawamata S, Kobayashi K, Nishikawa S, Akuta T.  A simple and highly effective method for slow-freezing human pluripotent stem cells using dimethyl sulfoxide, hydroxyethyl starch and ethylene glycol.  PLoS One  2014  9(2):e88696  PubMed ID: 24533137
5729  Matsuura K, Kodama F, Sugiyama K, Shimizu T, Hagiwara N, Okano T.  Elimination of remaining undifferentiated induced pluripotent stem cells in the process of human cardiac cell sheet fabrication using a methionine-free culture condition.  Tissue Eng Part C Methods  2015  21(3):330-8  PubMed ID: 25245976
5732  Tokunaga K, Saitoh N, Goldberg IG, Sakamoto C, Yasuda Y, Yoshida Y, Yamanaka S, Nakao M.  Computational image analysis of colony and nuclear morphology to evaluate human induced pluripotent stem cells.  Sci Rep  2014  4:6996  PubMed ID: 25385348
5733  Ohnuma K, Fujiki A, Yanagihara K, Tachikawa S, Hayashi Y, Ito Y, Onuma Y, Chan T, Michiue T, Furue MK, Asashima M  Enzyme-free passage of human pluripotent stem cells by controlling divalent cations.  Sci Rep  2014  4:4646  PubMed ID: 24721898
5734  Tateno H, Onuma Y, Ito Y, Hiemori K, Aiki Y, Shimizu M, Higuchi K, Fukuda M, Warashina M, Honda S, Asashima M, Hirabayashi J.  A medium hyperglycosylated podocalyxin enables noninvasive and quantitative detection of tumorigenic human pluripotent stem cells.  Sci Rep  2014  4:4069  PubMed ID: 24518842
5735  Yamada R, Hattori K, Tachikawa S, Tagaya M, Sasaki T, Sugiura S, Kanamori T, Ohnuma K.  Control of adhesion of human induced pluripotent stem cells to plasma-patterned polydimethylsiloxane coated with vitronectin and γ-globulin.  J Biosci Bioeng  2014  118(3):315-22  PubMed ID: 24656306
5741  Tano K, Yasuda S, Kuroda T, Saito H, Umezawa A, Sato Y.  A novel in vitro method for detecting undifferentiated human pluripotent stem cells as impurities in cell therapy products using a highly efficient culture system.  PLoS One  2014  9(10):e110496  PubMed ID: 25347300
5745  Luo L, Kawakatsu M, Guo CW, Urata Y, Huang WJ, Ali H, Doi H, Kitajima Y, Tanaka T, Goto S, Ono Y, Xin HB, Hamano K, Li TS.  Effects of antioxidants on the quality and genomic stability of induced pluripotent stem cells.  Sci Rep  2014  4:3779  PubMed ID: 24445363
5752  Onuma Y, Higuchi K, Aiki Y, Shu Y, Asada M, Asashima M, Suzuki M, Imamura T, Ito Y.  A stable chimeric fibroblast growth factor (FGF) can successfully replace basic FGF in human pluripotent stem cell culture.  PLoS One  2015  10(4):e0118931  PubMed ID: 25850016
5753  Komatsu M, Konagaya S, Egawa EY, Iwata H.  Maturation of human iPS cell-derived dopamine neuron precursors in alginate-Ca(2+) hydrogel.  Biochim Biophys Acta  2015  1850(9):1669-75  PubMed ID: 25952075
5755  Konagaya S, Iwata H.  Microencapsulation of dopamine neurons derived from human induced pluripotent stem cells.  Biochim Biophys Acta  2015  1850(1):22-32  PubMed ID: 25281770
5757  Haraguchi Y, Matsuura K, Shimizu T, Yamato M, Okano T.  Simple suspension culture system of human iPS cells maintaining their pluripotency for cardiac cell sheet engineering.  J Tissue Eng Regen Med  2015  9(12):1363-75  PubMed ID: 23728860
5765  Tateno H et al  Development of a practical sandwich assay to detect human pluripotent stem cells using cell culture media.  Regen Ther  2017  6:1-8  PubMed ID: 30271833
5767  Ito M, Sun S, Fukuhara T, Suzuki R, Tamai M, Yamauchi T, Nakashima K, Tagawa Y, Okazaki S, Matsuura Y, Wakita T, Suzuki T.  Development of hepatoma-derived, bidirectional oval-like cells as a model to study host interactions with hepatitis C virus during differentiation.  Oncotarget  2017  8(33):53899-53915  PubMed ID: 28903311
5768  Alsayegh K, Matsuura K, Sekine H, Shimizu T.  Dinaciclib potently suppresses MCL-1 and selectively induces the cell death in human iPS cells without affecting the viability of cardiac tissue.  Sci Rep  2017  7:45577  PubMed ID: 28361959
5774  Miyagoe-Suzuki Y, Nishiyama T, Nakamura M, Narita A, Takemura F, Masuda S, Minami N, Murayama K, Komaki H, Goto YI, Takeda S.  Induction of Pluripotent Stem Cells from a Manifesting Carrier of Duchenne Muscular Dystrophy and Characterization of Their X-Inactivation Status.  Stem Cells Int  2017  2017:7906843  PubMed ID: 28491099
5773  Kim MH, Matsubara Y, Fujinaga Y, Kino-Oka M.  A Simple and Robust Method for Culturing Human-Induced Pluripotent Stem Cells in an Undifferentiated State Using Botulinum Hemagglutinin.  Biotechnol J  2018  13(2)  PubMed ID: 29027750
5777  Nakashima Y, Miyagi-Shiohira C, Noguchi H2, Omasa T.  Atorvastatin Inhibits the HIF1α-PPAR Axis, Which Is Essential for Maintaining the Function of Human Induced Pluripotent Stem Cells.  Mol Ther  2018  26(7):1715-1734  PubMed ID: 29929789
5779  Takenaka C, Nishishita N, Takada N, Jakt LM, Kawamata S.  Effective generation of iPS cells from CD34+ cord blood cells by inhibition of p53.  Exp Hematol  2010  38(2):154-62  PubMed ID: 19922768
5780  Nishigaki T, Teramura Y, Nasu A, Takada K, Toguchida J, Iwata H.  Highly efficient cryopreservation of human induced pluripotent stem cells using a dimethyl sulfoxide-free solution.  Int J Dev Biol  2011  55(3):305-11  PubMed ID: 21710436
5781  Matsuura K, Wada M, Shimizu T, Haraguchi Y, Sato F, Sugiyama K, Konishi K, Shiba Y, Ichikawa H, Tachibana A, Ikeda U, Yamato M, Hagiwara N, Okano T.  Creation of human cardiac cell sheets using pluripotent stem cells.  Biochem Biophys Res Commun  2012  425(2):321-7  PubMed ID: 22842572
5782  Ueda Y, Fujita S, Nishigaki T, Arima Y, Iwata H.  Substrates for human pluripotent stem cell cultures in conditioned medium of mesenchymal stem cells.  J Biomater Sci Polym Ed  2012  23(1-4):153-65  PubMed ID: 22133351
5783  Kanemura H, Go MJ, Nishishita N, Sakai N, Kamao H, Sato Y, Takahashi M, Kawamata S.  Pigment epithelium-derived factor secreted from retinal pigment epithelium facilitates apoptotic cell death of iPSC.  Sci Rep  2013  3:2334  PubMed ID: 23903667
5784  Hiroyuki KAMAO, Junko ISHIDA, Taiji SUDA, Junichi KIRYU  Generation of retinal pigment epithelium from human induced pluripotent stem cells showed polarized secretion of VEGF and PEDF.  Kawasaki Medical Journal   2013  39:155-162 
5785  Kamao H, Mandai M, Okamoto S, Sakai N, Suga A, Sugita S, Kiryu J, Takahashi M  Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application.  Stem Cell Reports  2014  2(2):205-18  PubMed ID: 24527394
5786  Sekine K, Kagawa Y, Maeyama E, Ota H, Haraguchi Y, Matsuura K, Shimizu T.  Oxygen consumption of human heart cells in monolayer culture.  Biochem Biophys Res Commun  2014  452(3):834-9.   PubMed ID: 25218502
5787  Kamao H, Mandai M, Wakamiya S, Ishida J, Goto K, Ono T, Suda T, Takahashi M, Kiryu J.  Objective evaluation of the degree of pigmentation in human induced pluripotent stem cell-derived RPE.  Invest Ophthalmol Vis Sci  2014  55(12):8309-18.  PubMed ID: 25389202
5788  Toriumi T, Takayama N, Murakami M, Sato M, Yuguchi M, Yamazaki Y, Eto K, Otsu M, Nakauchi H, Shirakawa T, Isokawa K, Honda MJ.  Characterization of mesenchymal progenitor cells in the crown and root pulp of primary teeth.  Biomed Res  2015  36(1):31-45  PubMed ID: 25749149
5789  Takaki Shiratsuchi, Hiroko Misawa, Asako Saito, Jun Shimizu, Masahiro Iinuma, Naruyoshi Fujiwara, Kenji Takai, Nagisa Arimitsu, Yuji Ueda, Sueshige Wakisaka, Tomoko Suzuki, Moroe Beppu, Noboru Suzuki  Sonic Hedgehog Supplementation Rapidly induces Myogenesis in Human Induced Pluripotent Stem Cells  Journal of St. Marianna University  2015  6:225-233 
5790  Konagaya S, Ando T, Yamauchi T, Suemori H, Iwata H.  Long-term maintenance of human induced pluripotent stem cells by automated cell culture system.  Sci Rep  2015  5:16647  PubMed ID: 26573336
5792  Nagaoka M, Kobayashi M, Kawai C, Mallanna SK, Duncan SA.  Design of a Vitronectin-Based Recombinant Protein as a Defined Substrate for Differentiation of Human Pluripotent Stem Cells into Hepatocyte-Like Cells.  PLoS One  2015  10(8):e0136350  PubMed ID: 26308339
5793  Arai D, Hayakawa K, Ohgane J, Hirosawa M, Nakao Y, Tanaka S, Shiota K.  An epigenetic regulatory element of the Nodal gene in the mouse and human genomes.  Mech Dev  2015  136:143-54  PubMed ID: 25528267
5794  Mitsui K, Ide K, Takayama A, Wada T, Irie R, Kosai K.  Conditionally replicating adenovirus prevents pluripotent stem cell-derived teratoma by specifically eliminating undifferentiated cells.  Mol Ther Methods Clin Dev  2015  2:15026  PubMed ID: 26269798
5795  Shigeru Yamada Yusuke Kubo Daiju Yamazaki Yuko Sekino and Yasunari Kandaa  Chlorpyrifos inhibits neural induction via Mfn1-mediated mitochondrial dysfunction in human induced pluripotent stem cells  Sci Rep.   2017  7:40925.  PubMed ID: 28112198
5796  Komae H, Sekine H, Dobashi I, Matsuura K, Ono M, Okano T, Shimizu T.  Three-dimensional functional human myocardial tissues fabricated from induced pluripotent stem cells.  J Tissue Eng Regen Med  2017  11(3):926-935  PubMed ID: 25628251
5797  Arauchi A, Matsuura K, Shimizu T, Okano T.  Functional Thyroid Follicular Cells Differentiation from Human-Induced Pluripotent Stem Cells in Suspension Culture.  Front Endocrinol (Lausanne)  2017  8:103  PubMed ID: 28588551
5798  Mihara Y, Matsuura K, Sakamoto Y, Okano T, Kokudo N, Shimizu T.  Production of pancreatic progenitor cells from human induced pluripotent stem cells using a three-dimensional suspension bioreactor system.  J Tissue Eng Regen Med  2017  11(11):3193-3201  PubMed ID: 28317340
5799  Yasuda SY1, Ikeda T1,Shahsavarani H, Yoshida N, Nayer B, Hino M, Vartak-Sharma N, Suemori H, Hasegawa K.  Chemically defined and growth-factor-free culture system for the expansion and derivation of human pluripotent stem cells.  Nat Biomed Eng  2018  2(3):173-182  PubMed ID: 31015717
5800  Sakai T et al  Phenotypic Screening Using Patient-Derived Induced Pluripotent Stem Cells Identified Pyr3 as a Candidate Compound for the Treatment of Infantile Hypertrophic Cardiomyopathy.  Int Heart J  2018  59(5):1096-1105  PubMed ID: 30101858



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